2,187 research outputs found
Seminal contributions of Timothy J. Crow
No full text© The Author(s), 2025. Published by Cambridge
University Press. This is an Open Access article,
distributed under the terms of the Creative
Commons Attribution licence (http://
creativecommons.org/licenses/by/4.0), which
permits unrestricted re-use, distribution and
reproduction, provided the original article is
properly cited.We recall the life and work of Timothy J. Crow, whose contributions provided great insights into the pathophysiology of schizophrenia and continue to shape many questions in the field. We compile his key works relating to psychotic disorders, focusing on the trajectory of his theoretical stance. Our account is interlaced with our own interpretation of the evidence that influenced Crow's arguments over the years as well as his scientific method. Crow has had a significant impact on the neuroscience of schizophrenia. Many of his observations are still valid and several questions he raised remain unanswered to date.https://www.cambridge.org/core/journals/psychological-medicine/article/seminal-contributions-of-timothy-j-crow/25B0EA70F496D0D3351937E44ADDD45
Tools for evolutionary acquisition : a study of Multi-Attribute Tradespace Exploration (MATE) applied to the Space Based Radar (SBR)
No full textThesis (S.M.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 2003.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Statement of responsibility on t.p. reads: 2nd Lieutenant Timothy J. Spaulding, USAF.Includes bibliographical references (p. 139-142).by Timothy J. Spaulding.S.M
Corrigendum to “High-pressure adsorptive storage of hydrogen in MIL-101 (Cr) and AX-21 for mobile applications: Cryocharging and cryokinetics” [Mater & Des 89 (2016) 1086–1094]
No full textRefers To Nuno Bimbo, Wesley Xu, Jessica E. Sharpe, Valeska P. Ting, Timothy J. Mays High-pressure adsorptive storage of hydrogen in MIL-101 (Cr) and AX-21 for mobile applications: Cryocharging and cryokinetics Materials & Design, Volume 89, 5 January 2016, Pages 1086-1094 The authors regret to inform that….. The Supplementary Information should have been included in the original paper and is now provided with this corrigendum. All the data and figures, contained in the manuscript and supporting information, are available and can be accessed free of charge at http://dx.doi.org/10.15125/BATH-00099. Any questions related to the data should be addressed to the corresponding author. Authors would like to apologize for the inconvenience caused
A simulation-based concurrent engineering approach for assembly system design
No full textThesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering; in conjunction with the Leaders for Manufacturing Program at MIT, 2002.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Includes bibliographical references (p. 81-82).by Timothy J. Sweitzer.S.M.M.B.A
Exploiting Domain Knowledge in Making Delegation Decisions
No full text@inproceedings{conf/admi/EmeleNSP11, added-at = {2011-12-19T00:00:00.000+0100}, author = {Emele, Chukwuemeka David and Norman, Timothy J. and Sensoy, Murat and Parsons, Simon}, biburl = {http://www.bibsonomy.org/bibtex/20a08b683088443f1fd36d6ef28bf6615/dblp}, booktitle = {ADMI}, crossref = {conf/admi/2011}, editor = {Cao, Longbing and Bazzan, Ana L. C. and Symeonidis, Andreas L. and Gorodetsky, Vladimir and Weiss, Gerhard and Yu, Philip S.}, ee = {http://dx.doi.org/10.1007/978-3-642-27609-5_9}, interhash = {1d7e7f8554e8bdb3d43c32e02aeabcec}, intrahash = {0a08b683088443f1fd36d6ef28bf6615}, isbn = {978-3-642-27608-8}, keywords = {dblp}, pages = {117-131}, publisher = {Springer}, series = {Lecture Notes in Computer Science}, timestamp = {2011-12-19T00:00:00.000+0100}, title = {Exploiting Domain Knowledge in Making Delegation Decisions.}, url = {http://dblp.uni-trier.de/db/conf/admi/admi2011.html#EmeleNSP11}, volume = 7103, year = 2011
PhosphoregDB: The tissue and sub-cellular distribution of mammalian protein kinases and phosphatases
No full textBackground: Protein kinases and protein phosphatases are the fundamental components of phosphorylation dependent protein regulatory systems. We have created a database for the protein kinase-like and phosphatase-like loci of mouse http://phosphoreg.imb.uq.edu.au that integrates protein sequence, interaction, classification and pathway information with the results of a systematic screen of their sub-cellular localization and tissue specific expression data mined from the GNF tissue atlas of mouse
