103 research outputs found
Concetta Zuccarello cooking in the family kitchen on Bloomfield Avenue.
No full textConcetta Zuccarello, an immigrant from Sicily, in the familiy kitchen 218 Bloomfield Ave., Cold Water Flat. Concetta is grandmother of Josephine Zuccarello, wife of photographer. Both 1910 and 1911 listed as a date for photograph
Ipilimumab for the treatment of metastatic prostate cancer
No full textIntroduction: Immunotherapy with checkpoint inhibitors is beginning to be recognized as a valid weapon for the treatment of metastatic prostate cancer (PCa) when chemotherapy fails. Ipilimumab (ipi) is a fully humanized monoclonal antibody that blocks the activity of CTLA4. It also has a molecular weight of 148 kDa and is water-soluble at physiological pH. Ipi was first approved by the FDA for the treatment of malignant melanoma and is currently being studied in metastatic castration-resistant prostate cancer, with promising early results. Areas covered: The aim of this review is to collate the most significant preclinical and clinical studies available that look at ipi to propose new strategies for the future. Expert opinion: Additional studies are required to reduce toxicity and increase the activity of ipi in PCa. A possible strategy is to combine ipi with standard anti-cancer therapeutics such as vaccines, PDL1 inhibitors, antiandrogen drugs, and chemotherapy agents. Several initial results have suggested that combination strategies are useful to increase the activity in mCRPC, even if the toxicity of the treatment can increase. The activity of combined treatments is still not predictable, but considering the ongoing studies, we believe that they have good potential that will lead to the discovery of an optimal therapeutic strategy
The strange connection between epidermal growth factor receptor tyrosine kinase inhibitors and dapsone: from rash mitigation to the increase in anti-tumor activity
No full textThe presence of an aberrantly activated epidermal growth factor receptor (EGFR) in many epithelial tumors, due to its overexpression, activating mutations, gene amplification and/or overexpression of receptor ligands, represent the fundamental basis underlying the use of EGFR tyrosine kinase inhibitors (EGFR-TKIs). Drugs inhibiting the EGFR have different mechanisms of action; while erlotinib and gefitinib inhibit the intracellular tyrosine kinase, monoclonal antibodies like cetuximab and panitumumab bind the extracellular domain of the EGFR both activating immunomediated anti-cancer effect and inhibiting receptor function. On the other hand, interleukin-8 has tumor promoting as well as neo-angiogenesis enhancing effects and several attempts have been made to inhibit its activity. One of these is based on the use of the old sulfone antibiotic dapsone that has demonstrated several interleukin-8 system inhibiting actions. Erlotinib typically gives a rash that has recently been proven to come out via up-regulated keratinocyte interleukin-8 synthesis with histological features reminiscent of typical neutrophilic dermatoses. In this review, we report experimental evidence that shows the use of dapsone to improve quality of life in erlotinib-treated patients by ameliorating rash as well as short-circuiting a growth-enhancing aspect of erlotinib based on increased interleukin-8 secretion.The presence of an aberrantly activated epidermal growth factor receptor (EGFR) in many epithelial tumors, due to its overexpression, activating mutations, gene amplification and/or overexpression of receptor ligands, represent the fundamental basis underlying the use of EGFR tyrosine kinase inhibitors (EGFR-TKIs). Drugs inhibiting the EGFR have different mechanisms of action; while erlotinib and gefitinib inhibit the intracellular tyrosine kinase, monoclonal antibodies like cetuximab and panitumumab bind the extracellular domain of the EGFR both activating immunomediated anti-cancer effect and inhibiting receptor function. On the other hand, interleukin-8 has tumor promoting as well as neo-angiogenesis enhancing effects and several attempts have been made to inhibit its activity. One of these is based on the use of the old sulfone antibiotic dapsone that has demonstrated several interleukin-8 system inhibiting actions. Erlotinib typically gives a rash that has recently been proven to come out via up-regulated keratinocyte interleukin-8 synthesis with histological features reminiscent of typical neutrophilic dermatoses. In this review, we report experimental evidence that shows the use of dapsone to improve quality of life in erlotinib-treated patients by ameliorating rash as well as short-circuiting a growth-enhancing aspect of erlotinib based on increased interleukin-8 secretion
“L’Animo ciascuna sua passion sotto el contrario manto ricopre”. Guichardin et les passions “italiennes” dans le livre I des Essais
