10 research outputs found
An investigation of the predictors of rejection and infection in the elderly kidney transplant recipients
No full textThe incidence of end-stage renal disease (ESRD) increases with age.
Transplantation is the treatment of choice for most patients with ESRD and improves
both the survival and quality of life of the older transplant recipients when compared
with dialysis. However, it is also associated with morbidity consequent to the
necessary pharmacological manipulation of the immune system, including infection
and malignancy. There is little evidence to inform any particular immunosuppression
regimen in older kidney transplant recipients. A United States(US) cross-specialist
working group recommended that future research directions include investigation of
the critical immune mechanisms that change with age, the need for
immunosuppressive strategies to vary by age and be based on measures of immune
exhaustion, investigation of clinical or laboratory parameters that could guide IS in
older adults and potential development of novel measures of immune status that
could be more valuable or informative in older adults.
In this thesis, I describe the existing literature on infection and frailty in older kidney
transplant recipients and confirm the existing evidence that older transplant
recipients (> 60 years) are at significantly increased risk of viral infections,
particularly cytomegalovirus (CMV), post-transplantation. This can lead to increased
frequency of hospitalization, frailty, and increased mortality. I then identified clinical
parameters that could predict outcomes and demonstrated that frailty before
transplantation in this cohort (>60 years old at the time of transplantation) is
associated with an increased risk of infections, particularly CMV, infection-related
hospitalization, and graft failure. Finally, I looked at laboratory parameters, in
particular a ratio of Interleukin-10(IL-10+) and tumour necrosis factor-α(TNF-α+) cells
within transitional B cells, which have been shown to predict transplant outcomes
based on recent evidence. Transitional B cell IL-10/TNF-α ratio was not affected by
age in this small cohort; however, a larger cohort is needed to study the association
between frailty and infection with transitional B cell cytokines
Urbicide and destruction in Eastern Europe: Warsaw, Mariupol, and Aghdam in comparative analysis
No full textThe term urbicide is generally understood as “violence against the city” or “destruction of the urban,” where urbs means “city” and cide refers to the “killing.” This term applies to a deliberate attempt to destroy a city or urban settlement. However, urbicide represents neither a supplement to mass extermination nor collateral to armed intervention, as its purpose is to ruin the city itself. The term was coined in 1963 by Michael Moorcock and has been widely employed to describe urban restructuring, mostly in Western countries. However, scholars began using this term in the context of destruction beginning with the Balkan Wars in the 1990s, especially after the “Siege of Sarajevo.” Besides the Balkan Wars, different types of urbicide have happened in the Middle East and Eastern Europe, including in post-Soviet countries. The present renewed interest in the topic of urbicide is connected with the wars in Syria and Ukraine. This study focused on the first incident of urbicide in modern warfare, Warsaw during the Second World War, and two recent cases: Mariupol in Ukraine and Aghdam in Azerbaijan. The author, by comparing different cases, posits that a warring party that embarks on urbicide might pursue different goals—not only to destroy a conflicting party’s defense, but also to erase the city’s cultural attribution as well as to prevent the future rehabilitation and return of the pre-war population
Older Kidney Transplant Patients Are Over Immunosuppressed Using Standard Protocols With Differential Sex-Based Complications
No full textBACKGROUND:
Increasing numbers of older patients are undergoing kidney transplantation. While there is evidence for both sex‐ and age‐related immunological variations increasing the risks of immunosuppression (IS), few centers enforce age‐ or sex‐specific IS adjustments.
METHODS:
We investigated outcomes of 148 kidney transplants performed in our center between April 2009 and March 2019 in recipients aged > 60 years and compared them to outcomes in 272 younger recipients (divided into age groups 18–34, 35–49, and 50–60 years), matched for degree of human leukocyte antigen (HLA) sensitization (calculated reaction frequency, cRF), number of donor–recipient HLA mismatches, and cytomegalovirus (CMV) serostatus, all treated with the same IS protocol. Outcomes were time to (i) first episode of biopsy‐proven acute rejection (BPAR), (ii) first CMV viremia within the first 6 months, (iii) incidence of any new‐onset malignancy, and (iv) development of donor‐specific anti‐HLA antibodies (DSAs).
RESULTS:
Overall rates of BPAR were highest in the recipients under the age of 35, but with no evidence of a difference between older age groups. Conversely, the risk of CMV viremia and malignancy was significantly higher in older recipients; in the > 60‐year‐old group, CMV viremia HR: 2.66 (95% CI: 1.49–4.75), and malignancy HR: 7.3 (95% CI: 1.7–31.10) versus the youngest group with little evidence was confounded by comorbidity or donor factors on multivariate analysis. The risk of CMV infection was most marked in the oldest female group, while the risk of malignancy was greatest in older males. The development of DSA was equal across all age groups.
CONCLUSION:
Our data indicate that older recipient age is associated with increased risk of CMV viremia and malignancy after transplantation, suggesting an age‐associated vulnerability to IS, with the risk occurring mostly in older women and older men, respectively. These data support the need to develop age‐ and sex‐specific protocol adjustments
Older Kidney Transplant Patients Are Over Immunosuppressed Using Standard Protocols With Differential Sex‐Based Complications
No full textBackgroundIncreasing numbers of older patients are undergoing kidney transplantation. While there is evidence for both sex- and age-related immunological variations increasing the risks of immunosuppression (IS), few centers enforce age- or sex-specific IS adjustments.MethodsWe investigated outcomes of 148 kidney transplants performed in our center between April 2009 and March 2019 in recipients aged > 60 years and compared them to outcomes in 272 younger recipients (divided into age groups 18–34, 35–49, and 50–60 years), matched for degree of human leukocyte antigen (HLA) sensitization (calculated reaction frequency, cRF), number of donor–recipient HLA mismatches, and cytomegalovirus (CMV) serostatus, all treated with the same IS protocol. Outcomes were time to (i) first episode of biopsy-proven acute rejection (BPAR), (ii) first CMV viremia within the first 6 months, (iii) incidence of any new-onset malignancy, and (iv) development of donor-specific anti-HLA antibodies (DSAs).ResultsOverall rates of BPAR were highest in the recipients under the age of 35, but with no evidence of a difference between older age groups. Conversely, the risk of CMV viremia and malignancy was significantly higher in older recipients; in the > 60-year-old group, CMV viremia HR: 2.66 (95% CI: 1.49–4.75), and malignancy HR: 7.3 (95% CI: 1.7–31.10) versus the youngest group with little evidence was confounded by comorbidity or donor factors on multivariate analysis. The risk of CMV infection was most marked in the oldest female group, while the risk of malignancy was greatest in older males. The development of DSA was equal across all age groups.ConclusionOur data indicate that older recipient age is associated with increased risk of CMV viremia and malignancy after transplantation, suggesting an age-associated vulnerability to IS, with the risk occurring mostly in older women and older men, respectively. These data support the need to develop age- and sex-specific protocol adjustments
External validation of the Berlin equations for estimation of GFR in the elderly
No full textChronic kidney disease prevalence increases markedly with age1 and accurate estimation of GFR is an important issue in older people. The Chronic Kidney Disease Epidemiology Collaboration creatinine equation (CKD-EPIcr)2 and variations including cystatin C (CKD-EPIcys) or both creatinine and cystatin C (CKD-EPIcr-cys)3 have been recommended for estimating GFR.4 Recently, the Berlin Initiative Study (BIS) reported 2 GFR equations specifically developed in older people: BIS1, which uses creatinine, and BIS2, which uses both creatinine and cystatin C.5 Here, we compare how the BIS and CKD-EPI equations perform in a large cohort of older people
Preclinical study of Siddha Drug Bojana Kudori Mathirai for its Ovulation inducing, Hypolipidemic and Anti-oxidant activities
No full textThe trial drug BOJANA KUDORI MATHIRAI is a herbo mineral formulation selected from the Siddha literature of "BOJANA KUDORI MATHIRAI(BKM)" which is quoted in anuboga vaithiya brama ragasiyam part 6, Pg.No.18 Author Munusamy muthaliyar, for the validation of safety, efficacy and therapeutic potency on SOOTHAGA VAAYU for its ovulation inducing, hypo lipidemic, anti oxidant.
❖ The raw drug chukku, perungayam, indhuppu, seeragam, milagu, inji, elumicchai were identified and authenticated by Gunapadam department, Govt. Siddha Medical College, Palayamkottai, Tamil Nadu.
❖ A review of the literatures and lateral research works reveals that all the ingredient of BOJANA KUDORI MATHIRAI traditionally used in treating soothaga vaayu.
