11 research outputs found
Henoch Schonlein Purpura as a Cause of Renal Failure in an Adult
No full textHenoch Schonlein purpura (HSP) is an immune mediated disease associated Immunoglobulin A (IgA) deposition within the affected organs. While the disease is commonly seen in the pediatric age group, it is rarely seen in adults. We report the case of a 93-year-old Caucasian lady who presented with nonthrombocytopenic purpuric rash and acute kidney injury after an episode of bronchitis. Rapid and progressive deterioration of renal function prompted a kidney biopsy, which showed findings consistent with IgA nephropathy confirming the diagnosis of HSP. The patient was treated with high dose intravenous methylprednisolone followed by oral prednisone; however, her kidney disease progressed to end stage renal disease requiring hemodialysis. HSP is usually a self-limiting disease in children. However, adults are at an increased risk of severe renal involvement including end stage renal disease. Purpuric skin rash with renal involvement should raise suspicion for HSP. This is the oldest known patient with HSP
Assesing variability in the Asiatic corn borer Ostrinia furnacalis (Guenee) (Lepidoptera : Pyralidae).
No full textariability in local populations of the Asiatic corn borer Ostrinla furnacalis Guenee was assessed based on: I) some life history parameters; 2) survival, and 3) feeding behavior and growth on diet with different concentrations of the Bacillus ihuringiensis delta-endotoxin, Cry IA(c). Significant differences in larval development time, pupal development time and hatching-to-emergence time were observed within and among the four populations of 0. filmacalis that were studied. Deviation from the expected 1:1 sex ratio was also observed in all populations. When fed with artificial diet containing Cry IA(c), neonates, day-old larvae and 4-5 day old larvae showed very high mortality at all concentrations of the toxin. Low mortality was observed in 6-7 day old larvae and 3rd instars. When given a choice between normal diet and Cry IA(c)-treated diet, neonates, day-old larvae and 3rd instars exhibited avoidance toward the toxin-containing diet and preferred the unadulterated diet. Significant weight loss was observed in 3rd instars that were fed Cry IA(c)- treated diet
Primary carcinoid tumors of the liver
No full textAbstract Background Primary carcinoid tumors of the liver are uncommon and rarely symptomatic. The diagnosis of primary hepatic etiology requires rigorous workup and continued surveillance to exclude a missed primary. Case Presentation We present a case of a 62-year-old female with a primary hepatic carcinoid tumor successfully resected, now with three years of disease-free follow-up. We present a review of the current literature regarding the diagnosis, pathology, management, and natural history of this disease entity. Conclusion Primary carcinoid tumors of the liver are rare, therefore classifying their nature as primary hepatic in nature requires extensive workup and prolonged follow-up. All neuroendocrine tumors have an inherent malignant potential that must be recognized. Management remains surgical resection, with several alternative options available for non-resectable tumors and severe symptoms. The risk of recurrence of primary hepatic carcinoid tumors after resection remains unknown.</p
<i>BRAF</i> Mutation Analysis of Fine-Needle Aspiration Biopsies of Papillary Thyroid Carcinoma: Impact on Diagnosis and Prognosis
No full text<i>Objective:</i> The <i>BRAF</i> V600E mutation has been associated with aggressive disease in papillary thyroid carcinoma (PTC). Molecular testing has been proposed as a useful adjunct to cytology in the diagnosis of malignancy and for tailoring clinical management. The aims of our study were to evaluate the <i>BRAF</i> mutational status using archived fine-needle aspiration biopsy (FNAB) material from patients with long-term follow-up and to correlate it with the original cytology diagnosis, clinicopathological stage at surgery, and prognosis. <i>Study Design:</i> FNAB material from 52 cases of PTC, with a mean follow-up of 8.4 years, was used in this study. DNA was extracted from archival cytology slides. Mutation analysis was performed by standard sequencing and locked nucleic acid-PCR/sequencing. <i>Results:</i> The <i>BRAF</i> V600E mutation was present in 46% of cases, but it was absent in all FNABs diagnosed originally as atypical and in 14 of 17 suspicious cases. Recurrence was significantly more frequent (p = 0.006) in cases with <i>BRAF</i> mutations and 54% of these cases presented with stage 2 or higher. <i>Conclusion:</i> The <i>BRAF</i> V600E mutation is associated with a higher pathological stage at surgery and a higher rate of recurrence. <i>BRAF</i> mutation analysis did not provide a significant increase in the accuracy of thyroid FNABs diagnosed as suspicious or atypical in our institution.</jats:p
Application of the Milan System for Reporting Salivary Gland Cytopathology: Experience of an academic institution in a tertiary academic medical center
No full textSinonasal adenocarcinoma: A rare second malignancy in long term retinoblastoma survivors
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