266 research outputs found
Effect of intralesional sodium stibogluconate alone versus combinations with topical trichloroacetic acid 50% or fractional carbon dioxide laser on cutaneous leishmaniasis
No full textBackground: Cutaneous leishmaniasis (CL) is a vector-borne protozoal disease. Antimonial drugs remain the first-line treatment for CL despite the widespread drug resistance and high incidence of side effects. The present study aimed to compare the efficacy and safety of traditional intralesional sodium stibogluconate (SSG) alone and its combinations with trichloroacetic acid (TCA) 50% and fractional carbon dioxide (CO2) laser for the treatment of CL. Materials and Methods: An interventional study was carried out on 25 CL patients. In each patient, three lesions were assigned to treatment either by SSG alone (GI), SSG plus TCA 50% (GII), or SSG plus fractional CO2 laser (GIII). The overall clinical improvement and changes in the sizes of lesions and scars were assessed and compared among the three groups. Results: GIII patients had significantly lower treatment sessions as compared to GI patients (3.6 ± 1.29 versus 4.04 ± 2.11, P = 0.042). Moreover, GII and GIII patients had significantly shorter healing times when compared with GI (3.63 ± 1.35 and 3.46 ± 1.25, respectively, versus 4.0 ± 2.15 weeks, P = 0.019). Also, it was shown that GIII patients had significantly lower scar scores (1.40 ± 1.52) when compared with GI (3.00 ± 0.0) and GII (2.80 ± 1.10), P = 0.017. Conclusions: Intralesional SSG with TCA 50% is more effective than SSG alone and is comparable to SSG and fractional CO2 combination in the treatment of CL with better safety profile and patient satisfaction
Integrating HBIM (Heritage Building Information Modeling) Tools in the Application of Sustainable Retrofitting of Heritage Buildings in Egypt
Get PDFAbstractHeritage buildings are crucial to the human perception of culture. Sustainable retrofitting of such buildings represents an opportunity for their reuse while considering sustainability. HBIM tools (Historic building Information Modeling) can be used as a comprehensive data set of information, related particularly to the restoration of buildings. The aim of this paper is to integrate HBIM tools in the application of sustainable retrofitting of heritage buildings through a conservation framework. The paper provides a literature review and a qualitative analysis of worldwide examples. Findings of this paper provide useful framework for sustainable retrofitting of heritage buildings in the Egyptian context
Assessing the Activity of Renin and GST in the Serum of Ladies Suffering from Polycystic Ovary Syndrome and COVID-19 to Predict the Danger of Cardiac Disease
Get PDFThe coronavirus-pandemic has a major impact on women's-mental and physical-health. Polycystic-ovary-syndrome (PCOS) has a high-predisposition to many cardiometabolic-risk factors that increase susceptibility to severe complications of COVID-19 and also exhibit an increased likelihood of subfertility. The study includes the extent of the effect of COVID-19-virus on renin-levels, glutathione-s-transferase-activity and other biochemical parameters in PCOS-women. The study included 120 samples of ladies that involved: 80 PCOS-patients, and 40 healthy-ladies. Both main groups were divided into subgroups based on COVID-19 infected or not. Blood-samples were collected from PCOS-patients in Kamal-Al-Samara Hospital, at the period between December until June. Some biochemical parameters were measured for all study-groups, which included: determination of serum renin levels by using the ELISA-technique, GST-activity, lipid-profile. FBS was assessed manually, and hormones were assessed using VIDAS-analyzer-hormones. The result showed a possible relationship between FBS-levels and renin in PCOS-ladies (Stein-Leventhal-Syndrome), while GST-activity were inversely associated with BMI in PCOS-ladies. Also, it