8 research outputs found

    Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective

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    We aimed to survey the monogenic causes of disorders of sex development (DSD) and thereby its prevalence in India. This study revealed mutations resulting in androgen insensitivity syndrome, 5α-reductase type 2 deficiency, and gonadal dysgenesis were commonly reported. Intriguingly, AR deficits were the most prevalent (32 mutations) and of 11/26 missense mutations were in exons 4–8 (encoding ligand binding domain). The unique features of SRD5A2 defects were p.R246Q (most prevalent) and p.G196S could be mutational hotspots, dual gene defects (p.A596T in AR and p.G196S in SRD5A2) in a patient with hypospadias and novel 8 nucleotide deletion (exon 1) found in a patient with perineal hypospadias. Deficits in SRY, WT1, DHH, NR5A1, and DMRT1 caused 46,XY gonadal dysgenesis. Notably, mutations in AR, SRD5A2, MAMLD1, WT1, and MAP3K1 have led to hypospadias and only one CYP19A1 mutation caused aromatase deficiency was reported to date. Data mining from various databases has not only reinforced the role of well-established genes (e.g., SRY, WT1, DHH, NR5A1, DMRT1, AR, SRD5A2, MAMLD1) involved in DSD but also provided us 12 more potential candidate genes (ACVR1, AMHR2, CTNNB1, CYP11A1, CYP19A1, FGFR2, FGF9, PRKACA, PRKACG, SMAD9, TERT, ZFPM2), which benefit from a close association with the well-established genes involved in DSD and might be useful to screen owing to their direct gene–phenotype relationship or through direct functional interaction. As more genes have been revealed in relation to DSD, we believe ultimately it holds a better scenario for therapeutic regimen. Despite the advances in translational medicine, hospitals are yet to adopt genetic testing and counseling facilities in India that shall have potential impact on clinical diagnosis. Abbreviations: 5α-RD2: 5α-Reductase type 2; AIS: androgen insensitivity syndrome; AMH: antimullerian hormone; AMHR: antimullerian hormone receptor; AR: androgen receptor gene; CAH: congenital adrenal hyperplasia; CAIS: complete AIS; CAH: congenital adrenal hyperplasia; CHH: congenital hypogonadotropic hypogonadism; CXORF6: chromosome X open reading frame 6 gene; CYP19A1: cytochrome P450 family 19 subfamily A member 1 gene; DHT: dihydrotestosterone; DMRT1: double sex and mab-3 related transcription factor 1 gene; DSD: disorders of sexual development; GD: gonadal dysgenesis; HGMD: human gene mutation database; IH: isolated hypospadias; MAMLD1: mastermind like domain containing 1 gene; MIS: mullerian inhibiting substance; NTD: N-terminal domain; OT DSD: ovotesticular DSD; PAIS: partial AIS; SOX9: SRY-related HMG-box 9 gene; SRY: sex-determining region Y gene; STAR: steroidogenic acute regulatory protein gene; SRD5A2: steroid 5 alpha-reductase 2 gene; T DSD: testicular DSD; T: testosterone; WNT4: Wnt family member 4 gene; WT1: Wilms tumor 1 gene; Δ4: androstenedione</p

    Synthesis and characterization of (RSi0₁.₅)x cage compounds

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    Made available in DSpace on 2014-03-20T21:36:01Z (GMT). No. of bitstreams: 2 license.txt: 4923 bytes, checksum: 3568ab34bde24044ec8ea05b1192aa03 (MD5) 30112111742836_opt.pdf: 1045577 bytes, checksum: a28a62888e76c64e6d00ce9e6fe82444 (MD5) Previous issue date: 1985Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding ([email protected]) on 2014-03-20T21:49:59Z Item is restricted indefinitely.Restriction data tranferred 2014-07-01T11:38:28-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: Theses restricted to UIUC community onlyTheses restricted to UIUC community onlyU of I OnlyThesis (B.A.) in Chemistry -- University of Illinois at Urbana-Champaign, 1985.Includes bibliographical references (leaf 12)

    Termitozophilus parapilosus Silva & Zilberman & Carvalho-Filho 2022, sp. nov.

