119 research outputs found
Zinc deficiency in neuronal biology
No full textAdverse nutritional and environmental conditions during early development can irreversibly affect the nervous system. Zinc (Zn) deficiency associated with inadequate Zn intake and undernutrition is frequent throughout the world. Increasing evidence indicates that developmental Zn deficiency can lead to alterations in neonate and infant behavior, cognitive and motor performance that persist into adulthood. This review will address current knowledge on the events that are triggered in neuronal cells when Zn availability decreases and discuss their consequences on neuronal function and development. In neuronal cells, Zn deficiency induces oxidative stress, alters the normal structure and dynamics of the cytoskeleton, affects the modulation of transcription factors AP-1, NF-betaB and NFAT and induces a decreased cell proliferation and increased apoptotic death. Thus, these closely associated events can affect neuronal function and critical developmental events (neuronal proliferation, differentiation, plasticity and survival) when Zn availability decreasesFil: Mackenzie, Gerardo G.. University of California at Davis; Estados UnidosFil: Zago, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Aimo, Lucila. University of California at Davis; Estados UnidosFil: Oteiza, Patricia Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. University of California at Davis; Estados Unido
Reseña del libro "Trabajo y negociación colectiva. Los trabajadores en la industria argentina de los noventa a la posconvertibilidad" de Clara Marticorena
No full textRevista con referatoFil: D'Urso, Lucila Florencia. Universidad Nacional de General Sarmiento. Instituto del Conurbano; Argentina.Fil: D'Urso, Lucila Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: D'Urso, Lucila Florencia. Universidad Metropolitana para la Educación y el Trabajo. Centro de Innovación de los Trabajadores; Argentina.El presente texto analiza el libro "Trabajo y negociación colectiva. Los trabajadores en la industria argentina, de los noventa a la posconvertibilidad (Imago Mundi, 2014) de Clara Marticorena. La reseña focaliza en los argumentos a través de los cuales la autora del libro tensiona un discurso fuertemente instalado en los estudios recientes acerca de la emergencia de un nuevo régimen laboral a partir del año 2003.This article analyzes the book "Work and Collective Bargaining. Workers in Argentine Industry, from the 1990s to the Post-Convertibility Period" (Imago Mundi, 2014) by Clara Marticorena. The review focuses on the arguments through which the author of the book challenges a discourse strongly established in recent studies about the emergence of a new labor regime since 2003.Este artigo analisa o livro "Trabalho e Negociação Coletiva. Trabalhadores na Indústria Argentina, da década de 1990 ao Período Pós-Convertibilidade" (Imago Mundi, 2014), de Clara Marticorena. A resenha se concentra nos argumentos por meio dos quais a autora do livro questiona um discurso fortemente consolidado em estudos recentes sobre a emergência de um novo regime trabalhista desde 2003
Diverse and Active Roles for Adipocytes During Mammary Gland Growth and Function
No full textThe mammary gland is unique in its requirement to develop in close association with a depot of adipose tissue that is commonly referred to as the mammary fat pad. As discussed throughout this issue, the mammary fat pad represents a complex stromal microenvironment that includes a variety of cell types. In this article we focus on adipocytes as local regulators of epithelial cell growth and their function during lactation. Several important considerations arise from such a discussion. There is a clear and close interrelationship between different stromal tissue types within the mammary fat pad and its adipocytes. Furthermore, these relationships are both stage- and species-dependent, although many questions remain unanswered regarding their roles in these different states. Several lines of evidence also suggest that adipocytes within the mammary fat pad may function differently from those in other fat depots. Finally, past and future technologies present a variety of opportunities to model these complexities in order to more precisely delineate the many potential functions of adipocytes within the mammary glands. A thorough understanding of the role for this cell type in the mammary glands could present numerous opportunities to modify both breast cancer risk and lactation performance
α-Lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-κB and AP-1 transcription factors in human neuroblastoma IMR-32 cells
No full textThis work investigated the capacity of α-lipoic acid (LA) and N-acetyl-l-cysteine (NAC) to reduce zinc deficiency-induced oxidative stress, and prevent the activation of nuclear factor-κB (NF-κB) and activator protein-1 (AP-1), and the cross-talk between both activated cascades through β-Transducin Repeat-containing Protein (β-TrCP). IMR-32 cells were incubated in control media or media containing variable concentrations of zinc, without or with 0.5 mM LA or 1 mM NAC. Relative to control and zinc supplemented (15 μM Zn) groups, Hydrogen peroxide (H2O2) and total oxidant cell concentrations were higher, and total glutathione concentrations were lower in the zinc deficient groups (1.5 and 5 μM Zn). Both, LA and NAC, markedly reduced the increase in cell oxidants and the reduction in glutathione concentrations in the zinc deficient cells. Consistent with this, LA and NAC prevented zinc deficiency-induced activation of the early steps of NF- κB (IκBα phosphorylation) and AP-1 [c-Jun-N-terminal kinase (JNK) and p38 phophorylation] cascades, and the high NF-κB- and AP-1-DNA binding activities in total cell extracts. Thus, LA and NAC can reduce the oxidative stress associated with zinc deficiency and the subsequent triggering of NF-κB- and AP-1-activation in neuronal cells.Fil: Mackenzie, Gerardo G.. Universidad de Buenos Aires; Argentina. University of California at Davis; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Zago, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Erlejman, Alejandra Giselle. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Aimo, Lucila. University of California at Davis; Estados UnidosFil: Keen, Carl L.. University of California at Davis; Estados UnidosFil: Oteiza, Patricia Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. University of California at Davis; Estados Unido
