4 research outputs found
Trattamento ortopedico con i corsetti gessati
No full textThe treatment with plaster braces of young patients suffering from scoliosis should be performed in the presence of curves of middle degree, that cannot be corrected by orthopaedic braces, but are not yet so severe to require surgery. Indications are analyzed on the basis of angular values, skeletal maturation, evolution indexes, clinical and radiographic aspect and localization of the curve. The techniques for moulding the main types of plaster braces are described, together with recommandations on patient management after the cast has been made and possible complication
Supracondylar humerus fractures in children : a comparison of experiences
No full textThe most common elbow lesions found in pediatric practice are supracondylar fractures. We compared two groups of 34 patients each with a supracondylar humerus
fracture grade III (Gartland classification). The first group
was treated with percutaneous pinning with Kirschner wires, with patients in a supine position, sometimes preceded by transkeletal traction. The second group was treated with percutaneous pinning with Kirschner wires,
with patients in a prone position, within 6 h of the trauma. No statistically significant differences with regard to clinical outcomes and neurovascular complications were revealed in the comparison. Therefore, we can state that both
treatment techniques used are valid
Expression of αv Integrin in Feline Injection-Site Sarcoma (FISS): Preliminary Investigations
No full textFeline injection-site sarcomas (FISSs) are malignant skin tumors of mesenchymal origin arising at local post-vaccination (or injection) sites. In recent years, a fluorescence imaging technique based on probes targeting αvβ3 integrin has been effectively applied for the surgical complete resection of the tumor. In our study, we investigated the utility of a commercially available anti-αv integrin polyclonal antibody for the histopathological evaluation of FISS’s surgical excision margins. We collected 10 formalin-fixed paraffin-embedded (FFPE) feline excisional biopsies with a histopathological diagnosis of FISS (7 fibrosarcomas and 3 pleomorphic sarcomas) and wide margin tissue, along with one subcutaneous injection-site granuloma and 6 osteosarcomas. Samples were processed for histology, and slides were stained for IHC with the anti-αv integrin antibody. Immunostained slides were evaluated for the cellular localization and intensity of the staining in different neoplastic and non-neoplastic cell populations. Neoplastic and non-neoplastic spindle cells had cytoplasmic positivity in all fibrosarcomas. Inflammatory cells, including macrophages of the injection-site granuloma, were negative. Multinucleated giant cells in the pleomorphic sarcomas had an intense membranous positivity. Although the anti-αv integrin antibody was ineffective for the histopathological evaluation of surgical excision margins, the membranous localization of αv integrin in multinucleated giant cells of pleomorphic sarcomas suggests that it plays a role in the oncogenesis of this FISS variant
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Respiratory muscle work and inspiratory muscle training on cytokines, oxidative stress and diaphragm fatigue in younger and older populations
No full textIncreased respiratory muscle work is encountered during strenuous whole-body exercise, and at rest in older adults and those with pulmonary limitations such as chronic obstructive pulmonary disease (COPD). When sufficiently strenuous it can result in diaphragmatic fatigue, increased blood lactate concentrations, and an alteration in respiratory muscle recruitment patterns. Increased respiratory muscle work also elevates cytokines interleukin-6 (IL-6) and interleukin-1β (IL-1β) within the respiratory muscles and systemically. There is mounting evidence that inflammation contributes significantly to the ageing process and age related diseases. Enhanced oxidative stress, glycogen depletion and diaphragmatic fatigue are all potential stimuli for this production. Whole-body exercise training can attenuate systemic inflammation and oxidative stress in younger adults during exercise, and in older adults who experience this at rest. An attenuation of muscle glycogen or increases in antioxidant enzymes may explain such reductions. Inspiratory muscle training (IMT) may also elicit similar adaptations in the inspiratory muscles, and thus also attenuate these markers
