14 research outputs found
Association of aortic diameters with coronary artery disease severity and albumin excretion
No full textIntroduction. Aortic diameters, aortic distensibility, microalbuminuria, coronary artery disease which are all together related to vascular aging are investigated in this paper. Methods. Eighty consecutive nondiabetic patients undergoing elective coronary angiography were enrolled into the study. Systolic and diastolic aortic diameters, aortic distensibility, CAD severity by angiogram with the use of Gensini scoring, and albumin excretion rates were determined. Results. Cases with CAD had significantly larger systolic (30,72 +/- 3,21mm versus 34,19 +/- 4,03 mm for cases without and with CAD, resp.) and diastolic aortic diameters measured 3 cm above aortic valve compared to patients without CAD (33,56 +/- 4,07 mm versus 29,75 +/- 3,12 mm). The systolic and diastolic diameters were significantly higher in albuminuria positive patients compared to albuminuria negative patients (p = 0.017 and 0.008, resp., for systolic and diastolic diameters). Conclusion. In conclusion aortic diameters are increased in patients with coronary artery disease and in patients with microalbuminuria. In CAD patients, systolic blood pressure, pulse pressure, aortic systolic and diastolic pressure, and albumin excretion rate were higher and aortic distensibility was lower
SiSeRHMap v1.0: A simulator for mapped seismic response using a hybrid model
No full textThe SiSeRHMap (simulator for mapped seismic response using a hybrid model) is a computerized methodology capable of elaborating prediction maps of seismic response in terms of acceleration spectra. It was realized on the basis of a hybrid model which combines different approaches and models in a new and non-conventional way. These approaches and models are organized in a code architecture composed of five interdependent modules. A GIS (geographic information system) cubic model (GCM), which is a layered computational structure based on the concept of lithodynamic units and zones, aims at reproducing a parameterized layered subsoil model. A meta-modelling process confers a hybrid nature to the methodology. In this process, the one-dimensional (1-D) linear equivalent analysis produces acceleration response spectra for a specified number of site profiles using one or more input motions. The shear wave velocity-thickness profiles, defined as trainers, are randomly selected in each zone. Subsequently, a numerical adaptive simulation model (Emul-spectra) is optimized on the above trainer acceleration response spectra by means of a dedicated evolutionary algorithm (EA) and the Levenberg-Marquardt algorithm (LMA) as the final optimizer. In the final step, the GCM maps executor module produces a serial map set of a stratigraphic seismic response at different periods, grid solving the calibrated Emul-spectra model. In addition, the spectra topographic amplification is also computed by means of a 3-D validated numerical prediction model. This model is built to match the results of the numerical simulations related to isolate reliefs using GIS morphometric data. In this way, different sets of seismic response maps are developed on which maps of design acceleration response spectra are also defined by means of an enveloping technique. © Author(s) 2016
Effectiveness of olanzapine in neurosyphilis related organic psychosis: a case report
No full textThe clinicians usually do not consider syphilis in the differential diagnosis for patients with acute and chronic psychiatric symptoms. To familiarize clinicians particularly with neurosyphilis (NS) and to discuss the atypical antipsychotic alternatives, we wish to present a case with agitated, resistant psychotic symptoms related to neurosyphilis. The case was a 55-year-old male who has had anxiety, irritability, auditory hallucinations, ataxia, dysarthric speech, paranoid and persecutory delusions and agitated behaviour. Parenteral ziprasidone 20 mg/bid was initialized at the first day of admission to reduce agitation. Then it was switched to olanzapine velotab 10mg/bid because of inefficacy. Parenteral cephtriaxon 1 g/daily was administered because of seropositive VDRL and TPHA and positive cerebrospinal fluid VDRL. Olanzapine velotab may be a good alternative antipsychotic and should be considered in reducing agitation and psychotic symptoms in NS
Effect of trospium chloride therapy on intraocular pressure and tear secretion in overactive bladder patients
No full textInfluence of Formulation Methods on the In Vitro Controlled Release of Protein from Poly(Ester) Microspheres
