196,082 research outputs found
Blind receiver for space-time differentially-encoded CDMA systems on multipath fading channels
No full textConfidence Interval of Peak-Based Distance Estimation in Diffusive Molecular Communication
No full textMolecular Communication (MC) is a bio-inspired communication paradigm, where chemical signals (molecules) carry information. Using molecules as information carriers, rather than electrons or electromagnetic waves, allows communication in environments not considered before, as inside the human body or between nano-machines. This form of communication is particularly interesting due to its simplicity and the low energy cost with respect to the other communication systems.In this article, a specific aspect, which has been not given much attention in literature yet, is examined. Starting from the impulse response estimated for an MC diffusive channel between a point transmitter and a fully absorbing receiver in a three-dimensional space, the confidence interval of the distance from transmitter to receiver is estimated, based on the peak value of the channel impulse response. The analysis adopts the well-known Clopper-Pearson method for confidence interval evaluation
Dynamic properties of the Holocene age deposit in the Italian port of Ravenna
No full textBased on the collection of many data coming from a large survey carried out in the Ravenna Port channel, this paper focuses on the dynamic properties of the 30 m thick soil deposit whose poor geotechnical characteristics make the design of infrastructures in the area particularly challenging. The study included specific seismic in-situ investigations (e.g. Seismic CPTu and CH), laboratory tests on undisturbed bored samples (e.g. Resonant Column Test) and common in-situ testing (e.g. CPTu, DMT). The main objective is the estimate of the very small strain shear modulus and its decay with strain level (i.e. curves G0-gamma) for dynamic characterization. This is a fundamental aspect to consider for numerical modelling of geotechnical engineering problems considering soil-structure interaction under working loads and site response analysis. The availability of direct and indirect measurements of the dynamic soil properties allowed the comparison between the different estimates and an evaluation on the applicability of the correlations between the outcomes from possible in-situ investigations
SULFATE ESTERS OF HYDROXY AMINO-ACIDS AS STEREOSPECIFIC GLUTAMATE-RECEPTOR AGONISTS
No full textEnantiomerically pure sulfate esters of the hydroxy amino acids homoserine, hydroxyproline and 4-hydroxypipecolic acid were synthesized and tested on alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (NMDA) and N-methyl-D-aspartate (NMDA) receptors present in the mice cortical wedge preparation and on NMDA receptors present in the myenteric plexus of the guinea pig with the aim of finding new possible endogenous ligands (either agonists or antagonists) for excitatory amino acid receptors. The linear and flexible compound S-homoserine sulfate caused a depolarization of both AMPA and NMDA receptors. In the cortex its agonist action had an EC(50) of 150 mu M for NMDA and 300 mu M for AMPA receptors and in the myenteric plexus its EC(50) was 600 mu M. The stereoisomer R-homoserine sulfate did not depolarize the cortical wedges and failed to cause ileal contraction up to a concentration of 500 mu M. Among the four possible stereoisomers of 4-hydroxyproline sulfate, which are rigid structures and may be regarded as cyclization forms of homoserine sulfate, t-S-hydroxyproline sulfate was a selective AMPA receptor agonist with an EC(50) of 70 mu M in the cortex. The other three isomers were not active as agonists up to 500 mu M and none of them had antagonist activity. Finally, t-4-hydroxy-S-pipecolic acid-4-sulfate, a superior homologue of t-S-hydroxyproline sulfate, was found to be one of the most potent and selective NMDA receptor agonists so far described with an EC(50) of 0.7 mu M in the cortex and 250 mu M in the myenteric plexus. The cis-stereoisomer was significantly less potent (EC(50) 75 mu M in the cortex and no activity up to 500 mu M in the myenteric plexus). In conclusion, S-homoserine sulfate, t-S-hydroxyproline sulfate and t-4-hydroxy-S-pipecolic acid-4-sulfate are natural compounds able to interact as agonists in a stereospecific and selective manner with ionotropic glutamate receptors
Sulla variabilità spaziale dell'accelerazione nel calcolo delle opere di sostegno in condizioni sismiche
No full textPer il calcolo delle opere di sostegno in condizioni sismiche con il metodo pseudo-statico si assume che un fissato valore di accelerazione equivalente, costante nello spazio e nel tempo, agisca uniformemente nel cuneo di spinta. Al fine di definire tale accelerazione, la nuova proposta di Eurocodice 8 (EN 1998-5) introduce una metodologia che tiene conto dell’asincronia del moto sismico agente sulle opere di sostegno per mezzo di un’analisi di risposta sismica locale 1D. Si tratta di un affinamento delle usuali metodologie che prevedono la definizione di un coefficiente di deformabilità in funzione di due soli parametri: altezza dell’opera e categoria di sottosuolo (v. NTC 2018). In questa memoria, l’applicazione ad un caso reale mostra come la nuova metodologia consenta un utilizzo più consapevole del metodo pseudo-statico; d’altra parte, i risultati di analisi dinamiche 2D evidenziano significativi effetti di variabilità spaziale del moto invitando a riflessioni sull’opportunità di considerare anche gli effetti geometrici nella propagazione delle onde sismiche
Stone structure properties determination by Nuclear Magnetic Resonance Imaging and relaxation
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Thalidomide, dexamethasone, and pegylated liposomal doxorubicin (ThaDD) for patients older than 65 years with newly diagnosed multiple myeloma.
No full textBlood. 2006 Oct 1;108(7):2159-64. Epub 2006 Jun 8.
Thalidomide, dexamethasone, and pegylated liposomal doxorubicin (ThaDD) for patients older than 65 years with newly diagnosed multiple myeloma.
Offidani M, Corvatta L, Piersantelli MN, Visani G, Alesiani F, Brunori M, Galieni P, Catarini M, Burattini M, Centurioni R, Ferranti M, Rupoli S, Scortechini AR, Giuliodori L, Candela M, Capelli D, Montanari M, Olivieri A, Poloni A, Polloni C,
Marconi M, Leoni P.
Clinica di Ematologia Ospedali Riuniti Ancona, Via Conca, 71, 60020 Ancona, Italy. [email protected]
We present the results of a phase 2 study using thalidomide, dexamethasone, and pegylated liposomal doxorubicin (ThaDD) in the treatment of 50 patients older than 65 years with newly diagnosed multiple myeloma. Thalidomide 100 mg was administered orally at bedtime continuously, dexamethasone 40 mg was administered orally on days 1 to 4 and 9 to 12, and pegylated liposomal doxorubicin 40 mg/m2
was administered intravenously on day 1 over the 28-day cycle. Response was assessed according to the EBMT criteria. Seventeen (34%) patients achieved CR, 7 (14%) nCR, 5 (10%) VGPR, 15 (30%) PR, and 5 (10%) MR, resulting in an ORR of 98%.
Only 1 patient (2%) presented progressive disease. Time to progression (TTP), event-free survival (EFS), and overall survival (OS) projected at 3 years were 60%, 57%, and 74%, respectively, and these parameters were significantly higher in those patients achieving a response of at least VGPR versus those who did not.
Grade 3 and 4 nonhematologic adverse events were constipation (10%), fatigue (6%), tremors (4%), mucositis (4%), and palmar-plantar erythrodysesthesia (2%).
Grade 3 and 4 neutropenia occurred in 12% of patients. Grade 3 and 4 infections and thromboembolic accidents were observed in 22% and 14% of patients, respectively. In the treatment of elderly patients with newly diagnosed multiple
myeloma, ThaDD is a very effective regimen with manageable toxicity
Effetti del superfluidificante sull’idratazione del silicato tricalcico studiati tramite Risonanza Magnetica Nucleare
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