1,721,033 research outputs found
Prognostic and predictive relevance of circulating tumor cells in patients with non-small-cell lung cancer
No full textReply to the Letter to the Editor by C. Nicolazzo et al.: “Circulating Cell-Free DNA and Circulating Tumor Cells as Prognostic and Predictive Biomarkers in Advanced Non-Small Cell Lung Cancer Patients Treated with First-Line Chemotherapy”
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Organometallic compounds in oncology: implications of novel organotins as antitumor agents
No full textSince the introduction of cisplatin in cancer therapy, metal complexes and organometallic compounds
have been gaining growing importance in oncology.The impressive clinical effectiveness of cisplatin is
limited by significant side effects and the emergence of drug resistance. Thus, novel classic and
unconventional PtII and PtIV complexes have been introduced in therapy or are presently in advanced
clinical trials.Moreover, innovative non-platinum metal-based antitumor agents, whose activity does
not rely on direct DNA damage and may involve proteins and enzymes, have been developed.Gold and
tin derivatives are enjoying an increasing interest and appear very promising as potential drug
candidates
Control of cyclin D1 expression by antisense oligonucleotides in three ovarian cancer cell lines.
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