661 research outputs found
OR.NET - Approaches for Risk Analysis and Measures of Dynamically Interconnected Medical Devices
No full textNowadays, it lacks an open, standardized and dynamic interconnection of medical devices. All existing combinations of medical devices consist of isolated solutions with proprietary interfaces, as no common standards for networking and the exchange of data of medical devices exist. This situation leads to confusing operating rooms and inefficient operations. Thus, new strategies need to be developed for the authorization of dynamically interconnected medical devices. Primarily, those concern of an acquisition and methodical adaption of new requirements and risks resulting from this way of interconnection.
The approach is to develop a method for a risk analysis for interconnected medical devices, which is structured modular and consists of a risk assessment of the standalone device and a risk analysis for the interconnection considering the risks involved in the transfer of functions. When interconnecting the medical devices the risk analysis of each of the devices is taken and they are compared by a gap analysis. Through this strategy it will be possible to realize a standard-compliant dynamic interconnection of medical products, which would be advantageous both for clinic operators and producers. This paper presents the current situation of the authorization of combined medical devices and proposes a strategy for the risk management of dynamically interconnected medical devices as a substantial part of the authorization
Ghosts in the shell: identification of microglia in the human central nervous system by P2Y12 receptor
No full textCCR2 expression on myeloid cells is sufficient for disease development in a mouse model of multiple sclerosis.
No full textThe brain endogenous I kappa B kinase complex is crucially involved in demyelination but not myelin formation of the CNS
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Innate immunity mediated by the MyD88-independent pathway modulates CNS autoimmunity via type I interferon induction
No full textThe presence of type 1 interferon receptor (IFNAR) determines the course of experimental autoimmune encephalomyelitis
No full textThe presence of the chemokine receptor CCR2 on specific myeloid cells determines the outcome of autoimmune encephalomyelitis
No full textLack of Type 1 Interferon Receptor (IFNAR) leads to exacerbation of experimental autoimmune encephalomyelitis
No full textExpression of a dominant-negative chemokine receptor 2 mutant in hematopoietic cells for use in a mouse model of multiple sclerosis
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