1,720,987 research outputs found
AGM_FKS: 2021 JNP Paper
No full textSupplemental Figures to "Deciphering how specialized interneuron-specific cell types contribute to circuit function
Experimental data: 2020 Frontiers in Cellular Neuroscience
No full textAs used in the Frontiers 2020 paper
https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2020.00277/ful
Weak and equally balanced synaptic inputs to interneurons in the CA1 hippocampus characterize <i>in vivo</i> rhythmic states
No full textAbstractBrain coding strategies are enabled by the balance of synaptic inputs that individual neurons receive as determined by the networks in which they reside. Inhibitory cell types contribute to brain function in distinct ways but recording from specific, inhibitory cell types during behaviour to determine their contributions is difficult. In particular, the in vivo activities of vasoactive intestinal peptide-expressing interneuron specific 3 (IS3) cells in the hippocampus that only target other inhibitory cells are unknown at present. We perform a massive, computational exploration of possible synaptic inputs to IS3 cells using multi-compartment models and optimized synaptic parameters. We find that asynchronous in vivo-like states that are sensitive to additional theta-timed inputs exist when excitatory and inhibitory synaptic conductances are equally balanced and there are low amounts of correlated inputs. Thus, using a generally applicable computational approach we predict the existence of balanced states in hippocampal circuits during rhythmic activities.</jats:p
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