1,721,033 research outputs found
Farmaci antidepressivi, intervallo QT e rischio cardiovascolare. Timori fondati?
No full textOver the last 20 years there were multiple initiatives of Regulatory
Agencies, both in the U.S. (FDA) and in Europe (EMA),
which created disconcert and alarm in the world of psychiatry.
Most often these initiatives have involved interactions, considered
potentially dangerous, between antipsychotics or antidepressants
and cardiovascular risks. The latest were related to
two drugs known to be effective antidepressants such as citalopram
(by FDA) and its active enantiomer, escitalopram (only by
the EMA), in connection with a possible lengthening of the QT
interval. This critical review, which provides the joint opinion
of a cardiologist and a psychiatrist both with specific expertise,
aims to put into perspective the actions of regulatory agencies
regarding the association between antidepressants, QT interval
and cardiac arrhythmias; to review the physiological basis and
mechanisms underlying this issue; to critically analyze the relevant
evidences and the other cardiovascular effects of these
drugs, and to draw reasonable conclusions for psychiatrists who
treat depressed patients
Duration of untreated illness in major depressive disorder: a naturalistic study
No full textBACKGROUND:
Most of the studies on the duration of untreated illness (DUI) as a possible predictor of the clinical outcome and the course have focused on the psychotic disorders. The present naturalistic study was aimed to evaluate the possible relationship between the DUI and some clinical characteristics of a sample of patients with major depressive disorder (MDD).
METHODS:
Sixty-eight patients with MDD, according to the Diagnostic and Statistical Manual of Mental Disorders, IV Edition, Text Revision (DSM-IV-TR) criteria, followed-up for 4 years, were selected, interviewed and their clinical charts reviewed. The DUI was defined as the interval between the onset of the first major depressive episode and the first adequate antidepressant treatment. The sample was divided in two groups according to a DUI 12 months (n = 23). The main demographic and clinical course variables were compared between the two groups using t-tests or chi-squared tests.
RESULTS:
Patients with a DUI > 12 months were more frequently women (chi2 = 4.005, p = 0.045), had an earlier onset (t = 2.515, p = 0.014), a longer duration of illness (t = -2.483, p = 0.016), a higher number of recurrences (t = -2.262, p = 0.027) and had more frequently comorbid Axis I disorders with onset later than MDD (chi2 = 5.595, p = 0.05).
CONCLUSIONS:
These findings suggest that a longer DUI may negatively influence the clinical course of MDD. Further studies on larger samples are warranted to confirm these preliminary results
Long-term outcome of panic disorders with and without agoraphobia. Results from a naturalistic study
No full textSintomi depressivi subclinici ricorrenti e depressione ricorrente breve in un campione di popolazione generale
No full text
Uno studio retrospettivo in pazienti con Depressione Maggiore Ricorrente: remisisone, ricadute, cronicizzazione e depressioni ricorrenti brevi
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