33 research outputs found
Role of CXCL7 in Colon Cancer Proliferation
No full textColorectal cancer (CRC) is the third commonly diagnosed cancer worldly and the second cause of cancer-related mortality in the United States. It is a complex disease, and despite the improvements in CRC screening and treatments approximately half of the patients discovered their cancers at late and aggressive stage of the disease. Thus, there is a need to increase public awareness for the importance of early diagnosis that can interrupt CRC progression, especially among populations who are at higher risk for CRC. Furthermore, understanding the predisposition factors and molecular mechanisms can help to improve preventative strategies and develop an effective-targeted therapy for CRC.
The tumor microenvironment (TME) is heterogeneous, consisting of blood vessels, lymph vessels, secreted proteins, extracellular matrix (ECM), stromal cells, immune/inflammatory cells, and other components. The continuous and dynamic interaction between cancer cells and the TME can promote cancer progression. One of the important players in the TME is the chemokines family, a class of pro-inflammatory cytokines with small molecular weights (~8–14 kDa) that are capable of chemotactic cell-directed movement. Recently, the role of chemokines in the TME has received great attention, and a vast number of studies indicate their role in cancer progression, especially in CRC.
Chemokine (C-X-C motif) ligand 7 (CXCL7)/ NAP2 is an immediate mediator for neutrophils recruitment released from platelets at sites of inflammation, and it has been suggested as a potential biomarker for CRC diagnosis. Literature has reported that CXCL7 drives tumor progression and metastasis by binding to its receptor (CXCR2) in various cancer types such as cholangiocarcinoma, breast cancer, and CRC. Furthermore, several pieces of evidence indicate that the encoding gene for CXCL7 (PPBP) and CXCR2 receptors are highly expressed in patients with CRC. Thus, CXCL7 has been a potential biomarker for diagnosis of many cancers including early lung and CRC. CXCL7 also has been shown to stimulate glucose transporters and glycolysis in non-cancer cells. Additionally, recent evidence reports a correlation between CXCL7 and the key glycolytic enzyme; lactate dehydrogenase (LDH) and it is an independent risk factor for CRC prognosis. However, the role of the CXCL7-CXCR2 axis in CRC progression has not been fully understood. Hereby, we carried out this study to examine the role of the CXCL7-CXCR2 axis in mediating colon cancer proliferation. This study was the first to demonstrate that CXCL7 stimulates proliferation, lactate production, and glycolytic function in human colon cancer cells, suggesting that CXCL7 may stimulate colon cancer proliferation by enhancing aerobic glycolysis
Suggesting new words to extract keywords from title and abstract
No full textWhen talking about the fundamentals of writing research papers, we find that keywords are still present in most research papers, but that does not mean that they exist in all of them, we can find papers that do not contain keywords. Keywords are those words or phrases that accurately reflect the content of the research paper. Keywords are an exact abbreviation of what the research carries in its content. The right keywords may increase the chance of finding the article or research paper and chances of reaching more people who should reach them. The importance of keywords and the essence of the research and address is mainly to attract these highly specialized and highly influential writers in their fields and who specialize in reading what holds the appropriate characteristics but they do not read and cannot read everything. In this paper, we extract new keywords by suggesting a set of words, these words were suggested according to the many mentioned in the researches with multiple disciplines in the field of computer. In our system, we take a number of words (as many as specified in the program) that come before the proposed words and consider it as new keywords. This system proved to be effective in finding keywords that correspond to some extent with the keywords developed by the author in his research
Structural and photoluminescence properties of Ni doped CdS nanoparticles synthesis by sol gel method
No full textMicrostructural and optical properties of CdS nanoparticles synthesized by sol gel method
No full textMicrostructural and optical properties of sol gel synthesized CdS nano particles using CTAB as a surfactant
No full textCaries, oral hygiene status and dates consumption among Saudi female university students
No full textAuthors: Al Essa, Noura A., Al Mutairi, Manal A., Al Ohali, Hadeel M. From
Intern, King Saud University College of Dentistry
Authors: El Hejazi, Ahmed, Associate Professor, RDS Department, Operative Dentistry Division, King Saud University
College of Dentistry, Riyadh.