❖ The raw materials of drug chukku, perungayam, indhuppu, seeragam, milagu, inji were bought from the ASN drug shop. Lemon was collected from Palyamkottai, Tirunelveli District. All raw drugs were identified and authenticated by the
experts of Gunapadam (Pharmacology), Department in Government Siddha Medical College, Palayamkottai, Tirunelveli District. The specimen samples of the identified raw drugs were presented in laboratory of PG Gunapadam Department for future references. The trail drug was prepared as per the procedure given in the literature of
anuboga vaithiya brama ragasiyam part -6
❖ The Siddha standardization of the trial drug Bojana kudori Mathirai indicates the drug is brown in colour. Organoleptic characters are brown in colour, pleasant odour, salt taste, fine powder in appearance and nice to touch.
❖ Mathirai process of this drug help to change the particle size of drug for its better bio availability.
❖ The Bojana kudori mathirai was screened for various standardization paramaters as per Siddha pharmacopoeial standards. The Preclinical research outcoming of the standardization can be used for evaluating the quality, Purity and efficacy of BKM.
❖ As per modern standardization methods, following parameters were followed. The Physio-chemical analysis, Biochemical analysis, Phyto-chemical analysis, Microbial limit test, Instrumental analysis such as SEM, FT-IR, ICP-OES, XRD and the Experimental analysis such as the Toxicological study and the Pharmacological study.
❖ Physicochemical analysis of BKM shows determination of moisture content it was within acceptable range. It indicates the longer shelf life period. pH of the drug is
7.20. It is very weak base. The ash value of BKM such as total ash, water soluble ash and acid insoluble ash were found to be 10.8%, 9.90%, 0.90%. respectively. Water
soluble ash is higher than the acid insoluble ash value. It represents good quality of the drug.
❖ Biochemical analysis shows the presence of calcium, chloride,Starch, ferrous iron, Phosphate, Unsaturated compounds and amino acid.
❖ Phyto chemicals study shows the presence of these compounds such as terpenoid, dihydro quinidine, coronaridine, linolenic acid, estradiol glucuronide.
❖ Microbial limit test shows that, the total bacterial count and the total fungal count was nill. This indicates that the drug is free from microbial contamination. The
other pathogens like Escherichia coli, Salmonella sps, Staphylococcus aureus and Pseudomonas aeruginosa were found to be completely absent in the drug.
❖ SEM analysis of the BKM shows most of the particles present in the sample are micro size, average particle size is 1μm - 300nm.
❖ FTIR analysis of this drug revealed the presence of alcohol, amides, amines, alkenes,carboxylic acid,aromatic compound, conjugated alkene, nitro compound, aliphatic ether, halogen compound. Alkenes are used as a general anaesthetic. They play in important role in pharmaceutical industries. Alkyl halides have little biological activity. They product against baceteria and fungi. Esters have anti-microbial and anti-spasmodic property. Halocompounds have anti-cancer, antibacterial activity.
❖ ICP- OES Result shows the trial drug has below detection level of Arsenic, Mercury, Lead, Cadmium. It is evident that the drug “BOJAN KUDORI MATHIRAI” is devoid of heavy and toxic metals. This reveals the safety of the drug.
❖ The XRD fingerprint shows both the similarities and differences of the sample successfully and is a valuable primary tool for checking the quality control of herbomineral formulations. The different peaks shows the presence of minerals in the samples.
❖ From the Acute oral toxicity study, the rats were treated with different concentration of BOJANA KUDORI MATHIRAI from the range of 5mg/kg to 2000mg/kg.
❖ This dose level did not produce the signs of toxicity, functional and behavioral changes, and mortality in the test groups as compared to the controls when observed during 14 days of the acute oral toxicity experimental period. So No-Observed-Adverse-Effect- Level (NOAEL) of BOJANA KUDORI MATHIRAI in 2000 mg/kg.However the Body weight, Water intake and food intake does not produce much significant. The results are in non-significant.In Acute oral toxicity test the BOJANA KUDORI MATHIRAI was found to be nontoxic upto the dose level of 2000mg/ kg body weight. These results showed that a single oral dose of the BKM showed no mortality of these rats even under higher dosage levels indicating the high margin of safety of this drug. the drug BKM has be considered safe. As it did not cause either any lethality or adverse changes with general behavior of rats and also there were no observable detrimental effects (200 to 600mg/kg) over a period of 28 days.Hence the drug BKM can be considered to be safe drug for prolonged use as revealed by toxicological studies.
❖ From the pharmacological studies, The results of ovulation effect of BOJANA KUDORI MATHIRAI revealed the significant influence at the dose level of 200mg/kg and this marked effect was ensured with the histological evaluation of ovary of experimental rats also. Hence it may be concluded that the BOJANA KUDORI MATHIRAI is an excellent traditional medicine in the treatment for an ovulatory conditions like PCOS and the effect may be attributed to the elevation of the ovulation stimulatory hormones in animal models.The drug BKM at high dose (200mg/kg) and low dose (400mg/kg) exhibited significant hyperlipidemic activity in atherogenic diet induced rats. This drug showed improvement in the parameter like body weight, serum and atherogenic index, SGOT, SGPT, urea, protein and blood glucose level as well as normalization of liver parenchyma and so might be of value in hypolipidemic activity.
❖ The Antioxidant activity of the drug BKM was tested by DPPH assay. The results showed that there was a concentration dependent Antioxidant activity of BKM. At the concentration increased from 20 to 300 μg/ml, percentage of inhibition increased from 24.08 % to 68.12%. At a concentration of 300 μg/ml there was an increased percentage of inhibition (86.10 %) in scavenging the free radicals (DPPH).
❖ The IC50 value was obtained at 26.93μg/ml.It showed that BKM is having significant anti oxidant activity.
Microbiological analysis of BOJANA KUDORI MATHIRAI showed that it is sensitive against both gram + and gram – bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, E.coli, Protes vulgaris and sensitive against fungi such as
Candid albicans.
❖ As per Siddha literature, diseases are caused due to change in mukkutram. In my disease, vaadha humor is affected. To treat vaadha, the drug must be in suitable taste that lower the effect of vaadha.
❖ So according to kannusamyiam,
“வாதம் மேலிட்டால் மதுரம் புளியுப்பு”
Hence the drug “BOJANA KUDORI MATHIRAI” is having salt taste, it act as antagonist for the taste which increase vaadha humor in the disease “Soothaga Vaayu”.
❖ Thus the medicine “BOJANA KUDORI MATHIRAI” proves its potency to cure the disease “Soothaga Vaayu” (PCOS).
CONCLUSION:
The trial drug of Bojana Kudori Mathirai was selected for the elaborate study of its efficacy on soothaga vaayu from the literature review physicochemical, biochemical, pharmacological, microbiological, instrumental analysis, it has been good,ovulation inducing, hypolipidemic, anti oxidant activities and hence be effective for soothaga vayu
0003
No full textTHE DAILY PALO ALTO TIMES.
_Vallv_f>ato Hlto Htmce
lam -1 t.rrj atutmooii -■■'ii "•:.'-»» St
Iftt-o A**aaa *«•• H-a-** Sweat.
totttti a* ****** ckat aalwi Tttrman
1*. i***, U ik M **** yt l-al* Alt*. Cah
torn*-, s**(f dw tcl »( _an#rcw «( Hard.
SUBSCRIPTION RATES:
Mo Advance)
One Year H.6->
Six Months LIB
Three V-ntbs 1 JO
Blngl* C ;.***- ...: Ot
By Wall or by Carrier.
TUESDAY. MARCH IJ. 1»»"
A committee waa appointed by tbe
student body of Stanford fnlveraity
yesterday to discover th* sonrce of
the recent ■bogie" reflecting upon
th* character of a number of prominent students. Thla committee
might do well to consult wltb Profeeaor R. L. Oreen during th* investigation, for he has had aucceesful
experience In aim I lat caese.
At Indiana Unlveralty la the
spring of 18*4 there was distributed
broadcast a bogus, compared with
which the "bogle" Issued at Stanford laat week wsa as pure as th*
drlv*n *now, a* sweet aa the page
of a ladlaa' magaxin*. Tbe unlveralty wa* agbaat. A court of Inquiry was instituted st once and
Profeasor Oreen beaded the Investigating committee
Tb* unfailing deduction* of the
detective* traced th* bogus to
boy'* printing oflce In a small town
over a hundred mile* from th* university. Tbe author* and distributor* of the foul *h*et were dlscov-
er*d to be aeveral of tb* most hrtl-
llant and prominent mea of th* senior class, on* of them a aon ot the
Heutetkaal-governor of th* state. Tb*
author* were expelled, the dlatrlbu
tor* suspended from th* university
The origin of tb* term "bogle" is
traceable to an Innocent custom
practiced In eastern colleges forty
year* ago. of Issuing a false or bogus program on the eve of a college j
event each a* the annual oratorical;
contest. The bogus waa mad* as
ridiculous a* possible, the chief ob-:
J*et being to poke tun at the per-
form or a of the evening. The temptation of anonymous writing soon
led to vulgarity aad culminated at!
