3,280 research outputs found
Letter from C. M. Conrad to A. H. H. Stuart with letters from E. A. Hitchcock and Henry Heth, 1853
No full textConrad sends Stuart communication from E. A. Hitchcock about Indian Affairs' proposed plan by E. F. Beale in California. Enclosed another letter from Lieut. Heth regarding the Kioways and Comanches on Santa Fe Route
Oral history interview with Harold Allen, May 13 and July 22, 1965
No full textOral history interviews with Harold Allen conducted by Wayne Mann on May 13 and July 22, 1965. In part 1 of the May 13th interview, Harold Allen discusses how he came to Kalamazoo in 1915 from Three Rivers and attending Kalamazoo College on a scholarship grant by Dr. Herbert L. Stetson. He describes working for various Kalamazoo residents including L. H. Kirby and Mr. Taylor, VP of the Kalamazoo Paper Company. He recalls stories of Dr. Stetson and C. B. “Tuffy” Williams while attending K College. In 1917, Allen left school to work at the First National Bank for C. S. Campbell. He describes meeting J. H. Doing, an honorary VP officer of the bank and owner of the largest lumber company in the area; when Campbell was indicted for bank fraud; how World War II stocks and the Depression affected the bank; and car trips with Fred S. Parsons, VP of bank operations. Allen returned to Kalamazoo College completing his Bachelor’s degree in 1921. He was promoted to Trust Officer of the bank in 1927. He attended the LaSalle Correspondence School and completed the law program in four years. He recalls becoming guardian of Kalamazoo resident Alice Louis McDuffy’s estate. He describes his home at 418 Stuart Avenue, originally built by Charles Stuart, and where the street names of Douglas Avenue and Stuart Avenue originated. In part 2, Allen recounts his experiences in the Rotary Club of Kalamazoo. He describes working for the Upjohn Company as secretary of W. E. Upjohn’s estate, his activities with the Kalamazoo Foundation, and meeting W. E. Upjohn. He recalls how the Kalamazoo Foundation started and gives an account of its financial history. In the final part on July 22, Allen describes Kalamazoo College's administrative and financial history.Transcripts unavailable. End of the July 22 interview contains a portion of a William Mckinley Robinson interview, date unknown
Redemption in the work of Francis Stuart
No full textThe idea of redemption is central to an understanding of the work
of Francis Stuart. Through an examination of its development and
expression, it is possible to demonstrate the integrity of his work and
its distinctive qualities. Such a demonstration is necessary because
Stuart's writing has been subjected to comparatively little scholarly
inquiry, although reviews of his work, especially that produced since
1949, suggest that it is impressive and important.
First, a general background to Stuart's work, a discussion of the
special problems associated with reading it, and a summary of his corpus
is provided. This indicates that the idea of redemption is important to
his earliest writing. The state of redemption is shown to be a
necessary apotheosis for Stuart's outcast heroes; it involves spiritual
suffering through which may be found a sense of reintegration and a
higher reality. This is expressed through interrelated themes such as
those of gambler, artist and ordinary man; mystic and criminal; sacred
and profane love; and spirituality and the mundane. The nature of the
redemptive experience is further elaborated by distinctive, complex
motifs, especially the hare, the ark and the woman-Christ. Their
recurrence provides an important element in the unity of Stuart's work.
Because Stuart's idea of the outcast raises important biographical
questions, an examination of the relationship between Stuart's life and
his work is made. Finally, the way in which the idea of redemption
exists in the language structures of Stuart's novels is examined, with
especial reference to his most recent work, The High Consistory. The
thesis shows that the development of the these of redemption
demonstrates the integrity of Stuart's work
Letter from C. M. Conrad to A. H. H. Stuart with a letter from E. A. Hitchcock, 1852
No full textEncloses a letter from Hitchcock about Dr. Wozencraft's deal with "William" in the sale of beef cattle
Letter from C. M. Conrad to A. H. H. Stuart with an extract of report from Maj. Wessells, 1852
No full textConrad sends an extract of Major Wessells' report of the land and inhabitants which he encountered as an escort to Col. McKee (Indian Agent) in 1851
Delivery of c-myb antisense oligodeoxynucleotides to human neuroblastoma cells via disialoganglioside GD(2)-targeted immunoliposomes: antitumor effects
No full textBACKGROUND:Advanced-stage neuroblastoma resists conventional treatment; hence, novel therapeutic approaches are required. We evaluated the use of c-myb antisense oligodeoxynucleotides (asODNs) delivered to cells via targeted immunoliposomes to inhibit c-Myb protein expression and neuroblastoma cell proliferation in vitro.METHODS:Phosphorothioate asODNs and control sequences were encapsulated in cationic lipid, and the resulting particles were coated with neutral lipids to produce coated cationic liposomes (CCLs). Monoclonal antibodies directed against the disialoganglioside GD(2) were covalently coupled to the CCLs. (3)H-labeled liposomes were used to measure cellular binding, and cellular uptake of asODNs was evaluated by dot-blot analysis. Growth inhibition was quantified by counting trypan blue dye-stained cells. Expression