1,720,967 research outputs found
Smart Electronic Pen for Continuous Monitoring of Anaesthetics
Full text linkL'abstract è presente nell'allegato / the abstract is in the attachmen
Optimized Sampling Rate for Voltammetry-Based Electrochemical Sensing in Wearable and IoT Applications
Full text linkThe recent advancements in electrochemical measurements are guiding the development of new platforms for in-situ point-of-care monitoring of human-metabolite, markers and drugs. Despite this, the application of Voltammetry-Based Sensing (VBS) techniques is still limited in wearable, portable, or IoT systems. In order to use VBS approaches to measure analytes in small and low-power electronic platforms for diagnostics, several improvements are required. For example, the definition of a method to achieve the right trade-off between sample rate and sensing performance is still missing. To develop a method to define the best sampling rate, we present here an extensive analysis of experimental data to prove that is feasible to detect drugs such as paracetamol by Staircase Cyclic Voltammetry (SCV) or Differential Pulse Voltammetry (DVP) direct detection methods, with low sampling frequency. Our results prove that the proposed method helps the development of systems capable of discriminating the minimum pharmacology concentration of the metabolite under analysis with a massive reduction of the sampling frequency
Supplementary Material for Optimized Sampling Rate for Voltammetry-Based Electrochemical Sensing in Wearable and IoT Applications
No full textThe Voltammetry-Based Sensing (VBS) methods are extremely interesting due to high specificity in several biochemical applications. Several considerations can be applied to use this method to measure different analytes, and implement efficient and optimized electronic measurement platform for point-of-care diagnostic, in wearable, portable, or IoT systems. The dataset contains the data presented in [1], which proves on real experimental data a method to define the optimized setup to develop efficient and electronic bio-sensing platforms. Namely, the dataset contains Scan Cyclic Voltammetry (SCV) and Differential Pulse Voltammetry (DPV) waveform, obtained from APAP (Paracetamol) samples, considering different sampling rate.
[1] S. Aiassa, S. Carrara and D. Demarchi, "Optimized Sampling Rate for Voltammetry-Based Electrochemical Sensing in Wearable and IoT Applications," in IEEE Sensors Letters. doi: 10.1109/LSENS.2019.2918575
Pencil Graphite Needle-Shaped Biosensor for Anaesthetic Monitoring in Human Serum
Full text linkDirect and online continuous monitoring of anaesthetic intake by the patient's blood stream improves practices in the critical procedure of anaesthesia. Several systems have been proposed to address this challenge. Electrochemical techniques are highly appealing because of speed and accuracy, while blood spot sampling and fluidic devices are discouraged in this application, due to the necessity of having constant and continuous monitoring. To overcome this limitation, we developed a sensor suitable for measuring anaesthetics directly in patient's vein. We present here, for the first time, a disposable and low-cost needle-shaped sensor based on a three-electrode electrochemical cell, made of pencil leads and platinum wire. The proposed sensor shows high linearity (99%) in measuring propofol directly in undiluted human serum at the temperature of 37 degrees C in its therapeutic range (30 - 240 mu M), with a limit of detection of 7.2 +/- 3.0 mu M.LSI
Quasi-Digital Biosensor-Interface for a Portable Pen to Monitor Anaesthetics Delivery
Full text linkMonitoring of patient response to the anaesthetic drugs is an attractive improvement for achieving a correct balance of sedation level, increasing the chance of success in the right
procedure of anaesthesia. Nowadays, there are no commercial tools able to offer real-time monitoring of anaesthetics, indeed, there is still a lack in sensing technologies able to maintain high performances in long term monitoring within a portable miniaturised hardware system. To overcome these limitations, we are here presenting the innovative concept of a portable pen-device able to sense anaesthetic compounds over time. This study is based on an electrochemical sensor to be fully integrated into a complete pen-shaped point-of-care for the monitoringof anaesthesia delivery. The design of the system is based on a bio-inspired event-based approach that is guaranteeing low complexity, low power consumption and is therefore suitable to be scaled to fit the barrel of a pen. An exhaustive comparison between the proposed system and a lab instrument proves that the presented approach obtains comparable performances in terms of sensitivity and resolution with the ones obtained by expensive commercial instrumentation, meanwhile, the results show a 95 % power consumption reduction and a 92 % area decrease w.r.t. previously presented implementation