Indiana tn a volcano of obscenity In
tbe bog*a of ltto.
It 1* a aatlafartloa to disinterested cttiseus to see the Stanford student body denouncing the cowardly
bogle Issued last week and taking
active steps to check the apparent
tendency to such unwholesome publications.
BLACK REDEEMED
CAMPAIGN PLEDGE
VOTEH FOR HTCTWOX I'M M Alt Y !
KLMTION HI I J-.. TIlorOH NOT
iUi-KATLY IX jM*OB OP IT. --!
Meeaure IVfeeted After 1 t- t- ■ Flgbt
In tlte Henaii- In Him i. Walker
N'M**ka la OpptM.lt ion.
8arram«nto, March IJ.—One of
Origta of Foanh WK- Maa t'skeoww
Dr, Henry Van Dyke, who has re-
algned bla professorship at Princeton t'ntversity to devote himself entirely to literary work. Is the author
of "The Story of the Other Wise
Man," which ta probably the most
popular Christmas story, barring
Clement Moore's "The Night Before
Chrlstmaa." tbat ibe world know*.
aay. the Outsider la the San Pranciaco Oan, The atory appeared about
twelve yeara ago and ha* been trana-
l.ted Into every language, new editions being brought out atary year.
Literary wtsnacres hav* found In-
eumerebte Imaginary origins for It.
bat Van Dyke himself aay* tbat It
haa noe* that he know* of.
"I do not know where It came
from," h* told Inquirers, "out of the
au. perhaps. I had long atmiied and
loved the tale* nf the "Three Wlae
M.-n uf the East" aa told In the Gold-
en 1-egend ot Jacobus de Voraglne
and other medieval books, but of the
Fourth Wise Man 1 bad never heard
nntll that night."
Princeton's "Triangle Song" was .
comIHMItion of Vnn Dyke l» bis college day*; it goes to tbe tune of
"Marching Through Georgia." He
haa written any number of quotable
things.'and "The Footpath to Peace"
U huag by Steteasoa's fatuous
"Prayer" on many a woman a bau-
dolt wall. Thla ta one of bta say.
Ings:
"Time Is
Too Slow for those who Walt..
Too Swift for thoae who Fear.
Too l-xmg for thoae who Qrie-re,
Too Short for thoae who Rejoice—
But to rthoae who Love.
Time la Eternity "
n****ma_mt.m.. ** m^.a, a-m* m
| M. H. mile i
th* hardest Bgbta of the
caused Saturday tn the senate wben
the Stetson primary election bill,
which bad pasaed the assembly,
came up for third reading and waa
turned down by a vote of twenty-two
to eleven. The bill waa also one of
tbe best "test*" of the closing days,
as every msn to the senate either
■tood plainly with the organisation
and Burke « crowd, or struck out for
lnd*p«ndence. And not only for
himself, but for tbe voter at tbe
poll*.
There were many speakers on the
measure. Including Sanford. Willi-*,
Curtin, Belshaw. Leavitt and Black.
Sanford said tbat tb* bill la tbe best
primary tbat can*be obtained and
cited Instance* of It* aucce—ful operation In otber state*. Leavitt, tor
the machine, branded It aa a rank
mean* uf placing ex-Governor Pardee In the I'nlled State* senste. by
providing for s straw vote for that
offlce. with the members of ths next
legislature pledged by Ute result He
aald that tbe wbole bill revolved
around tbe ambitions of on* man.
meaning Pardee, and affected to be
agalnat It for that reason.
Senator Black favored tha bill,
aad apprised the senate th.t he
would vote for It. to redeem the,
pledg* h* made during tb* campaign. \
He aald: "I am under a pledge toj
my people, made during the laat
campaign, snd I Intend lo vote for
thla bill, lo fulfill that promise. I
am not tn favor of Pardss's candidacy for th* Catted State* senate,
and I am aot altogether In favor of
this Mil, bat I am fulfilling my
pledge, and If It Is passed, and two
year* hence a man Is recommended
under th* provisions of thla .ct for
tbe I'nited Htates senate, I .hall caat
my vote for blm. In accordance with
the people*, choice."
Senator Walker stood agalnat the
measure, aad voted wltb the majority. He aald last alght tbat It ts
only a go-between, half direct prlmsry and half convention •y.tsm. He
said th.t It It had been |taeaed It
could not last more than one campaign: but, curiously enough. It ba*
atod well In aeveral states.
Tbe Coastttstloa Working All KlgM.
The alaMoce of new and startling
proposal* to tinker the ronstltutloa Is
the last siseVm of tbe Fifty-ninth con*
Itrees I* pretty good evUenr* tbat tbe
natV>nal legislators do not find events or
tbelr constituent* pushing tbem to Improve ou tbe structur* of tb* fathers.
ChiniK'*-* and Improvement* brought
forward alnce Dec. ::. 1W«. bave been
few. and Ihsair in- It sn M—■ tli
loat or dee to sodden streaks. In tbe
boos* of lapswawtetlve* It wa* proposed to mat* tb* constitution autbor-
ixe unJfurui divorce lawa, to fix tbe
terms of preaident and rice president
st six years Instead ot four, for tbe
election of United State* senators aud
all Judges and postmasters by direct
vote of tb* people,
In tbe senate tbe pr_i>uslMon to
cbange tb* teem* of tb* president and
vie* presided from four to *lx year*
waa alau advanced as well aa another
relating to tbe electloo and matters
connected with tbe presidentlal ane
cession. This last measure, intrttducvd
by S--n.-it.ir Frye. la tbe only uew oue
amotuf tbe alx bills In both bouses, aud
tb* power It proposes to confer asT-Mtfr
exists, altbotigb not ao clearly drflosd
ss socoe legislators deem neceaaar*-
WANTS
CLASSIFIED
****** *******
'WaaieJ-—T-ao'' girls to work on
skins Permaaeat' position* Address Box F, Times office. U-It-c
For Rent—Four-room furnished
Sals, with bath. 761 Bryaat aad
31? Ramona T-lm-c
i
the toggery
Wanted — Lady stenographer
Must be rapid and accurate. Oood
pay for satisfactory service. Address "Stenographer." care tbls of-
See. ll-Ji-c
Wsnted—A
terrlor. Addr
good bulldog or bull
is* "X," Time* offlc*.
»-tf
Inc.
Palo Alto
- For R*nt—8t*ck piano.
Box 23. Stanford.
Addr***
t-lw»
For Rent—Nice modern furnished
tit Brysnt street. It-Jw*
Rooms aad board at SS* Emerson street, the old Phi Kappa Pal
Tbe eecund article of tbe constitution j House. X.-lm-c
author!-**-*-, coiign-s* to provide for tb«*
case of tbe death or removal or the
president *nd vice president Iu 110
coogrea* peaated aa act -**t*l-4l*htug tbe
enter In wblcb a vacaucy In the other
Of preaideot must be Oiled pending a
new election, and tbe Forty-ninth eon-
gt-i-s* In lltti enacted a new and eoni*
prebenalve measure entitled "an act to
provide fur the performance of tbe dn
ties of tbe office uf president In Um
caae of tbe removal, of tbe death, re**
Igasttoa er inability both-of tbe preal
For Rent—In Menlo Park—House
of eight room.; bath aad modern
convenience*: One location. Inquire
of O. H Klngham, or Cbarlaa Hazel-
burst, Menlo Park, Cal. T-tw-c
Hughes
Bansbach
Driscoll
FURNISHERS
HATTERS
TAILORS
t
!
:
e
:
For Rent—A hn* six-room cot-
lag* with all modern improvements,
bathroom, pantry, bot and cold
water, fit per moatb. Including
water. ttt Hawthorne av*au*.
Inqulr* H. Haald. ttt Hawthorn*
avenu*. JC-Jw*
t'or Sale — Branawlck-Bolke-Col-
lender billiard table, new cuabtoaa.
Addree* M. R. S.. Pslo Alto P. O
ll-St-c
For Sat*—California fan palm*,
boxed. Apply 111* Byron street.
Palo Alto. J«-lw«
For Sal*—Setting* B, P. Rock
eggs; stock direct from Bradley
Bro*. (Mas*.) Prlca reaaonsble. Inquire Tlfi Channing avenue. P-tf.
For Sale—An English T.adeui-
aad harness; nearly new; at a
Alma street.