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    Termitozophilus parapilosus sp. nov. (Figs. 10–13, 27B, 28) Type material. HOLOTYPE &male; (MPEG): Brasil [= Brazil], Pará, Peixe-Boi / Fazenda Abalém [= Abalém Farm], 15.VII.2021 / R. F. Silva [collector], hospedeiro [= host]: Cornitermes pilosus. PARATYPES. Same data as holotype, 1 &female; in MPEG (in alcohol), 1 &female; and 1 &male; in MZSUP (MZSP 21302) (dissected in slides). Diagnosis. Paratergites fused neither to each other nor to tergites and sternites; sclerotized parts of the abdomen mostly light brown, with a large white-colored membranous area exposed in dorsal view. Head with three pairs of bristles, one behind the eye, one on medial-posterior region, and one below medial-posterior area. Elytra subquadrate with a heavily scaled anteromesial border. Apex of sternite VIII with six bristles. Description. Male—length ~ 1.4 mm (Figs. 10A–B); female—length ~ 1.7 mm (Figs. 10C–F). Head subquadrate, about as wide as long, widest behind eye, almost narrowing posteriorly; eye about 1/3 of head length; three pairs of bristles on vertex, one bristles behind eye, one bristle on medial-posterior region, and one bristle below the medial-posterior region (Fig. 11A). Antenna: scape almost longer than remainder antennomeres, except antennomere XI; antennomere XI about three times longer than wide and more than twice longer than antennomere X; antennomeres II–VI elongate, gradually decreasing in length, antennomere VII–X moniliform. Mouthparts. Labrum more than twice wider than long, with slight sinuous anterior margin; five main long bristles on each lateral half, arranged in two diagonal rows each with two bristles and one bristle on middle of labrum length (Fig. 11C); epipharynx covered with sensilla and numerous short bristles, two of which longer. Mandible apex narrow, bearing a tooth on mesal region; with many punctuations on basal 2/3 (Fig. 11B). Labium with ligula narrowed at base and with a median-apical emargination, resulting in two lobes; mentum and submentum distinct, both trapezoidal, with three bristles distributed on each lateral margin, as follows: apical, pre-apical, and proximal (Fig. 11E). Thorax. Elytra subquadrate, almost longer than wide and almost wider at posterior region (Fig. 12C), covering mesonotum and metanotum; anteromesial border densely scaled in internal view (Figs. 13A–B); covered with long bristles. Hind wing membrane shed in post-imaginal stage, present as a stump (Fig. 12B). Abdomen with short tergites and with secondary sclerotization not reaching inner paratergites; outer paratergites close to margin of sternites by the former secondary sclerotization; inner and outer paratergites not fused (Fig. 27B); first segment represented by a weak sclerotized tergite joined to metanotum (Fig. 12B); sternites III–V with pores sparsely distributed; tergite VII (Fig. 12D) subquadrate, wider than long, with two rows of bristles, two bristles on medial region and six bristles on apical region, anterior margin with conspicuous glandular area; tergite VIII (Fig. 12G) almost subquadrate, with two rows of bristles, each with six main long bristles on medial and posterior regions, and four moderated sized bristles on posterior margin; sternite VIII (Fig. 12H) subquadrate, with acute posterior margin; with a row of six medial bristles, a row of eight posterior bristles, and six moderated sized bristles on posterior margin; male sternite IX (Fig. 12F) elongate and tongue-shaped, with four bristles on posterior half; female sternite IX represented by a pair of hemisternites laterally attached to tergite IX (Fig. 12I); tergite X (Fig. 12E) not bilobed, with three long bristles on each side and with two bristles on medial region. Etymology. The specific epithet “ parapilosus ” is a combination of “para”, of Greek origin, which means “close to” and “pilosus”, referring to the species T. pilosus sp. nov., due to the morphological similarity between these species. Geographic distribution. Brazil (Pará). Host termites. This species was found in epigeal (above-ground) nests of Cornitermes pilosus Holmgren. This is the first record of a termitophilous rove beetle in the nest of this termite species. Discussion. Termitozophilus parapilosus sp. nov. is similar to T. pilosus sp. nov. and T. favachoi sp. nov. in having paratergites fused neither to each other nor to tergites and sternites (Figs. 27A–E). Termitozophilus parapilosus sp. nov. can be easily distinguished from T. pilosus sp. nov. in having six bristles on vertex (Fig. 11A) (T. pilosus sp. nov. has four bristles). In addition, it has four bristles on posterior margin of tergite VIII (Fig. 12G) (six in T. pilosus sp. nov.) and six bristles on the posterior margin of sternite VIII (Fig. 12H) (four in T. pilosus sp. nov.). Termitozophilus parapilosus sp. nov. also has anteromesial border of elytra densely scaled in the internal view (Figs. 13A–B). See the discussion under T. favachoi sp. nov. for differences between these similar new species.Published as part of Silva, Ruan Felipe Da, Zilberman, Bruno & Carvalho-Filho, Fernando Da Silva, 2022, Hidden Brazilian Amazon diversity: four new species, redescription and notes on natural history of Termitozophilus Silvestri, 1901 (Coleoptera: Staphylinidae: Aleocharinae), pp. 501-534 in Zootaxa 5209 (5) on pages 512-516, DOI: 10.11646/zootaxa.5209.5.1, http://zenodo.org/record/746935

