1,353 research outputs found
Marriage record of Sixen, J. Alex and Sutton, Gussie
No full textMarriage license for J.Alex Sixen and Gussie Sutton. E.P. Herrick was the officiant
sj-docx-1-smm-10.1177_09622802211070253 - Supplemental material for Challenges of modelling approaches for network meta-analysis of time-to-event outcomes in the presence of non-proportional hazards to aid decision making: Application to a melanoma network
No full textSupplemental material, sj-docx-1-smm-10.1177_09622802211070253 for Challenges of modelling approaches for network meta-analysis of time-to-event outcomes in the presence of non-proportional hazards to aid decision making: Application to a melanoma network by Suzanne C Freeman, Nicola J Cooper, Alex J Sutton, Michael J Crowther, James R Carpenter and Neil Hawkins in Statistical Methods in Medical Research</p
Sutton Hoo and Sweden Revisited
No full textThis paper revisits the idea that there was a direct link between Sweden and the the rites and materials found in the cemetery at Sutton Hoo. It argues instead that both Sweden and and East Anglia were frontier regions on the edge of a core located in Danish territories
Searching for Indirect Evidence and Extending the Network of Studies for Network Meta-Analysis: Case Study in Venous Thromboembolic Events Prevention Following Elective Total Knee Replacement Surgery
No full textAbstractObjectiveTo evaluate the effect of study identification methods and network size on the relative effectiveness and cost-effectiveness of recommended pharmacological venous thromboembolic events (VTEs) prophylaxis for adult patients undergoing elective total knee replacement surgery in the United Kingdom.MethodsA stepwise literature search specifically designed to identify indirect evidence was conducted to extend the original clinical review from the latest National Institute for Health and Care Excellence (NICE) VTE technology appraisal. Different network sizes or network orders, based on the successive searches, informed three network meta-analyses (NMAs), which were compared with a replicated base case. The resulting comparative estimates were inputted in an economic model to investigate the effect of network size on cost-effectiveness probabilities.ResultsSearches increased the number of indirect comparisons between VTE interventions, progressively widening the relevant network of studies for NMA. Precision around mean relative treatment effects was increased as the network was extended from the base case to first-order NMA, but further extensions had limited effect. Cost-effectiveness analysis results were largely insensitive to variation in clinical inputs from the different NMA orders.ConclusionsNo standard methodology is currently recommended by NICE to identify the most relevant network of studies for NMA. Our study showed that optimizing the identification of studies for NMA can extend the evidence base for analysis and reduce the uncertainty in relative effectiveness estimates. Although in our example network extensions did not affect the acceptability of available treatments in VTE prevention based on cost-effectiveness results, it may in other applications
On morphology, molecular composition and breakdown behaviour in semi-crystalline polymers
No full textPreclinical evaluation of the effect of the combined use of the Ethicon Securestrap® Open Absorbable Strap Fixation Device and Ethicon Physiomesh™ Open Flexible Composite Mesh Device on surgeon stress during ventral hernia repair [Corrigendum]
No full textSutton N, MacDonald MH, Lombard J, et al. [Med Devices (Auckl)]. 2018;11:1–9. On page 1, the co-author’s name was incorrectly listed as Bodgan Ilie. His correct name should be Bogdan Ilie. Read the original articl
Limiting Avoidable Microbiological Variability
No full text[ "Microbiology Topics" discusses various topics in microbiology of practical use in validation and compliance. We intend this column to be a useful resource for daily work applications. Reader comments, questions, and suggestions are needed to help us fulfill our objective for this column. Case studies from readers are most welcome. Please send your comments and suggestions to column coordinator Scott Sutton at scott.sutton@microbiol. org or journal coordinating editor Susan Haigney at [email protected]. KEY POINTS The following key points are discussed in this article: • Quality control (QC) microbiology test data are subject to significant variability, both avoidable and unavoidable • Good microbiological procedures, backed by sound microbiological practices, can serve to minimize avoidable variability • The lab's standard operating procedure (SOP) system is a powerful tool to describe and document compliance with good practice • The lab should determine critical areas of coverage for the SOP system to ensure a comprehensive program • The