»-lw-e
Thr April Hmait Hrt-
Beatrlx Detaarest Lloyd ts the au-
Dior of the novel whlcb opens tbe
April Smart Set Her story Is entl-
tied "Tbe Miniature." and she ha*
never written a finer piece of work.
The scene* are laid In Paris, and the
absorbing narrative, whlcb grip* the:
reader's attention at the outset,
moves along to a tno*l unexpected
and thrilling conclusion.
John 0 Nelhardt contribute, a
piece of Action entitled "Beyond the
Spectrum," which, becau** of Its!
power and wlerd setting, deserve* a
place side by aide with some of Edgar Altan Poe'a stories. Harriet Gay-
lord, ta "Cousin Dellee." tell* a pathetic tai* of a young singer wbo sac-
rIBrea her career, and lr*rn* too Inte
bow unnecessary th.t sacrifice waa
A powerful story la "Penalty." b> -h
young English writer. Michael
Storm. Katheriae Metcair R.Hif
write* a fanciful llttl* story raited
"The Edge of the Wood." fall ot
poetic charm Arthur Stanley
Wheeler la at hla beet In a lore story.
Indian Hummer." Other fiction la
bU Mu. Luther Harris, Mary L
Pt*9*t*4, Mary Glascock, R. k :
Weeke* and Maio de ta Koch-.*. In
hla most delightful vein. Bllw Carman write* aa essay called """he Mu*.
sic of Ufe," whlcb contain* uiany
quotable passage*. The poetry la varied and excellent, and 99999 trum
mii-h .•'.-..'Hi-it,**!-. :.« mtti ! M Kelly,
FA na Bnrker. Edwin L Sablu. Arthur Stringer, Gertrude . IL McGU*.
firt and Charlotte Becker.
dent and vice president. Tbia law
provides that a vacancy la tbe executive ebalr must be filled by tbe cabinet
officer* In tbe order beginning with tbe
secretary of state and egflliig with the
secretsrj of tli* Interior, Neither the
department uf agriculture nor tbe department of commerce and labor existed at tbat time, which accounts fur
the failure to Include tbe caMuet officers at the bead of tbe** departments
among tboar eligible for tbe soccvaaloa
tu the presidency.
At flrst liliu-i-e It would aeeui that
tb* question of prmldeutlsl auceesaloe
1* safe as the matter waa Wt by the
eoostltutlou and tbat congraa* ba* full
and imps* power ta fill vscsocie*
Senator Fry*** UU look* ratber to coo
tlngen.■!** which may artae tban to any
heretofore esperteuced In tbe blatory of! bargain. C
tbe government. Ou several --ccaslaoaj pa-0 A|1o_
the vie* prneldent haa succeeded to the j — — — _._■■, .
presidency upon tbe death of the prva* For Bale—French walnuts grafted
Meat It I* not clear. Itowever. wbation California black, also full Un* of
action 1* authorised Ln case tb* passl j -**■■--•» of all alie*. ssd general our-
dasit *booU be Incapacitated foe tbe < ***"? Stock. Deliver!** aad* la Palo
dotlOT or hi* oOce by essses other tban Alto arery Saturday. Morton Nur-
desth. Tbs Fry* bill woald sutborlse; sery. Oraat Road, Mountain Vl*w
eongreM to provld* by Uw for any [ R- F. D. No. 17, Box 10. Phone
defect or contingency not already pro- j Sub. 1T7. 3l-10t*
rlded for by tbe constitution reapectlng ■
tbe election .nl all other matter* coo-{ tATAft
Meted with tbe offire* of president and
view praelde.it ami tbe j-ce-l-iMitUl *UC* :
tiwtou. So ameo^t tbe rooatltuttou
would empower congrsea to act upon
any qovsttoo likely to arise ss to tbe
validity ot title to tbe presidency. t'»
der the avt of \*9n. It c-oukt-wm be not
In aession at tbe time a ra-.*ancy occur*'
In the office of pr-mhleul tbe person Found—Two bicycles. Owners
upon wbom th* dull** of pro-Went de caa h»T# wm. br proT,B)t prop*rty
rolv, moat coovw* coogr*** la ex-;.-^ w,„ for «|rertUlag.
tr«.s*dlaary earnSon. giving twenty
days' notice ef tb* time for s-eettng
An ons tbe alx new bHIa, Uh-ii, tbc
Frye bill .kmesuggest* that the funds
menial law of tb* Uud fall* ot com MABMAGK.
ptoteoes* hi Ita own field: If our new Mr. Vartan's system of massage Is
pr-.i.len.a suggest no changes or -lm curattv* tn nervous dlaeaaee, InJI-
l vetnenla mure radk-sl than that, tbe gestlos. kidney trouble*. *te Office I
cooMltntloti moal beMi soond d-jcuo>_ot hour*, room IS Madlaon-Tholu. tl
for suldanee aa thing* go In tbia age to IJ, t 30 to J:30s Patlenu caa
Loat—A buggy robe 4 red and
black plaabi. oa Marcb '•th. on or
near I'niversity avenue. Finder te
requested to notify Box *•: Palo
Alto. lJ-3t*
Simkins for Postals
Over
One Thousand
Kinds
H. W. Simkins
Bookseller
166 University Avenue
Palo Alto
For Your Wife's Sake
And Household
Happiness, You
Ought To
MISMkLLAXMOtB.
of evolution
be treated at hU home office or at
their residence* If preferred.
Residence telephone Red Mt. of-]
flee telephone Black 10S.
Hum- statistic* taw—Hi hav* b*__
coII.i-i.hI uf tbe savings of writers.
Seven realty dlsttugtil--h«d autbora
l«i.■!■ 9ttt**t9 ltw*lodiug Sir Edwin
Arnjld. (ieorge GUslng aud William
Sharp, left sautes which, addf-d to-
getber. amounted to at>oot |*Cuui Tne onI-r branch In Palo Alto of
Tbls m-ms to show that llterstor* 1. lh-« F Thomas Parlrtan Dye Works,
oot s very i-rufltable pron-salou. -: TM1-b atreet. San Francisco, la at
'■' ' - —**- IBS 1'nlverslty avenue, at tbe Three
Tbat wotuan who tltoticlit she wa-% I.lttle Tailors, I.. J. nioom manager.
Mtne. Cdlvo utul -wasn't nn*. tS.t.i;->f the Phon* Black 111 •
kind slrould have remeoitM*red bow tbe '
punled twboolU.y identified himself ly
tbe t.'i*-a and otber truck Is his tffoa-
i-ers pocket *o as to decUre. "U't just
uw*r Bar raOettls er "tans-alT woald
hav.^ MM th* 9■>!.-
Buy a Gas Range!
Install It Right Away
Palo Alto Gas Company
547 HIUM ST.
PHONE MAIN 02
University express. 171 L(>:verslt}
MM Phoas Black 1ST * I
FIFTY CENTS f
*H*^<miiiMWIl
Landscape
Gardener
Phone Blue -I1
1 Tress. Shrubs. Ptsau aad
f Baada Ezperteaeed mea for r
J all branches ot work. Coatract '
* or dar work. 9
j lt**ld*nc*. 170 W*v*rl.iy 8t J
} PALO AMtO. • \t I
•■ Af
mnmns* nmns*ns*nmn.mn.mnmnm
•*?he had played tn amateur the-'
atrirals. \uu know, and Ihf—Kaad
to go on tbe atage If' ber pa rent>
wutililn't let her mnrr*. lhe dalle "
"And what did her |>areots do*"
"Thev let her go on the »t-i-*.-.
gave the duke a check for a front
seat and were not nt all a-r-.ilM.-d.
yt..-n H ailled hack to France the
iM moyalag."—Clexeland Plai_,
Glvea Ip to IHe.
P. Sptegfl. ItAt N. Virginia street.
Rvancvltl*. Ind . srltes: "For over
live year* I wa* troubled wjth kld-
ncv and bladder affectlona which
Jockey illlli-r. wbo Is getting pttis**'. t*9tm me much pain and worry. I
a year, thtaha id* -.■*■ ■.- bottpt than Iogt fl**h **a w** *u f1111 **>*'*• ***
Pt*__hmt 9bo*e> ttV* Rol WagO had to absmlon work en-
ore of wurrytng tbc truats into a blor tir**?- J had three of the best phy-
fttok ta srorth th* dlffcrroce to the *»*claa* who did me ao good and I
president. m** practically given up to die.
"i Foley's Kidney Cure vr*a recom-
tlrester New Tost run* itself at a mended and the flrst bottle gsvs me
coet of |jtm,i.'(MM)o year, aud the oit.\ ter-^at ndlef. snd after taking the
newsiiapcra devote hair tbelr space second bottle I was entirely cured."
to telllnc h.>w aktmpj tbe run Is for Why aot let It help you? Eagle
'** Drug Co.