Author: Chohan, Arham, Lecturer, PDS Department, Pediatric Dentistry Division, King Saud University College of
Dentistry, RiyadhThe objectives of the present study were to determine the caries experience, oral hygiene
status and consumption of dates among Saudi female University students. A total of 406
female University students were examined for dental caries and oral hygiene. The information
about oral hygiene practices and consumption of dates was obtained through a selfadministered
questionnaire. The mean DMFT was 10.01 (SD 4.71) with a decay (D)
component of 5.87 (SD 4.28), missing (M) component of 0.83 (SD 1.44) and filled
component of 3.31 (SD 3.92). There was significant (p< .05) difference observed between the
mean DMFT scores of the students from various age groups. Only one-fourth (25.6%) of the
students had good oral hygiene. A positive correlation (p< .0001) was exhibited between the
mean DMFT scores and oral hygiene. Almost all (98.0%) students used brush to clean their
teeth. A majority of the students were cleaning their teeth twice (47.0%) or thrice (22.4%)
daily and only about one in ten (12.3%) students’ used miswak to clean their teeth. More than
three-fourth (81.0%) students were eating dates and about one-fourth (24.4%) of the students
were eating 5-10 dates per day. No significant (p> .05) correlation was observed between
caries and dates consumption. It was concluded that the caries prevalence and severity was
very high. Only small percentage of the students had good oral hygiene and eight in every ten
students was eating dates daily
Optical properties of cerium oxide (CeO2) nanoparticles synthesized by hydroxide mediated method
No full textInvestigation of feeding and nutritional problems related to long-term enteral nutrition support among children with disabilities: a pilot study
No full textBackgroundEnteral Nutrition (EN) is considered a standard intervention for patients with disabilities who cannot meet their nutritional requirements orally and are at risk for malnutrition secondary to eating difficulties. The current study examined common feeding and nutritional problems related to prolonged EN among disabled children.MethodsA cross-sectional, pilot study was conducted in Saudi Arabia between December 2023 and March 2024. Caregivers of children with disabilities were invited to complete an online questionnaire that gathered demographic data and explored feeding difficulties and challenges related to enteral nutrition.ResultsA total of 41 caregivers completed the survey regarding their children. The median age (IQR) of disabled children was 3.2 (1.7–6.6) years. The most frequently reported feeding and nutritional problems in this cohort were constipation [median = 3.0, IQR: 2.0–4.0], weight loss [median = 3.0, IQR: 1.0–4.0], and gastroesophageal reflux [median = 2.0, IQR: 1.0–3.0].The regression analysis showed a statistical association between the indication for nutrition support and the subsequent detected feeding/nutritional problem, p-value<0.05. It also showed that the primary diagnosis (r = 0.459, p-value = 0.003) and health status (r = 0.458, p-value = 0.003) were statistically significant predictors of the frequency of reported feeding and nutritional problems among this children group. Additionally, the challenges experienced by the caregivers were statistically related to the type of EN provided (r = 0.491, p-value = 0.001).ConclusionThe study provided insight into the typical feeding and nutritional problems associated with long-term EN among children with disabilities. Identifying these issues can support early diagnosis and the implementation of appropriate nutritional interventions, ultimately helping to optimize growth and improve quality of life for these children
Eco-conscious upcycling of sugarcane bagasse into flexible polyurethane foam for mechanical & acoustic relevance
No full textThis study explores the use of sugarcane bagasse (SCB), a byproduct of sugarcane processing, as a bio-filler in the production of flexible polyurethane foam (FPU), focusing on its benefits for both the environment and the economy. By varying the inclusion of SCB waste from 1 to 6 wt%, the research aims to enhance the FPU's mechanical and acoustic characteristics. Techniques such as Fourier transform infrared (FTIR) spectroscopy and field emission scanning electron microscopy (FESEM) were utilized to analyze the chemical structure and surface characteristics of both SCB and the FPU/SCB composites. Additionally, tests on gel fraction, density, and mechanical properties were conducted. The results indicate that adding 4 wt% SCB to FPU considerably improved the foam's properties. This modification resulted in a 148.63% increase in apparent density, a 228.47% rise in compressive strength, and a 116.24% boost in tensile strength. Furthermore, sound absorption across various frequency ranges was enhanced compared to the control foam. Additionally, the findings show that SCB effectively shifts sound absorption characteristics to lower frequencies. Specifically, at a low frequency of 500 Hz, the sound absorption coefficient increased to 0.4 with a foam thickness of 20 mm. This demonstrates that SCB can significantly improve FPU's performance, making it an attractive option for applications requiring noise mitigation, such as in the automotive and construction industries, thereby offering a sustainable solution to waste management and materials innovation.This article is published as El-Metwaly, Esraa A., Hadeel E. Mohamed, Tarek M. El-Basheer, Manal TH Moselhy, Sonia Zulfiqar, Eric W. Cochran, and Ahmed Abdelhamid Maamoun. "Eco-conscious upcycling of sugarcane bagasse into flexible polyurethane foam for mechanical & acoustic relevance." RSC advances 14, no. 33 (2024): 23683-23692.
doi: https://doi.org/10.1039/D4RA04025B. © 2024 The Author(s). This Open Access Article is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported Licence
Phonological development of typically developing Kuwaiti Arabic-speaking preschoolers
No full textThis study documents the development of the phonological skills of typically developing Kuwaiti Arabic-speaking preschool-age children and lays the foundation for a speech-assessment tool for Kuwaiti Arabic. Kuwaiti Arabic is the spoken dialect in Kuwait. The segmental inventory of Kuwaiti Arabic is similar to that of other spoken Arabic dialects and that of Modern Standard Arabic, although with some variation across dialects.
The current study used a standard single-word picture- and object-based elicitation that evaluates consonants and vowels across word positions, within a variety of word lengths and structures (88 words altogether). Speech samples were collected by the author from 80 monolingual 4- to 5-year-old Kuwaiti children and were recorded on an M-Audio Track II 24/96 recorder (Beier TGX 58 microphone). This age group was selected because previous research has shown that the Arabic phonological repertoire may be almost complete by age 4; thus, these children had reached an age where it would be essential to intervene if they showed speech delays. Children were recruited from preschools across the state of Kuwait in order to include all dialects and districts. The author, who is a native speaker of Kuwaiti Arabic, was the primary transcriber, with reliability checks conducted on 10% of the sample by phonetically trained transcribers. A nonlinear phonological framework based on Bernhardt and Stemberger (1998) was adopted for analysis of word structures, consonants and features.
Preliminary data show that Kuwaiti preschoolers have a rich consonantal inventory across the places of articulation, including emphatic and non-emphatic stops, nasals, approximants, and uvular and pharyngeal fricatives. Some features appear to be still undergoing development. Several word lengths have been acquired by this age, from monosyllabic to four-syllable words. Morphophonemic alternations appear to be still developing.
The data for relatively comparable groups of younger and older 4-year-olds were analyzed and showed developmental change across time. In addition, a group at-risk for protracted phonological development was identified which had notably less proficiency in phonological production than the other two groups. Finally, this study attempts to set some of the groundwork for the future development of a phonological test for Kuwaiti Arabic.Medicine, Faculty ofAudiology and Speech Sciences, School ofGraduat
