126 research outputs found
Measuring urinary cortisol and testosterone levels in male Barbary macaques: A comparison of EIA and LC–MS
No full textCorrelates of androgens in wild male Barbary macaques: Testing the challenge hypothesis
No full text© 2017 Wiley Periodicals, Inc. The attached document (embargoed until 17/08/2018) is an author produced version of a paper published in the American Journal of Primatology, uploaded in accordance with the publisher’s self- archiving policy. The final published version (version of record) is available online at the link below. Some minor differences between this version and the final published version may remain. We suggest you refer to the final published version should you wish to cite from it
Testosterone and cortisol are negatively associated with ritualized bonding behavior in male macaques
No full textComprehensive search filters for retrieving publications on nonhuman primates for literature reviews (filterNHP)
No full textModification of Loop 1 Affects the Nucleotide Binding Properties of Myo1c, the Adaptation Motor in the Inner Ear
No full textMyo1c is one of eight members of the mammalian myosin I family of actin-associated molecular motors. In stereocilia of the hair cells in the inner ear, Myo1c presumably serves as the adaptation motor, which regulates the opening and closing of transduction channels. Although there is conservation of sequence and structure among all myosins in the N-terminal motor domain, which contains the nucleotide- and actin-binding sites, some differences include the length and composition of surface loops, including loop 1, which lies near the nucleotide-binding domain. To investigate the role of loop 1, we expressed in insect cells mutants of a truncated form of Myo1c, Myo1c1IQ, as well as chimeras of Myo1c1IQ with the analogous loop from other myosins. We found that replacement of the charged residues in loop 1 with alanines or the whole loop with a series of alanines did not alter the ATPase activity, transient kinetics properties, or Ca2+ sensitivity of Myo1c1IQ. Substitution of loop 1 with that of the corresponding region from tonic smooth muscle myosin II (Myo1c1IQ-tonic) or replacement with a single glycine (Myo1c1IQ-G) accelerated the release of ADP from A.M 2?3-fold in Ca2+, whereas substitution with loop 1 from phasic muscle myosin II (Myo1c1IQ-phasic) accelerated the release of ADP 35-fold. Motility assays with chimeras containing a single ?-helix, or SAH, domain showed that Myo1cSAH-tonic translocated actin in vitro twice as fast as Myo1cSAH-WT and 3-fold faster than Myo1cSAH-G. The studies show that changes induced in Myo1c via modification of loop 1 showed no resemblance to the behavior of the loop donor myosins or to the changes previously observed with similar Myo1b chimeras
Imperfect Competition in the Labour Market
No full textIt is increasingly recognized that labour markets are pervasively imperfectly competitive, that there are rents to the employment relationship for both worker and employer. This chapter considers why it is sensible to think of labour markets as imperfectly competitive, reviews estimates on the size of rents, theories of and evidence on the distribution of rents between worker and employer, and the areas of labour economics where a perspective derived from imperfect competition makes a substantial difference to thought.Imperfect competition, labour markets, rents, search, matching, monopsony
Retinoic acid-induced growth arrest of MCF-7 cells involves the selective regulation of the IRS-1/PI 3-kinase/AKT pathway
No full textThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Oncogene. The definitive publisher-authenticated version is available online at http://www.nature.com/onc/journal/v22/n22/abs/1206485a.htm
Retinoic acid-induced growth arrest of MCF-7 cells involves the selective regulation of the IRS-1/PI 3-kinase/AKT pathway
No full textThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Oncogene. The definitive publisher-authenticated version is available online at http://www.nature.com/onc/journal/v22/n22/abs/1206485a.htm
Knowledge, attitudes, and practices of nursing professionals regarding inborn errors of metabolism in two neonatal intensive care units in Bogotá
No full textLos errores innatos del metabolismo constituyen un grupo de trastornos genéticos que afectan la capacidad del organismo para procesar nutrientes esenciales, lo que puede ocasionar la acumulación de sustancias tóxicas o la falta de compuestos necesarios para el correcto funcionamiento celular.
