1,932 research outputs found
sj-pdf-1-imr-10.1177_03000605221109392 - Supplemental material for Diagnosis of coronavirus disease 2019 and the potential role of deep learning: insights from the experience of Cairo University Hospitals
No full textSupplemental material, sj-pdf-1-imr-10.1177_03000605221109392 for Diagnosis of coronavirus disease 2019 and the potential role of deep learning: insights from the experience of Cairo University Hospitals by Marwa M. Ahmed, Amal M. Sayed, Dina El Abd, Inas T. El Sayed, Yasmine S. Elkholy, Ahmed H. Fares, Samar Fares in Journal of International Medical Research</p
Modulation of the glyoxalase system in the aging model Podospora anserina : effects on growth and lifespan
No full textThe eukaryotic glyoxalase system consists of two enzymatic components, glyoxalase I (lactoylglutathionelyase) and glyoxalase II (hydroxyacylglutathione hydrolase). These enzymes are dedicated to the removal of toxic alpha-oxoaldehydes like methylglyoxal (MG). MG is formed as a by-product of glycolysis and MG toxicity results from its damaging capability leading to modifications of proteins, lipids and nucleic acids. An efficient removal of MG appears to be essential to ensure cellular functionality and viability. Here we study the effects of the genetic modulation of genes encoding the components of the glyoxalase system in the filamentous ascomycete and aging model Podospora anserina. Overexpression of PaGlo1 leads to a lifespan reduction on glucose rich medium, probably due to depletion of reduced glutathione. Deletion of PaGlo1 leads to hypersensitivity against MG added to the growth medium. A beneficial effect on lifespan is observed when both PaGlo1 and PaGlo2 are overexpressed and the corresponding strains are grown on media containing increased glucose concentrations. Notably, the double mutant has a ‘healthy’ phenotype without physiological impairments. Moreover, PaGlo1/PaGlo2_OEx strains are not long-lived on media containing standard glucose concentrations suggesting a tight correlation between the efficiency and capacity to remove MG within the cell, the level of available glucose and lifespan. Overall, our results identify the up-regulation of both components of the glyoxalase system as an effective intervention to increase lifespan in P. anserina. Key words: Podospora anserina, aging, lifespan, glycation, glucose, methylglyoxal, advanced glycation end product
Libyan Stories
No full textFirst Published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.Front Cover -- Libyan Stories -- Copyright Page -- Contents -- Background Notes on Modern Libyan Literature: Ahmed Fagih -- The Oil and the Dates: Abdullah Algwiri -- Crying: Kamel el Maghor -- An Extract from Mussolini's Nail: Ali M Almisrati -- Screams in our Village: Bashir al Hashmi -- Dignity: Khalifa Takbali -- Come Let Me Whisper in Your Ear: Sayed Gaddaf-Addam -- The Road: Yousif Al Sharif -- She and the Dogs: Ibrahim el Kouni -- Signatures on Flesh: K H Mustafa -- The Choice: M El Shwihdi -- The Mission: Yusef Guwairi -- The Last Station: Ahmed Ibrahim al FagihFirst Published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Magnesium Sulfate in Pediatric Abdominal Cancer Surgery: Safety and Efficacy in Ultrasound-Guided Transversus Abdominis Plane (US-TAP) Block in Conjugation with Levobupivacaine
No full textFatma El Sherif,1 Doaa Gomaa Sayed,1 Khaled Mohamed Fares,1 Sahar Abdel-Baky Mohamed,1 Amira Mahmoud Osman,2 Ahmed Kamal Sayed,1 Shereen Mamdouh Kamal1 1Department of Anesthesia, ICU, and Pain Management, South Egypt Cancer Institute, Assiut University, Assiut, Egypt; 2Department of Pediatric Oncology, South Egypt Cancer Institute, Assiut University, Assiut, EgyptCorrespondence: Ahmed Kamal Sayed, Department of anesthesia, ICU, and pain management, South Egypt Cancer Institute, Assiut University, Assiut, Egypt, Tel +20 100677881, Fax +20 88 2348609, Email [email protected]: Magnesium sulfate (MgSO4) may enhance the effects of local anesthetics when used as an adjuvant in peripheral nerve blocks. Our objective was to evaluate efficiency and safety of utilizing MgSO4 alongside levobupivacaine in bilateral ultrasound-guided transversus abdominis plane (US-TAP) block for postoperative pain in pediatric cancer patients who underwent abdominal surgery.Methodology: A randomized double-blinded controlled trial at South Egypt Cancer Institute, Assiut University, Assiut, Egypt, included that 40 pediatric patients with Wilms’ tumor or neuroblastoma were randomly allocated to get bilateral (US-TAP) block and divided into two groups; M group: received US-TAP with 0.6 mL/kg levobupivacaine 0.25% + 2 mg/kg MgSO4 and C group: received with 0.6 mL/kg levobupivacaine 0.25% only. FLACC scores (Face, Leg, Activity, Cry, Consolability) were used to evaluate post-operative pain, first analgesic request, total analgesic