119 research outputs found
Expression of matrix metalloproteinase-2 and 9 with their inhibitors, tissue inhibitors of metalloproteinase-1 and 2 in oral lichen planus
No full textObjectives: The study aims to explore the expression of the matrix metalloproteinases (MMP-2, -9) and their inhibitors (tissue inhibitors of metalloproteinase [TIMP]-1, -2) as well as the correlation between them in the different morphological forms of oral lichen planus (OLP). Materials and Methods: 28, formalin-fixed, paraffin-embedded specimens of OLP and six specimens of squamous cell carcinoma, which served as the positive control and another six normal oral tissue specimens, which served as the negative control were used in this study. All the 40 samples were investigated immunohistochemically for the expression of MMP-2, -9 with their tissue inhibitors TIMP-1, -2. Results: The immune reactivity of MMP-2, -9, TIMP-1 and TIMP-2 were detected at significant levels within the keratinocytes and lymphocytes of the OLP cases when compared with the normal control group (P < 0.0001) while the MMP-2, -9 immune reactivity was found to be about 1/5-1/10 of that detected in the positive control group. The TIMP-1, -2 were strongly expressed in both keratinocytes and lesional lymphocytes. However, no significant relationship was discovered between the expressions of MMP-2, MMP-9, TIMP-1 and TIMP-2 and the morphological types of OLP. Conclusion: A distinct imbalance is observed between the MMP and TIMP activities when the normal mucosa and OLP sample are compared. The TIMP intensities, on the other hand, were found to be very high, suggesting an endogenous protection of the basement membrane against the degrading effect of the MMP enzymes
PIK3CB and K-ras in oral squamous Cell carcinoma. A possible cross-talk!
No full textBackground: PIK3 and K-ras are signal transducing proteins involved and mediating many responses related to cell cycle growth regulation. Until date, there has been only limited evidence about the expression of K-ras and PKI3CB in oral squamous cell carcinoma (OSCC). AIMS : This study aimed to examine both proteins in OSCC and their relation to clinic- pathological findings. Setting and Design: A total of 31 formalin-fixed paraffin-embedded specimens of OSCC were selected in this study. PIK3CB and K-ras expressions were detected using standard immunohistochemical techniques. Materials and Methods: PIK3CB and k-ras immune reactivity was semi-quantitatively evaluated in at least five representative fields at 400X magnification and recorded as percentage of PIK3CB and k-ras positive tumor cells over the total number of cells examined in the same area. Results and Conclusion: All examined specimens of OSCC were positive for monoclonal antibodies directed against PIK3CB and K-ras proteins especially at advanced stage of the disease. No significant relation was observed between the tested proteins and the clinic-pathological findings of OSCC; however a highly significant direct relationship was observed between K-ras and PIK3CB. This lead to conclusion that both K-ras and PIK3CB signaling pathway were activated in the advanced stage of OSCC, and possibly a cross-talk between them. This could make these mutant proteins a potential target for an effective molecular therapy
Prevalence of odontogenic cysts and tumors among UAE population
No full textBackground: Odontogenic cysts and tumors are lesions that tend to arise from the tooth apparatus or its remnants. Odontogenic cysts and tumors constitute an important aspect of oral maxillofacial pathology as they can be diagnosed in general dental practice. Aim: The purpose of this study was to evaluate the prevalence of odontogenic cysts and tumors diagnosed in the UAE and to compare the results with findings in the literature. Materials and Methods: Data of odontogenic cysts diagnosed between 1990 and 2010 were collected from the files of the Oral Pathology Laboratory and Oral Surgery Department of Tawam Hospital, UAE. Results: Most of the prevalent odontogenic cysts are radicular cysts (69.1%) - followed by dentigerous cysts (7.9%). Among the odontogenic tumors, the most prevalent is odontoma (12.2%) followed by ameloblastoma (2.9%). The middle and posterior mandible was the most common anatomic site for the formation of cysts and tumors. In fact, 93.4% of patients over 40 years presented with odontogenic cysts, whereas 6.3% presented with odontogenic tumor. Odontoma as odontogenic tumor was seen mostly in the first and second decades of life. Conclusion: The prevalence of odontogenic cysts was similar to that reported in the literature, with inflammatory cysts occurring most frequently
Oxidative stress, antioxidant status and lipid profile in the saliva of type 2 diabetics
No full textBackground: The aim of this study was to assess the salivary content of lipid peroxidation and antioxidants in patients with type 2 diabetes.Method: We studied 25 patients with type 2 diabetes and other 25 age- and sex-matched health control. To evaluate the oxidative status we measured the levels of malondialdehyde (MDA) in the saliva and serum of all participants. Lipid profile was also estimated through measuring total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and very low-density lipoprotein cholesterol (VLDL-C) levels. Antioxidant levels were also assessed through measuring the salivary and serum concentration of uric acid, superoxide dismutase and reduced glutathione (GSH).Results: The high concentration of lipid fractions in saliva usually follows that recorded in serum. Salivary MDA levels, a product of lipid peroxidation, were significantly increased among diabetics together with uric acid. However, GSH levels were similar to those of the control group.Conclusion: Lipid peroxidation and antioxidant parameters assessed in saliva of diabetic patients may be of great importance in evaluating the disease activity and severity. The increase in lipid peroxidation and the tendency of antioxidants to rise in diabetes is probably due to an adaptive response to the pro-oxidant status of diabetes.</jats:p