•And what Is your little bmthe,
"Th*.-> haveu't found out yet.
1*.„ iwubj. .«» of tt. .otbor «, ,„„ »,„ r,..-^ . Thuier _
______t*****,, at iw,
?■??"'■".?*"■. ** *m"u*** --■-*«***« ,.o™ or * N.ii--... !ii ernnmo
sv.au.. Klrst-cla**, r.l'alrir_ di-ra.i
lnue,t arltaa.
ba, s.>mi.!h!UK lo look (or-srvl to
Tli. ooJor of onion, s. n "kn.K'kout
.or conu. u auotbor rloar caw vt "raw
adr won. tbaa tb. diaassa.*
Sobacib. lor tb. Til
Tbe Dall) T!a«a—lec a reek
IN some conditions tht
gain from thc use
of Scott's Emulsion b
very rapid. For thb
reason we put up i
fifty-cent size, which b
enough for an ordinary
cough or cold or useful
as a trial for babies
and children. In other
conditions t)A gain b
slower—health cannot
be built up in a day.
In such cases Scott's
Emulsion must be taken
as nourishment: a food
rather than a medicine.
It's a food for tired and
weak digestions.
Scott & Bowne, **> • •- e.*i -
CS.-M. V- l-i
MEATS
I
Stanford Meat Co
Ooass* rutk-.-. svas-n
ssm CstvaMtrv ava
Delicacies
Ponttry
Fresh fish every Friday
t*-*m*m*m* tm* * 9099999 J?
Scientific flmerican.
*******-*>*rQTMt-M*4 ih«:i, \*r~r- -:r
•asssse'Os-ui.a*rn*w_* n«ti«.D,
1
No full text'-■:
PALO ALTO TIMES.
VOL. it.
1'iVI.O ALTO, SANTA CLAKA COUNTY, t-AI... KItlDAV. MAY 10,1885.
NO. 19.
EMERALD WISE £UP.
Mrs. Potter Tells ut One She Saw
In lndfn.
WILL SOT S.*_U THDR TREASURES.
Prtaeat or th. Fsr last will Olva Awejr
ABj-lhla* Tbat Ihair Priaad*
Ba, WUB,
Mrs. Jbiiios Brown 1-oltur lost wool,
gavo an Interview to tho Cotiitacrciat
a il v. m -t. lu part 11 ia as t Ilea •
"Ah*.'* said Mrs. Putter. *'*n*a sre
haikinaj at my bolt, Tho Mahara)ah
Itetiali s-. in, th<-<i last rout In Calcutta.
jf*rn It tu mo. Ilo wb* ancb a generous
(food frlen.l ami pamlot.atoly Btlachstl
to ilif Un atn-. He came stiaoat every
night sad always did Mr. Bellow and
myself tbo honor of coming lu full
aisle, Ilo waa a great 'awoll' ami a
member n| council—-a am—I henrr lu
India. Ila wars the 'Star of India.'
Many of tbta* ladlso prince* an* hifibly
odncalrd and espocally woll read In
siiiii.i-.ja.':.ii■ A ShakcajK-aroan pro-
dnctloa waa a auro draw with them
at any tim**, (lh. yer*; I bare visile,1
i-a«t of tbo bia eooif. iu India ami
• ■■■.•jut aiming my friend, most of the
leading jiniHtts I wa. on a 11 Hit In Ihn
'Nlratnoof Hyderabad,' tit tl.o Uusli.r-
Ilajth. iiU'iiin'irnt palaeo .mt-u.l,, lly-
•Irrsbad. In whleb bo receives and fit-
trrtains -dt>tin-*aishnl ..-;:.-■.' Tbe
j.rinc*-* of Nrpanl, tho Maharajah*,
of >• unit.,. •...*-■■)-. i... ii. Bc*haii.
Itetian.-a.nml many . tin i >••■ i,, ■■■ nirnugi
nam.-* would be 11 reek to yon nro
si::- ■!;_ my friend. I think lli'.i i hs*
had a .listinet infliM-iHv oj>.ai ray lifo.
In >*hat si,n ■ uii. well. 11 has bott-od
.mjiait.l my I.IenHof lifo. of roll-llou,
af jioetry. oolor, ts**uty, every Mil ng.
llefore 1 went there I w.o> a* crumra-d
and cir*-jniu*crlt*—1 in my thought* a. I
was in my lifo before I weal nu lho
"For I lis I mice." aaid I.
"Well, for inat.ncn. my ideas nf
(*—mwloo "
' "yoa!" Tlie wonderful eye* raised
run,ui-i. i" li.uif Thi-ro want ftiuh
iu tbnm. ■ r.,. >■ -.:■■:, — thnt jMiwrr
which, next to love, nl« evt-rylhtug.
I 1. iTTi--l In India to ..-i.*t.- the
ICIi atll.-ss Of It, Bad l" *■ . Ill,- i.th.T
aide of it—tbo littlomsB—lhat horrihl.1
llltloui-M Unit ftriters .iv.*rybndv *ln
what wo ri.1t elv||lr~l countries, and
whieh 1* ni'*. in eviik-ncw here where
"I eonli***, Mr*. JVtter. I ..don't.,
ijuite understand.*'
"Isit ino ir*< lo explain. At Hytl.tr-
absd HI* lllRbMsa tho Nliam Invited
me to hts own pulsr—, and knowing
htm to bo the j tat t of perbap* tho
most Triiin'terfol J,**weJ* In thu world I
asked him to show mo Ihniu. Ho wits
a* childlike and slmplu over Iho mutter as could he- Jewel*—by thnt I
tamiB " aacel. otn-t stoats—were
brought in em tray* for mn to am. I
ws* bow 11 dent I with thuir .jonlity.
Hh..k*>*j**-ori< sjh-.i1, a In Iti.-hnrd of
'heap* of pearl*.' Hero thoy were, aud
|—ni* of svrry oilor sad qaaltly.
Thi.' were tbn Nizam'* delight. '1 :■■■ •
wore tbe t—satleei thnt iifid hnd put
nit-, tho faith for innli'* !'!..mui. .
Thoy beloaaiil to bim.- Th.. cnlnt*. the
braDiy of thorn mado him happy. Yet
hs himself wa* aim pi icily |_Mf in hi*
attire.
" lie showed mo a .linmoii.l uncut, 1
think any Jeweler will hour me .ml
tbat it Is luppoactl to Iw the lai-g-Hl In
tbs world. I aik-I bim why be did
not have* it cut. Ile answered rae simply, wltbonl affect at luu Aii. no,
Mrs, 1'eHter, It is tho ono diamond of
the world, i It i- .,- (lod imule it. It
la mine. No ouo .hall inueh it. 1 do tint
wear ;■.'•:■ I In---- it ts mine, tied bs*
rhtasrn I «h»ll t*«*gtt»i print— ia Ind in,
but overy onr knows 1 run n prince. I do
imt slum- myself. My .ll.iiuund i* my
diamond. It I* u Rrent |**..*■*• ton, and
I am-rei—gralrfai I would nut sell,
ray diatsoml. 1 would not sell my
wife." Hera wa* a poworfnl priuee;
now for tho othor *iiIo—llm Iiil-orvr. 1
•si-iii Int.. a jeweler's nt Colombo. Tlio
Joweler, n C'ingnle****, showed mo b lot
nf t-nolifnl su <*•**. bat he bad oar, an
rnurrmoo* cat's rye. said to bs the
1 ararst ami im-st perfect alonn In eii*t-
.■in-,- I had heard of lho att.no. In fni't,
had *esn It ill London during tho I.tdln
Kihlbttlun wbrn ths Trrssoicr of Ceylon, aa old friend of mine, tbe Urn.
Fred S-t-inI, r.. br-r*ngbt it over in his
chat-go.
"Thia j"«.-!i'i' kept tho atom) In a
gold box—tbo lid ws* ■*•! with th*. unlit
ratten, or nine slont-s of ("eylon. It
ws* a pri-n *- cradle tot thl* -a kales*
ilewo. I offrrod htm *15.01MI in onr
ti.nii.ry for lho st.ii.o— ho B...il.il and
* said: 'Momashll., itUinyaiono; It ia
v.-iy 11 ii'ii if nl. nn man can bay. I sell
any >t. =-.- here—-yoa buy—tbls is my
■Mt**I no aril.
"ArbIu, in Urn-ire* | went Into n
cloth worker... and lti Loi-know lino'
a allver brater'* hat-—lho -same thing.
