64 research outputs found
The historical landscape in Liguria: architecture heritage in Ventimiglia
No full textThe peculiarity of the coastal landscape of the Ligurian Riviera of Ponente has been the settle of urban centers and the development of productive activities. During late Middle Age the foundation of new settlements promoted the development of the coasts and the rise of a local architectural heritage
Lionello Venturi e Riccardo Gualino
No full textNell'articolo si analizzano i primi contatti intercorsi tra il critico d'arte Lionello Venturi e il mecenate Riccardo Gualin
La Casa Rossa affacciata sul Mediterraneo: arte e cultura tra Otto e Novecento nelle lettere a Angiolo Silvio Novaro
No full textAttraverso le lettere inedite conservate presso l’archivio di Angiolo Silvio Novaro, si indagano i rapporti dell’imprenditore, poeta e accademico d’Italia, con il mondo artistico e letterario e il suo ruolo di promotore culturale e mecenate d’arte. Il saggio ripercorre le più importanti vicende artistiche e letterarie del Ponente Ligure tra Otto e Novecento, che hanno avuto nella dimora del poeta ligure, la Casa Rossa affacciata sul Mediterraneo, un punto di riferimento imprescindibile e un luogo di raccoglimento e d’ispirazione. Tra ospiti illustri, amici, giovani poeti in cerca di consigli, pittori, scultori e illustratori che ne hanno abbellito gli interni e il giardino, si recuperano e interpretano le tracce del loro passaggio affidate in origine a ricordi, lettere e opere d’arte: i pittori Plinio Nomellini e Giuseppe Pellizza da Volpedo, gli scultori Leonardo Bistolfi e Edoardo De Albertis, gli incisori e illustratori Giulio Cisari e Domenico Buratti, i poeti e gli scrittori Ceccardo Roccatagliata Ceccardi, Giovanni Marradi, Salvatore Quasimodo, Renzo Laurano e Edmondo De Amicis, sono alcune tra le maggiori personalità con cui Angiolo Silvio Novaro intrattiene corrispondenze epistolari e rapporti di lavoro e d’amicizia
Trioctahedral smectites and zeolites as transformation products of the Cala Pozzolana di Ponente pyroclastic rocks (Linosa Island - Italy)
No full textOn Linosa Island the pyroclastites of Cala Pozzolana di Ponente have been affected by post depositional alteration phenomena. Field and laboratory study point out that this pyroclastic deposit was affected by hydrothermal circulation with formation of secondary minerals like smectite, zeolites, calcite. The transformation processes were accomplished in two stages; a first one was brought about by the circulation of abundant hydrothermal fluids that reacted with the glass fragments producing a thin regular crust of smectite surrounding glass fragments and a second one, responsible for the zeolite growth, was accomplished by fluids enriched in alkalis and calcium released by the altered glass, in conditions of decreasing fluid circulation and falling temperature. -from Author
Sapromyza plumicheta Rondani 1868
No full text<i>Sapromyza plumicheta</i> Rondani, 1868 <p>ORIGINAL DESCRIPTION: 1868c: 236 (key), 243 (description).</p> <p> TYPE LOCALITY: “ <i>in agri parmensis … in agro tridentino … in Pedemontio</i> [Parmese territory … Trento’s territory … Piedmont (Italy)]”.</p> <p> TYPE MATERIAL: 1 ♂, lectotype (abdomen with terminalia prepared in balsam between cover slips) (MZUF: Box 29): <i>Sapromyza</i> Fall. / <i>plumicheta</i> Rndn. / 1556 / Lectotypus <i>Minettia plumicheta</i> (Rondani, 1868), des. by L. Papp, 1981.</p> <p> PARALECTOTYPES EXAMINED: 8 ♂♂ (one with terminalia and abdomen in balsam in a microvial on a separate pin next to the specimen and one leg in a plastic vial pinned below specimen), 6 ♀♀ (one with right wing in a plastic vial pinned below specimen) (MZUF: Box 29): <i>Sapromyza</i> Fall. <i>plumicheta</i> Rndn. / 1556 / Paralectotypus <i>Minettia plumicheta</i> (Rondani, 1868).</p> <p> PARALECTOTYPES NOT EXAMINED: 1 ♂ (MRSN): 3 64 / 805 / <i>Sapromyza</i> Fall. <i>plumicheta</i> Rond., Sestri P. [= Sestri Ponente (Liguria)], ♂; 1 ♀ (MRSN): [illegible word] / 804 / <i>Sapromyza</i> Fall. <i>plumicheta</i> Rond., Sestri P. [= Sestri Ponente (Liguria)], ♀; 1 ♀ (MRSN): [illegible word] / <i>Sapromyza</i> Fall. <i>plumicheta</i> Rond., Sestri P. [= Sestri Ponente (Liguria)], ♀; 1 ♀ (MRSN): 3 64 / <i>Sapromyza</i> Fall., <i>plumicheta</i> Rond., Sestri P. [= Sestri Ponente (Liguria)], ♀.</p> <p> CURRENT STATUS: valid species, as <i>Minettia plumicheta</i> (Papp 1984a: 201, Nartshuk <i>et al.</i> 1995: 5).</p> <p> REMARKS: Rondani (1868c: 243) described <i>Sapromyza plumicheta,</i> without specifying the number, the sex or the length of the specimens, from material that he had collected and that he had also received from S. Bertolini and L. Bellardi. Papp (1981: 180) designated a lectotype (♂) and paralectotypes (8 ♂♂, 6 ♀♀) but did not mention an additional four specimens in the MRSN (all are paralectotypes). We consider the four MRSN specimens as paralectotypes even if they are labeled “Sestri Ponente” (Liguria) because this latter is a locality bordering with Piedmont.</p>Published as part of <i>Sforzi, Alessandra & Sommaggio, Daniele, 2021, Catalog of the Diptera types described by Camillo Rondani, pp. 1-438 in Zootaxa 4989 (1)</i> on page 133, DOI: 10.11646/zootaxa.4989.1.1, <a href="http://zenodo.org/record/4980621">http://zenodo.org/record/4980621</a>
PML promotes metastasis of triple-negative breast cancer through transcriptional regulation of HIF1A target genes
No full textElucidating the molecular basis of tumor metastasis is pivotal for eradicating cancer-related mortality. Triple-negative breast cancer (TNBC) encompasses a class of aggressive tumors characterized by high rates of recurrence and metastasis, as well as poor overall survival. Here, we find that the promyelocytic leukemia protein PML exerts a prometastatic function in TNBC that can be targeted by arsenic trioxide. We found that, in TNBC patients, constitutive HIF1A activity induces high expression of PML, along with a number of HIF1A target genes that promote metastasis at multiple levels. Intriguingly, PML controls the expression of these genes by binding to their regulatory regions along with HIF1A. This mechanism is specific to TNBC cells and does not occur in other subtypes of breast cancer where PML and prometastatic HIF1A target genes are underexpressed. As a consequence, PML promotes cell migration, invasion, and metastasis in TNBC cell and mouse models. Notably, pharmacological inhibition of PML with arsenic trioxide, a PML-degrading agent used to treat promyelocytic leukemia patients, delays tumor growth, impairs TNBC metastasis, and cooperates with chemotherapy by preventing metastatic dissemination. In conclusion, we report identification of a prometastatic pathway in TNBC and suggest clinical development toward the use of arsenic trioxide for TNBC patients