Use of Address Terms by Jordanian Students: A Sociolinguistic Perspective
No full textThis study investigated the usage of terms of address by Jordanian students from a sociolinguistic view. To identify the appropriateness of using these terms, the researchers rely on a politeness theory to analyze the data. Thus, this study adopted Brown and Levenson’s politeness theory (1987) to identify the exact meaning of politeness. To achieve the aim of this study, the researchers used a quantitative method of role-play. This study revealed that using the terms of address is desired by Jordanian students. They are keen to use them in order to soften their speech with others. Moreover, they considered that using them saved the face want of the hearers. This study recommends future researchers to conduct comparative research with other cultures to find the similarities and differences in using address terms
The Relation between Periodontopathogenic Bacterial Levels and Resistin in the Saliva of Obese Type 2 Diabetic Patients
Get PDFThis study aims to investigate the relation between resistin and periodontopathogenic bacterial levels in the saliva of obese adults compared to healthy control and to examine whether salivary resistin can serve as a biomarker of type 2 diabetes in obese patients. A total of 78 saliva samples were collected from patients attending to the University Dental Hospital, Sharjah, UAE. The patients were divided into three equal groups: obese diabetics, obese nondiabetics, and nonobese nondiabetic control. Salivary resistin was measured using ELISA. The levels of bacterial species associated with periodontitis (Treponema denticola, Porphyromonas gingivalis, Tannerella forsythia, and Actinobacillus actinomycetemcomitans) and gingivitis (Fusobacterium spp.) were measured using real-time PCR. Both salivary resistin and periodontopathogenic bacteria including Fusobacterium spp., P. gingivalis, and T. forsythia were detected in significantly higher quantities in the obese patients (diabetics and nondiabetics) than nonobese nondiabetic control. Resistin concentrations were significantly correlated with BMI; however, its level was not correlated with the blood glucose. In this study, high salivary resistin was associated with obesity, which is a major predisposing factor for type 2 diabetes and also a risk factor for oral diseases. The high levels of salivary periodontopathogenic bacteria could upregulate the local release of salivary resistin in obese people
Unpacking Cultural and Linguistic Refusal Strategies in Jordanian EFL Discourse: A Conceptual Paper
No full textRefusal strategies are ubiquitous linguistic tools employed in everyday communication. Understanding the application of these strategies is crucial for interpreting the reactions of those receiving the refusals. This study investigates the diverse refusal strategies Jordanian students utilize to explore the cultural and linguistic factors influencing their choices. Data will be collected through interviews and observations and analyzed using Beebe et al.’s (1990) framework. The anticipated results include the identification of the significant influence of linguistic and cultural factors on the forms of refusal strategies employed by the students. The study also expects to identify direct and indirect refusal strategies. Ultimately, this research will provide a foundation for future investigations into the syntactic and morphological processes underlying Jordanian students\u27 construction of refusal strategies in their interactions. A deeper understanding of these processes will contribute to a more nuanced comprehension of pragmatic communication within this cultural context
Beyond Linguistic Gaps: Types of Code-Switching Among Jordanian Bilingual speakers
No full textThis study investigates the motivations and types of code-switching among bilingual Jordanian speakers of Arabic and English. It explores the reasons why these speakers switch between their first language (L1), Arabic, and their second language (L2), English, during interactions. Data are collected through observation and detailed note-taking. A theoretical model is employed to analyze the data and provide an in-depth understanding of this phenomenon. The findings reveal two key aspects of code-switching among the participants. First, code-switching serves distinct motivational purposes, notably expressing identity and self-confidence through the simultaneous use of both languages. Additionally, it compensates for lexical gaps when expressing reactions to others\u27 speech or actions. Second, the study identifies three distinct types of code-switching employed: inter-sentential switching, tag-switching, and intra-sentential switching. Intra-sentential switching is the most frequent (43 instances), followed by inter-sentential switching (29 instances) and tag-switching (21 instances). This research contributes valuable insights into the dynamics of code-switching in a specific bilingual community and recommends future research on the sociolinguistic functions of code-switching in diverse contexts, such as multilingual classrooms, kings and presidents in different settings or media
The Predisposing Factors of Periodontal Disease in the Development and Chronification of Migraines: Systematic Review
No full textMigraine is a neurological disorder that causes severe throbbing pain on one side of the head, and approximately more than one billion people all over the world suffer from it. Recent studies have shown that periodontitis is linked to chronic migraine. Therefore, this study aims to verify the link between chronic migraine and periodontitis by conducting a systematic review
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