7,266,056 research outputs found
Extracorporeal life support and systemic inflammation
No full textAbstract
Extracorporeal life support (ECLS) encompasses a wide range of extracorporeal modalities that offer short- and intermediate-term mechanical support to the failing heart or lung. Apart from the daily use of cardiopulmonary bypass (CPB) in the operating room, there has been a resurgence of interest and utilization of veno-arterial and veno-venous extracorporeal membrane oxygenation (VA- and VV-ECMO, respectively) and extracorporeal carbon dioxide removal (ECCO2R) in recent years. This might be attributed to the advancement in technology, nonetheless the morbidity and mortality associated with the clinical application of this technology is still significant. The initiation of ECLS triggers a systemic inflammatory response, which involves the activation of the coagulation cascade, complement systems, endothelial cells, leukocytes, and platelets, thus potentially contributing to morbidity and mortality. This is due to the release of cytokines and other biomarkers of inflammation, which have been associated with multiorgan dysfunction. On the other hand, ECLS can be utilized as a therapy to halt the inflammatory response associated with critical illness and ICU therapeutic intervention, such as facilitating ultra-protective mechanical ventilation. In addition to addressing the impact on outcome of the relationship between inflammation and ECLS, two different but complementary pathophysiological perspectives will be developed in this review: ECLS as the cause of inflammation and ECLS as the treatment of inflammation. This framework may be useful in guiding the development of novel therapeutic strategies to improve the outcome of critical illness
A Novel Enhancement Approach Following MVMD and NMF Separation of Complex Snoring Signals
No full textSnoring is a prominent characteristic of sleep-disordered breathing, and its detection is critical for determining the severity of the upper airway obstruction and improving daily quality of life. Home snoring analysis is a highly invasive method, but it becomes challenging when a sleeping partner also snores, leading to distorted evaluations in such environments. In this article, we tackle the problem of complex snore signal separation of multiple snorers. This article introduces two audio-based methods that efficiently extract an individual's snoring signal, allowing for the analysis of sleep-breathing disorders in a normal sleeping environment without isolating individuals. In the first method, Principal Component Analysis (PCA) identifies the source components from the finite number of modes generated by the decomposition of the snoring mixture using Multivariate Variational Mode Decomposition (MVMD). The second method applies Blind Source Separation (BSS) based on Non-Negative Matrix Factorization (NMF) to separate the single-channel snoring mixture. Furthermore, the decomposed signals are tuned using the iterative enhancement algorithm to adequately match the source snoring signals. These methods were evaluated by simulating various real-time snoring recordings of 7 subjects (2 men, 2 women, and 3 children). The correlation coefficient between the source and its separated signal was computed to assess the separation results, exhibiting good performance of the methods used. The enhancement approach also demonstrated its efficiency by increasing the correlation over to 80% in both methods. The experimental results show that the proposed algorithms are effective and practical for separating mixed snoring signals
Hedonic pricing models for metropolitan bus services
No full textConventional studies on the pricing of bus services use the cost structure to explain bus fares. In this paper, a hedonic pricing model for bus services in Hong Kong is estimated. The contributions of cost and market factors are uncovered. It is found that the cost factors dominate the determination of bus fares. In contrast to our expectation, bus fares do not react to competition faced by bus companies. Moreover, except the three cross-harbour tunnels, the bus fare has no direct relationship with the tolls of other tunnels. Our model serves well as a reference tool for bus companies to set market-acceptable bus fares.Hedonic Pricing Model, Bus Fares, Kowloon Motor Bus.