of c-Myb protein was examined by western blot analysis.RESULTS:Our methods produced GD(2)-targeted liposomes that stably entrapped 80%-90% of added c-myb asODNs. These liposomes showed concentration-dependent binding to GD(2)-positive neuroblastoma cells that could be blocked by soluble anti-GD(2) monoclonal antibodies. GD(2)-targeted liposomes increased the uptake of asODNs by neuroblastoma cells by a factor of fourfold to 10-fold over that obtained with free asODNs. Neuroblastoma cell proliferation was inhibited to a greater extent by GD(2)-targeted liposomes containing c-myb asODNs than by nontargeted liposomes or free asODNs. GD(2)-targeted liposomes containing c-myb asODNs specifically reduced expression of c-Myb protein by neuroblastoma cells. Enhanced liposome binding and asODN uptake, as well as the antiproliferative effect, were not evident in GD(2)-negative cells.CONCLUSIONS:Encapsulation of asODNs into immunoliposomes appears to enhance their toxicity toward targeted cells while shielding nontargeted cells from antisense effects and may be efficacious for the delivery of drugs with broad therapeutic applications to tumor cells
Letter from C. M. Conrad to A. H. H. Stuart with a letter from E. A. Hitchcock, 1852
No full textConrad encloses a letter from E. A. Hitchcock who reports on the temporary settlement of the Indian troubles on the San Joaquin, and recommending an adjustment of Indian rights in California
Hydrogen isotopic differences between C-3 and C-4 land plant lipids: consequences of compartmentation in C-4 photosynthetic chemistry and C-3 photorespiration
No full textThe H-2/H-1 ratio of carbon-bound H in biolipids holds potential for probing plant lipid biosynthesis and metabolism. The biochemical mechanism underlying the isotopic differences between lipids from C-3 and C-4 plants is still poorly understood. GC-pyrolysis-IRMS (gas chromatography-pyrolysis-isotope ratio mass spectrometry) measurement of the H-2/H-1 ratio of leaf lipids from controlled and field grown plants indicates that the biochemical isotopic fractionation (epsilon H-2(lipid_biochem)) differed between C-3 and C-4 plants in a pathway-dependent manner: epsilon H-2(C4)>epsilon H-2(C3) for the acetogenic pathway, epsilon H-2(C4
John Stuart Mill’s projected science of society: 1827-1848
No full textThe purpose of the thesis is to examine John Stuart Mill’s political thought from
about 1827 to 1848 as an exercise in intellectual history. It focuses, first, on Mill’s view,
formulated by the late 1830s, that contemporary society was ‘civilized’, and second, on
his project of a science of society, which he aspired to develop in the late 1830s and
early 1840s.
By the late 1830s, Mill came to the view that his contemporary society was a
‘commercial society or civilization’, dominated by the middle, commercial class. The
first part of my thesis, constituted by Chapters 2-4, discusses the way in which Mill
formed his notion of civilization, and what he meant by the term ‘civilization’. Mill paid
attention to the implications of the rise of the middle class, and regarded such
phenomena of contemporary society as the corruption of the commercial spirit and
excessive social conformity as an inevitable consequence of the rise of the middle class.
The second part of the thesis, constituted by Chapters 5-9, examines Mill’s
projected science of society. In the late 1830s and early 1840s, Mill attempted to
develop a new science of society whose subject-matter was the nature and prospects of
commercial, civilized society. This aspiration culminated in A System of Logic,
published in 1843. In examining Mill’s projected science, I pay particular attention to
the fact that he conceived new sciences of history and of the formation of character,
both of which were indispensable in his project, although he failed to give a complete
account of these sciences. My thesis shows that the implications of his interest both in
history and in the formation of character are more significant than Mill scholars have
assumed
Image of Mary Stuart in Tragedies of C. H. Spiess and F. Schiller
No full textFeatures of the interpretation of events related to the life and death of the Queen of Scotland, Mary Stuart (1542-1587), in the works of the outstanding German playwright F. Schiller (1759-1805) and his contemporary, the famous writer Christian Heinrich Spiess (Spiess, 1755-1799) is considered. The originality in the image of the last days of Mary by C. H. Spiess and F. Schiller is emphasized. The question is raised about the various literary and aesthetic positions of both German writers. Attention is paid to the review of works in various genres and genres of art dedicated to Mary Stuart by Spiess and Schiller. First, an analysis of the work of the author, which is secondary in the framework of German and European literature, is presented, since Spiess wrote his tragedy many years before the great German playwright. It is shown that Schiller’s tragedy was written with a characteristic thirst for epic coverage of reality, while the stage play of Spiess is more focused on the events of the last days of Mary Stuart’s life and turns into a chamber work. The results of the study can be used when giving lecture courses on foreign literature of the XVIII-XXI centuries, special courses on the literature of Western European countries, on the problems of classical literature in Germany, as well as literature of the Western European Enlightenment and pre-romanticism
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