215 research outputs found
Michael David Loftus and Lydon Burgin
No full textThis 1967 photograph taken by photographer Juanita Wilson shows Michael David Loftus and Lydon Burgin of South Toe River School performing in the Mountain Youth Jamboree. Founder and director of the Mountain Youth Jamboree, Hubert H. Hayes (1901-1964) auditioned and directed youth to perform in folk dance, music, and folk and ballad singing. The jamboree was held in the Asheville City Auditorium (now known as Thomas Wolfe Auditorium) from 1948 to 1973, and Hayes’ wife, Leona Trantham Hayes (1913-1989) continued to direct the program after his death in 1964. Hubert Hayes was an author, playwright, and alumni of Duke University
An everyday carnival : designing for freedom of expression within a multifunctional landscape at loftus versfeld stadium
No full textMini Dissertation (ML(Prof))--University of Pretoria, 2015.This dissertation is an effort towards a better understanding of public open space within Pretoria [Tshwane]. The author identified a lack of freedom of expression within the Pretoria parks and that people actually have a need to be able to express themselves.
The study investigates Carnivalesque as a means of human expression, as well as Loftus Versfeld stadium which occasionally, during sporting events, allows for freedom of expression. Loftus Versfeld provides this incredible experience which unfortunately occurs on only a few weekends within a year. The site becomes derelict and the stadium becomes a white elephant and monofunctional space.
A focus is also on the future predicted growth of the area surrounding the Loftus Versfeld stadium and investigates resilient landscapes for the future.
The design objective is to create a multifunctional resilient landscape where people are able to express themselves freely. The proposal also finds a balance between a programmed and unprogrammed landscape as well as a robust and ecological landscape.tm2016ArchitectureML(Prof)Unrestricte
Town of Highland Park, Texas: An Assessment of Water Use and Conservation Potential
No full textThe Town of Highland Park, Texas would like to take steps towards improving their water use conservation as a demonstration of community leadership. To do this, they have partnered with the Texas State University team (TSU) - Dr. Tim Loftus and the author as graduate research assistant - in a nine-month project to delve into the town's potential for reducing water use. The purpose of this research is three-fold:
1. Gather information about Best Management Practices (BMPs) applied to city- and town-owned properties for the purpose of conserving water from the following cities in Texas: Alamo Heights, Irving, Southlake, The Woodlands, West University Place, Westlake, and Westover Hills. Similar information was also gathered from Cary, North Carolina, Santa Fe, New Mexico, and Scottsdale, Arizona;
2. Develop a water use conservation program scenario that promises to reduce water use in Highland Park and will have the additional potential to improve the town's score as determined by the Texas Living Waters Project, Texas Water Conservation Scorecard (2016). The conservation program scenario will be developed with application of a water conservation planning tool;
3. Analyze WaterSmart-derived monthly water-use data to create new information that enables the Town of Highland Park to better understand recent water use and target water-use conservation.Geography and Environmental Studie
False claims about false memory research
No full textPezdek and Lam [Pezdek, K. & Lam, S. (2007). What research paradigms have cognitive psychologists used to study “False memory,” and what are the implications of these choices? Consciousness and Cognition] claim that the majority of research into false memories has been misguided. Specifically, they charge that false memory scientists have been (1) misusing the term “false memory,” (2) relying on the wrong methodologies to study false memories, and (3) misapplying false memory research to real world situations. We review each of these claims and highlight the problems with them. We conclude that several types of false memory research have advanced our knowledge of autobiographical and recovered memories, and that future research will continue to make significant contributions to how we understand memory and memory errors
Test a Witness’s Memory of a Suspect Only Once
No full textEyewitness misidentifications are almost always made with high confidence in the courtroom. The courtroom is where eyewitnesses make their last identification of defendants suspected of (and charged with) committing a crime. But what did those same eyewitnesses do on the first identification test conducted early in a police investigation? Despite testifying with high confidence in court, many eyewitnesses also testified that they had initially identified the suspect with low confidence or failed to identify the suspect at all. Presenting a lineup leaves the eyewitness with a memory trace of the faces in the lineup, including that of the suspect. As a result, the memory signal generated by the face of that suspect will be stronger on a later test involving the same witness, even if the suspect is innocent. In that sense, testing memory contaminates memory. These considerations underscore the importance of a newly proposed
recommendation for conducting eyewitness identifications: Avoid repeated identification procedures with the same witness and suspect. This recommendation applies not only to additional tests conducted by police investigators but also to the final test conducted in the courtroom, in front of the judge and jury.This Unpublished paper is done by John T. Wixted, Gary L. Wells, Elizabeth F. Loftus, & Brandon L. Garrett, Test a Witness’s Memory of a Suspect Only Once. 2021. Posted with permission
Abstract 1878: PDZ-RhoGEF functions as a critical signaling effector for TROY
No full textAbstract
Glioblastoma Multiforme (GBM) is the most common tumor of the CNS with a median survival of approximately 15 months. The highly aggressive invasion of malignant cells into the surrounding normal brain tissue renders complete surgical resection impossible, increases therapeutic resistance, and virtually assures tumor recurrence. We have previously demonstrated that TROY (TNFRSF19) has an important role in GBM invasion and resistance. TROY expression is correlated with glial tumor grade and inversely correlated with patient survival. Increased TROY expression stimulated cell migration/invasion in vitro and in vivo and confers resistance to both ionizing radiation- and temozolomide-induced apoptosis via activation of Akt and NF-κB. These data indicate that TROY stimulated migration/invasion is associated with signaling pathways that also increase survival and therapeutic resistance, however, the mechanistic basis of this signaling remains unclear. To investigate the mechanism by which TROY induces GBM cell invasion, we performed immunoprecipitation of the TROY receptor coupled with MALDI-TOF and MS/MS analysis and identified PDZ-RhoGEF as a binding partner for TROY. We validated the interaction of TROY with PDZ-RhoGEF by immunoprecipitation and western blotting, and demonstrated that PDZ-RhoGEF can exchange for both RhoA and RhoC in glioma cells and is implicated in GBM cell invasion, proliferation, and survival. In order to assess the specific role of PDZ-RhoGEF in TROY signaling, we examined the effects of PDZ-RhoGEF on TROY-mediated activation of NF-κB. While overexpression of TROY alone strongly stimulated NF-κB transcriptional activity in serum-free conditions, increased expression of PDZ-RhoGEF alone had no effect on NF-κB activity. Co-transfection of PDZ-RhoGEF with TROY synergistically promoted NF-κB activation. Mutation of the TRAF binding domain (TBD) in the cytoplasmic domain of TROY abolished its capacity to activate NF-κB, even in the presence of PDZ-RhoGEF, suggesting that the TBD is important for TROY induced NF-κB activation. Furthermore, knockdown of PDZ-RhoGEF by shRNA attenuated NF-κB activation in TROY expressing cells, blocked TROY mediated invasion of primary GBM xenograft cells and increased sensitivity to temozolomide. Collectively, these data indicate that PDZ-RhoGEF plays an important role in TROY signaling and provides insights into a potential node of vulnerability to limit GBM cell invasion and decrease therapeutic resistance.
Citation Format: Zonghui Ding, Alison Roos, Jean Kloss, Harshil Dhruv, Marc Symons, Nhan L. Tran, Joseph C. Loftus. PDZ-RhoGEF functions as a critical signaling effector for TROY [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1878. doi:10.1158/1538-7445.AM2017-1878</jats:p
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Raw dog ::the naked truth about hot dogs /
No full text"Part travelogue, part culinary history, all capitalist critique-comedian Jamie Loftus's debut, Raw Dog, will take you on a cross-country road trip in the summer of 2021, and reveal what the creation, culture, and class influence of hot dogs says about America now. Hot dogs. Poor people created them. Rich people found a way to charge fifteen dollars for them. They're high culture, they're low culture, they're sports food, they're kids' food, they're hangover food, and they're deeply American, despite having no basis whatsoever in America's Indigenous traditions. You can love them, you can hate them, but you can't avoid the great American hot dog. Raw Dog: The Naked Truth About Hot Dogs is part investigation into the cultural and culinary significance of hot dogs and part travelog documenting a cross-country road trip researching them as they're served today. From avocado and spice in the West to ass-shattering chili in the East to an entire salad on a slice of meat in Chicago, Loftus, her pets, and her ex eat their way across the country during the strange summer of 2021. It's a brief window into the year between waves of a plague that the American government has the resources to temper, but not the interest. So grab a dog, lay out your picnic blanket, and dig into the delicious and inevitable product of centuries of violence, poverty, and ambition, now rolling around at your local 7-Eleven. The hardcover edition of Raw Dog: The Naked Truth About Hot Dogs includes gorgeous endpapers, an illustrated case, as well as illustrations by the author throughout. "One of the freshest and most insightful new comedic voices of this decade." -LINDSAY ELLIS"-
Decentralizing the provision of health services : an incomplete contracts approach
No full textThe author studies the allocation-between a central government and a local authority--of responsibility for planning, financing, and operations for the delivery of health services, in the context of an incomplete contracts model. In this model, inputs are required of both the central government and local authorities but they are unable to write down, and commit to, a complete and binding contract describing the actions both should take. The model is meant to capture the tradeoff between central and local authority in decisions about both financing and the provision of services. Each party provides a specific input--for example, the central government establishes a drug procurement system while the local authority designs and implements an incentive scheme to get doctors to carry out their responsibilities appropriately. The responsibility for delivery of services is identified with the ownership of essential infrastructure, such as the clinic or hospital. The author finds that to maximize the joint surplus of the two public bodies: Ownership of the facility should be given to the party that most values the well-being of local residents. (This way, if ex post bargaining breaks down, each still enjoys some benefits from the other's actions.) Financing authority and responsibility for delivering services should be negatively correlated. Generally it is optimal to allocate tax authority to the party that values the residents'well-being less--in other words, separate spending responsibility (ownership) from financing authority. A heavier financing burden (access to a small and inefficient tax base) has the same incentive effect as asset ownership: It increases the return to effort. If transferring ownership of the physical asset is costly (because the party that builds the asset has an inherent advantage in operating it-that is, there is some human capital embodiment), it may be optimal for the party with the higher construction costs to have planning authority. Somewhat paradoxically, the greater the costs of transferring assets from one party to the other, the more likely that ownership of the facilities and their provision should be separated.International Terrorism&Counterterrorism,Decentralization,Environmental Economics&Policies,Economic Theory&Research,Labor Policies,Economic Theory&Research,National Governance,International Terrorism&Counterterrorism,Banks&Banking Reform,Environmental Economics&Policies
A Complete Mitochondrial Genome Sequence from a Mesolithic Wild Aurochs (Bos primigenius)
No full textBackground
The derivation of domestic cattle from the extinct wild aurochs (Bos primigenius) has been well-documented by archaeological and genetic studies. Genetic studies point towards the Neolithic Near East as the centre of origin for Bos taurus, with some lines of evidence suggesting possible, albeit rare, genetic contributions from locally domesticated wild aurochsen across Eurasia. Inferences from these investigations have been based largely on the analysis of partial mitochondrial DNA sequences generated from modern animals, with limited sequence data from ancient aurochsen samples. Recent developments in DNA sequencing technologies, however, are affording new opportunities for the examination of genetic material retrieved from extinct species, providing new insight into their evolutionary history. Here we present DNA sequence analysis of the first complete mitochondrial genome (16,338 base pairs) from an archaeologically-verified and exceptionally-well preserved aurochs bone sample.
Methodology
DNA extracts were generated from an aurochs humerus bone sample recovered from a cave site located in Derbyshire, England and radiocarbon-dated to 6,738±68 calibrated years before present. These extracts were prepared for both Sanger and next generation DNA sequencing technologies (Illumina Genome Analyzer). In total, 289.9 megabases (22.48%) of the post-filtered DNA sequences generated using the Illumina Genome Analyzer from this sample mapped with confidence to the bovine genome. A consensus B. primigenius mitochondrial genome sequence was constructed and was analysed alongside all available complete bovine mitochondrial genome sequences.
Conclusions
For all nucleotide positions where both Sanger and Illumina Genome Analyzer sequencing methods gave high-confidence calls, no discrepancies were observed. Sequence analysis reveals evidence of heteroplasmy in this sample and places this mitochondrial genome sequence securely within a previously identified aurochsen haplogroup (haplogroup P), thus providing novel insights into pre-domestic patterns of variation. The high proportion of authentic, endogenous aurochs DNA preserved in this sample bodes well for future efforts to determine the complete genome sequence of a wild ancestor of domestic cattle
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