Live Demonstration: Quasi-Digital Portable Pen to Monitor Anaesthetics Delivery
Full text linkThe live demonstration presents the innovative concept of a portable pen-device able to sense anaesthetic compounds over time for improved anaesthesiology practice. A custom Printed Circuit Board (PCB) manage in the event-based quasi-digital domain the sampling procedure, while a commercial Screen Printed Electrode (SPE) acts as an electrochemical sensor for measuring paracetamol (APAP) as benchmark drug. The system is controlled by an FPGA board implementing a custom logic and the results are displayed through a Matlab ® graphical user interface. The visitors can experience and confirm on real-time the reliability of the here presented portable pen for anaesthetic monitoring.LSI
New Measurement Method in Drug Sensing by Direct Total-Charge Detection in Voltammetry
Full text linkElectrochemical biosensors are promoting point-of-care and wearable instrumentation due to their high versatility in measuring human metabolites. There is a considerable number of biological compounds that can be detected and measured through voltammetry based techniques. Voltmmetry some times requires peak identification and quantification that are non-trivial to be efficiently implemented by automatic instrumentation. To overcome the complexity of automatic peak estimation, we propose here an instrumentation circuit for edge-computing in pharmacology relying on an entirely novel measurement method via TotalCharge Detection in Cyclic voltammetry (TCDC). Namely, our TCDC method innovatively applies the coulometry measurement to the well-established voltammetry procedure. The proposed instrumentation accumulates the total charge exchanged in the faradaic process, exploiting a Nagaraj integrator as charge suppressor to fit the application-specific constraints. The work shows accurate simulations of the TCDC circuit on a set of experimental measures, acquired on paracetamol as benchmark drug. The proposed measurement technique and the developed circuit are compared to the peak detection method usually adopted in literature. The results demonstrate that the proposed system is a perfect trade-off between the doubled limit-of-detection and a tenfold reduction in measurement errors. At the same time, we eliminate any need for data oversampling and processing, promoting the TCDC as an efficient new measurement method for point-of-care and wearable monitoring of biological compounds
A low power architecture for AER event-processing microcontroller
Full text linkThis paper presents a custom MSP430TM-compatible microcontroller, specifically tailored for quasi-digital processing Address Event Representation (AER) events. Main target applications are fully reprogrammable sensory systems where events pre-processing has to be carried out by means of easily-tunable elaboration algorithms; a microcontroller-based design could provide the right trade-off between flexibility and performance. Key features are good time resolution, high reactivity, on-demand only processing and power consumption reduction. The proposed architecture has been analyzed and compared with an open source MSP430TM-compliant microcontroller (openMSP430) in terms of performance and power consumption. Accurate and wide cases-spectrum simulations (targeting ASIC technology) show an average power consumption reduction ranging from 50 % (same operating frequency) up to 79 % (same maximum event rate); equivalently, with the same power budget, an average improvement of either resolution of 84 % or maximum event rate of 1020 % is obtained
New Approach for Making Standard the Development of Biosensing Devices by a Modular Multi-Purpose Design
Full text linkThe fast widening of biosensing applications, such as healthcare, drug delivery, food, and military industries, is increasing the need for generality and compatibility among different sensors. To address this challenge, we present here an innovative approach for the fast development of new electronic biosensing systems, linking a custom-designed front-end with a multi-purpose system. We envision an open tool to help designers to focus on the target molecule and related detection method instead of designing each time a dedicated electronic device. The architecture of the proposed system is based on a modular approach, where only the front-end and the software need to be custom re-designed according to the application. Considering current research and applying a rigorous definition of the technical requirements, the core of the system is designed to fit the highest number of biosensing methods. The flexibility of this approach is successfully demonstrated with three different types of biosensors, i.e., amperometric, ion-sensitive, and memristive
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