1,722,151 research outputs found
Psychophysiologie
No full textMasure M.-C., Parot Françoise, Agostini M. Psychophysiologie. In: L'année psychologique. 1984 vol. 84, n°4. pp. 610-613
Psychophysiologie
No full textMasure M.-C., Parot Françoise, Agostini M. Psychophysiologie. In: L'année psychologique. 1984 vol. 84, n°4. pp. 610-613
Modifiche di clearing per componenti LFR/SFR
No full textIn questo rapporto vengono confrontate alcune metodologie di pulizia di componenti meccanici di reattori LFR/SFR per la rimozione del piombo, delle sue leghe e composti. Le metodologie sono valutate in funzione del loro costo, delle tecniche e dei tempi di trattamento (per componenti di piccola, media e grande taglia) e della loro efficacia, come anche dalle problematiche relative alla gestione dei rifiuti liquidi e solidi derivanti dai vari process
Rapporti tra attività cambiale e fogliazione in piante di Fagus sylvatica L. in località Monte Carpegna (Appennino Marchigiano)
No full textLong non-coding RNA and extracellular matrix: the hidden players in cancer-stroma cross-talk
No full textCurrently available high-throughput technologies combined with bioinformatics analyses revealed that nearly 80% of the genome is transcribed, whereas only 2% of the genetic code is translated in proteins. In the landscape of non-coding RNA, the long non-coding RNA (>200 nucleotides) is a newer class of ncRNAs, with a potential pivotal role in homeostatic and pathological mechanisms, confirmed by increasing emerging evidences in different diseases, especially in cancer. In parallel, recent studies have demonstrated that as cancer progresses, extracellular matrix co-evolves into an activated state through continuous biochemical and structural modifications. In this review, we synthesize these themes by exploring the functional cross-talk between lncRNAs and their involvement in ECM regulation and remodeling within the tumor microenvironment
La Neuromodulazione sacrale nelle disfunzioni del pavimento pelvico
Full text linkLa disfunzione vescico-uretrale rappresenta un importante problema nella pratica medica quotidiana a causa dei disturbi psicologici, i costi sociali e l’elevato impatto sulla qualità di vita. Recentemente, la neuromodulazione sacrale, cioè la stimolazione elettrica dei nervi sacrali, sembra rappresentare un’alternativa nei casi di iperattività vescicale idiomatica resistente alla terapia medica.
Il meccanismo di azione è soltanto parzialmente noto, ma sembra coinvolgere la modulazione nel midollo spinale per via della stimolazione degli interneuroni inibitori.
La prima tappa è rappresentata da un test di prova (PNE test). Comprende l’applicazione di un elettrodo monopolare temporaneo quale test diagnostico per determinare la sede migliore per l’impianto e per verificare, dopo un periodo di applicazione della neuromodulazione di 7-14 giorni la risposta clinica. Se il test di simulazione è efficace, viene impiantato un elettrodo quadripolare connesso ad un neuromodulatore definitivo.
L’iperattività vescicale idiopatica rappresenta la principale indicazione per questa tecnica. I pazienti che hanno le minori probabilità di beneficiare da questa procedura sono coloro con lesioni spinali complete o quasi complete, mentre le lesioni spinali incomplete sembrano rappresentare una potenziale indicazione. Questa tecnica è attualmente indicata anche nei casi di ritenzione cronica non ostruttiva e nella sindrome del dolore pelvico cronico.
Quando si effettua la selezione, oltre tre quarti dei pazienti hanno mostrato una risposta clinicamente significativa con una riduzione di almeno 50% nella frequenza di episodi di incontinenza, ma i risultati variano in base alla metodica di valutazione di ciascun Autore. Dal punto di vista economico, l’investimento iniziale per l’apparecchiatura è ammortizzato nel medio termine dalla riduzione dei costi legati alla disfunzione delle basse vie urinarie. Infine, questa tecnica richiede un attento follow-up ed adattamenti dei parametri elettrici per ottimizzare l’equilibrio tra i sistemi neurologiciVesico-urethral dysfunction is a major problem in daily medical practice due to its psychological disturbances, its social costs and its high impact on quality of life. Recently, sacral neuromodulation, namely the electrical stimulation of the sacral nerves, appears to have become an alternative for radical bladder surgery particularly in cases of idiopathic bladder over¬activity. The mechanism of action is only partially understood but it seems to involve a modulation in the spinal cord due to stimulation of inhibitory interneurons.