No full textJournal of Controlled Release, 17, 23-32Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.Poly (dl-lactide/glycolide, 50:50) microspheres containing bovine serum albumin (BSA) were pre-pared with and without Carbopol® 951 (a potential adjuvant agent) by o/o, o/w and (w/o) /w emul-sion methods. The protein loading of the microspheres reached 50%–70% of the theoretical amount of protein put into the formulation medium. The microsphere particle size was approximately 500 μm, 25–100μm, 10–20/nn using o/o, o/w, or (w/o)/w emulsion techniques, respectively. The release of BSA was dependent on the preparation method. The greatest burst of release was found for vacuum-dried microspheres formulated using the (w/o)/w method. This burst effect could be eliminated by lyophilizing the microspheres following their preparation. BSA was released at a higher initial rate from microspheres prepared by the o/w emulsion method that contained Carbopol® 951 than from micro-spheres not containing Carbopol® 951. Release studies also suggested that the release of BSA could be sustained for 54, 36, or 34 days for microspheres prepared by o/o, o/w, or (w/o)/w methods, respectively.https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/0168-3659(91)90127-
DFT and semi-empirical analyses of Cr-3(+) and Fe3+ impurity centers in Cs2NaYF6: Microscopic insight into structural properties
No full textErbahar, Doğan (Dogus Author)A detailed microscopic study of the local geometry was performed for the cation sites in fluoroelpasolite Cs2NaYF6 crystal doped with 3d ions (Cr3+ and Fe3+). Electronic structure of pure, Crdoped and Fe-doped Cs2NaYF6 has been studied by determining various properties: substitution energies of dopant ions, ionic Mulliken charges, atomic coordinates and unit cell parameters for the optimized structures. Also, the optimized local geometry of all three cation sites before and after the possible dopant ions substitutions has been deduced by DFT calculations. It is shown that the local symmetry of both Y3+ and Na+ sites maintains its cubic form after both Fe and Cr substitution; however, Fe ions lead quite larger distortion on ligand lengths at Y-site. The optimized structure has been used independently to calculate zero-field splitting parameters (ZFSPs) and crystal field parameters (CFPs) of both Cr3+ and Fe3+ centers. The calculated ZFSPs of Fe(3+ )ions indicate that the results predicted by SPM for both Y3+ site and Na+ site agree well with the previous experimental observations of ZFSPs. It can be inferred from the findings regarding both electronic structure and local optimized geometry that substitution of both Cr3+ and Fe3+ ions for Y3+ is more likely in C(s)2NaYF(6)
Microscopic insight into electronic and structural properties of Cr3+ and Fe3+ impurities in Cs2NaAlF6 via DFT and SPM analyses
No full textErbahar, Doğan (Dogus Author)Allowing high transition metal (TM) ions doping concentrations makes the fluoroelpasolite crystals Cs2NaMF6 (M=Al, Ga) quite interesting in various laser applications. In this study, we explored the influence of the dopant ions on the electronic and structural properties of Cs2NaAlF6. Particular attention is paid to the influence of trivalent TM ions (Cr3+ and Fe3+) on the local structure around the possible substitutional cation sites by investigating the optimized geometry around impurity sites due to Cr3+ and Fe3+ using density functional theory (DFT). The obtained structural data are utilized for the calculations of zero-field splitting (ZFS) parameters (ZFSPs) and crystal field parameters (CFPs) of both dopant ions independently in the frame of semi empirical superposition model (SPM). It is shown that remarkable change on the ZFSPs comes not from the distortion on metal-ligand distance but from that on the angular positions of the ligands around the impurity centers. It is clearly shown that the substitution of both Cr3+ and Fe3+ ions take place with significant influence on electronic structure and geometry for the trivalent Al3+ sites. The presented results here have significant potential to better understand the low-symmetry effects in especially optical applications of Cs2NaAlF6:Cr3+ and Cs2NaYF6:Fe3+ systems. Particularly, the calculated CFPs for Cs2NaYF6:Fe3+ system may serve as the only record in literature
The Attitudes of Patients toward the Presence of Students in Internal Medicine Inpatient and Outpatient Practice
No full textObjective: The medicine educators increase the clinical skills and professional thinking ability of students by examining patients, showing their attitudes towards them, and attracting their response in the presence of medical students. In this study, we aimed to investigate the attitudes of patients who applied to internal medicine toward the presence of medical students and the possible factors that may influence such attitudes
The Effects of Metabolic Syndrome on TpTe Interval and TpTe/QT Ratio in Patients with Normal Coronary Arteries
No full textComparison of the Systemic and Local Pharmacokinetics of Clonidine Mucoadhesive Buccal Tablets with Reference Clonidine Oral Tablets in Healthy Volunteers: An Open-Label Randomised Cross-Over Trial
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