12 research outputs found
Ramadan fasting and type 1 diabetes: a scoping review protocol
No full textIntroduction Ramadan fasting is globally observed and a great majority of the residents of Islamic countries and elsewhere fast during Ramadan all across the world every year. Many patients with type 1 diabetes fast during Ramadan according to (or against) medical and jurisprudence advice. Nonetheless, there is a paucity of scientific evidence regarding the risks patients with diabetes who fast may be confronted with. The current scoping review protocol aims at systematic analysis and mapping of existing literature in the field and highlighting scientific gaps.Methods and analyses This scoping review will be conducted based on the Arksey and O'Malley’s methodological framework with consideration of later modifications and amendments. Three major scientific databases, namely PubMed, Scopus and Embase up to February 2022 will be systematically searched by expert researchers in collaboration with a medical librarian. Considering the fact that Ramadan Fasting is a cultural-dependent subject, which may be studied in the Middle Eastern and Islamic Countries in languages other than English, local Persian and Arabic Databases will also be included. Grey literature will be sought too, and unpublished works such as conference proceedings and academic degree dissertation will be considered. Subsequently, one author will screen and record all abstracts, and two reviewers will independently screen and retrieve eligible full texts. A third reviewer will then be designated to resolve potential discrepancies. Standardised data charts and forms will be used for information extraction and reporting of the outcomes.Ethics and dissemination No ethical considerations apply to this research. Results will be published and presented in academic journals and scientific events
Safety and efficacy of hematopoietic and mesanchymal stem cell therapy for treatment of T1DM: a systematic review and meta-analysis protocol
No full textSafety and efficacy of hematopoietic and mesanchymal stem cell therapy for treatment of T1DM: a systematic review and meta-analysis protocol
No full textAbstract Introduction Insulin standard treatment of T1DM cannot cure the patients as different chronic complications occurred subsequently. Investigations on a curative treatment in T1DM propose cell replacement or maintenance instead of exogenous insulin therapy, but different dimensions of this novel treatment are not clarified. Methods and analysis We will include all clinical trials which have evaluated the efficacy MSC or HSC transplantation in T1DM treatment; electronically search bibliographic databases, country registration data banks, and gray literatures; and hand-search two key journals, two experts’ article, and references of the included articles with no language restriction. Primary outcome is the extent of reduction in insulin requirement and secondary outcomes are safety of MSC and HSC therapy, effect of this therapy on diabetic parameters, effect of the rout of transplantation and origin of the MSC or HSC on efficacy of treatment, studies heterogeneity and potential reasons of it. Heterogeneity and its severity will be calculated with Q Cochrane test, P value, and I 2 index. STATA software version 12 will be used for meta-analysis. PROSPERO Registration number: CRD42016047176. Ethics and dissemination We will publish the systematic review in a peer review journal; as it presents an analysis of published literature, the study does not require ethical approval. Strengths and limitations of this study This systematic review and meta-analysis will investigate the efficacy of MSC and HSC transplantation in T1DM treatment with no language restriction. Also we will evaluate gray literatures after hand searching. This protocol is prepared according to Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). Two reviewers will evaluate screened full texts, extract data, and asses risk of bias of eligible primary studies independently. As there is the possibility that we miss some unpublished primary studies due to negative results, we will use funnel plot to detect this and correct it with fill and trim method
Comparability of hemoglobin A1c level measured in capillary versus venous blood sample applying two point-of-care instruments
No full textAssessment of quality of life of Iranian nurses
No full textNurses’ Quality Of Life (QOL) may be affected by many different factors that can in turn influence their job competency. The aim of this study was to assess the QOL of Iranian nurses to provide evidence to enable policy makers to take the necessary steps needed to make improvements. Using a cross-sectional study design, we evaluated the QOL of Iranian nurses by the assessment of four health indicators: physical, psychological, social and environmental. A total of 850 nurses from 17 different provinces of Iran were recruited by random sampling. They were requested to complete the World Health Organization QOL-BREF questionnaire. Data were then analyzed. Results indicated that half of the nurses scored in the moderate range, suggesting that they had a reasonably good QOL. They scored considerably higher in terms of physical health indicators and achieved significantly lower scores regarding environmental health issues. Although the χ2 test did not show any significant association between the QOL indicators and different factors such as work experience, gender, job position and patients group. We found a significant association between the subject’s position at work in the hospital shift pattern and their overall QOL score. The results of our study showed that more than half the nurses evaluated their QOL to be at a moderate level. The results from this study can be used by policy makers to help make improvements to nurses’ QOL that may enhance the quality of care they deliver to their patients. Future research including a group of nurses from over the whole country is essential so that a more representative cohort can be studied. It would also pave the way for the establishment of a QOL database for nurses in Iran that could monitor changes in the nursing population
The Global Syndemic of Obesity, Undernutrition, and Climate Change: The Lancet Commission report
No full textMalnutrition in all its forms, including obesity, undernutrition, and other dietary risks, is the leading cause of poor health globally. In the near future, the health effects of climate change will considerably compound these health challenges. Climate change can be considered a pandemic because of its sweeping effects on the health of humans and the natural systems we depend on (ie, planetary health). These three pandemics—obesity, undernutrition, and climate change—represent The Global Syndemic that affects most people in every country and region worldwide. They constitute a syndemic, or synergy of epidemics, because they co-occur in time and place, interact with each other to produce complex sequelae, and share common underlying societal drivers. This Commission recommends comprehensive actions to address obesity within the context of The Global Syndemic, which represents the paramount health challenge for humans, the environment, and our planet in the 21st century.Additional co-authors: Prof Corinna Hawkes PhD, Mario Herrero PhD, Prof Peter S Hovmand PhD, Prof Mark Howden PhD, Lindsay M Jaacks PhD, Ariadne B Kapetanaki PhD, Matt Kasman PhD, Prof Harriet V Kuhnlein PhD, Prof Shiriki K Kumanyika PhD, Prof Bagher Larijani MD, Tim Lobstein PhD, Michael W Long PhD, Victor K R Matsudo MD, Susanna D H Mills PhD, Gareth Morgan PhD, Alexandra Morshed, Patricia M Nece JD, Prof An Pan PhD, David W Patterson, Gary Sacks PhD, Meera Shekar PhD, Geoff L Simmons, Warren Smit PhD, Ali Tootee PhD, Stefanie Vandevijvere PhD, Wilma E Waterlander PhD, Luke Wolfenden PhD, Prof William H Dietz M
Evaluation of fetal cell transplantation safety in treatment of diabetes: a three-year follow-up
No full textThe Global Syndemic of Obesity, Undernutrition, and Climate Change: The Lancet Commission report
No full textMalnutrition in all its forms, including obesity, undernutrition, and other dietary risks, is the leading cause of poor health globally. In the near future, the health effects of climate change will considerably compound these health challenges. Climate change can be considered a pandemic because of its sweeping effects on the health of humans and the natural systems we depend on (ie, planetary health). These three pandemics—obesity, undernutrition, and climate change—represent The Global Syndemic that affects most people in every country and region worldwide. They constitute a syndemic, or synergy of epidemics, because they co-occur in time and place, interact with each other to produce complex sequelae, and share common underlying societal drivers. This Commission recommends comprehensive actions to address obesity within the context of The Global Syndemic, which represents the paramount health challenge for humans, the environment, and our planet in the 21st century