was found that the renin-levels were higher in PCOS-patients groups compared with healthy-groups. On the other hand, the renin levels and Glutathione-S-Transferase-activity were lower in PCOS-patients-infected-with-COVID-19 than female-patients-without-COVID-19. The statistical-data-displayed that the level of renin is associated negatively with glutathione-s-transferase-activity in PCOS-cases. Renin level was higher in PCOS-ladies, this may lead to increase renal-dysfunction and risk of cardiovascular-disease that may be expected in patients. A decrease in the antioxidant-capacity may be because the high number of free-radicals that enter the body by the virus and high levels of renin which lead to a higher risk of PCOS-complication like cardiovascular-disease
Effect of COVID-19 on the Role of Renin Enzyme and ACE2 and Hormones in PCOS Females
Get PDFمتلازمة تكيس المبايض (PCOS) هي اكثر مشاكل الغدد الصماء شيوعًا لدى النساء في سن الانجاب. النساء المصابات بمتلازمة تكيس المبايض عادة ما تنتمي الى فئة العمر والجنس المعرضة لخطر الإصابة بمرض فيروس كورونا الشديد (COVID-19). يستهدف COVID-19 الخلايا من خلال مستقبل الإنزيم المحول للأنجيوتنسين 2 (ACE2) الموجود على الخلايا في الأوردة والرئتين والقلب والجهاز الهضمي والكلى. تم وصف فرط نشاط نظام الرينين أنجيوتنسين (RAS) أيضًا في اضطرابات التمثيل الغذائي ، وداء السكري من النوع 2 (T2DM) ، وهي حالات مشتركة بين النساء المصابات بحالة تكيس المبايض . الهدف من هذه الدراسة هو معرفة وظيفة الرينين والإنزيم المحول للأنجيوتنسين 2 في متلازمة تكيس المبايض وفيروس كورونا وعلاقته بالهرمونات ومعايير التمثيل الغذائي الأخرى ذات الصلة. تتكون مجموعة الدراسة من 120 عينة تتكون من 80 امرأة مصابة بمتلازمة تكيس المبايض ، حيث تم تقسيمهن إلى مجموعتين 40 امرأة مصابة بمتلازمة تكيس المبايض و مصابة بـ COVID-19 و 40 امرأة مصابة بمتلازمة تكيس المبايض و غير مصابة بـ COVID-19) و 40 امرأة بصحة جيدة مقسمة إلى مجموعتان: - 20 امرأة مصابة بـ COVID-19 ، و 20 امرأة غير مصابة بـ COVID-19) ، تتراوح أعمارهم بين 15-40 سنة. الرينين و ACE2، FBS ، ملف الدهون ، الأنسولين ، HOMA IR ، FSH ، LH ، و التستوستيرون تم قياسها لجميع المشاركين . كانت هناك زيادة في مستوى الرينين ، الإنزيم المحول للأنجيوتنسين 2 ، ومستوى الأنسولين ، HOMA-IR ، LH ، ونسبة LH / FSH ، ومستويات هرمون التستوستيرون ، باستثناء HDL و FSH كانت منخفضة عند المقارنة بين مرضى متلازمة تكيس المبايض مع مجاميع الاصحاء. هناك انخفاض في الرينين و ACE2 في النساء المصابات بمتلازمة تكيس المبايض ومصابة بعدوى كوفيد- 19بالمقارنة مع النساء المصابات بمتلازمة تكيس المبايضوغير مصابات بعدوى كوفيد-19. دخول covid-19 إلى الجسم و انخفاض مستويات ACE2 يؤدي إلى تلف الجهاز التنفسي ومشكلة في الإنجاب لدى النساء المصابات بمتلازمة تكيس المبايض. أيضًا ، في نفس الوقت ، فإن ارتفاع مستوى ACE2 في مريضات متلازمة تكيس المبايض يجعلهن أكثر عرضة لخطر الاصابة بفيروس كورونا وليس متورطًا في التسبب بمتلازمة تكيس المبايض ، ومع ذلك قد يتأثر إنزيم الرينين بمؤشر كتلة الجسم المرتبط بمتلازمة تكيس المبايض.Polycystic ovary syndrome (PCOS) is the most endocrine problem in women of regenerative age. PCOS women typically belong to an age and sex group which is at higher risk for severe coronavirus disease (COVID-19). COVID-19 targets cells through angiotensin-converting enzyme 2 (ACE2) receptor presents on cells in veins, lungs, heart, digestion tracts, and kidneys. Renin-Angiotensin System (RAS) over activity has likewise been described in metabolic disorders; type 2 diabetes mellitus (T2DM), and conditions shared by women with polycystic ovary condition. The point of this study is to know the job of renin and ACE2 in PCOS and coronavirus and its relationship with hormones and other metabolic parameters related. The study groups consist of 120 sample subjects consisting of 80 PCOS-women divided into two groups: - (40 PCOS-women infected with COVID-19 and 40 PCOS-women non-infected with COVID-19) and 40 healthy-women divided into two groups: - 20 women-COVID-19 infected, and 20 women non-COVID-19 infected, ranging in age from 15–40 years old. Renin and ACE2, FBS, lipid profile, level of