2,829 research outputs found

    L’isola di domani. Cultura materiale e contesti archeologici a San Giacomo in Paludo (Venezia)

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    Il libro è la storia dell’isola di ieri e soprattutto della relazione tra i suoi spazi, i suoi abitanti, gli edifici che hanno occupato ed i loro oggetti quotidiani, dal basso medioevo ad oggi. San Giacomo in Paludo è un’isola della laguna nord di Venezia, oggi disabitata, ma che a partire dal XIII secolo ha ospitato prima una comunità di monache cistercensi, poi un priorato francescano ed infine alcuni presidi militari. La prima parte del libro racconta le ricerche archeologiche e storiche: la descrizione generale degli spazi occupati e delle singole aree scavate è seguita dalla discussione su specifiche tipologie di dati quali ceramica, resti umani, fauna e fonti storiche. La seconda parte del lavoro cerca di comprendere il significato di questo luogo nel corso dei diversi momenti storici attraverso il punto di vista degli abitanti e quello di più ampio respiro della laguna. Il tema principale della ricerca sono le comunità che vi hanno abitato e i loro resti materiali. Le tre principali variabili utilizzate per la loro carattterizzazione sono state l’uso dello spazio, le relazioni con l’area esterna all’isola e, infine, il trattamento dei rifiuti. In passato il sito è sempre stato uno specchio del rapporto tra Venezia e la sua laguna. Quale sarà l’isola di domani? Sommario Ieri, oggi, domani. Storie di un’isola e delle sue genti, di Sauro Gelichi 1. Introduzione, di Margherita Ferri, Cecilia Moine 2. La sequenza insediativa, di Margherita Ferri, Cecilia Moine 3. Tecnologie edilizie, di Fulvio Baudo 4. UTS 1000, di Margherita Ferri, Cecilia Moine 5. UTS 4000, di Carlo Beltrame, Margherita Ferri, Cecilia Moine 6. UTS 3000, di Fulvio Baudo, Margherita Ferri, Cecilia Moine 7. UTS 2000, di Margherita Ferri, Cecilia Moine 8. La sequenza della UTS 7000, di Margherita Ferri 9. La ceramica, di Margherita Ferri, Alberto García Porras, Laura Martín Ramos 10. Ossa animali di mammiferi e di uccelli dal monastero e dal priorato, di Aleks Pluskowski, Kris Seetah, Silvia Garavello 11. Le sepolture di San Giacomo in Paludo, di Francesca Bertoldi, Carlotta Sisalli 12. Le monete rinvenute nello scavo di San Giacomo in Paludo, di Michele Chimienti 13. L’Isola attraverso le fonti scritte, di Cecilia Moine, Elisa Corrò 14. Anima di un’isola, di Margherita Ferri, Cecilia Moine 15. L’isola di domani, di Margherita Ferri, Cecilia Moine Bibliografia Summar

    L'indulgenza di Dio

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    Nella sezione "Dalla sala Ferri" viene riportato il testo della conferenza "L'indulgenza di Dio" tenuta da Alberto Melloni il 1° ottobre 2015 in occasione della mostra "Bellezza divina"

    Profili processuali della responsabilità civile del giudice

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    Il contributo analizza i profili processuali della responsabilità civile dei giudici dopo la riforma del 201

    Atti 76° Congresso Nazionale SISvet

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    Hepatitis E virus is a cosmopolitan emerging foodborne pathogen, and raw or undercooked liver and pork products can cause infection through the orofecal route. The domestic pig (Sus scrofa domesticus) represents the main “urban reservoir” both for humans and wild animals (Priemer et al., 2022). In Central-Southern Italy, the small traditional farming method, and the possibility of environmental sharing with wild species can represent crucial aspects for HEV diffusion and persistence. The aim of this study was to detect HEV RNA (genotype and subtype) from home slaughtered domestic pigs in the Ascoli Piceno province (Central Italy) and more specifically from Monti Sibillini National Park. For this purpose, a total of 236 liver and muscle tissue samples were collected from subjects with a final age of 1 year and half and weight of 200±20 Kg. Each tissue aliquot (15g) was conferred at slaughterhouse level. Laboratory workflow started from omogenization, followed by the RNA extraction using the Trizol LS method. The last analytical steps were bio-molecular screenings: nested RT-PCR and qRT-PCR amplifying specific genetic determinants belonging to the HEV ORF-1, ORF-2, and ORF-3 genes. Sanger sequencing and phylogenetic analysis were performed. The IBM® SPSS® Statistics Software was used for the statistical data analysis calculating the chi-square value (with Yates’s correction). A total of 42/236 (17.79% CI 95%: 12.92-22.66%) liver samples resulted positive for the HEV RNA detection (ORF- 1 and 2); while 8/42 (19.04% CI 95%: 7.17-30.91%) of positive subjects (liver organ) detected HEV RNA from diaphragm specimens too. Sequences presented high nucleotide similarities (over than 98.00%) with genotype 3. The discovered HEV-3 was the same amplified from wild boars’ populations screened in the same province (Ferri et al., 2022). Basing on the farming systems and on the possible environmental sharing with wildlife, the scientific hypothesis of cross-infection possibility was supported by the obtained data. This study wants to focus further attention on the importance of HEV environmental surveillance that represents a crucial public health concern (following a One-health approach)

