101 research outputs found
Optimization of the extraction of bioactive molecules from <i>Lycium barbarum</i> fruits and evaluation of the antioxidant activity: a combined study
No full textNovel food, super food, wolfberry, the Himalayan longevity fruit. Several different and, even more, colourful names define the fruits of Lycium barbarum L., one of the most popular food supplements and anti-aging remedies of the recent years. Goji derivatives find application at the interface between food and medicine thanks to the claimed antioxidant and immunomodulatory properties. Aiming at identifying the most effective extraction protocol for processing different goji berries samples (fresh and dried, commercial and from an Italian cultivar), combinations of extractive and analytical techniques were attempted. The concentration of bioactive compounds and of total phenols were measured and the antioxidant activity of the obtained extracts was studied. The results highlight the most suitable combination of source and process to obtain an extract that can be suitable for nutraceutical applications.</p
MIINT: Middleware for IIoT Platforms Integration
No full textIn the last recent years Internet of Things has extended its adoption to the industrial manufacturing field. The digitalization of industry brings the new concept of Industry 4.0 to light. In fact, the enormous value for the companies generated from the adoption of Industrial IoT and Edge Computing has led to a vertiginous increments of IIoT platform demands. Therefore, world-wide big IT players and Foundations start to introduce their own flagship IIoT platforms into market. This multitude of platforms presents similar common features, but with different APIs. These platforms are hardly interoperable, and they are frequently bounded to their own vertical solution stack. To overcome these limitations, in this paper, we propose MIINT, a Middleware for IIoT platforms INTegration. MIINT groups the common functionalities of IIoT frameworks, and it integrates different platforms by providing standard access APIs. To prove the feasibility of MIINT, in this paper, we show an integration use case of Azure IoT and EdgeX Foundry IIoT platforms. Moreover, we also thoroughly assess MIINT by executing on the edge a field data reading functionality in the two considered IIoT platforms, by showing their advantages and limitation
A cavallo della guerra
No full textIl saggio disegna la metamorfosi della mappa del potere in architettura nel passaggio tra fascismo e post fascismo. Evidenzia in particolare gli elementi di continuità espressi da alcune figue chiave come Piacentini, Giovannoni, Calza Bini, Foschini
Hibiscus sabdariffa L. una fonte sostenibile di antocianine. Caratterizzazione fitochimica e attività antiossidante di estratti dai calici
No full textQuesto lavoro è stato indirizzato alla caratterizzazione quali-quantitativa e alla valutazione dell’attività antiossidante di estratti della specie Hibiscus sabdariffa L. Le attività di ricerca sono state condotte sui calici di due diverse varietà della stessa specie, chiamate rispettivamente kibeleza e tenonderà. Le piante, coltivate in Paraguay, sono state fornite dall’azienda Edynea Srl. Sono stati studiati due lotti di materia prima; la raccolta e l’essiccamento sono avvenuti in due momenti diversi dell’anno.
Il lavoro di ricerca ha previsto l’identificazione del metodo estrattivo più adatto. Successivamente sono state svolte le analisi per stabilire il contenuto di antocianine monomeriche totali, ingredienti caratterizzanti del prodotto, attraverso il metodo spettrofotometrico del pH differenziale, e il contenuto in fenoli totali attraverso il metodo Folin-Ciocalteu. Si è deciso di saggiare l’attività antiossidante degli estratti di Hibiscus sabdariffa L. in quanto essa risulta un’interessante caratteristica per un’eventuale applicazione cosmetica. Si sono utilizzate le metodiche DPPH e ABTS e inoltre l’analisi FRAP. L’analisi quali-quantitativa degli estratti è stata effettuata tramite analisi HPLC. La caratterizzazione di tali matrici e la rilevazione dell’attività antiossidante rappresentano uno studio preliminare all’impiego di Hibiscus sabdariffa L., e in particolare delle due varietà della specie studiate, in applicazioni nutri-cosmetiche che possano prevedere l’utilizzo combinato di integratori e cosmetici per il mantenimento del buono stato di salute della pelle
Università La Sapienza, Roma di Marcello Piacentini
No full textIl saggio ripercorre le vicende storico progettuali relative alla progettazione della Città universitaria di Roma tra il 1932 e il 1935. In particolare sono analizzati i significati, anche contrastanti, attribuiti a questa importante operazione urbanistica dalla cultura architettonica, il significato del coinvolgimento di architetti diversi tra loro – Piacentini, Pagano, Ponti, Michelucci, Capponi, Foschini – in un intervento che mira ad avere un carattere architettonico unitario, le scelte stilistiche adottate di compromesso tra tradizione e modernità, il ruolo di coordinatore svolto da Piacentini, i rapporti intercorsi tra quest’ultimo e Mussolini
Oral field cancerization: History and future perspectives
No full textNotwithstanding extended surgical approaches or adjuvant chemoradiotherapy, the development of multiple neoplastic lesions arising in the oral cavity after treatment still represents a critical clinical challenge in the management of patients with oral squamous cell carcinoma. Such clinical behavior of oral squamous cell carcinoma is nowadays better known as "field" cancerization effect as suggested by Slaughter, the author that for the first time tried to describe it in a scientific paper. Field cancerization is now widely accepted not only in head and neck oncology but also in other anatomical districts as well as in different types of epithelial neoplasia. A brief history of the theory of field cancerization is here proposed and future perspectives deriving from new molecular techniques are discussed
