1,721,058 research outputs found
Demonstration of NPY transmitter receptor mismatches in the central nervous system of the male rat
No full textLe basi razionali della terapia delle malattie neurodegenerative e il concetto di farmaco astrocita-cinetico [The treatment of neurodegenerative diseases and the astrocytokinetic drug]
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Morphometrical and microdensitometrical studies on peptide immunoreactivities in methylazoxymethanol prenatal treated rats
No full textInner speech mis-exaptation can cause the “Hubris” that speeds up ecosystem over-exploitation
No full textFROM THE HIERARCHICAL ORGANIZATION OF THE CENTRAL NERVOUS SYSTEM TO THE HIERARCHICAL ASPECTS OF BIOCODES
No full textThe quite recent (at least on the evolutionary time scale) emergence of nervous systems in complex organisms enabled the living beings to build a wide-ranging model of the external world in order to predict and evaluate the outcomes of their actions. Such a process likely represents a real coding activity, since, by proper handling of information, it generates a mapping between the external environment and internal cerebral activity patterns. The patterns of neural activity that correspond to the final maps, however, emerge from the holistic assembly of a multilevel functional organization. Nerve tissue components, indeed, appear organized in compartments, also called functional modules (FM), that contain system components and circuits of different miniaturizations not only arranged to work together either in parallel or in series but also nested within each other. At least three levels can be recognized in a functional module and it is possible to point out that such a hierarchical organization of the brain circuits could be mirrored by a corresponding hierarchical organization of biocodes. This feature can also suggest the hypothesis that the same logic could operate also at system level to integrate FM into functional brain areas and to associate areas to generate the final map used by humans to image the external world and to imagine untestable worlds
Further evidence for the existence of interactions between receptors for dopamine and neurotensin. Dopamine reduces the affinity and increases the number of 3H?neurotensin binding sites in the subcortical limbic forebrain of the rat
No full textL'articolo illustra gli effetti modulatori del peptide neurotensina sulle vie dopaminargiche con particolare riferimento al sistema limbico, al fine di indagare l'eziopatogenesi dei disturbi psichici, con particolare riferimento alle psicos
Neurohistochemical studies on striatal lesions induced by transient forebrain ischemia. Evidence for protective effects of the ganglioside analogue AGF2
No full textChronic but not acute uridine treatment reduces haloperidol-induced dopamine release in neostriatum as studied by intracerebral microdialysis
No full textBy using the intracerebral microdialysis technique, it has been shown that chronic but not acute uridine treatment reduces haloperidol-induced dopamine release in neostriatum. This finding has posible implications in the understanding of efficaty of psychotropic drug
Extra-Cellular Proteins are Key Elements of a Global Molecular Network Enmeshing the Whole Central Nervous System: Physiological and Pathological Implications
No full textProteins are endowed with the “Lego property”, i.e., the capability of steric
fitting with other proteins to form high molecular weight complexes with emergent functions. These interactions may occur both as horizontal molecular networks at the plasma membrane level and as vertical molecular networks, i.e., towards the extra- and/or intracellular side of the cell. The present paper broadens this view by proposing the existence of three dimensional molecular networks, mainly made by proteins and carbohydrates, which might interact with each other at boundaries of compartments such as plasma membranes to form a “global molecular network” (GMN) that pervades the intra as well as the extra-cellular environment of the entire central nervous system. The GMN is a potentially plastic structure regulated through several means. For example, its extracellular part is under the remodeling action of the matrix metalloproteinases
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