71 research outputs found
T cell trafficking in human chronic inflammatory diseases
No full textSummary: Circulating T cells, which migrate from the periphery to sites of tissue inflammation, play a crucial role in the development of various chronic inflammatory conditions. Recent research has highlighted subsets of tissue-resident T cells that acquire migratory capabilities and re-enter circulation, referred to here as “recirculating T cells.” In this review, we examine recent advancements in understanding the biology of T cell trafficking in diseases where T cell infiltration is pivotal, such as multiple sclerosis and inflammatory bowel diseases, as well as in metabolic disorders where the role of T cell migration is less understood. Additionally, we discuss current insights into therapeutic strategies aimed at modulating T cell circulation across tissues and the application of state-of-the-art technologies for studying recirculation in humans. This review underscores the significance of investigating T trafficking as a novel potential target for therapeutic interventions across a spectrum of human chronic inflammatory diseases
E-cigarettes and health: segmentation of risk awareness with latent class analysis
No full textElectronic cigarette (e-cig) use, especially among young people, has become
widespread. The aim of this study was to use Latent Class Analysis (LCA) to
identify and categorize distinct groups of individuals based on their awareness of
the health risks and characteristics of e-cigs. We administered a questionnaire
to 83 participants, with an average age of 27.22 years, that included 83 questions
on different aspects of e-cigs, including composition, health effects and risk
perceptions. Only 23 questions were considered suitable for analysis. We found
that the probability of belonging to the ‘Low awareness’ class is higher than the
‘High awareness’ class. We observed that there is a distinction between subjects
with Low and High awareness about the risks of e-cigs, this is observed as the
response probability of the ‘High Awareness’ class is greater than that of the ‘Low
Awareness’ class. Among those who were surveyed, only 55.4% had a high
awareness of the risks of e-cig
Digital Health Adoption in Pediatric Respiratory Care in Italy: A National Survey and Machine Learning-Based Clustering Analysis
No full textThe integration of digital health technologies into pediatric respiratory care is growing, yet patterns of adoption and clinician readiness remain poorly understood. This study explores the integration of digital technologies in pediatric respiratory care through the first nationwide survey officially supported by the Italian Pediatric Respiratory Society (IPRS/SIMRI). Conducted in January 2025, the survey collected responses from 132 clinicians and aimed to identify distinct profiles based on digital technology use, competencies, and perceived barriers. Using Random Forest analysis and t-distributed Stochastic Neighbor Embedding, two main clusters emerged: “Users” (76.5%), primarily younger professionals working in tertiary settings and managing complex respiratory conditions, and “Non-Users” (23.5%), mainly older clinicians in primary or secondary care with no adoption of digital tools. The most commonly used technologies included electronic health records, telemedicine, and portable spirometry. Barriers reported by Users included lack of resources, high costs, and system complexity, despite a generally high level of digital skills. These findings provide a unique perspective on the current state of digital readiness and clinical integration in pediatric respiratory medicine. This nation-wide survey is among the first to explore digital health adoption in pediatric respiratory care using machine learning techniques for pattern identification. Despite the limitations inherent to its cross-sectional design and possible self-selection bias, the study establishes a valuable foundation for developing targeted educational strategies, guiding health policy, and informing future longitudinal research
Evidenze sommerse e reperti emergenti. Il disegno multicriteri@ della Turris ad mare
No full textPercorrendo la via alberata che costeggia la riva meridionale del fiume Garigliano riscopriamo i ruderi dell'antica Turris ad mare costruita nella seconda metà del X secolo dal principe longobardo Pandolfo Capodiferro con obiettivi militari antisaraceni. I resti dell'antica torre, offesi dalle ingiurie del tempo, raccontano la storia di un territorio, la costa del Litorale Domitio, fortemente interessato da violenti attacchi da parte dei Saraceni. I segni indelebili della permanenza delle incursioni saracene restano scolpiti sul territorio attraverso le numerose torri costiere di difesa e di controllo sorte, in Terra di Lavoro come in ogni regione di frontiera, durante il periodo medioevale. I lacerti della torre di vedetta, in parte celati dalla vegetazione incolta ed in parte