    Hepatitis E Virus in the Food of Animal Origin: A Review

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    Hepatitis E virus (HEV) is a cosmopolitan foodborne pathogen. The viral agent infects humans through the consumption of contaminated food (uncooked or undercooked). Most cases of infection are asymptomatic and for this reason, this pathology is considered underdiagnosed. Domestic and wild animals are considered natural reservoirs: that is, domestic pig, wild boar, sheep, goat, deer, rabbit, and so on. Therefore, various work categories are at risk: that is, veterinarians, farmers, hunters, slaughterhouse workers, and so on. In these last decades, researchers found a high percentage of positivity to the molecular viral detection in several food matrices included: ready-to-eat products, processed meat products, milk, and shellfish. This review aims to provide an international scenario regarding HEV ribonucleic acid (RNA) detection in several foodstuffs. From this investigative perspective, the study aims to highlight various gaps of the current knowledge about technologies treatments' impact on viral loads. The purpose was also to provide an innovative point of view "One Health"-based, pointing out the strategic role of environmental safety

    Prediction of Air Permeability Using a Finite Element Method

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    Air permeability is one of the most important parameters in the study of thermo-physiological comfort of fabrics. The main goal of this work is to develop a virtual process that allows the prediction of air permeability of any fabric without realizing a sample. The Free and Porous Media Flow physics interface was used in COMSOL Multiphysics® software; this allows to use Navier-Stokes equation in the air free volume through yarns and the Brinkman equation inside yarns. This work confirms that air permeability can be predicted with good accuracy, from the basic design parameters of any fabric

    Ruolo della fosfolipasi A2 secretoria e della fosfolipasi associata alle lipoproteine nel rischio cardiovascolare

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    Phospholipase A2(PLA2) are enzymes that hydrolyze the ester bond of glycerophospholipids releasing free fatty acids and lysophospholipids, including the arachidonic acid, the precursor of the eicosanoids and the inflammatory cascades. PLA2are present in the atherosclerotic plaques and their direct involvement in the proatherogenic inflammatory response is well documented. Epidemiological and genetic studies have demonstrated the correlation of the PLA2 mass and enzymatic activity with the incidence of cardiovascular diseases. The potential pro-atherogenic role of PLA2led to the development of two small molecules, varespladib, a reversible sPLA2 inhibitor, and darapladib, a selective Lp-PLA2inhibitor. Both molecules have demonstrated antiatherosclerotic properties in animal models, and positive effects on atherosclerotic plaque composition evaluated in phase 2 clinical trials. On these grounds, the results of three phase 3 studies have recently been published: the VISTA-16 study with varespladib in patients with acute coronary syndrome, and the STABILITY and SOLID-TIMI 52 studies with darapladib in patients with stable coronary heart disease and acute coronary syndrome, respectively. Unexpectedly, both studies did not demonstrate an additional protective action of PLA2inhibitors over the standard of care treatment with statins, antiplatelet drugs, and coronary revascularization.In the present article, the enzymatic properties and the involvement of sPLA2 and Lp-PLA2in atherogenesis are reviewed, with a focus on the results of experimental studies and clinical studies with both varespladib and darapladib inhibitors

    Clinical evidence of statin therapy in non-dyslipidemic disorders

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    The clinical benefits of statins are strongly related to their low density lipoprotein cholesterol (LDL-C) lowering properties. However, considering that the pharmacological target of statins, the 3-hydroxy-3-methyl-3-glutaryl coenzyme A (HMG-CoA) reductase, is one of the upstream enzyme of the mevalonate pathway, its inhibition may determine a substantial impoverishment of additional lipid moieties required for a proper cellular function. From this hypothesis, several experimental and clinical evidences have been reported indicating additional effects of statins beyond the LDL-C lowering, in particular anti-inflammatory and immunomodulatory effects. Thus statin therapy, indicated for hyperlipidemic patients for primary and secondary prevention of coronary heart disease (CHD) has begun to be considered effective in other diseases not necessarily linked to altered lipid profile. In the present review we summarized the current clinical evidence of the efficacy and safety profile of statins in a variety of diseases, such as rheumatoid arthritis, venous thromboembolism, liver diseases, polycystic ovary syndrome, and age-related macular degeneration. As discussed in the review, pending large, well designed, randomized trials, it is reasonable to conclude that there is no definitive evidence for the use of statins in the aforementioned diseases

    Ferri sobre el río Magdalena. Foto 2

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    El Ferri Casabe en aguas del río Magdalena, frente al muelle de Barrancabermeja (Santander). Los buses de la Shell Condor S.A. que se ven en la imagen a la derecha llegaban hasta el muelle con los trabajadores, punto donde estos embarcaban en el ferri para ser llevados hasta el puerto de la empresa en el campo Casabe (Yondó), en la margen izquierda del río Magdalena. Junto a los trabajadores también se transportaba material para los trabajos de perforación del pozo petrolero. Junto al ferri se observa un típico trasportador o chalupero y al fondo del muelle las torres de la refinería de Barrancabermeja (Lozano Vásquez, M., comunicación personal, 20 de mayo de 2025). Investigación y descripción realizada con la colaboración de Clara Inés Carreño Tarazona (Historiadora)
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