    Immunogenicity and safety of the 4CMenB and MenACWY-CRM meningococcal vaccines administered concomitantly in infants - A phase 3b, randomized controlled trial

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    Mercedes Macias Parra, Angela Gentile, Jorge Alejandro Vazquez Narvaez, Alejandro Capdevila, Angel Minguez, Monica Carrascal, Arnold Willemsen, Chiranjiwi Bhusal, Daniela Toneatto. Immunogenicity and safety of the 4CMenB and MenACWY-CRM meningococcal vaccines administered concomitantly in infants: A phase 3b, randomized controlled trial. Vaccine. 2018;36(50):7609-7617

    Termitozophilus favachoi Silva & Zilberman & Carvalho-Filho 2022, sp. nov.

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    Termitozophilus favachoi sp. nov. (Figs. 3–9, 27B, 28) Type material. HOLOTYPE &male; (MPEG): Brasil [= Brazil], Pará, Barcarena / Vila de Arapari [= Arapari Village], 05.VIII.2021 / R. F. Silva [collector], hospedeiro [= host]: Cornitermes sp. PARATYPES. Same data as holotype, 1 &female; in MPEG (in alcohol), 1 &female; and 1 &male; in MZSUP (MZSP 21291) (dissected in slides). Diagnosis. Paratergites fused neither to each other nor to tergites and sternites; sclerotized areas of the abdomen light brown, with a large reddish brown membranous area exposed in dorsal view. Head with two pairs of bristles on vertex, one behind eye and one on medial-posterior portion of vertex. Elytra trapezoidal with heavily scaled anteromesial border. Hind wing membrane shed during post-imaginal growth. Sternite VIII with posterior margin bearing two bristles. Description. Male—length ~ 1.6 mm (Figs. 3A–B); female—length ~ 1.7 mm (Figs. 4A–B). Head subquadrate, about as wide as long, widest behind eye, almost narrowing posteriorly; length of eye about 1/3 of head length; vertex bearing two pairs of bristles: one bristle behind eye and one bristle on medial-posterior region (Fig. 5A). Antenna: scape almost longer than remainder antennomeres except antennomere XI; antennomere XI about three times longer than wide and more than twice longer than antennomere X; antennomeres II–VI elongate, gradually decreasing in length, antennomeres VII–X moniliform. Mouthparts. Labrum more than twice wider than long, with slight sinuous anterior margin, five main long bristles on each lateral half, distributed in two diagonal rows each with two bristles and one bristle placed above middle of labrum length (Fig. 5C); epipharynx covered with sensilla and numerous short bristles, two of which are rather longer. Mandible apex narrow, bearing a tooth on mesal region; with many punctuations on basal two thirds (Figs. 5B, 7A). Labium with ligula narrowed at base and with a median-apical emargination, resulting in two lobes; mentum and submentum distinct, both trapezoidal, with three bristles distributed on each lateral margin, as follows: apical, pre-apical, and proximal (Fig. 5E). Thorax. Elytra almost trapezoidal, wider at posterior region (Fig. 6C), covering mesonotum and metanotum; anteromesial border densely scaled, in internal view (Figs. 8A–B); covered with long bristles. Hind wing represented by a small pad (Fig. 6B). Abdomen with short tergites and with secondary sclerotization, not reaching inner