sommersi dalle acque del fiume, sono i frammenti di un patrimonio materiale -le fortificazioni costiere ed interne- custodito nel radicato storico del paesaggio domitio; fragili spie insediate dal tempo che il rilevatore/archeologo è in grado di scorgere con il suo traditum di cultura, formazione, esperienza, memoria e di trasferire nel disegno multicriteri@ che, coniugando l'approccio multidimensionale ed il sapiente uso delle tecnologie digitali, realizza la sintesi dei processi cognitivi.Covering the tree-lined street coasting the southern shore of the river Garigliano, it is possible to re-discover the ruins of the ancient Turris ad mare, built in the second half the X century by the longobard prince Pandolfo Capodiferro to defend the territory from the Saracens. The rests of the ancient tower, offended by the insults of the time, tell about the history of a territory, the coast of the Litorale Domitio, systematically and violently attacked by the Saracens. The indelible signs of the frequency of Saracen raids stay graven on the territory as numerous coastal towers of defense and control built up, in Terra di Lavoro as in every frontier region, during the medieval period. The lacerates of the look-out tower, partly concealed by the uncultivated vegetation and partly submerged by the waters of the river, are fragments of a material patrimony - the coastal and inside fortifications - guarded in the history of the landscape domitio, fragile spies installed by the time that the recorder/archaeologist is able to perceive with his traditum of culture, education, experience, memory and to move to the multicriteri@ sketch, which, conjugating the multidimensional approach and the wise use of digital technologies, realizes the synthesis of all knowledge processes
Association between ecological momentary assessment of awake bruxism by a novel smartphone device and psychological anxiety features
No full textEcological momentary assessment of awake bruxism by a novel smartphone device. Frequency over one week and course over time
No full text
Asthma Prediction Tool in Preschool Children: Evidence from Predictive Performance Comparison by Using Innovative Statistical Approach
No full textThis study aims to develop a non-invasive tool for early asthma diagnosis in preschool children. The tool leverages co-morbidities, environmental factors, and socio-economic determinants. The research compares Traditional Statistical Models, Machine Learning Techniques, and Deep Neural Networks to assess the predictive capabilities of various models against the Leicester tool, which is used as a benchmark. The study’s results, evaluated on accuracy and AUC metrics, indicate that the proposed tool outperforms the Leicester model across all applied models. This research highlights the potential of integrating diverse variables for asthma prediction, suggesting directions for future enhancements and underscoring the need for comprehensive evaluations to validate these findings
«De le cose più degne li più importanti capi da molti illustri scrittori estratti». Sulle fonti del Compendio di Pandolfo Collenuccio per l’età aragonese
No full textIl Compendio de le Istorie del Regno di Napoli di Pandolfo Collenuccio (pubblicato postumo nel 1539) è la prima ricostruzione complessiva della storia del Regno. È un testo molto compatto ideologicamente, dettato dalla convinzione che il Mezzogiorno sia stata sempre stato caratterizzato da un’insita instabilità politica. Nonostante la sua importanza, non esistono molti studi sulle fonti usate, che servono a farci capire il metodo di lavoro e le effettive idee dell’autore. In questo articolo si indagano le fonti usate per ricostruire le vicende di Alfonso il Magnanimo: le principali sono il De Europa di Enea Silvio Piccolomini (papa Pio II) e il De dictis et factis Alphonsi regis di Antonio Beccadelli (Panormita), probabilmente nella versione commentata dallo stesso Piccolomini. Sorprendentemente manca Bartolomeo Facio, autore dell’opera storiografica più ampia sul re aragonese.The Compendio de le Istorie del Regno di Napoli by Pandolfo Collenuccio (published posthumously in 1539) is the first complete historical reconstruction of the Kingdom. It is an ideologically compact text, dictated by the conviction that the Mezzogiorno has always been characterized by an inherent political instability. Despite its importance, there are few studies on its sources: they can help us to understand the working method and the author’s ideas. This paper investigates the sources relating to the life of Alfonso the Magnanimous: the main ones are De Europa by Enea Silvio Piccolomini (Pope Pius II) and De dictis et factis Alphonsi regis by Antonio Beccadelli (Panormita), probably in a version commented by Piccolomini himself. Surprisingly, is not used the work by Bartolomeo Facio, author of the most extensive historiographical work on the Aragonese king
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