1 he—- peopl* were pocr— faot—poor—
|..it—l'ui tbelt best werrks of art IrKy
would aot soil, When ther -..■.■. you
■ pjireeiati-l then, ihey wontu givi*. you ,
,,mi,■! hint,- . !.-t-,ind price-—al B WOrk '
of art but ihey woold not aril. If ever
job curse lr> !-■ nd. a t will show yoa
thing*—(-it ■ n to nt, you ■ .!!-;■■! !--.is -
111.' thn Ni.'siu1. tlinuit,n.l; lilt' his
Wilis _ln-.« cut mil of a slnjth. I'ltier-ihl
—iiuoKlii.- It* j,rn.■!.-.■ worth. They
sre mine ami ptrSSO Ood Ihey will be
tins detlxht of my eyes and my friends'
Byra for many, b year to come. I am
romantic bu.1 rnmaneo la to mo bcaull*
ful. Aa a child, J live! a a-reat,'.
lirus.l. tsraotlfnl i-ii-p. •■ •■. I.was a'
child. < hil,lit ij know notbiait of *o-
i-lt-iv, its uaiiuBuoa*. ia .*• .v.anlit-e- of
faabioa, of iln-**. of ,-ii.j...■ n- and thn
tratnmuli of aoelal life. • 'Cbriiinpher
t iihi.i. lm*, (if uw- w * * I, ni„ [.m. Nelaon,
tba Dak* of Wellington. Napolacat
wore area! men to ino—they fllW my
lire. i.'i" only i ■. ■ .-.,. - ... i ty wben iu
t-ui-ditioaa* chaii_. After Bitlbi».l
mino was empty and osrJr-M until I
lauuohnd e.nt njioii tht) -i-tu ould tlRbt
of lifo upon th.. -I..tie. Tbo worltl
opon.Kl up to mo then and I felt 1 bad
a parpuMi, a goal lo reach. I want yoa
to uaikrslaad nin\ to follow as*, inlo
tbo land I cam*, from. My mother wa*
i a • t rn ni'' woman and any dan-thier uf
huraei.uhl not bnt .li.it- her tempa.a-
mont. My child and girl lifo waa lived
amnajtidrB-Sibat Ihey were j-rtstsl ld-f—1*.
I rains tbe telephotio. the eJoctrtowon*
'• dors of to-day*, bnt whou 1 left my child
; lifo I cnuio lo s brick nnd mortar ono
i that waa aiuyuipalhutic, that mraiit
Bulbil)-*, it oamo from uowbero and
west ii v. h'.-,. I was like a rat in a
hole and until I wont oa the ftta--e 1
net '-r Rut out of Ihnl bole.
"Vrhxit I Gist wool ou tho «I*ki- I
did SO— I.) USO B .Hull, —ill B li",.'. l.lllji
man woald catch al a alraw. I waa
the rat wbu saw a way oet of lbe bulo,
and daahod fr*r it. At ftm the Int-mst
lu my now lifo sbatirbed me; tbuti my
inability to ,n tm ti in) ideals broke tu; .
heart. Tho banl work came Itwu—
the labor, lho heartbreak*.the i_u-n.iiuy
of ;.--:...: is:*l and abase, ii-- ■;■-
liL-artiiiliiR lickuesaof aiironso erillolsm i
—nntil at hist tbe dawn bmke. nud tho;
most beautiful city, my dearly loved'
Sydney, In Kew Sunlh Wat*—, Australia, fell at my f***t, ewR-rstr***I itm*
and jtsre mo tiopo. Life was beaulifnl
aud new lu me. It wa* a gnal In*
llouiuv, h an*«t imwutivo to n.*w ***Tnrl.
If I wa* what thoy told mo then, what
■bonlrf I be iu b few year* rnore?
Hem* I am tack in America. 1 thank
.■verylKxIy who hn* etnoouraged me—
.ivory mini wbo ha* writtttia nin*j-lo en-
eeiurajilUK lino about lliu it nil give*
ms h- ,.i t and hope to work. 1 am your
own woman, ami I want to do my
utmost to ho worthy of my own country. 1 havo traveled Iho wrold over.
II ho* broadened my mind; ll' haa
helped in in.iki- uie thn woman I am.
If I am able lo sn*e>iapli*h what I havi*
today, why -li-u.il! I pnt a limit to lho
fatm— ? 1 ful low tbeexample ut my
oonntry In my»wu life— independence.
Tliu ellaa.lvauta-tes 1 have I i-ait und
will overcome. What I have I havo,nud
no ewe ■ui take fisatu .ui-. Tbe **. rid
ba* bceaavery bard, very cru.'l, very
kind and very jnat lo inn. I havo of ten
imurled under it, cried over it, In.ikon
my heart ovor it and loved it for iu
■..u-hi'*- Thepahllo to ma i* Just
like a area! big mother—like my own
beautiful mother, wbo tliiil.d bm whin
I wa* svioug, kisied m.> wh.-u I was
good, innih) mo *-ry and made mo lauali.
and mado mo love hrr always. 1 am
_■').!_ to win ia my own coaalry. I
will'wln. Yoa know when a Iran
Anicrlmn woman saya «he will—welt,
alio will, and that'* all abont il."
A FEW SOISGS OF BISHAKK.
A Ilorlln dispatch to tbe la-utlun
Times ijiu.tca kiuiii intinMing any*
inji* of I'rtnco Bismarck. To mm
nm* who spoke nf bim its a happy man
be>*plird that h>* h—I seldom t*eu
happy, ami lhal if be could ooont op
th unu.uta of real hapjiineai he hnd
enjoyed in all bi* life Ihey )nl|*l>t par*
hup* ilmoui.t to Iwetity-f.mr ln.nrs.
lVditlcsl aarcTa* had not brought him
happiotsa. !*t*ii»- h.- had"not had
;■■■.:*. to .n.: -s it. I' : iti,- wltb him
had been nn int-i**«*ut struggle, and
lho u.*e**->*ity of holtllng what was
galBtd ''-i'l always brought lucreaavd
car* wllh rach .atts*-.. In private life
be said be hsd bad moment* ol bap-
pines*, a* In boybt.)d wh.-u ho *hoi hi*
lirntlisn-. and he hi..! ban tiajipr latat
with lit* wife nnd ehil.lruu aud h* a
farnur He ibonght lhat toen>iy hup-
ptuew •■■*■ ms**.*-.! s ■*,-*-It ar t. mj-ra-
nti-rit. like that of hi* old master, who
had B milium of tbo sanguine, and
jili|i'_mi.lli< itiiij- rsi—t in- "It wa*
often diltlcult to bring him tu a di>ti-r-
mtnalhiu. bul oam iskan, baaaA conld
tr«-halites. It.** trf him be aaid that
clearness aud tmDijuility pi-eserve.1 his
mind and .1i*i*uilifon lu lho most hnr-
mouion* vijulliliriiini. and he adih-d:
"Bt plaeeil trulh nbovs ovorylblng;
and talsoalmnlal being trathfaliumy
li; :■ .■..',':■ ,.i-,--;, bat aoraetlmn.
atTalni wintred u* both tn illver—. j.nl*-
Holy tsitiinwliMt fre.it. the trntri. Il..w'
hurd lhat ws* f»r tbo old Smperor Uo
invariably lilashe*! on an-h oce.-a.ious,
and woold not look at him, ami
turned quickly away."—Har-ier'*
Weekly. ______^
iSl.i. hi! ! ■' ii a widow a year nr so.
and abe waa dickering for a to*jJtJ«to*-te,
for tbr •■'!■• it'-'l '■*)( tsjors*-." »sld
the tombstuno man. "you wsnt the
.Isle of his death on tho inaiV 'Ihn
day of llio month nud '.he yc*r>" -
"Well." sighed the wl.t.iw, "I *Bp|~*o
other ;-'-,■■' may like to read them—
but I don't need -njch rernlnder; they
arc lutlellhly imgrnven on my hr-j.rt and
ln.ju.orv-" "What WB* Iho dot.'''"
asked HW li'inbstone man. Tho widow
lie*list* ., thm she torneel s rioton*
■■.::•:. tt»a-n sit* *atd; •''.-... n-
gtrndnrs**! I can't r.'m.-nilieT whether
it was January 21) or 31, I'll go homo
' nn.l Dpd oat."
The coloorl.oa his toar of inspection,
uoerpretedly entered tho drttl'MBn
whom he came upon noimpleof miIiII.t*
imn of whom wbh reading a let tern load
while lho other was listrnlna. nud, at
the same lime, stopping up the cars «f
lbe i-ader. "Whst are yea doing
he-re:-"* tbe pnirjcd offieor inqaln-d of
thelalt.-r. "You ar-j, eolonel, I am
r. -i.tiTii.t- to I'ilou, who can't road himself, a teller from ht* *w*-cthcart."