Correction to: Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions) (Breast Cancer Research and Treatment, (2019), 174, 2, (279-296), 10.1007/s10549-018-05071-1)
No full textThe article Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions), written by Christoph J Rageth, Elizabeth AM O’Flynn, Katja Pinker, Rahel A Kubik-Huch, Alexander Mundinger, Thomas Decker, Christoph Tausch, Florian Dammann, Pascal A. Baltzer, Eva Maria Fallenberg, Maria P Foschini, Sophie Dellas, Michael Knauer, Caroline Malhaire, Martin Sonnenschein, Andreas Boos, Elisabeth Morris, Zsuzsanna Varga, was originally published electronically on the publisher’s internet portal (currently SpringerLink) on November 30, 2018 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on May 30, 2019 to © The Author(s) 2018 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creat iveco mmons.org/licen ses/by/4.0/), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. The original article has been corrected
p16 protein expression and correlation with clinical and pathological features in osteosarcoma of the jaws: Experience of 37 cases
No full textBackground: In literature, no markers have been reported as predictive and prognostic factors in osteosarcoma of the jaw. Methods: A retrospective analysis of p16 expression was performed in 37 patients with high-grade osteosarcoma of the jaw to investigate its potential prognostic and predictive value. Results: p16 positivity was found in 56.7% of cases. The absence of p16 expression was associated with an adverse disease-free survival (P=.003). At the multivariate Cox regression, positive margins were the only independent factor. In the subgroup of 17 patients who underwent neoadjuvant chemotherapy, a significant association was noted between p16 expression and pathological response to chemotherapy (P=.015) and the negativity of p16 increased the risk of negative outcome (P=.01). Conclusion: Our data indicate that the wide surgical margin is the most important prognostic factor. The expression of p16 confers greater sensitivity to chemotherapy and its loss of expression is associated with a worse prognosis
The changing faces of corticotroph-cell adenomas: the role of proconvertase 1/3
No full textIntroduction: The possible change in the pattern of hormonal secretion by pituitary tumours is a very intriguing issue indeed, notably in the case of corticotroph-cell adenomas.
Methods/design: We retrospectively reviewed the records of 1259 consecutive endoscopic endonasal surgical procedures for pituitary adenomas from 1998 to 2013. Of these, 132 were ACTH-secreting adenomas associated with Cushing’s disease (CD) and 44 were silent corticotroph-cell adenomas (SCA). During the follow-up, seven patients (four men and three women) showed a transformation of their clinical expression from SCA to CD or, more rarely, vice versa. Of these, to date only three patients with corticotroph-cell adenomas changing their pattern of hormonal secretion during the follow-up were re-operated. Then, we examined the expression of proconvertase 1/3 (PC1/3), which plays an important role in the POMC processing within the pituitary, in tissue specimens obtained from these three patients with SCA that had developed clinical and laboratory features of CD at the time of recurrence, using both immunohistochemistry and quantitative real time-PCR.
Results: The data indicated that the immunohistochemical PC1/3 expression was negative or weak and focally positive in tissue specimens obtained in the three patients at the time of first operation (SCA), whereas we observed a strong expression in the majority of the neoplastic cells in the same three patients at the time of recurrence, when they had become CD. The PC1/3 expression, as evaluated using immunohistochemistry, showed a significant correlation with the PC1/3 levels obtained by qRT-PCR in assessing the increase of PC1/3 expression from SCA to CD. Twelve cases of SCA without changing their phenotype during the follow-up were used as controls: both the immunohistochemical PC1/3 expression and level of PC1/3 obtained by qRT-PCR were absent or weak in scattered neoplastic cells.
Conclusion: This study provides insight into the crucial role of the PC1/3 in the mechanism(s) of transformation of phenotype from SCA to CD
The changing faces of corticotroph cell adenomas: the role of prohormone convertase 1/3
No full textThe spectrum of corticotroph cell adenomas is very wide. Though rarely, silent corticotroph cell adenomas (SCA) may transform into corticotroph cell adenomas associated with Cushing’s disease (CD). The aim of the study was to investigate the role of prohormone convertase 1/3 (PC1/3) in the transformation of SCA into CD. We reviewed the records of 1259 consecutive endoscopic endonasal procedures for pituitary adenomas from 1998 to 2013. Of these, 132 were CD and 44 were SCA. During the follow-up, three patients with SCA showed a clear transformation from SCA into CD and underwent surgery once again to remove the recurrent tumour. The PC1/3 expression was analysed by both immunohistochemistry and quantitative real time-polymerase chain reaction (qRT-PCR) in primary and recurrent tumours. The immunohistochemical PC1/3 expression was negative or weak in the three patients in the initial phase of SCA, while a strong expression was observed in the majority of neoplastic cells in tissue specimens obtained from the same three patients at the time of recurrence as CD. The immunohistochemical PC1/3 expression showed a strict correlation with the PC1/3 levels obtained by qRT-PCR. In 14 cases of SCA with no change of phenotype during the follow-up, the immunohistochemical PC1/3 expression was low and strictly associated with the level of PC1/3 obtained by qRT-PCR both in primary (14/14 cases) and in recurrent tumours (4/4 cases). Our study provides insight into the crucial role of the PC1/3 protein in the transformation of phenotype from SCA to CD
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