insulin, HOMA IR, FSH, LH, and testosterone, were measured for all participants. There was an increase in the levels of renin, ACE2, insulin, HOMA-IR, LH, LH / FSH ratio, and testosterone, except HDL and FSH were low when comparing PCOS patients groups with healthy groups. There was a decrease in renin and ACE2 in PCOS women infected with COVID-19 compared with PCOS women non-infection with COVID-19. Infection of COVID-19 and low ACE2 levels lead to respiratory damage and problem in reproductive in PCOS patients. Also, at the same time ACE2 high level in PCOS makes them more risk for coronavirus and is not involved in the cause of PCOS, however renin enzyme may be affected by BMI associated with PCOS
A Study of Apelin-36 and GST Levels with Their Relationship to Lipid and Other Biochemical Parameters in the Prediction of Heart Diseases in PCOS Women Patients
Get PDF هذا العمل يتضمن دراسة دورالأبلين-36 وفعالية انزيم الكلوتاثيون وعلاقتها بالهرمونات والعوامل ذات الصلة بالتمثيل الغذائي, وارتباطها بخطرالاصابة بأمراض القلب الوعائيه في النساء الأصحاء والنساء المصابات بمتلازمة تكيس المبايض. اشتملت الدراسة على 54 مصابة بمتلازمة تكيس المبايض و31 امراة بصحة جيدة (المجموعة الضابطة). مرضى PCOS تم تقسيمهم حسب مؤشر كتلة الجسم BMI الى مجموعتين (المجموعة الاولى يعانون من السمنة المفرطة BMI≥30والمجموعة الثانية لايعانون من السمنة .(BMI≤30 AP-36, GST-activity, Fasting-insulin, HOMA-IR, Testosterone, LH, FSH, Lipid-profile تم قياس المتغيرات التالية لجميع المجاميع. أظهرت السيدات المصابات بمرض تكيس المبايض ارتفاع في تركيز مصل Apelin-36 أعلى من السيدات الأصحاء (160.43±20.81 (pg/ml) مقابل 85.49±17.85 (pg/ml) ، P=0.008) ، بينما كان فعالية انزيم GST منخفضا في المرضى ومرتفعا في الأصحاء (7.99± 1.19 (IU/L) مقابل 12.96±1.90 (IU/L), P=0.022). ترتبط مستويات APLEN-36 ارتباطًا مباشرًا بمؤشر كتلة الجسم و VLDL في المرضى ، لكن مستويات فعالية انزيم GST مرتبطة عكسيا مع (BMI) في المرضى. علاوة على ذلك ، وجد ان هنالك زيادة في مستويات AP-36 في مرضى PCOS البدناء أكثر من مرضى PCOS غير البدناء (185.76± 92.0 (pg/ml) مقابل 123.59± 27.65 (pg/ml) ، P=0.127) ، في حين وجد أن نشاط أنزيم GST كان منخفضا في مرضى PCOS البدناء اكثر من مرضى PCO غير البدناء (6.99 ± 1.4 (IU/L) مقابل 9.44 ± 2.0 (IU/L) ، P=0.102). يتضح من المعلومات التالية بأن مستوى AP-36 يرتبط عكسيا بفعالية أنزيم GST في مرضى تكيس المبايض. AP-36 لايرتبط مباشرةً في التسبب في اضطراب PCO ، ومع ذلك فقد يتم إدراجه باعتباره مادة دهنية تتأثر بمؤشر كتلة الجسم. أن زيادة المواد المؤكسدة بسبب زيادة مستوى VLDL وانخفاض فعالية إنزيمات مضادات الأكسدة قد تكون استجابة للمستويات العالية للأجهاد التأكسدي. ان انخفاض قدرة مضادة الأكسدة و زيادة تركيز AP-36 قد يؤدي الى توسع خطر الإصابة بأمراض القلب الوعائيه لدى السيدات المصابات بمتلازمة تكيس المبايض ، بالأضافة إلى عوامل الخطر ، مثلا:- مقاومة الأنسولين، ارتفاع ضغط الدم، السمنة المفرطة، ارتفاع مستوى الدهون.This work studies the role of serum apelin-36 and Glutathione S-transferases (GST) activity in association with the hormonal, metabolic profiles and their link to the risk of cardiovascular disease (CVD) in healthy and patients' ladies with polycystic ovary syndrome (PCOS). A total of fifty-four (PCOS) patients and thirty-one healthy woman as a control have been studied. The PCOS patients were subdivided on the basis of body-mass-index (BMI), into 2-subgroups (the first group was obese-PCOS with BMI ≥ 30 and the second group was non-obese PCOS MBI<30). Fasting-insulin-levels and Lipid-profile, Homeostatic-model assessment-of-insulin-resistance (HOMA-IR), follicle-stimulating-hormone (FSH), luteinizing-hormone (LH), testosterone and serum Apelin-36 (AP-36) levels, GST-Activity were done for all groups. PCO patients showed higher concentricity of apelin-36 than healthy (160.43 ±20.81 (pg/ml) versus 85.49 ± 17.85 (pg/ml), P=0.008),while GST-activity decreased in PCOS patients and was higher in the control (7.99 ± 1.19(IU/L)versus 12.96 ±1.90(IU/L)respectively,with a P-value=0.022). Apelin-36 levels are directly interrelated with BMI and Very-low-density-lipoprotein (VLDL) in PCOS patients, but GST-activity levels correlated significantly negatively with (BMI) in PCOS patients. Moreover, obese-PCOS patients show increased AP-36 levels more than non-obese PCOS (185.76± 92.0(pg/ml) versus 123.59±27.65 (pg/ml), P=0.127) respectively, whilst the GST-activity was exhibited to be lower in obese-PCO patients more than in non-obese PCOS (6.99 ± 1.4(IU/L) versus 9.44 ± 2.0(IU/L), P=0.102). The data showed that AP-36 level is negatively associated with GST-activity in PCOS patients. AP-36 isn't legitimately ensured in the pathogenesis of PCO disorder, yet it may be included as an adipokine that is influenced by BMI. The oxidants increased because of the highly levels of VLDL and the lower in the activities of antioxidant, that may be a response to higher levels of oxidative stress. A decrease in the antioxidant capacity and an increase in AP-36 levels leads to an increased the risk of cardiovascular disease in PCOS patients
The response of skin hardness and pain sensation to ultrasonic treatment in lipodermatosclerosis patients
Get PDFAbstractBackgroundLipodermatosclerosis (LDS) is considered a type of panniculitis (inflammation of subcutaneous fat). Patient experiences severe pain, increased stress, swelling, walking problems and decreased quality of life. The end result of untreated LDS is ulcer formation with high incidence of delayed healing and infection. In addition to psychological problem, the financial costs can be significant.Aim of the studyTo evaluate the efficacy of ultrasonic waves (U.S.) in the treatment of lipodermatosclerosis.MethodsForty patients with lipodermatosclerosis from both sexes aged from 42 to 65years were assigned into two groups of equal number. The study group (group A) received continuous U.S. three times/week at frequency of 3MHz in addition to routine treatment which consisted of wearing grade 2 compression stocking (30–40mmHg) during weight bearing conditions, patients were advised to try to decrease weight bearing as much as possible during the treatment period and circulatory exercise for 15min at least 5times/day, control group (group B) received placebo U.S. plus routine treatment. Pain sensation and skin hardness were assessed in both groups using numeric rating scale (NRS) and durometer.ResultsThe results revealed a significant decrease in mean values of pain sensation and skin hardness in the study group compared to the control group after treatment.To conclude that therapeutic ultrasound was effective in controlling of lipodermatosclerosis disease as regards, decreasing pain sensation and skin hardness
Efficacy of gold nanoparticles against isoproterenol induced acute myocardial infarction in adult male albino rats
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Diversity Measurement Indices of Diatom Communities in the Tigris River within Wasit Province, Iraq
Get PDFThe study was conducted to measure diatom species diversity in the lotic ecosystem across the Wasit Province for 12 months. The quantitative study of diatoms (phytoplankton) was investigated in the Tigris river. The density of algae was ranged from 60989 cell×103/l to 112780.82 cell×103/l in the five sites. These algae were belonging to 39 genera. The richness index values ranged from 1.53 at site 5 in January 2016 to 6.34 at site 1 and June2015. Shannon-Weiner diversity index (H´) was 2.33 in February 2016 and 3.72 in June 2015 both values at site 3, whereas Evenness index was 0.54 at site 5 in March2016 and 0.98 at site 1 in both August2015 and May2016. The lack of homogeneity of the appearance of species indicates the dominance of a few species with high densities, which is an indicator of the existence of environmental pressure. All studied indices showed that the Tigris River quality is suitable for the living aquatic life or may be slightly affected by the pollutants
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