318 research outputs found
Specific role of combination aclidinium: Formoterol in the treatment of chronic obstructive pulmonary disease
No full textCo-administration of a long-acting β2-agonist and a long acting muscarinic antagonist produces superior bronchodilation compared with their individual effects. Our preclinical data indicated that combining aclidinium bromide (ACLI) and formoterol fumarate (FORM) provides synergistic benefit on smooth muscle relaxation of both large and small human airways. Data from more than 2,000 patients in eleven clinical trials documented that ACLI/FORM, a twice- daily fixed-dose combination, produces a greater degree of bronchodilation than ACLI or FORM monotherapy alone and is safe and well tolerated. Two large key trials have shown that there is a benefit in using ACLI/FORM when the clinical target is the variability of symptoms and mainly nighttime and/or early morning symptoms. ACLI/FORM is the only long acting muscarinic antagonist/long acting β2-agonist fixed-dose combination that has been studied for this therapeutic indication
Screening della tubercolosi in fase iniziale o latente nell’ambito di una coorte costituita da familiari o conviventi di ammalati di tubercolosi italiani ed extracomunitari
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Congresso “I grandi temi della Pneumologia a confronto: dalle linee guida ai documenti condivisi”
No full textSeminario in memoria del Prof. Gaetano Melillo “Aggiornamenti sull’ossigenoterapia a lungo termine”
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