paratergites; outer paratergites close to margin of sternites by the former secondary sclerotization; inner and outer paratergites not fused (Fig. 27B); first segment represented by a weak sclerotized tergite joined to metanotum (Fig. 6B); sternites III–V with sparsely distributed pores; tergite VII (Fig. 6D) almost subquadrate, wider than long, with two rows of bristles: two bristles on medial region and six bristles on posterior region; anterior margin with conspicuous glandular area (Figs. 8C–D); tergite VIII (Fig. 6G) subquadrate, with two rows of six long main bristles on medial and apical regions, and four moderately sized bristles on posterior margin; sternite VIII (Fig. 6H) almost subquadrate, with acute posterior margin, with a row of six medial bristles, a row of eight apical bristles, and two moderately sized bristles on posterior margin; male sternite IX elongate and tongue-shaped, with four bristles on apical region (Fig. 6F); female sternite IX represented by a pair of hemisternites laterally attached to tergite IX (Fig. 6I); tergite X not bilobed, with three long bristles on each lateral half, two on medial region and two bristles on posterior region. Etymology. The specific epithet is patronymic in honor of the wildlife photographer, researcher and science communicator César Favacho, for having contributed many photos of termitophilous beetles for this study. Geographic distribution. Brazil (Pará) (Fig. 28). Host termites. This species was found in epigeal (above-ground) nests of an unidentified species of Cornitermes, that possibly belongs to an undescribed species. Behavior. The behavior of Termitozophilus favachoi sp. nov. is similar to that described for T. pilosus sp. nov. (Figs. 9A–D) (see behaviour under T. pilosus sp. nov.). Discussion. Termitozophilus favachoi sp. nov. shares with T. pilosus sp. nov. and T. parapilosus sp. nov. abdominal sclerites and paratergites fused neither to each other nor to tergites and sternites (Figs. 27A–E). It differs from T. pilosus sp. nov in having four moderately large bristles on posterior margin of tergite VIII (Fig. 6G) (six in T. pilosus sp. nov.) and two bristles on sternite VIII (Fig. 6H) (four in T. pilosus sp. nov.). Termitozophilus favachoi sp. nov. can be distinguished from T. parapilosus sp. nov. in having four bristles on the vertex (Fig. 5A) (six in T. parapilosus sp. nov.) and two moderately sized bristles on the posterior margin of sternite VIII (Fig. 6H) (six in T. parapilosus sp. nov.). Additionally, the elytra of T. favachoi sp. nov. has an anteromesial border densely scaled in the internal view (Figs. 8A–B), a feature shared with T. parapilosus sp. nov. In T. pilosus sp. nov. the anteromesial border of elytra is wrinkled (Figs. 17A–B).Published as part of Silva, Ruan Felipe Da, Zilberman, Bruno & Carvalho-Filho, Fernando Da Silva, 2022, Hidden Brazilian Amazon diversity: four new species, redescription and notes on natural history of Termitozophilus Silvestri, 1901 (Coleoptera: Staphylinidae: Aleocharinae), pp. 501-534 in Zootaxa 5209 (5) on pages 506-508, DOI: 10.11646/zootaxa.5209.5.1, http://zenodo.org/record/746935

    Termitozophilus pilosus Silva & Zilberman & Carvalho-Filho 2022, sp. nov.