"And you. Pitoa?" "PI—**e. —alone-1.
1 am stopping up !>-[-.:i ;!,-,■- esr* with
. loth hands, l-reauito I don't mind hi*
n-ndiijft my *wecthe_rt'a letter, hul I
don't want him to know what *h«
-/rites*-1'
A Mt-mphls paper >j* aLr of a "*>d
■nicide." Tbiwe irsy. insouciant sol*
cidea are nnt aa common bs thoy nanI
: to be when our mmhsr* were girls —
Miastap.IU Joarnil.
TO TILLERS OF SOIL :-y^„
I*agiit Hound—while wn abnti-
tbe jtri.tt. ti.ai at *-•■'■ wo obtain
from 1000 lo 1100 pound ■( fiU-r worth
all the ss-ay from IS to 35 ■ ■ *.-:- I*r ■
Hlnta That May Prove ol Benefit j "i"""1 *******
,_ V„_ _r_.___.__ l*r *",r"- '
to Onr Neighbor*.
ooOD ADVICE FOR THE FARMERS
anient or tladaut-ta-. WorU. la Itaa Hor-
tituliurm. Celiact*4 rram
asllabl* Sonrc.l.
istuf pn*loi
a vsjnable orliiite i. gmtirr,
argin of protlt i* also is
DOMESTIC NEWS.
interesting .Occurrences From all
Over the Country.
ALONG THE COAST..
l*i*-cr.
Bam uroBlna.
,' David Rr—*<<, president ol tin. Fl"rin
i Frnit-l-iorwena'A-soeiBth.u. myt tu thn
; s ir.iii, ::;,, Hoc: Tben- I* bssine**
; .-n-rofh io ibo berry lino to ta.p].-y
;.'■'■■' familirs in tb« udghhorhoud <■!
Dotm-r uli.no .nn use all
NEWS OF THE WEEK C0I*U>E_.SF.D-
A buit.el at MIicsIisdsou. Jultlngi
BriaP. as* CsrUr tsl* Is IMi
COlUDSO.
J. Kiagsbary and l.,i-i..,-, Q, 1.-...- i
tin-ut-l oo Jaae I. is-;.
Tbs l*-ly of Hoy U. (■ulr-r haa b<*»
fimnd In lho Clyde rlvr-r.t-tv.-~.il Clyde ^"
and aavBunuh. Ho hail be,. nnli.tfii The Newa oMhe Slope Condensed
and tbn.wu into lho wairr. Ho was .*..-» n_ _
the mmmtf t>t the Yc-wg Mm. IW ttw Buay Beader
<*hn»ti*n Aa**-*cistii—i i*f Ness ark wboj —,
my* t.*r inn sly dinpjriml-d m-cutl*.
, this
irfa.
Tba*
«.- five carloada a .
jt. Thoy gel
inn !:,.i . Alksnsa*
and Northern
.sa*. The berry ia vei
v moch irifi-r-
,r In that gtown here.
Dantva. can
Au imjalrur wlsho* to know what ti
do to get rid of the wona* tbat bo titid
■;-. -I.' • .:._■ tbo I...,.. *,:- -nil . in hia bee'
hives. Ho at a to* that ouo biro bad bnl
slew hoe* aud lho wnrtn* had about lalto ull our surplus, and when wo oiu.
all tbn new comb* eaten np. thougb, ship for 00 ceiita Wo snuly aro BM
tt-cy did not seem lo Uither the old cou.tdcring rates ranging from fft.?l
Tbo vrorni he speakti ot 1* lho larva There are from 120 to 130 -"-ower,
ttttfao breswsx muth (HalliTiii mollo- In this saa-jolailnu. There are probably
nollal, cunnionly csllod lr~. tntitli. and fnitn siity.fiv.. lo sovui.lv acre* in ber-
-wheroeot-^—i sre k.'j.t a I.uigiiii.u iitn'rU'* and sovtntat ttnt.-a a* much in
ut ihe hive» daring wirn wvaiher are erspea and dn-idaoa* fruits. Fn-m the
quits a nnli-aee (f jaaper |seesutiuns V~i*gs.. now tu Iwrric*, we can. wln-a
are not taken, hul lo the praetfcal l*'rrie* an. in tneir prime, ship on a*i
j Ust'koopiir thoynio no longer e-t.ti*idL-r**.I; uvi-rage nr nine nr ten carl, mi I a a w*,
: th*. dread euoiuy tlnty used tn 1-. In The Net rihijijiiug ls-iry i*tln. Triuio|)h.
sido nf a hivo whew there, t. a living Tlio l»-*t p*nj>Iueor i* the Jessie berry,
colony ofbt**, It t* s heavy berry. Urg* ami flm-ly
1 might menti.in befon* going fartht-r «olnr.*l. but will not carry. Ir* is ibe
thnt his noting thnt ll.u Inrui- ihslroy 't-al t**rry for the hs-al trade, bdag «f
the now r-einilw lu pn fnence tn thu olil i-Miltetit tliivor nml .juiti* slnmy.
on.-, i. mvre.lv a matlcr of clniuev. fur All unlluary family uf u man and
ss .-. rale tbey w.-rfc la old etaaba In wife *u.l.v.-.- ii children eon cutti-
whleh se-rrrsl generations ol t*«* hav*. ial- five ae-)jrf>s,and it will yield Ibem a
been reared iu proferi-ucsts] to now It"**! living. They will uewt nltout
comb*.. Hit") windmill* in i>anip water *uni-
The rcnu-ily I wonld recommend is clini fur itrlunli.it) There 1. u msrer-
t,. Halt.un/. Hi- !*• - iiii.I -•■■■ tl.,ii all failing rnpplyuf wanr a fow feet ba-
i..'., iii. - are kept streng. A weak low lho sarface. A **f_a*atlne engitre l*
colony of black bee* will fdien sac- tl»'U*rt amlcbeajiesst ti.odo.if pumpiOB.
en iu b to tho ravage* of itu-ao - larva* S inietimi** them will bo n .lay nr two
whiles enhmy of lli.Iluu bee* of lho »f i-nliii. and tli.'.i Ifto IhttIo* auffer for
mmo siret.gth would sism rt.l their a lack of water. I h.ive i. six horse-
ho.iiat- ol the Dtn'tuv. provided they aro f«iw*-r gs*«llm* ennims which rou* a
in a nn-h-rn hli. having movable fioiim:b pomp up lo it* fal I rat «*r-_c-
framra which j*-tu.lts tln-m to have ity. It i* suillrlent to irrigate iw.lvo
aeetsa lo nti part* of the cum Its. , ae|r—» and o**l* *l.4*i a daj- to run it.
1 will h.ni tjoulo frnitr tbe editor of Ttml I*, it ..*.% lou |*all.)ti* of paaoHtie
Ul. ntiln.t* in Bee Co 11 ah- in the Sep- h day. ami it ct-*i* m* 11 cout* a gatl"U
-l.-ail* r 13th is.ii. *'Tbr Ilaliant are laid down at toy j>! .-, ^,
s*> ib'irougbly t! i-at-mluate-d lu tbi* MiM of tbe labor perforuierl In the
onmilty that tho wan moth.-so far from lierry jisleh.s I* j*-rformed l.y white*.
Iming nu iitiottij*, may bo regard.*.) muro A lew Jape an.l Chin.-—* itro .iii.|ili*ye.l.
as b cnri-Mtty, au.lat Iho pre-u-ut lituo bul thoy are being -t,-.,,iily repined by
it bids fair to hc*-ornc extinct. In while- l.ibir. Kuniierly. all liv* labor
Karope, and,*,.;... i!',, in —aglsad, I lu lb** viiaeysrd* saas'-perfiTinied liy-
Ulk-v.' hlark be.-. predomiiiBl.-, and" M*.tig...ian.- now it i* n.-arly all dtitH.
bonce t-is'km-jn'T* BerOW the water have hv A lute*. Doting the jinst fine year.
tiuin' loruhle with lho In*- moth and Nvend tamlllM Imvo movent int. "'
are more* ewecruod with meimxls of iioighlsirhood ol Fl
extermioaling th**—• p>**I*thxu wi-aiivs or tru sen* lr**t.. p
I have often had eomb* that vr*-i-oat ami are pro*!*'ting,
of the hives badly li.fo.-ted wilh -Is—*-. - Si.rr'i,"*1,
wax in.ilh larvie, then cleaned uj. nicely .. . .
aud m-edcd only to give. Hint., to a ',.''"J .C'.'-' ,",'i!