consumption, adverse effects, as well as hemodynamics were monitored for 24 h and recorded at time points (2, 4, 6, 8, 12, 18, and 24h). Parent’s satisfaction at discharge, also, was evaluated.Results: FLACC score in M group was significantly lower than in C group from 4 h to 24 h with the first analgesic request being longer (15.95 ± 1.99 vs 7.70 ± 0.80 (h); p < 0.001) and lower total analgesic consumption (231.75 ± 36.57 vs 576.00 ± 170.71 (mg); p < 0.001) when comparing M group to C group, respectively. Both groups had insignificant differences regarding hemodynamics, parent satisfaction, postoperative agitation, and side effects except vomiting occurred in two patients in the C group and one patient in the M group.Conclusion: We conclude that adding magnesium sulphate as an adjuvant to local anaesthetic in US-TAP block for pain management in pediatric abdominal cancer surgeries resulted in better and longer analgesia, with less consumption of rescue analgesics with no serious side effects.Keywords: abdominal cancer surgery, analgesia, levobupivacaine, magnesium sulfate, pediatrics, postoperative pain, US-TAP bloc
Intrathecal Drug Delivery Systems Survey: Trends in Utilization in Pain Practice [Corrigendum]
No full textAbd-Sayed A, Fiala K, Weisbein J, et al. J Pain Res. 2022;15:1305–1314.
The authors have advised there is an error in the author list on page 1305. The author name “Alaa Abd-Sayed” should read “Alaa Abd-Elsayed”.
The authors apologize for this error
Figure 2 in Target-site insensitivity to some acaricides in a field population of Tetranychus urticae Koch (Acari: Tetranychidae) from Egypt
No full textFigure 2. Multiple alignment of the amino acid sequences of T. urticae acetylcholinesterase (AChE) between Eg-Bernasht population and GenBank published populations. Tetranychus urticae AChE sequences were performed local as well as global alignments, using BLASTX search protein databases, using a translated nucleotide (NCBI). Three different specific primer sets (1, 2, and 3; Table 1) contained 422 amino acids of AChE gene. Dots: indicate amino acid similarity. Digital number: amino acid position on the AChE protein.Published as part of Zein, Haggag S., Afifi, Abdallah M., Ali, Fatma S., Shaurub, El-Sayed H. & Ahmed, Mahmoud M., 2022, Target-site insensitivity to some acaricides in a field population of Tetranychus urticae Koch (Acari: Tetranychidae) from Egypt, pp. 323-337 in Persian Journal of Acarology 11 (2) on page 329, DOI: 10.22073/pja.v11i2.71694, http://zenodo.org/record/717353
Experiencing the armed struggle : the Soweto generation and after
No full textIncludes bibliographical references (p. 354-369).This study explores the experiences of the rank-and-file soldiers of Umkhonto we Sizwe and the Azanian People's Liberation Anny. Extensive interviews by the author and other researchers reveal the voices of the soldiers themselves. The African National Congress and Pan African Congress archives at the University of the Western Cape and the University of Fort Hare supplement and verify these oral testimonies, as do some published sources. Most previously published materials about the armed struggle against apartheid have already focused on diplomacy, strategy and tactics, operations, leadership, and human rights abuses to the neglect of the soldiers' actual experiences. This study complements these with significant new oral history materials from the Soweto generation of soldiers and their successors. When dealing with MK, many authors have documented issues of the camp structure in Angola, and operations inside South Africa, so much of this detail is only addressed briefly, leaving space to explore the soldiers' experiences. In the case of APLA, very little has been written on its history, and more detail is provided on these subjects. This study therefore deals with the soldiers' politicisation and motivation for joining the armed struggle, their experiences in leaving South Africa and training in exile, the crises in exile which limited their effectiveness for a time, their return to fight in South Africa, and their difficulties in the "new" South Africa. These materials reveal that vast problems remain facing these veterans of the struggle against apartheid, and that they have the potential, if properly supported and employed, to contribute substantially to the development of present day South Africa. Conversely, if their neglect continues, they also have the potential to bring vast harm to the country. Further use of the investigative tools of oral history, especially if extended to the former soldiers' vernacular languages, is necessary to augment the history of South Africa, and these soldiers' contributions
Silicon derivatives induced host plant resistance against Tetranychus urticae (Acari: Tetranychidae) in eggplants farms