Temporary sacral nerve stimulation is the first step. It comprises the temporary application of neuromodulation as a diagnostic test to deter¬mine the best location for the implant and to control the integrity of the sacral root. If test stimulation is successful, a permanent device is implanted. This procedure is safe in experienced hands.
So-called idiopathic bladder overactivity still the major indication for this technique. Patients not likely to benefit from the procedure were those with complete or almost complete spinal lesions, but incomplete spinal lesions seemed to be a potential indication. This technique is now also indicated in the case of idiopathic chronic retention and chronic pelvic pain syndrome.
When selection is performed, more than three-quarters of the patients showed a clinically significant response with 50% or more reduction in the frequency of incontinent episodes, but the results vary according to the author’s mode of evaluation. From the economic point of view, the initial investment in the device is amortized in the mid-term by savings related to lower urinary tract dysfunction.
Finally, this technique requires an attentive follow-up and adjustments to the electric parameters so as to optimize the equilibrium between the neurological system
Estimación de daños probables por sismo de un edificio en altura considerando la vulnerabilidad de sus componentes
Full text linkFil: Gerbaudo, G. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Estructuras; Argentina.Fil: Agostini, M. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Estructuras; Argentina.Este trabajo se estima los daños probables en un edificio y los costos de reparación asociados. Para ello se aplica la metodología Assembly Based Vulnerability (ABV) que permite considerar las características particulares de una construcción, ya que la estimación del daño se basa en las curvas de fragilidad de sus componentes que representan la vulnerabilidad al daño debido a la acción del sismo. Los pasos básicos consisten en el análisis estructural detallado del edificio, seguido de una evaluación de los daños en una variedad de componentes basados en respuesta estructural mediante funciones de vulnerabilidad del componente apropiado. Posteriormente, la relación de daños para cada componente se evalúa para cada planta y se multiplica por el valor de cada componente. El daño a todo el edificio se obtiene sumando el daño a sus módulos o piezas. La aplicación de este método a edificios existentes es de gran utilidad para la determinación de las primas de seguro o para construir curvas de fragilidad. También puede ser utilizado en la etapa de diseño de nuevos edificios para aplicar el diseño por desempeño.https://conpat2017.com/noticia/11Fil: Gerbaudo, G. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Estructuras; Argentina.Fil: Agostini, M. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Estructuras; Argentina.Ingeniería Estructura
Ritmo climatico e ritmo vegetativo in rami di Quercus pubescens L. nella zona di Urbino (anni 1984-1985)
No full textBig data and analytics: Opportunities and challenges for firm performance
No full textThe phenomenon called Big Data (BD) refers to the presence of large amounts of data that are both structured and unstructured, coming from heterogeneous sources, both internal and external to the companies. These must coexist with such amounts of data, affording challenges, and taking opportunities to improve their performance. For this reason, there is a growing demand for systems, methods, and tools favoring data processing and analysis (i.e., Big Data Analytics or BDA). The literature regarding the impact of BD and BDA on firm performance still appears fragmented and lacks an overall perspective on the matter. This work aims to systematize the recent literature about such impact, providing four perspectives of analysis. First, the corporate decision-making process needs to change because of BD exploitation and BDA implementation, inducing entities to change routines and require additional skills. Second, education and training represent a central matter to state peoples’ centrality in the process of change implied by the digital transformation. Indeed, data users remain the cornerstone of the entire process if they are and will increasingly be able to adequately manage data. In this sense, people, together with culture and technology, represent both the main barriers and the potential solutions to the here examined process of change. In particular, technology (i.e., the last perspective of analysis here examined) is increasingly and continuously going toward unexplored and unthinkable frontiers, enlarging the gap between what is recommended by scholars and what is actually implemented by decision-makers. These should embrace that the data-driven process of change is not a topic of discussion for future occurrence: It is a present corporate opportunity implying some risks and challenges
Embryonic stem cells and inducible pluripotent stem cells: two faces of the same coin?
No full textEmbryonic stem cells (ESCs) are derived from the inner cell mass of the blastocysts and are characterized by the ability to renew themselves (self-renewal) and the capability to generate all the cells within the human body. In contrast, inducible pluripotent stem cells (iPSCs) are generated by transfection of four transcription factors in somatic cells. Like embryonic stem cells, they are able to self-renew and differentiate. Because of these features, both ESCs and iPSCs, are under intense clinical investigation for cell-based therapy. In this review, we revisit stem cell biology and add a new layer of complexity. In particular, we will highlight some of the complexities of the system, but also where there may be therapeutic potential for modulation of intrinsic stem cells and where particular caution may be needed in terms of cell transplantation therapies
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