11,907 research outputs found
piers-ch-allen/Automated-Modelling-System: Initial Release of The Automated Modelling System Code
No full text<p><strong>Full Changelog</strong>: https://github.com/piers-ch-allen/Automated-Modelling-System/commits/V1.0</p>
TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
No full textThe interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we report that TACC3 is recruited to the plus-ends of microtubules by its association with ch-TOG and that this pool is independent of phosphorylation and binding to clathrin. The plus-end binding of TACC3–ch-TOG persists in interphase and we propose that one cellular function of TACC3–ch-TOG is to modulate cell migration. We also describe the distinct subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification
Allen, Hortense
No full textAmericus Allen - husbandhttps://stars.library.ucf.edu/cfm-ch-memoranda-1925/1208/thumbnail.jp
Allen, Bertha
No full textHarvel C. Allen - husbandhttps://stars.library.ucf.edu/cfm-ch-memoranda-1940/1693/thumbnail.jp
Allen, Gourlay
No full textBody cremated. Ella Allen - wife.https://stars.library.ucf.edu/cfm-ch-memoranda-1932/1219/thumbnail.jp
Allen, Hugh C.
No full textJosephine Allen - wifehttps://stars.library.ucf.edu/cfm-ch-memoranda-1932/1612/thumbnail.jp
Allen, Americus C.
No full textIdalene Allen - wifehttps://stars.library.ucf.edu/cfm-ch-memoranda-1939/1306/thumbnail.jp
Allen, Harvey C.
No full textBertha Allen - wifehttps://stars.library.ucf.edu/cfm-ch-register-vol26/1509/thumbnail.jp
Allen, Lexley D.
No full textCarrie Allen - wifehttps://stars.library.ucf.edu/cfm-ch-memoranda-1936/1001/thumbnail.jp
Allen, Helen W.
No full textAlvin Allen - husbandhttps://stars.library.ucf.edu/cfm-ch-memoranda-1927/1528/thumbnail.jp
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