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    Termitozophilus pilosus sp. nov. (Figs. 14–18, 27B, 25, 28) Type material. HOLOTYPE &male; (MPEG): Brasil [= Brazil], Pará, Peixe-Boi / Fazenda Abalém [Abalém Farm], 15.VII.2021 / R. F. Silva [collector], hospedeiro [= host]: Cornitermes pilosus. PARATYPES. Same data as holotype, 5 &male;&male; and 5 &female;&female; in MZSUP (MZSP 21290, MZSP 21291) (1 &female; and 1 &male; dissected in slides, and 8 specimens in alcohol 70%); 5 &male;&male; and 5 &female;&female; in MPEG (in alcohol 70%); 1 &female; and 1 &male; in the CESP (in alcohol 70%); and 5 &male;&male; and 5 &female;&female; in the FMNH (in alcohol 70%). Diagnosis. Paratergites fused neither to each other nor to tergites and sternites; sclerotized areas of abdomen mostly light brown, with a large white-colored membranous area exposed in dorsal view. Head with vertex bearing two pairs of bristles, one bristle behind the eye and one on medial-posterior area. Elytra trapezoid with anteromesial border barely scaled. Hind wing membrane shed during post-imaginal growth. Posterior margin of sternite VIII with four bristles. Description. Male—length ~ 1.3 mm (Figs. 14C–D); female—length ~ 1.4 mm (Figs. 14A–B). Head subquadrate, about as wide as long, widest behind eye, almost narrowing posteriorly; eye about 1/3 of head length; vertex bearing two pairs of bristles: one bristle behind eye and one bristle on medial-posterior region (Fig. 15A). Antenna: scape longer than remainder antennomeres, except antennomere XI; antennomere XI about three times longer than wide and more than twice longer than antennomere X; antennomeres II–VI elongate, gradually decreasing in length, antennomeres VII–X moniliform. Mouthparts. Labrum more than twice wider than long, with slight sinuous anterior margin; five main long bristles on each lateral half, arranged in two diagonal rows each with two bristles and one bristle placed above middle of labrum length (Fig. 15C); epipharynx covered with sensilla and numerous short bristles, two of which longer. Mandible apex narrow, bearing a tooth on mesal region; with many punctuations on basal two thirds (Figs. 15B, 18A–C). Labium with ligula narrowed at base and with a median-apical emargination, resulting in two lobes; mentum and submentum distinct, both trapezoidal, with three bristles distributed on each lateral margin, as follows: apical, pre-apical, and proximal (Fig. 17D). Thorax. Elytra trapezoidal, longer than wide and wider at posterior region (Fig. 16C), covering mesonotum and metanotum; anteromesial border barely scaled in internal view (Figs. 17A–B); covered with long bristles. Hind wing membrane shed during post-imaginal growth, present as a stump (Fig. 16B). Abdomen with short tergites and with secondary sclerotization, not reaching inner paratergites; outer paratergites close to sternites margin by the former secondary sclerotization; inner and outer paratergites not fused (Fig. 27B); first segment represented by a weak sclerotized tergite joined to metanotum (Fig. 16B); sternites III–V with sparsely distributed pores; tergite VII (Figs. 16D, 18D–E) subquadrate, wider than long, with two rows of bristles, two bristle on medial region and six bristles on posterior half, anterior margin with conspicuous glandular area; tergite VIII (Fig. 16G) almost subquadrate, with two rows of bristles, each with six main long bristles on medial and posterior regions, and with six moderated sized bristles on posterior margin; sternite VIII (Fig. 16H) subquadrate, with acute posterior margin, with a row of six medial bristles, a row of eight posterior bristles, and four moderated sized bristles on posterior margin; male sternite IX (Fig. 16F) elongate and tongue-shaped, with four bristles on posterior half; female sternite IX represented by a pair of hemisternites laterally attached to tergite IX (Fig. 16I); tergite X (Fig. 16E) not bilobed, with three long bristles on each lateral half and two bristles on medial region. Etymology. The specific epithet “ pilosus ” referring to the host species “ C. pilosus ”. Geographic distribution. Brazil (Pará). Host termites. This species was found in epigeal (above-ground) nests of Cornitermes pilosus. This is the first record of a termitophilous rove beetle in the nest of this termite species. Notes on behavior. During laboratory observations (Fig. 1F), T. pilosus sp. nov. appears to be completely integrated into the colony of its host termite, since no agonistic interactions were observed, and the termites were seen palpating the beetles’ antennae, mouthparts, and abdomens. This species spent much of its time with the distal region of abdomen curled up over its body, not leaving the dorsal portion of the abdomen exposed. However, on other occasions, the abdomen was extended, exposing the tergites, which attracted termites that licked the gland present on tergite VII. Discussion. Termitozophilus pilosus sp. nov. is similar to T. parapilosus sp. nov. in having abdominal sclerites mostly light brown and paratergites fused neither to each other nor to tergites and sternites (Figs. 27A–E). See discussion under T. favachoi sp. nov. and T. parapilosus sp. nov. for the resemblances and differences between these species.Published as part of Silva, Ruan Felipe Da, Zilberman, Bruno & Carvalho-Filho, Fernando Da Silva, 2022, Hidden Brazilian Amazon diversity: four new species, redescription and notes on natural history of Termitozophilus Silvestri, 1901 (Coleoptera: Staphylinidae: Aleocharinae), pp. 501-534 in Zootaxa 5209 (5) on pages 517-522, DOI: 10.11646/zootaxa.5209.5.1, http://zenodo.org/record/746935