Esta tesina busca determinar los conocimientos, actitudes y prácticas de los profesionales de enfermería sobre los errores innatos del metabolismo en neonatos, en dos unidades de cuidado intensivo en Bogotá-Colombia, ya que el profesional de enfermería desempeña un rol esencial en la identificación temprana y la gestión adecuada de estas alteraciones, además, a través del tamizaje neonatal se busca mejorar la calidad de vida de los pacientes y reducir la mortalidad asociada a estas enfermedades. Dado que los errores innatos del metabolismo son trastornos de baja incidencia individual, pero con alta prevalencia acumulada, su manejo requiere de profesionales de enfermería con competencias actualizadas y una comprensión integral de las condiciones, lo que les permite actuar eficazmente en la detección, tratamiento y seguimiento de los casos.
La metodología empleada en esta investigación combina una revisión de literatura científica, la creación y la aplicación de una encuesta de conocimientos, actitudes y prácticas validado por expertos en el área, el cual permitirá determinar el conocimiento de los profesionales; Además, se analizarán factores que puedan influir en los conocimientos y prácticas del personal, como la experiencia en el manejo de neonatos con errores innatos del metabolismo en unidades de cuidados intensivos, o el acceso a formación continua con relación a estas alteraciones.
La investigación tiene como objetivo no solo determinar los conocimientos y prácticas de los enfermeros en relación con este tema, sino también proporcionar herramientas que favorezcan la mejora de la atención neonatal. A través de este estudio, se generarán productos diversos que permitirán difundir y aplicar los resultados obtenidos en el ámbito clínico, contribuyendo así al fortalecimiento de las estrategias de cuidado en la práctica profesional.
La formación continua es un aspecto prioritario, ya que brinda al personal de enfermería las herramientas necesarias para reconocer signos tempranos de errores innatos del metabolismo y ofrecer una atención integral que abarque tanto el bienestar del neonato como el apoyo a las familias.
Por último, la correcta implementación del tamizaje neonatal y el seguimiento de los pacientes con errores innatos del metabolismo no solo dependen de las políticas de salud, sino también del compromiso y preparación del personal de enfermería. Con base en los resultados obtenidos, se pretende ofrecer recomendaciones que impulsen el desarrollo de programas educativos y actualizaciones continuas, orientadas a garantizar un cuidado neonatal de calidad y a mejorar los resultados en esta población vulnerable.Especialista en Enfermería neonatalEspecilizaciónInborn errors of metabolism constitute a group of genetic disorders that affect the body’s ability to process essential nutrients, which can lead to the accumulation of toxic substances or a deficiency of compounds necessary for proper cellular function.
This thesis aims to determine the knowledge, attitudes, and practices of nursing professionals regarding inborn errors of metabolism in neonates, in two intensive care units in Bogotá, Colombia. The nursing professional plays a key role in the early identification and proper management of these conditions. Moreover, through neonatal screening, the goal is to improve the quality of life of patients and reduce mortality associated with these diseases. Since inborn errors of metabolism are low-incidence disorders individually, but with a high cumulative prevalence, their management requires nursing professionals with up-to-date competencies and a comprehensive understanding of these conditions, enabling them to act effectively in detection, treatment, and follow-up.
The methodology employed in this research combines a review of scientific literature, the creation and application of a knowledge, attitudes, and practices survey validated by experts in the field, which will assess the knowledge of the professionals. Additionally, factors that may influence the knowledge and practices of staff will be analyzed, such as experience in managing neonates with inborn errors of metabolism in intensive care units or access to ongoing training related to these conditions.
The goal of the research is not only to determine the knowledge and practices of nurses regarding this topic but also to provide tools that foster improvement in neonatal care. Through this study, various outcomes will be generated that will allow for the dissemination and application of the findings in the clinical setting, thus contributing to the strengthening of care strategies in professional practice.
Ongoing education is a priority, as it provides nursing staff with the necessary tools to recognize early signs of inborn errors of metabolism and deliver comprehensive care that supports both the well-being of the neonate and the families.
Finally, the proper implementation of neonatal screening and the follow-up of patients with inborn errors of metabolism depend not only on health policies but also on the commitment and preparation of nursing staff. Based on the results obtained, it is expected that recommendations will be offered to promote the development of educational programs and continuous updates, aimed at ensuring high-quality neonatal care and improving outcomes for this vulnerable population
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