Digressions on the Concept of History in Hannah Arendt
No full textEn el futuro artículo ofreceremos algunas reflexiones sobre la historia en la obra de Hannah Arendt, partiendo de la premisa de que esta se asienta en su concepto de acción. Con tal fin, recurriremos a distintos textos en los que la autora alemana discutió nociones cruciales para su definición de la condición humana, a saber, las tres actividades bajo las cuales se le dio vida al hombre en la tierra y la separación entre lo público y lo privado. Nuestro vínculo con el pasado y su relación tanto con el presente como con el futuro estarán también en el centro del recorrido que aquí proponemos.In the following article we will offer some reflections on history in Hannah Arendt’s work, starting from the premise that it is based on her concept of action. To this end, we will turn to different texts in which the German author discussed crucial notions for her definition of the human condition, namely, the three activities under which man was given life on Earth –labor, work and action– and the separation between the public and the private. Our link with the past and its relation to both the present and the future will also be at the center of the journey we will propose here.Fil: Svampa, María Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Instituto de Investigaciones "Gino Germani"; Argentina. Consejo Interuniversitario Nacional. - Ministerio de Educacion, Cultura, Ciencia y Tecnologia. Consejo Interuniversitario Nacional.; Argentina. Humboldt-Universität zu Berlin; Alemani
The Role of Zinc in the Modulation of Neuronal Proliferation and Apoptosis
No full textAlthough a requirement of zinc (Zn) for normal brain development is well documented, the extent to which Zn can modulate neuronal proliferation and apoptosis is not clear. Thus, we investigated the role of Zn in the regulation of these two critical events. A low Zn availability leads to decreased cell viability in human neuroblastoma IMR-32 cells and primary cultures of rat cortical neurons. This occurs in part as a consequence of decreased cell proliferation and increased apoptotic cell death. In IMR-32 cells, Zn deficiency led to the inhibition of cell proliferation through the arrest of the cell cycle at the G0/G1 phase. Zn deficiency induced apoptosis in both proliferating and quiescent neuronal cells via the intrinsic apoptotic pathway. Reductions in cellular Zn triggered a translocation of the pro-apoptotic protein Bad to the mitochondria, cytochrome c release, and caspase-3 activation. Apoptosis is the resultant of the inhibition of the prosurvival extracellular-signal-regulated kinase, the inhibition of nuclear factor-kappa B, and associated decreased expression of antiapoptotic proteins, and to a direct activation of caspase-3. A deficit of Zn during critical developmental periods can have persistent effects on brain function secondary to a deregulation of neuronal proliferation and apoptosis.Fil: Adamo, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Zago, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Mackenzie, Gerardo G.. University of California at Davis; Estados UnidosFil: Aimo, Lucila. University of California at Davis; Estados UnidosFil: Keen, Carl L.. University of California at Davis; Estados UnidosFil: Keenan, Alison. University of California at Davis; Estados UnidosFil: Oteiza, Patricia Isabel. University of California at Davis; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Ciencia y tecnología. Los múltiples senderos de la intolerancia
No full textEn este artículo se trazan los senderos de intolerancia que se abren a partir de los nuevos descubrimientos en ciencia y tecnología. La globalización está alterando las identidades tradicionales, aquellas creadas por el Estado-nación. Se presentan las nuevas ramas del conocimiento para abrir una discusión sobre nuevas identidades y sus consecuencias. Se pone el énfasis en un grupo planetario que navega por las autopistas de Internet, los extropianos o "transhumanos", quienes culturalmente están ligados con la ciencia y la tecnología de punta. Se describen sus puntos de vista sobre el presente y el futuro de la humanidad, sobre lo que rechazan y por qué, y la necesidad de discutir los alcances de la tolerancia.Tliis article traces the paths of intolerance as a result of the new discoveries in Science and technology. Globalization is a process which is breaking traditional identities created by tlie modem State. The author presents the new scientific branches to open a discussion on its consequences and also to introduce the link of this research with a new identity, a planetary group called "extropians" or "transhumanists" who are using multimedia to spread tlieir believes. Next, tliere is description of their points of view on the present and future of humanity, what tliey reject and why, and tlie need to discuss tlie scope of tolerance
Low extracellular zinc increases neuronal oxidant production through nadph oxidase and nitric oxide synthase activation
No full textDel caballero épico al caballero novelesco: acercamiento a la evolución del personaje
No full textThe goal of this paper is to review the medieval literary knight's transformations upon its rising in the chansons de geste through its entrenchment as the protagonist character into the most representatives medieval romances of chivalry. The author analyzes the added features from the design of the Romanic epic hero, passing through the classic romances and the Chrétien de Troyes' creations, until the works in prose of the XIIIth Century. Features that include the love and the religion, items so important for the knight design as we known
The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases
No full textThe SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to turn the exponentially growing amount of data into knowledge. Here, we provide an overview of SIB's resources and competence areas, with a strong focus on curated databases and SIB's most popular and widely used resources. In particular, SIB's Bioinformatics resource portal ExPASy features over 150 resources, including UniProtKB/Swiss-Prot, ENZYME, PROSITE, neXtProt, STRING, UniCarbKB, SugarBindDB, SwissRegulon, EPD, arrayMap, Bgee, SWISS-MODEL Repository, OMA, OrthoDB and other databases, which are briefly described in this article
- …
