1,143 research outputs found
Transparency of Information and Coordination in Economies with Investment Complementarities
No full textOdorants could elicit repair processes in melanized neuronal and skin cells
No full textThe expression of ectopic olfactory receptors (ORs) in melanized cells, such as the human brain nigrostriatal dopaminergic neurons and skin melanocytes, is here pointed out. ORs are recognized to regulate skin melanogenesis, whereas OR expression in the dopaminergic neurons, characterized by accumulation of pigment neuromelanin, is downregulated in Parkinson's disease. Furthermore, the correlation between the pigmentation process and the dopamine pathway through α-synuclein expression is also highlighted. Purposely, these ORs are suggested as therapeutic target for neurodegenerative diseases related to the pigmentation disorders. Based on this evidence, a possible way of turning odorants into drugs, acting on three specific olfactory receptors, OR51E2, OR2AT4 and VN1R1, is thus introduced. Various odorous molecules are shown to interact with these ORs and their therapeutic potential against melanogenic and neurodegenerative dysfunctions, including melanoma and Parkinson's disease, is suggested. Finally, a direct functional link between olfactory and endocrine systems in human brain through VN1R1 is proposed, helping to counteract female susceptibility to Parkinson's disease in quiescent life
FGV/EPGE - 2014 Workshop on Economic Theory - Muhamet Yildiz (MIT)
No full textImportant economic theorists such as David Martimort (Paris School of Economics), Alessandro Pavan (Northwestern University), David Rahman (University of Minnesota), Yuliy Sannikov (Princeton University), Federico Echenique (California Institute of Technology), Muhamet Yildiz (MIT) and Roland Strausz (University of Berlim) presented their work. This workshop represents a great opportunity to disseminate some of the recent developments in the field. The workshop was organized by the FGV/EPGE and sponsored by the FGV EPGE "Mestrado em Economia e Finanças Empresariais
Noisy Business Cycles
No full textThis paper investigates a real-business-cycle economy that features dispersed information about the underlying aggregate productivity shocks, taste shocks, and, potentially, shocks to monopoly power. We show how the dispersion of information can (i) contribute to significant inertia in the response of macroeconomic outcomes to such shocks; (ii) induce a negative short-run response of employment to productivity shocks; (iii) imply that productivity shocks explain only a small fraction of high-frequency fluctuations; (iv) contribute to significant noise in the business cycle; (v) formalize a certain type of demand shocks within an RBC economy; and (vi) generate cyclical variation in observed Solow residuals and labor wedges. Importantly, none of these properties requires significant uncertainty about the underlying fundamentals: they rest on the heterogeneity of information and the strength of trade linkages in the economy, not the level of uncertainty. Finally, none of these properties are symptoms of inefficiency: apart from undoing monopoly distortions or providing the agents with more information, no policy intervention can improve upon the equilibrium allocations.
Workshop on Economic Theory
No full textImportant economic theorists such as David Martimort (Paris School of Economics), Alessandro Pavan (Northwestern University), David Rahman (University of Minnesota), Yuliy Sannikov (Princeton University), Federico Echenique (California Institute of Technology), Muhamet Yildiz (MIT) and Roland Strausz (University of Berlim) presented their work. This workshop represents a great opportunity to disseminate some of the recent developments in the field. The workshop was organized by the FGV/EPGE and sponsored by the FGV EPGE "Mestrado em Economia e Finanças Empresariais
Equilibrium Selection in Static and Dynamic Entry Games
No full textWe experimentally examine equilibrium refinements in static and dynamic binary choice games of complete information with strategic complementarities known as “entry†games. Our aim is to assess the predictive power of two different equilibrium selection principles. In static entry games, we test the theory of global games as an equilibrium selection device. This theory posits that players play games of complete information as if they were playing a related global game of incomplete information. In dynamic entry games, individuals decide not only whether to enter but also when to enter. Once entry occurs it is irreversible. The number of people who have already entered is part of the state description, and individuals can condition their decisions on that information. If the state variable does not indicate that entry is dominated, the efficient subgame perfect equilibrium prediction calls for all players to enter. Further, if there is a cost of delay, entry should occur immediately, thereby eliminating the coordination problem. This subgame perfect entry threshold in the dynamic game will generally differ from the global game threshold in static versions of the same entry game. Nevertheless, our experimental findings suggest that observed entry thresholds in both static and dynamic versions of the same entry game are surprisingly similar. The mean entry threshold in the static game lies below the global game equilibrium threshold while the mean entry threshold in the dynamic game lies above the efficient subgame perfect equilibrium threshold. An important implication of this finding is that if one were to observe only the value of the state variable and the number of people who enter by the end of the game one could not determine whether the static or the dynamic game had been played.
Retinal pigment epithelial cells as a therapeutic tool and target against retinopathies
No full textRetinal pigment epithelium (RPE) is a cell monolayer essential for photoreceptor function and forming the blood–retinal barrier. RPE and retinal neurons share the same origin and a polarized cytoarchitecture. Several factors determine the phagocytosis and permeability of RPE, influencing photoreceptor renewal and drug delivery, efficacy and toxicity. Adult human RPE expresses neuronal markers in vitro, indicating a potential transdifferentiation. Degeneration of the RPE leads to death of photoreceptors and retinal neurons, resulting in the vision loss of retinopathy. Here, we suggest tools for cell engineering to discover new ways for activating the endogenous regeneration of barrier functions and/or of the retinal precursors in RPE cells
Prodrugs and Endogenous Transporters: Are They Suitable Tools for Drug Targeting into the Central Nervous System?
No full textHydrophilic drugs, or neuroactive agents characterized by high molecular weight, do not have the physico-chemical properties required for passive diffusion across the blood brain barrier (BBB). The prodrug approach by lipidization of hydrophilic drugs generally allows to sensibly increase their permeability across BBB, even if this phenomenon is often not associated to an effective entry into the brain of the lipidized drugs. It has been understood that active efflux transporters (AET) can have a very important role in extruding from the brain not only prodrugs obtained by lipidization processes, but also lipophilic drugs. On the other hand, it has been also demonstrated carrier mediated transporters (CMT), able to transport essential nutrients and hormones from the bloodstream to the CNS, can be employed for the brain targeting of appropriated designed prodrugs. This approach consists on the chemical modification of a drug into a “pseudonutrient” or, differently, on drug conjugation to essential nutrients transported by CMT systems. This review focuses the molecular aspects that regulate the activity of the CMT and AET systems for the transport of their substrates, taking into account the in vitro and in vivo studies related to these transporters and, thus, the prodrug approaches useful to target the neuroactive agents in the central nervous systems are described. Among these, the molecular Trojan horses systems are briefly illustrated as carriers for the transport in the brain of large molecular weight neuroactive agents
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