No full textThe article analyzes the relationship between history and the passions thorough the borrowings from the Storia d’Italia. Guicciardini by Francesco Guicciardini. Guicciardini's influence on the author of the Essais seems to extend to both the content and the form of the borrowed texts (their style, description techniques, and so on), and indeed to the treatment of the passions described. The analysis of the examples borrowed from Guicciardini in Book I fo the Essais leads to some initial conclusions ; although, there is further research yet to be done.L’étude analyse le rapport entre l’Histoire et les passions à travers les emprunts à la Storia d’Italia de Guichardin. L’influence de Guichardin sur l’auteur des Essais semble toucher tant le contenu des textes empruntés que la forme (style, modalités de la description, etc.), ainsi que le traitement des passions décrites. L’analyse des exemples empruntés à Guichardin dans le livre I des Essais permet de tirer les premières conclusions ; cependant, la recherche aurait besoin d’être poursuivie
"J'ay un dictionnaire tout à part moy": la pratique du 'dictionnaire' chez Montaigne écrivain italien
No full textThe article focuses on the writing of the italian part of Montaigne's "Journal the voyage". The author has maybe read or used grammar books, dictionaries or linguistic works to learn how to write correctly. The article gives a general overview of such linguistic production in the period of Montaigne's travel to Italy (1580-81)
La formazione filosofica di Orazio nella lettura degli esegeti antichi
No full textIn una delle Vite di Orazio riportate dai manoscritti che conservano gli scolii antichi alla sua opera si legge che il poeta, in seguito alla formazione culturale romana, si sarebbe recato ad Atene per il tradizionale ‘viaggio d’istruzione’ al fine di apprendere la filosofia; tale insegnamento sarebbe stato innanzitutto epicureo. L’elemento costituisce una novità rispetto a quanto riportato da Svetonio, con cui le vite dei manoscritti presentano in generale evidenti affinità. L’autore della Vita riferisce inoltre che Orazio avrebbe ammesso di essere epicureo 'in principio carminis' ritenendo d’altronde felice chi agisce secondo il proprio istinto, chi considera la 'voluptas' il sommo bene. Nella lettura di un commentatore tardoantico ne derivava pertanto che Orazio fosse epicureo in questa prospettiva vengono così lette le Satire e anche - ma in maniera differente, come l’analisi mette in luce - le Epistole.One of the Lives of Horace in the manuscripts preserving the ancient scholia to his work records that the poet, following the Roman cultural education, would have gone to Athens for the traditional ‘educational journey’ in order to learn philosophy; this teaching would have been mostly epicurean. This constitutes a novelty with respect to what is reported by Suetonius, with which the lives of manuscripts generally have evident affinities. The author of the Life also says that Horace would have admitted to being an epicurean in principio carminis, considering happy who acts according to his own instinct and looks at voluptas as the highest good. Thus, in the reading of the late commentator, Horace was epicurean and the Satires and also - but in a different way, as clarified in the analysis - the Epistles are evaluated in this perspective
Compliance mechanisms under selected multilateral environmental agreements, (Co-author Ulrich Beyerlin)
No full textThe Figure of the Limit: Metalepsis
No full textIn 1972, Gérard Genette introduced in narratology the figure of metalepsis, that is «any intrusion by the extradiegetic narrator or narratee into the diegetic universe (or by diegetic characters into a metadiegetic universe, etc.), or the inverse». In other words, metalepsis is a transgression of narrative levels, a perturbation of hierarchy that raises the question of the porosity of boundaries between diegetic and metadiegetic, author and reader, fact and fiction.
In my presentation, I will show how this phenomenon is ubiquitous nowadays, and how it is settled both in highbrow and lowbrow cultural representations across various media.
Furthermore, I wish I can discuss the role of metalepsis in poetics: in my opinion, it is possible to relate this device with the history of the novel. In XVIII and XIX centuries authorial narrators made extensive use of rhetoric metalepsis for humoristic purposes (such as playing with the story-time and the discourse-time) or to exhibit their authority (through the manipulation of different threads of the narration). With Naturalism and Modernism metalepsis disappeared, according to the poetic of impersonality: authors stopped being intrusive and eclipsed behind their characters. The golden era of the figure came in the temper of Postmodernism, where ontological metalepsis flourished and the public got used to author and reader literary entering the fiction or characters exiting from it and chitchatting with their creators
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