    Termitozophilus tenebrus Silva & Zilberman & Carvalho-Filho 2022, sp. nov.

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    Termitozophilus tenebrus sp. nov. (Figs. 19– 24, 27E, 28) Type material. HOLOTYPE &male; (MPEG): Brasil [= Brazil], Pará, Magalhães Barata / Vila de Calafate [= Calafate Village], 11.III.2021 / R. F. Silva [collector] / hospedeiro [= host]: Cornitermes pilosus. PARATYPES. Same data as holotype, 5 &female;&female; and 5 &male;&male; in MPEG (in alcohol 70%), 1 &female; and 1 &male; in MZSUP (MZSP 21288)(dissected on slides). Diagnosis. Paratergites fused neither to each other nor to tergites and sternites; sclerotized areas mostly dark brown, with a large white membranous area exposed in dorsal view. Head with vertex bearing two pairs of bristles, one behind the eye and a pair on medial-posterior region. Hind wings present in post-imaginal growth. Elytra trapezoidal, with anteromesial border densely scaled. Posterior margin of sternite VIII with two bristles. Description. Male—length ~ 1.6 mm (Figs. 19A–B); female—length ~ 1.8 mm (Figs. 20A–C). Head subquadrate, about as wide as long, widest behind eye, narrowing conspicuously through posterior region; eye about 1/3 of head length; vertex bearing two pairs of bristles: one bristle behind eye and one on medialposterior region (Fig. 21A). Antenna: scape almost longer than remainder antennomeres, except antennomere XI; antennomere XI about three times longer than wide and more than twice longer than X; antennomeres II–VI elongate, gradually decreasing in length, VII–X moniliform. Mouthparts. Labrum more than twice wider than long, with almost sinuous anterior region; five main long bristles on each lateral half, distributed in two diagonal rows, each with two bristles and one bristle placed on middle of labrum length (Fig. 21C); epipharynx covered with sensilla and numerous short bristles, two of which longer. Mandible apex narrow, bearing a tooth on mesal region; with many punctuations on basal two thirds, and with some pores on outer margin (Figs. 21B, 23C–D). Labium with ligula narrowed at base and with a median-apical emargination, resulting in two lobes; mentum and submentum distinct, both trapezoidal, with three bristles distributed on each lateral margin, as follows: apical, pre-apical, and proximal (Figs. 21E, 24C). Thorax. Elytra trapezoidal, almost longer than wide and wider at posterior region, covering mesonotum and metanotum (Fig. 22B); anteromesial border densely scaled in internal view (Figs. 23A–B); covered with long bristles. Hind wing present, membrane not shed during post-imaginal growth (Fig. 22A). Abdomen with short tergites and with secondary sclerotization not reaching inner paratergites; outer paratergites fused to sternites by former secondary sclerotization; inner and outer paratergites fused (Fig. 27E); first segment represented by a strong sclerotized tergite attached to metanotum, with medial region strongly projected backwards (Fig. 22A); sternites III–V with pores clustered; tergite VII (Fig. 22C) almost subquadrate, wider than long, with two rows of bristles, two bristles on medial region and six bristles on posterior half, anterior margin of tergite VII with conspicuous glandular areas (Figs. 24E–F); tergite VIII (Fig. 