12,313 research outputs found
A Response to commentary on faust, bridges, and ahern\u27s (2009) methods for the identification of sexually abused children
No full textOur series of three chapters (Faust, Bridges, & Ahern, 2009a, 2009b; Bridges, Faust, & Ahern, 2009) on the methodology of identifying sexually abused children elicited a number of comments, both supportive and critical. The criticisms appear related to three primary issues or apparent misconceptions of our work, perhaps due in part to incomplete exposition or ambiguity in presented material: our use of hypotheticals, our argument against double-dipping, and our use of Bayesian analyses. We address each of these criticisms here in the hope of clarifying any misunderstandings and contributing in a constructive way to progress in this critical arena. © 2012 Copyright Taylor and Francis Group, LLC
Evolution of cooperation among tumor cells
No full textThe evolution of cooperation has a well established theoretical framework based on game theory. This approach has made valuable contributions to a wide variety of disciplines, including political science, economics, and evolutionary biology. Existing cancer theory suggests that individual clones of cancer cells evolve independently from one another, acquiring all of the genetic traits or hallmarks necessary to form a malignant tumor. It is also now recognized that tumors are heterotypic, with cancer cells interacting with normal stromal cells within the issue microenvironment, including endothelial, stromal, and nerve cells. This tumor cell???stromal cell interaction in itself is a form of commensalism, because it has been demonstrated that these nonmalignant cells support and even enable tumor growth. Here, we add to this theory by regarding tumor cells as game players whose interactions help to determine their Darwinian fitness. We marshal evidence that tumor cells overcome certain host defenses by means of diffusible products. Our original contribution is to raise the possibility that two nearby cells can protect each other from a set of host defenses that neither could survive alone. Cooperation can evolve as byproduct mutualism among genetically diverse tumor cells. Our hypothesis supplements, but does not supplant, the traditional view of carcinogenesis in which one clonal population of cells develops all of the necessary genetic traits independently to form a tumor. Cooperation through the sharing of diffusible products raises new questions about tumorigenesis and has implications for understanding observed phenomena, designing new experiments, and developing new therapeutic approaches.Author manuscript. Published in final edited form as: Proc Natl Acad Sci U S A. 2006 September 5; 103(36): 13474-13479.The final published version of this article is located at: www.pnas.org/cgi/doi/10.1073/pnas.0606053103NIH U56 CA113004; to David E. AxelrodR.A. was supported by National Science Foundation (NSF) Grant SES-0240852. D.E.A. was supported by NSF Grant IIS-0312953, National Institutes of Health (NIH) Grant U56 CA113004, and New Jersey Commission on Cancer Research Grant 1076-CCR-SO. K.J.P. is an American Cancer Society Clinical Research Professor and is supported by NIH Grants CA69568, CA102872, and CA093900.NIH CA69568; to Kenneth J. PientaNIH CA102872; to Kenneth J. PientaNIH CA093900; to Kenneth J. PientaNSF SES-0240852; to Robert AxelrodNJ Commission on Cancer Research 1076-CCR-SO; to David E. AxelrodAlso available in PubMed Central. PMCID: PMC155738
The Arts Interview. Dr. David Pitt : The Truant Years, E. J. Pratt
No full textHost Fred Hollingshurst interviews Dr. David Pitt of Memorial University, who discusses the life and work of Newfoundland poet E. J. Pratt. Pitt is the author of E. J. Pratt: The Truant Years, 1881-1927
sj-docx-2-son-10.1177_23779608231186026 - Supplemental material for Student Employment Models for Undergraduate Nurses and Midwives in Australia: A Scoping Review
No full textSupplemental material, sj-docx-2-son-10.1177_23779608231186026 for Student Employment Models for Undergraduate Nurses and Midwives
in Australia: A Scoping Review by David J. Lindsay, Tracey A. Ahern, Madelyn K. Pardon, Marie T. McAuliffe and Sam G. Rannard in SAGE Open Nursing</p
sj-docx-1-son-10.1177_23779608231186026 - Supplemental material for Student Employment Models for Undergraduate Nurses and Midwives in Australia: A Scoping Review
No full textSupplemental material, sj-docx-1-son-10.1177_23779608231186026 for Student Employment Models for Undergraduate Nurses and Midwives
in Australia: A Scoping Review by David J. Lindsay, Tracey A. Ahern, Madelyn K. Pardon, Marie T. McAuliffe and Sam G. Rannard in SAGE Open Nursing</p
sj-docx-5-son-10.1177_23779608231186026 - Supplemental material for Student Employment Models for Undergraduate Nurses and Midwives in Australia: A Scoping Review
No full textSupplemental material, sj-docx-5-son-10.1177_23779608231186026 for Student Employment Models for Undergraduate Nurses and Midwives
in Australia: A Scoping Review by David J. Lindsay, Tracey A. Ahern, Madelyn K. Pardon, Marie T. McAuliffe and Sam G. Rannard in SAGE Open Nursing</p
sj-docx-4-son-10.1177_23779608231186026 - Supplemental material for Student Employment Models for Undergraduate Nurses and Midwives in Australia: A Scoping Review
No full textSupplemental material, sj-docx-4-son-10.1177_23779608231186026 for Student Employment Models for Undergraduate Nurses and Midwives
in Australia: A Scoping Review by David J. Lindsay, Tracey A. Ahern, Madelyn K. Pardon, Marie T. McAuliffe and Sam G. Rannard in SAGE Open Nursing</p
sj-docx-3-son-10.1177_23779608231186026 - Supplemental material for Student Employment Models for Undergraduate Nurses and Midwives in Australia: A Scoping Review
No full textSupplemental material, sj-docx-3-son-10.1177_23779608231186026 for Student Employment Models for Undergraduate Nurses and Midwives
in Australia: A Scoping Review by David J. Lindsay, Tracey A. Ahern, Madelyn K. Pardon, Marie T. McAuliffe and Sam G. Rannard in SAGE Open Nursing</p
Fly about round me coursing, swallow sweet birds come near [first line]
No full textstrophicpiano and voiceCover is duplicated in 125.115b.Johns Hopkins University, Levy Sheet Music Collection, Box
125, Item 115aTranslated From the French of Volney L'Hotelier by Samuel J. Gardner, Esq. The Music by Felicien David (Author of "Le Desert").E.G. Warren, Engr
Fly about round me coursing, swallow sweet birds come near [first line]
No full textstrophicpiano and voiceCover is duplicated in 125.115b.Johns Hopkins University, Levy Sheet Music Collection, Box
125, Item 115aTranslated From the French of Volney L'Hotelier by Samuel J. Gardner, Esq. The Music by Felicien David (Author of "Le Desert").E.G. Warren, Engr
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