Targeted genetic testing for familial hypercholesterolaemia using next generation sequencing:a population-based study
No full textBACKGROUND: Familial hypercholesterolaemia (FH) is a common Mendelian condition which, untreated, results in premature coronary heart disease. An estimated 88% of FH cases are undiagnosed in the UK. We previously validated a method for FH mutation detection in a lipid clinic population using next generation sequencing (NGS), but this did not address the challenge of identifying index cases in primary care where most undiagnosed patients receive healthcare. Here, we evaluate the targeted use of NGS as a potential route to diagnosis of FH in a primary care population subset selected for hypercholesterolaemia.METHODS: We used microfluidics-based PCR amplification coupled with NGS and multiplex ligation-dependent probe amplification (MLPA) to detect mutations in LDLR, APOB and PCSK9 in three phenotypic groups within the Generation Scotland: Scottish Family Health Study including 193 individuals with high total cholesterol, 232 with moderately high total cholesterol despite cholesterol-lowering therapy, and 192 normocholesterolaemic controls.RESULTS: Pathogenic mutations were found in 2.1% of hypercholesterolaemic individuals, in 2.2% of subjects on cholesterol-lowering therapy and in 42% of their available first-degree relatives. In addition, variants of uncertain clinical significance (VUCS) were detected in 1.4% of the hypercholesterolaemic and cholesterol-lowering therapy groups. No pathogenic variants or VUCS were detected in controls.CONCLUSIONS: We demonstrated that population-based genetic testing using these protocols is able to deliver definitive molecular diagnoses of FH in individuals with high cholesterol or on cholesterol-lowering therapy. The lower cost and labour associated with NGS-based testing may increase the attractiveness of a population-based approach to FH detection compared to genetic testing with conventional sequencing. This could provide one route to increasing the present low percentage of FH cases with a genetic diagnosis.</p
A Holmes and Doyle Bibliography, Volume 1: Monographs and Serials by Main Entry
No full textThis bibliography is a work in progress. It attempts to update and compliment Ronald B. De Waal’s comprehensive bibliography, The Universal Sherlock Holmes, but does not claim to be exhaustive in content. New works are continually discovered and added to this bibliography. Readers and researchers are invited to suggest additional content. This first volume focuses on monographic and serial titles, arranged alphabetically by author or main entry.Johnson, Timothy J. (2018). A Holmes and Doyle Bibliography, Volume 1: Monographs and Serials by Main Entry. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/200078
At Brief History of the Sherlock Holmes Collections at the University of Minnesota
No full textProvides a brief history on the origins of the Sherlock Holmes Collections, a unit within the Department of Archives and Special Collections for the University of Minnesota Libraries. The article traces the history of the Collections from the initial purchase in 1974 of the James Iraldi collection--the beginning of the Collections--through the 1990s. The acquisition of additional collections over those three decades resulted in the world's largest gathering of material related to Mr. Sherlock Holmes and his author, Sir Arthur Conan Doyle.Johnson, Timothy J. (2025). At Brief History of the Sherlock Holmes Collections at the University of Minnesota. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/276483
Friends of the Sherlock Holmes Collections Newsletter, 2015, Vol 19, No. 2
No full textQuarterly newsletter of the Friends of the Sherlock Holmes Collections. This issue features stories on the Japan Sherlock Holmes Club, author Carolyn Wells, Great Detective Stories About Doctors, a visit to southeast Minnesota, a KFAI radio report on the Collections, and an April Fool's prank.Higorashi, Masamichi; McKuras, Julie; Sveum, Richard J; Johnson, Timothy J; Thaden, Gary. (2015). Friends of the Sherlock Holmes Collections Newsletter, 2015, Vol 19, No. 2. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/200041
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