22F) almost subquadrate, with two rows of bristles, six main long bristles on medial and posterior regions; sternite VIII (Fig. 22G) subquadrate, with one pair of median bristle, one row of six bristle close to posterior margin and eight bristles along posterior margin; male sternite IX (Fig. 22E) elongate and tongue-shaped, with two bristles on posterior half; female sternite IX (Fig. 22H) represented by a pair of hemisternites laterally attached to tergite IX; tergite X (Fig. 22D) not bilobed, with three long bristles on each lateral half, two on medial region and two on posterior region. Etymology. The specific epithet is a Latin adjective that means “dark”, alluding to dull coloration of the examined specimens. Geographic distribution. Brazil (Pará). Discussion. Termitozophilus tenebrus sp. nov. is similar to T. laetus in having inner and outer paratergites fused, and paratergites fused to sternites (Figs. 27A–E). It differs from T. laetus in having head, thorax and abdomen with dark brown sclerites (light brown in T. laetus) and pores on sternites distributed in circular clusters (Figs. 19A–B, 20A–C) (scattered in T. laetus). In addition, T. tenebrus sp. nov. has a trapezoidal elytron (Fig. 22B), tergite VII with bristles (Fig. 22C) and posterior margin of tergite VIII without bristles (Fig. 22F). In T. laetus, the elytron is subquadrate, the bristles on tergite VII are absent and the posterior margin of tergite VIII has four bristles (see figs. 16–18 in Zilberman (2019)). Termitozophilus tenebrus sp. nov. is associated with nests of C. pilosus in pastures, while T. laetus is associated with nests of C. cumulans in savanna-like environments.Published as part of Silva, Ruan Felipe Da, Zilberman, Bruno & Carvalho-Filho, Fernando Da Silva, 2022, Hidden Brazilian Amazon diversity: four new species, redescription and notes on natural history of Termitozophilus Silvestri, 1901 (Coleoptera: Staphylinidae: Aleocharinae), pp. 501-534 in Zootaxa 5209 (5) on pages 522-529, DOI: 10.11646/zootaxa.5209.5.1, http://zenodo.org/record/746935

    FIGURE 16 in Hidden Brazilian Amazon diversity: four new species, redescription and notes on natural history of Termitozophilus Silvestri, 1901 (Coleoptera: Staphylinidae: Aleocharinae)

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    FIGURE 16. Termitozophilus pilosus sp. nov. A) Meso-metaventrite, ventral view. B) Meso-metanotum and tergite I, dorsal view. C) Elytron, dorsal view. D) Tergite VII, dorsal view. E) Male tergites IX and X, dorsal view. F) Male sternite IX, ventral view. G) Tergite VIII, dorsal view. H) Sternite VIII, ventral view. I) Female tergites IX and X, dorsal view. J) Median lobe of aedeagus, lateral view. K) Aedeagus, paramere, dorsal view. L) Spermatheca, lateral view. Scales: A, B, D, E, H, I = 2 mm; C, F, G = 1,5 mm; L = 0,5 mm; J–K = 0,2 mm.Published as part of Silva, Ruan Felipe Da, Zilberman, Bruno & Carvalho-Filho, Fernando Da Silva, 2022, Hidden Brazilian Amazon diversity: four new species, redescription and notes on natural history of Termitozophilus Silvestri, 1901 (Coleoptera: Staphylinidae: Aleocharinae), pp. 501-534 in Zootaxa 5209 (5) on page 519, DOI: 10.11646/zootaxa.5209.5.1, http://zenodo.org/record/746935
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