Enhanced recording paradigms and advanced analyses of peripheral nerve fibers SPiike software
No full textPrograma de Doctorat en BiomedicinaThe aim of this work is to investigate the human nociceptive system at the peripheral level. Researchers are still debating how the pain perception arises from this very intricate network. The human perception is the most elusive part of our knowledge since different subsystems are involved. The external information such as noxious stimuli must be processed at the peripheral level and through signal cascades and transduction this signal must reach the brain. At the brain level the information is processed and some decisions are taken, such as the well-known fight-or-flight response.
In the introduction, the author describes how the human nociceptive system works and in which way the noxious stimulus is converted into a signal understandable by the brain. Several cortical and subcortical areas are involved in this signal processing and going deeper in this assembly line the information becomes more abstracted. The whole pathway is fundamental for pain perception, however some diseases start at the peripheral level. This in turn makes wrong signals reaching the brain. The brain is then processing information that are not real and the responses do not suit with the needs. Therefore, the peripheral system must be investigated and understood firstly, since some central diseases may have a peripheral component as well. With this purpose in mind the microneurography technique has been used. This technique has got some complexity and a computer-aided system must be implemented. The hardware aims to filter out the noisy signal and perform recording and stimulation of the neural fibers. The software is instead used to make the stimulation and recording as automatic as possible in a way that researchers do not have to deal with a lot of parameters and steps to carry out this powerful but also time consuming technique. Some software are already available in the market however even if they work fine with slow conduction fibers such as C-fibers they cannot cope with faster neurons (e.g. Aδ fibers). The aim of this work is to create a software (i.e. SPiike) able to stimulate and record every type of fibers implementing advanced analysis technique as well. Furthermore, considering that some in vivo experiments have been pursued within the project to check the functionality of the software, more specifically in rats and mice, the comparison between human nociceptors and mouse nociceptors is depicted in this section.
In the method section, the experimental approach is described step by step. This is composed by several systems that work together for the stimulation, recording and analysis of the neural fibers. The control and acquisition module is composed by the software and a data acquisition board that trigger the stimulator and record the filtered signal. The stimulation module is composed by a stimulator that can be tuned as wish through dedicated knobs. Then the stimulus is delivered to the animal model (or the human patient) and the signal is recorded though a microelectrode inserted into the sciatic nerve. The amplification module is filtering out the noisy signal and is feeding a audio monitor for helping the researcher during the insertion of the electrode inside the nerve and it provides support during the whole experiment giving insights on fiber discharges. In this section the whole setup is described in details as well as the devices needed for the recording. Furthermore, the software development that is the core of this project is described as well, with all the considerations that must be considered during coding. Indeed, the flow chart must be followed methodically in order to minimize bugs and errors that may arise in the final product. Thus a description of the compiler and the Matlab IDE is given along with system and software requirements for the making of the SPiike software. Eventually the explanation of embedded functionalities and capabilities of SPiike is depicted in the final part of this section. This software is indeed able to stimulate slow conducting fibers as well as faster ones, and enhanced analysis techniques such as supervised machine learning are implemented.
In the results section, the graphical user interface of the Spiike software is reveled. It resembles the one of another software already available in the market, with a filtered signal and a raster plot embedded on it. However, this software is more user-friendly and it accounts with icons and drop-down menus that enhance the experience of the users during the use of the tool, making their interactions smooth and intuitive. The SPiike software is subdivide into two different tools, a recording module and a analysis module. The former allows the stimulation and recording of neural fibers with a stimulation frequency up to 1000Hz and some online analysis can be conducted to have insights on fibers type and behavior. The analysis module is instead a more powerful analysis environment that can retrieve the dataset recorded with the other module or with the LabChart software. Advanced analysis techniques are implemented in this module, this is meant to speed up fiber classification and analysis.
Conclusion and discussion provide a overview on some results. These will be compared to those obtainable through other software available in the market. In this section, pros and cons of the new implemented software, SPiike, will be described as well
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