.troug.-.ilmiyi.f lt-iant.es. Kvea ^_^^ _!_..'!__!, _
weak olooy of Iiallaas will not sab-
mil tn the depredation* of thi-a*, nasty
Se-cretary alotton ileuli-a thnt lbe
raising ol tbe i]usrlatiite agalnat Caaa-
■ li.i:. ealtle la euutrtujilatod.
Hot. John llan-n While has boon
eoiiiKcraiid lli.hnp of lho Protestant
Kpisoo-sil .II.MS'rS* of Indiana.
The jory in lbo fam.iu* Fieid-Adkir**
case la Itarboanvillf, Ky., rita-racd a
venlirt of gnilty. Tbey wilt get a Hto
H'litence.
William It. Mi-ijnlr, MssiilBUt
cashier of tho First National Bank In
i"..ah.s.ts.-oiU!it..l auleide by Bbeatating.
No raa*r> u known. ,
Heceiror Jidin McNnlt.i ut tl.eul.li.ky
iru.t ha* begun lho ojH-rsli..u of the
"" rdalcand lh.* S.*haf.i.lt di.i.lll.r-
A apodal to tho Itej.ublio fio.n
Austin. Toe., say*: Tho Irt t.i I .liver-
itt-s In Texas have iaiurd a ;:-:.,■..,
iiuu calling im all tbe I. n.-.-rat* of
their faith to rally to the - .- j, ,i: of
tbal h. HI th-wry. Kx-C.*nj.*r,-*mnu
U.-iKon i* Iho author of ttie i-rot-lama-
il.iii, which i* very luuglhy.
NOTES BOTH BY MAIL AND BY WIR&
A Briar a***—* art_a*etSBt Bapasslstrs
Is Csasl Ststsa That WUI Ia-
tsrsii irsrr soar.
Tho i r. -.- --its-.:) baa cto-ed iiacaae
larjprs Boor milling plsaU of i in Uw> toirstigstioti .f J. T. Job-, of
Milwaakex harm ]-.:. .:. :.-■ ■ ■.-..,.. ., :t>- i ..i~.:i Mini now being bold at
onmhiiiatK.li or trust, with the i.bjoot * Hen... Nov.
of redm-Uig .i*.|s<n*es by .huiig nwi.y Henry Villard, .x-Sorthcrn I'aclDc
With hsaU-ru repre-xiil:.lives and Kailr.*..! magnale.*!.** tinrcha_rd A.O..
traveling ph Tbe mil pat of Ihe oou w,*rth of Tares-a prot-rty from
mills will bo re.-uUi.d-.\sjTdii.g I.. t__ TaniBia Lsnd exaapany.
the requlrvnicuu id tho trade. - ..„.,_,,.. Nm|ib, „,_ ^^ ^^
DtMlwell, Csm.11 .V Sley.-r. g-mrol or friuii Fuirtleld jail. ba. 1-ooti rocap-
ugunls nf Ihe N.irtli.i. I'uett..- C.>n.|*aiiy ,utrlj liv Cltli,.rM1.-r.lT Biililnson. Mar-
Bt Hnugkong. adviie tlio ttalTac ollielal* pfaT J, tuJW fclgBlna. irsanity.
Jacob il.r-, * i.ti, h, t. fllty-n
bi* own nunc.
of Hurl
t la.
rBn
liaa, -i
la, parcha.-d Hv.
.111.Ml.
A* an lm rued ta lo remedy 1 wonld do
ov.-rythlug possibt" to strength-., tht
colony, by giving brood or ben. ni
both, from s rironger oilony; or. f!
BadBMI^a unite with a stri'lig.-r col*,
ny. Tlio coinb* lliouhl lie oxuniincrt..
holding llit'io up to the light ami mil
a sharp-point—1 Jn.itau.cuti.uy a darn
e all of toe lai
a ho *aen.
rmmtly I wotild pro
nlliblo
l-lai
msunrr in which tbeir Jwt*>t* are pre-
tMreel for market. The in'i-awd m>*
jHirtullon id fornign Wool*. In IpllO of
higher .I.ttii-*. wn* duo in a ntMrarp to'
the *apcri.tr iiuiin, r In which ■!,-■!■ *-■
rigu wuoU are prepared for the Inipse
thm ol the haver. With tho duties
now entirely ii indeed the . loin est It:
growot* iiiu.i iiiiiviluhly liiij.rovt* bi*
iiikiIi.hI nl jin.patlug wn.il d-r the market. Keep oat »f the Orxe-r-s all 'long-
lot-k*. lii*-•■■ tag*, stick* and *IBlT f re—i
lbo floor of the shearing jwii.
All of tlii-n.' UK" ami rito'... should
aa Italli
cording lo instruclt.'U* Ibat will ss-uni
pany ber. Such nn***u* eaa nuw h>
bought for twenty-tlv„ cal* osch am
in somo oa**-* at even .. less figure
WhetherjroaItatp boot fur j,;- •■■u<
or profit yon can not aifnnl In *p.*uc
yoar time with black br-rs.
l-la* Mp.lxttl..
Dr. A. W. Thomton in tho SeattI
l\*st Intelligence*: The culture nf 0_
may t*> earrivd nut nn thnt- di.ilne
lii-aM.-f i-r.win**. all diffenng u.at. r
iatly aowriling to tho molt rv*|Ulr—1
Flrsl, growing fnr -.s'd unly. regitnlli—
uf tho IItier, a *.y*tnm adiij-t.-il to dry
hot climate whire only it
tof-rw aboet thrtss j- ■-•
pound. ;*-r acre, where, a yield .if say- (*„_,, B
ickt'd Bej.unit.lv. n* nl*" tli- Luck*'
tl.---. . ami atld un their merit*. If
dnn_ hei,* adhere totbow..! in.he-r-
ing, tiihsT clip tbnm oft and ihrniv
-.'*..li .,r jtar-t, tie '111 -r-;tl.t. ..■]-.. Til"
Itu.hit will gel nn im wed I site ndvali*
tag,* li*--price.- hv trying thi* e-uirao a*
well in hy keeping out of hi* il- ,-ss*. il,..
rrfaw of tbe sbmring _k*I.
lirowcrs an* alio caotini.Hl agalnM
BHlug isr'nr paltii in marking or hraml-
iug their Hhoeji, a* the iuii.il nud tar
'..•leltioslb.. elippod off nud thrown
away before t
Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial
No full textBackground
Low-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or ventilatory support (non-invasive mechanical ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation). We evaluated the use of a higher dose of corticosteroids in this patient group.
Methods
This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing multiple possible treatments in patients hospitalised for COVID-19. Eligible and consenting adult patients with clinical evidence of hypoxia (ie, receiving oxygen or with oxygen saturation <92% on room air) were randomly allocated (1:1) to either usual care with higher dose corticosteroids (dexamethasone 20 mg once daily for 5 days followed by 10 mg dexamethasone once daily for 5 days or until discharge if sooner) or usual standard of care alone (which included dexamethasone 6 mg once daily for 10 days or until discharge if sooner). The primary outcome was 28-day mortality among all randomised participants. On May 11, 2022, the independent data monitoring committee recommended stopping recruitment of patients receiving no oxygen or simple oxygen only due to safety concerns. We report the results for these participants only. Recruitment of patients receiving ventilatory support is ongoing. The RECOVERY trial is registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936).
Findings
Between May 25, 2021, and May 13, 2022, 1272 patients with COVID-19 and hypoxia receiving no oxygen (eight [1%]) or simple oxygen only (1264 [99%]) were randomly allocated to receive usual care plus higher dose corticosteroids (659 patients) versus usual care alone (613 patients, of whom 87% received low-dose corticosteroids during the follow-up period). Of those randomly assigned, 745 (59%) were in Asia, 512 (40%) in the UK, and 15 (1%) in Africa. 248 (19%) had diabetes and 769 (60%) were male. Overall, 123 (19%) of 659 patients allocated to higher dose corticosteroids versus 75 (12%) of 613 patients allocated to usual care died within 28 days (rate ratio 1·59 [95% CI 1·20–2·10]; p=0·0012). There was also an excess of pneumonia reported to be due to non-COVID infection (64 cases [10%] vs 37 cases [6%]; absolute difference 3·7% [95% CI 0·7–6·6]) and an increase in hyperglycaemia requiring increased insulin dose (142 [22%] vs 87 [14%]; absolute difference 7·4% [95% CI 3·2–11·5]).
Interpretation
In patients hospitalised for COVID-19 with clinical hypoxia who required either no oxygen or simple oxygen only, higher dose corticosteroids significantly increased the risk of death compared with usual care, which included low-dose corticosteroids. The RECOVERY trial continues to assess the effects of higher dose corticosteroids in patients hospitalised with COVID-19 who require non-invasive ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation
Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
No full textSummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication
