136 research outputs found
“Text up his name”: The Authorship of the Manuscript Play Dick of Devonshire
No full textThe manuscript play Dick of Devonshire has been attributed to several early modern dramatists, including Thomas Heywood, Robert Davenport, James Shirley, and Thomas Dekker. Identifying the author is important to obtaining a better understanding of the play's place in the Caroline commercial theater industry and how it came to be staged by Queen Henrietta Maria's Men in the summer of 1626. This article reviews the arguments that have been made for and against the various authorial candidates and, using historical and literary evidence as well as new computational analysis, establishes that Thomas Heywood is the play's most likely author
Unfortunate attachment
No full text"Published anonymously in 1773 and attributed to Georgiana, Duchess of Devonshire"--P. [4] of cover. "Seven independent sources list her [Georgiana, Duchess of Devonshire] as author, including the most recent and definitive work on the subject, The English novel, which atttibutes the novel to her with a question mark"--P. 10.Includes bibliographical references and index.Georgiana, Duchess of Devonshire ; edited and with an introduction by Jonathan David Gross
President's address. [Devonshire authors and their works]
No full textRepr.: Transactions of the Devonshire Association for the Advancement of Science, Literature, and Art. July 26, 1893. Title from cover.Mode of access: Internet.Letter from the author inserted
Interlaboratory evaluation of quality control methods for circulating cell-free DNA extraction
No full text: Analysis of circulating cell-free DNA (ccfDNA) isolated from liquid biopsies is rapidly being implemented into clinical practice. However, diagnostic accuracy is significantly impacted by sample quality and standardised approaches for assessing the quality of ccfDNA are not yet established. In this study we evaluated the application of nucleic acid "spike-in" control materials to aid quality control (QC) and standardisation of cfDNA isolation for use in in vitro diagnostic assays. We describe an approach for the design and characterisation of in-process QC materials, illustrating it with a spike-in material containing an exogenous Arabidopsis sequence and DNA fragments approximating to ccfDNA and genomic DNA lengths. Protocols for inclusion of the spike-in material in plasma ccfDNA extraction and quantification of its recovery by digital PCR (dPCR) were assessed for their suitability for process QC in an inter-laboratory study between five expert laboratories, using a range of blood collection devices and ccfDNA extraction methods. The results successfully demonstrated that spiking plasmid-derived material into plasma did not deleteriously interfere with endogenous ccfDNA recovery. The approach performed consistently across a range of commonly-used extraction protocols and was able to highlight differences in efficiency and variability between the methods, with the dPCR quantification assay performing with good repeatability (generally CV <5%). We conclude that initial findings demonstrate that this approach appears "fit for purpose" and spike-in recovery can be combined with other extraction QC metrics for monitoring the performance of a process over time, or in the context of external quality assessment. AVAILABILITY OF DATA AND MATERIALS: Processed data is available in Supplementary File 4. Raw data available upon request. Declaration of Competing Interest
Comparison of microfluidic digital PCR and conventional quantitative PCR for measuring copy number variation
No full textACKNOWLEDGEMENTS The authors would like to acknowledge Dr Malcolm Burns and Dr Alison Devonshire for critical review of the manuscriptPeer reviewe
The life of the right honourable and religious Lady Christian[a], late Countess Dowager of Devonshire [electronic resource]
No full textRunning title: The life of the Countess of Devonshire."The epistle dedicatory" signed: Tho. Pomfret.Reproduction of original in Huntington Library.WingElectronic reproduction
Aliso Creek and Alison Debris Basin
No full textAerial view of Northridge fields. Two marked locations are Devonshire Street and Aliso Creek
International Interlaboratory Digital PCR Study Demonstrating High Reproducibility for the Measurement of a Rare Sequence Variant
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