SOP for a lab test should describe critical parameters of the test and meet the criteria of regulatory requirements and guidance for that procedure. The documentation of compliance with these requirements is both a legitimate good manufacturing practice (GMP) audit concern and a useful source of information for investigations. • A sound SOP system can serve to minimize avoidable variability in the microbiology lab • SOPs may be categorized into testing methods, documentation and SOPs, environmental monitoring, and laboratory support activities • Training for the members of the lab should be tightly tied to the SOP system, and can support functional specialization of staff • SOPs for each functional area are described • The content of this discussion should serve to benchmark your system, guide regulatory compliance, and be a framework for training • Considering the SOP system from a functional perspective links job skills to SOPs and facilitates tracking of revisions • Controlling variability and avoidable error is critical to successful microbiology laboratory operation because microbiology is exquisitely sensitive to personnel performance and techniques. INTRODUCTION Microbiology in the QC laboratory is subject to variability in the test results, in the samples taken, in the manner in which they are taken (with severe limitations in sample size contributing to the problem), and Limiting Avoidable Microbiological Variability Scott Sutton ABOUT THE AUTHOR Scott Sutton, Ph.D., is owner and operator of The Microbiology Network (www.microbiol.org), which provides services to microbiology-related user's groups. Dr. Sutton can be reached at scott. [email protected]. g x p a n d j v t . c o
Control strategies to prevent total hip replacement-related infections: a systematic review and mixed treatment comparison
No full textObjective: To synthesise the available evidence and estimate the comparative efficacy of control strategies to prevent total hip replacement (THR)-related surgical site infections (SSIs) using a mixed treatment comparison.\ud
Design: Systematic review and mixed treatment comparison.\ud
Setting: Hospital and other healthcare settings.\ud
Participants: Patients undergoing THR.\ud
Primary and secondary outcome measures: The number of THR-related SSIs occurring following the surgical operation.\ud
Results: 12 studies involving 123 788 THRs and 9 infection control strategies were identified. The strategy of ‘systemic antibiotics+antibiotic-impregnated cement +conventional ventilation’ significantly reduced the risk of THR-related SSI compared with the referent strategy (no systemic antibiotics+plain cement+conventional ventilation), OR 0.13 (95% credible interval (CrI) 0.03–0.35), and had the highest probability (47–64%) and\ud
highest median rank of being the most effective strategy. There was some evidence to suggest that ‘systemic antibiotics+antibiotic-impregnated cement +laminar airflow’ could potentially increase infection risk compared with ‘systemic antibiotics+antibiotic impregnated cement+conventional ventilation’, 1.96 (95% CrI 0.52–5.37). There was no high-quality evidence that antibiotic-impregnated cement without\ud
systemic antibiotic prophylaxis was effective in reducing infection compared with plain cement with systemic antibiotics, 1.28 (95% CrI 0.38–3.38). Conclusions: We found no convincing evidence in favour of the use of laminar airflow over conventional ventilation for prevention of THR-related SSIs, yet laminar airflow is costly and widely used. Antibiotic-impregnated cement without systemic antibiotics may not be effective\ud
in reducing THR-related SSIs. The combination with the highest confidence for reducing SSIs was ‘systemic antibiotics+antibiotic-impregnated cement+conventional ventilation’. Our evidence synthesis underscores the need to review current guidelines based on the available\ud
evidence, and to conduct further high-quality doubleblind randomised controlled trials to better inform the current clinical guidelines and practice for prevention of THR-related SSIs
The English Law Commission: A New Philosophy of Law Reform
No full textMr. Sutton discusses the newly formed English Law Commission in an effort to present constructive suggestions for the establishment and maintenance of effective law revision programs for other jurisdictions. He examines the structure of the English commission and points out that the qualities of flexibility, independence, and opportunity for early compromise of its proposals with legislators are essential for a successful law revision commission. The author concludes that the major value to be gained from the English commission is its adoption of a new philosophy of law reform--give the commission sufficient latitude to enable it to stimulate advanced legislation
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