Maktabat Al Muthanna Baghdad Feb-May 1962
No full textOn the same date, Ali Al-Mansouri issued an official financial statement confirming that the Al-Khanji Foundation owed a total of 11.375.أصدر علي المنصوري بيانًا ماليًا رسميًا بتاريخ 25 نيسان 1962 يُفيد بأن مؤسسة الخانجي مدينة بمبلغ إجمالي قدره 11,375
Deregulation of Domestic Aviation - the First Year
No full textThe Commonwealth's regulation of interstate aviation, in place for over thirty years, came to an end at midnight on 30 October 1990. This study reviews the developments in the last few months of regulation and in the first year of deregulation. Based on the first year's evidence, deregulation of domestic aviation in Australia has, from the consumer's perspective, been very successful. Reliance on market forces and competition, as opposed to regulation, has so far provided clear benefits to consumers in terms of lower fares and improved servcie quality. In particular, discount air fares have been much deeper and more readily available under deregulation. Between September 1990 and June 1991quarters, real average fares of a large sample of the top 20 routes fell by 12 per cent. Service quality on a number of dimensions has also improved with deregulation. Most notably, an analysis of the services provided by domestic and commuter operators on the top 40 routes indicated that there was a 21 per cent increase in the number of flights between the June quarters of 1990 and 1991. The airlines have been able to reduce costs, but their financial performance has been adversely affected by the recession and the increased level of competition in the industry. the analysis suggests that the expected outcomes from deregulation are being realised so far.airlines; deregulation; microeconomic reform; Australia
Head and facial injuries due to cluster munitions
No full textCluster munitions are weapons that scatter smaller sub-munitions intended to kill or mutilate on impact. They have been used by the Israeli army in the south of Lebanon and are now scattered over wide rural areas affecting its inhabitants. Because of their easily pickable nature, sub-munitions can inflict injuries to the head and face regions. In this study, we aimed to explore the head and face injuries along with their clinical features in a group of Lebanese patients who suffered from such injuries due to a sub-munition's detonation. The study included all the cases reported between 14 August 2006 and 15 February 2013, with head and face injuries related to cluster bombs. Injuries were classified into brain, eye, otologic and auditory impairments, oral and maxillofacial, and skin and soft-tissue injuries. Psychological effects of these patients were also examined as for post-traumatic stress disorder, major depressive disorder, generalized anxiety disorder and acute stress syndrome. During the study period, there were 417 casualties as a result of cluster munitions' blasts. Out of the total number of victims, 29 (7 percent) were injured in the head and the face region. The convention on cluster munitions of 2008 should be adhered to, as these inhumane weapons indiscriminately and disproportionately harm innocent civilians, thereby violating the well-established international principles governing conflict and war today. © 2014 Springer-Verlag.American Psychiatric Association, 2013, DIAGN STAT MAN MENT, P271; Bandak FA, 1996, TRAUMATIC BRAIN INJU, P167; Beehner L, 2006, BACKGROUNDER; BRANDVOLD B, 1990, J NEUROSURG, V72, P15, DOI 10.3171-jns.1990.72.1.0015; Bryant K, 2009, B WORLD HEALTH ORGAN, V87, P8; Campbell DG, 2007, J GEN INTERN MED, V22, P711, DOI 10.1007-s11606-006-0101-4; COOPER PR, 1979, NEUROSURGERY, V4, P373; Corbman GR, 1997, ANXIETY DISORDERS CU; Fares Youssef, 2013, J Infect Public Health, V6, P482, DOI 10.1016-j.jiph.2013.05.006; Fares Y, 2013, NEUROL SCI, V34, P2095, DOI 10.1007-s10072-013-1343-7; Fares Y, 2013, NEUROL SCI, V34, P1971, DOI 10.1007-s10072-013-1427-4; Torpy Janet M, 2011, JAMA, V305, P522, DOI 10.1001-jama.305.5.522; GUALTIERI T, 1991, Brain Injury, V5, P219, DOI 10.3109-02699059109008093; Hurley RA, 2004, J NEUROPSYCH CLIN N, V16, P1, DOI 10.1176-appi.neuropsych.16.1.1; KAUFMAN HH, 1986, NEUROSURGERY, V18, P689; Mendez CV, 2005, J NEUROPSYCH CLIN N, V17, P297, DOI 10.1176-appi.neuropsych.17.3.297; Muzaffar W, 2000, BRIT J OPHTHALMOL, V84, P626, DOI 10.1136-bjo.84.6.626; RISH BL, 1983, J NEUROSURG, V59, P775, DOI 10.3171-jns.1983.59.5.0775; Sayer NA, 2008, ARCH PHYS MED REHAB, V89, P163, DOI 10.1016-j.apmr.2007.05.0250
Homenaje a Michael Fares
No full textEntrevista al musico holandés Michael Fares sobre algunas de sus experiencias artísticas.#EmisoraHJUT#Utade
Principi erogativi ed elementi organizzativi del Servizio sanitario italiano. La prospettiva del giurista
No full textLa garanzia di effettività attraverso l'accesso ai farmaci innovativi. La prospettiva del giurista
No full text3 STEM Projects by Fares Soliman
No full textMy name is Fares Soliman. I am a fourth grade student from John Hill School Boonton NJ. I created a 3 STEM project. The first project that I made was a doll. I used pink yarn for the dress and brown yarn for the hair. I also used a round wooden ball for the face. The second project that I created was a diorama of a farm. I put some grass, trees, a barn, hay sticks, some animals, a bridge, a fence, some plastic food and corn for the crop. My third project was a diorama of a park. It has some grass area, a swing and a slide made of cardboard and aluminum foil. I also used some turf or the road and added a little pond. I enjoy creating dioramas and building things from scratch. I also love drawing many things. I learn a lot from STEM projects and enjoy them very much
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