No full textIsmail, Manal S., Abdallah, Asmaa M., Aboghalia, Ahmed H. (2022): Silicon derivatives induced host plant resistance against Tetranychus urticae (Acari: Tetranychidae) in eggplants farms. Persian Journal of Acarology 11 (4): 681-693, DOI: 10.22073/pja.v11i4.7524
Design and in vitro/in vivo evaluation of sustained-release floating tablets of itopride hydrochloride
No full textSayed M Ahmed,1 Adel Ahmed Ali,2 Ahmed MA Ali,2,3 Omiya A Hassan2,4 1Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, 2Department of Pharmaceutics, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt; 3Department of Pharmaceutics, Faculty of Pharmacy, Taif University, Taif, Kingdom of Saudi Arabia; 4Department of Pharmaceutics, Faculty of Pharmacy, Deraya University, El-Minia Gadida, Egypt Purpose: The aim of the present study was to improve the bioavailability of itopride (ITO) and sustain its action by formulating as a floating dosage form. Materials and methods: Sustained-release floating tablets of ITO hydrochloride (HCl) were prepared by direct compression using different hydrocolloid polymers such as hydroxypropyl methylcellulose and ethylcellulose and/or methacrylic acid polymers Eudragit RSPM and Carbopol 934P. The floating property was achieved using an effervescent mixture of sodium bicarbonate and anhydrous citric acid (1:1 mol/mol). Hardness, friability, content uniformity, and dissolution rate of the prepared floating tablets were evaluated. The formulation F10 composed of 28.5% Eudragit RSPM, 3% NaHCO3, and 7% citric acid provided sustained drug release. Results: In vitro results showed sustained release of F10 where the drug release percentage was 96.51%±1.75% after 24 hours (P=0.031).The pharmacokinetic results indicated that the area under the curve (AUC0–∞) of the prepared sustained-release floating tablets at infinity achieved 93.69 µg·h/mL compared to 49.89 µg·h/mL for the reference formulation (Ganaton®) and the relative bioavailability of the sustained-release formulation F10 increased to 187.80% (P=0.022). Conclusion: The prepared floating tablets of ITO HCl (F10) could be a promising drug delivery system with sustained-release action and enhanced drug bioavailability. Keywords: itopride HCl, oral drug delivery, stability study, bioavailabilit
The Diagnostic Utility of Natural Killer Cell Subsets in Deep Vein Thrombosis
No full textAlshaymaa M Alhabibi,1 Maisa A Wahab,2 Ahmed Khairy Sakr,2 Samar M Abd El-Hamid,1 Mohamed Yahia Zakaria,3 Azza Ali Althoqapy,4 Hanaa Mohammed Eid El Sayed,5 Sammar Ahmed Kasim,5 Hanan F Ibrahim,4 Ola I Saleh,6 Howida A Ahmed,6 Alaa H Sayed,7 Mahmoud Lotfy8 1Department of Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt; 2Department of Vascular Surgery, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt; 3Department of Vascular and EndoVascular Surgery, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt; 4Medical Microbiology and Immunology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt; 5Internal Medicine Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt; 6Department of Radio-Diagnosis, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt; 7Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt; 8Molecular Biology Department, Genetic Engineering & Biotechnology Research Institute, University of Sadat City, Sadat City, Minufiya, EgyptCorrespondence: Alshaymaa M Alhabibi, Tel +201002894075, Email [email protected]: Natural killer (NK) cells are important components of adaptive and innate immune responses. NK cell subsets have different functions and may play a role in vascular disorders. This study aimed to evaluate the proportions of NK cells and their subsets to determine whether they can be used as markers of venous thrombosis and to identify whether there was a link between NK cell proportion and citrullinated histone (H3) levels.Patients and Methods: This study included 100 participants divided into Group I (n=50, patients with deep venous thrombosis (DVT)) and Group II (n=50, age- and sex-matched healthy controls). Group I was further categorized into Group Ia (n=25, patients with acute DVT) and Group Ib (n=25, patients with chronic DVT). The proportions of NK cells and their subsets were evaluated by flow cytometry using CD3/CD16/CD56. The levels of citrullinated histones (H3) were estimated using enzyme-linked immunosorbent assay (ELISA).Results: Compared to the control group, DVT patients had a significantly lower proportion of (CD56 dim/CD16+) NK cells, a significantly higher proportion of (CD56-/CD16+) NK cells and a high level of citrullinated histone (H3).Conclusion: NK cell subsets and citrullinated histone (H3) could be used as markers for DVT and as targets for therapeutic drugs to inhibit the formation or progression of thrombosis.Keywords: natural killer cell, natural killer cell subsets, citrullinated histone, deep venous thrombosi
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