31 research outputs found
Modern approaches to the treatment of chronic urticaria
No full textThe article provides modern definitions and classification of urticaria. The general provisions of the treatment of chronic urticaria, the treatment of which is often very difficult, are outlined. The main provisions of the treatment of urticaria were formulated, according to which the patient should be treated until the rash is completely resolved. In chronic urticaria, it is necessary to identify and eliminate the causes of dermatosis; avoid exposure to identified triggers; increase tolerance; pharmacological treatment should be aimed at preventing the release of mast cell mediators and/or the effects of mast cell mediators. The goal of treatment should be to relieve the symptoms of urticaria as completely as possible, taking into account the safety and quality of life of the patient in each individual case. The importance of identifying and addressing underlying causes and avoiding identified triggers is emphasized. The therapy algorithm is considered in detail, including 4 lines according to the European guidelines and domestic clinical guidelines. Particular attention is paid to the treatment of various subtypes of chronic urticaria. A comparative description of the most effective antihistamines is given
To the question of the effect of isotretinoin on the neuropsychic state of patients with acne
No full textPatients with acne often develop neuropsychiatric disorders of varying severity, correlating, as a rule, with the severity of dermatosis. Isotretinoin is the most commonly used drug for the treatment of moderate acne. Due to the fact that in a number of studies isotretinoin was considered as a trigger for the development of various neuropsychiatric disorders, numerous studies were conducted to prove this possibility or to refute it. An analysis of the literature showed that, according to the vast majority of studies, isotretinoin does not lead to neuropsychiatric disorders. However, given the opposite opinion of some authors, it is advisable to actively identify, including in the anamnesis, any psycho-emotional disorders, and monitor them during therapy. In these cases, it is indicated to start treatment with small doses (recommendations have not been developed)
Клинические особенности течения акне у женщин
No full textThe author generalizes and summarizes information about epidemiology, pathogenesis, diagnostics and treatment of acne in women. Anti-inflammatory, anti-microbial and keratolytic properties of azelaic acid for the external therapy of acne are examined.В обзоре обобщены и систематизированы сведения об эпидемиологии, патогенезе, диагностике и лечении акне у женщин. Рассмотрены противовоспалительное, противомикробные и кератолитические свойства Скинорена для наружной терапии акне
Современная патогенетическая терапия акне
No full textThe article provides an overview of literature on new data in studying acne pathophysiology. A particular attention is given to modern interpretation of the role played by inflammation in dermatosis development. The author presents an analysis of the most effective modern pathogenetically-based topical preparations, as well as an algorithm for their application.В статье приводится обзор литературы о новых данных в изучении патофизиологии акне с акцентом на современную трактовку роли воспаления в развитии дерматоза. Представлен анализ наиболее эффективных современных патогенетически обоснованных топических средств, а также алгоритм их применения
Современные средства лечения акне
No full textThe author provides data about the efficacy and side effects of current drugs for treatment of acne. He pays special attention to
the problem of developing resistance in case of application of antibiotics. The article describes current approaches to the reduction
of this problem in patients with acne. It lists main currently available hormone drugs taking into account their efficacy and side
effects. The article presents a current algorithm for evaluating possible side effects of application of isotretinoin and measures of
their prevention, and describes a new form of isotretinoin with extra bioavailability - Acnecutan. It also discusses characteristics
of external drugs.Приведены данные об эффективности и побочном действии современных средств лечения акне. Обращено особое вни-
мание на проблему резистентности, развивающейся при применении антибиотиков. Описаны современные подходы
к ее уменьшению у больных акне. Перечислены основные используемые в настоящее время гормональные препараты
с учетом их эффективности и нежелательных явлений. Представлен современный алгоритм оценки возможных побочных
эффектов применения изотретиноина и мерах их профилактики, сообщается о новой форме изотретиноина с экстра-
биодоступностью - акнекутана. Обсуждены особенности применения наружных средств
Новое в лечении крапивницы
No full textThe article presents the European Guidelines for the Diagnostics and Management of Urticaria (revised in 2013) and new data on the physiopathology of urticaria related to the role of the platelet-activating factor (PAF) activating mast cells, attracting eosinophils and neutrophils, improving vascular permeability (it is more potent than histamine by 1,000 times) and mucosal edema, and increasing the level of pro-inflammatory cytokines. The data promoted the creation of a new rupatadine molecule, which blocks histamine and PAF receptors at the same time improving the therapeutic effect during urticaria treatment as compared to other antihistamine drugs. The author presents the study results confirming the efficacy and safety of rupatadine.Приводятся Европейские рекомендации по диагностике и лечению крапивницы (ревизия 2013 г.), новые данные о патофизиологии крапивницы, касающиеся роли тромбоцитактивирующего фактора (ТАФ), который активирует тучные клетки, привлекает эозинофилы и нейтрофилы, увеличивает сосудистую проницаемость (в 1000 раз активнее гистамина) и отек слизистой, повышает уровень провоспалительных цитокинов. На основании этих данных создана новая молекула рупатадин, которая одновременно блокирует рецепторы гистамина и ТАФ, тем самым усиливая терапевтический эффект при лечении больных крапивницей по сравнению с другими антигистаминными препаратами. Приводятся результаты исследований, свидетельствующие об эффективности и безопасности рупатадина
NEW APPROACH IN URTICARIA TREATMENT
No full textThe article presents the European Guidelines for the Diagnostics and Management of Urticaria (revised in 2013) and new data on the physiopathology of urticaria related to the role of the platelet-activating factor (PAF) activating mast cells, attracting eosinophils and neutrophils, improving vascular permeability (it is more potent than histamine by 1,000 times) and mucosal edema, and increasing the level of pro-inflammatory cytokines. The data promoted the creation of a new rupatadine molecule, which blocks histamine and PAF receptors at the same time improving the therapeutic effect during urticaria treatment as compared to other antihistamine drugs. The author presents the study results confirming the efficacy and safety of rupatadine
