131,097 research outputs found

    Agius, D

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    Seismic anisotropy indicates organised melt beneath the Mid-Atlantic Ridge aids seafloor spreading

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    Skip Nav Destination RESEARCH ARTICLE| AUGUST 04, 2023 Seismic anisotropy indicates organized melt beneath the Mid-Atlantic Ridge aids seafloor spreading J.M. Kendall; D. Schlaphorst; C.A. Rychert; N. Harmon; M. Agius; S. Tharimena Author and Article Information Geology (2023) 51 (10): 968–972. https://doi.org/10.1130/G51550.1 Article history Standard View Open thePDFfor in another window Cite Share Icon Share Permissions Abstract Lithospheric plates diverge at mid-ocean ridges and asthenospheric mantle material rises in response. The rising material decompresses, which can result in partial melting, potentially impacting the driving forces of the system. Yet the geometry and spatial distribution of the melt as it migrates to the ridge axis are debated. Organized melt fabrics can cause strong seismic anisotropy, which can be diagnostic of melt, although this is typically not found at ridges. We present anisotropic constraints from an array of 39 ocean-bottom seismometers deployed on 0–80 Ma lithosphere from March 2016 to March 2017 near the equatorial Mid-Atlantic Ridge (MAR). Local and SKS measurements show anisotropic fast directions away from the ridge axis, which are consistent with strain and associated fabric caused by plate motions with short delay times, δt (<1.1 s). Near the ridge axis, we find several ridge-parallel fast splitting directions, φ, with SKS δt that are much longer (1.7–3.8 s). This is best explained by ridge-parallel sub-vertical orientations of sheet-like melt pockets. This observation is much different than anisotropic patterns observed at other ridges, which typically reflect fabric related to plate motions. One possibility is that thicker sub-ridge lithosphere with steep sub-ridge topography beneath slower spreading centers focuses melt into vertical, ridge-parallel melt bands, which effectively weakens the plate. Associated buoyancy forces elevate the sub-ridge plate, providing greater potential energy and enhancing the driving forces of the plates

    A dual origin for Bcr-Abl gene translocation/fusion as dynamics of synergism of the hematopoietic stem cell and hemangioblast in chronic myeloid leukemia

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    Contextual BCR-ABL tyrosine kinase over-activity determines in formulated fashion the emergence of proliferation and anti-apoptosis that arise largely as derived phenomena of otherwise homeostatic mechanisms of the c-ABL gene within hematopoietic stem cells and hemangioblasts in the bone marrow. The ability to suppress almost completely, both in terms of phenotype and cytogenetically, the myeloid cell line expansion by imatinib mesylate is indicative of a phenomenon that depends strictly on the transformed status of the cell of origin in the chronic myeloid leukemia process. It is with relevance to complex participation of the dynamics of the fused BCR- ABL protein product that contextual conditioning of the cells of origin of the gene translocation further motivates the dimensional expansion of the transformed myeloid cell clones to increasing proliferative rates, thus leading to blast crisis as eventual loss of differentiating potential.peer-reviewe

    Performance evaluation of Wied Dalam (WDD) seismic station in Malta

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    The continual operation of a permanent seismograph, now exceeding a couple of decades in some cases, naturally involves changes of hardware and software over time. Nonetheless, the long-term, consistent performance of the seismic station, and the good quality of its data, is very important for national seismic studies investigating the local seismicity, and also important for the international seismological community researching regional tectonics and deep Earth structures. Here we investigate the data availability and quality of the currently only seismic station on Malta (WDD) since its installation in 1995, and establish spectral patterns in the seismic data that may be influenced by diurnal variations, seasonal weather changes, and/or site-specific settings. The results are important for the future deployment of permanent seismic stations on the Maltese islands, and for the analysis of local seismic hazard and ground motion studies

    Exploring the crop epigenome: a comparison of DNA methylation profiling techniques

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    COST (European Cooperation in Science and Technology) [CA19125]Agius DR, Kapazoglou A, Avramidou E, Baranek M, Carneros E, Caro E, Castiglione S, Cicatelli A, Radanovic A, Ebejer JP, Gackowski D, Guarino F, Gulyás A, Hidvégi N, Hoenicka H, Inácio V, Johannes F, Karalija E, Lieberman-Lazarovich M, Martinelli F, Maury S, Mladenov V, Morais-Cecílio L, Pecinka A, Tani E, Testillano PS, Todorov D, Valledor L, Vassileva

    Education in Family Medicine : What has been achieved?

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    Contents: Education... historical landmarks - Pierre Mallia; The Malta College of Family Doctors and the Royal College of General Practitioners - John V. Howard; The MRCGP [INT] Qualification and Programme - Adrian Freeman; Malta from the view of an External Development Advisor - Jeremy Stupple; The Specialist Training Programme in Family Medicine - Malta - Mario R. Sammut and Gunther Abela; Psychometrics – MCFD/MRCGP[INT] summative examination - Dominic Agius; Continued professional development - Philip Sciortino; The Diploma in Family Practice in retrospect - Pierre Mallia; Report on MCFD Assessment Course - Renzo De GabrieleThe mission of the Journal of the Malta College of Family Doctors (JMCFD) is to deliver accurate, relevant and inspiring research, continued medical education and debate in family medicine with the aim of encouraging improved patient care through academic development of the discipline. As the main official publication of the Malta College of Family Doctors, the JMCFD strives to achieve its role to disseminate information on the objectives and activities of the College.peer-reviewe

    Is-sisien ta' Dizzjunarju tal-lsien Malti [sic] ta' Michael Agius u aspetti mill-makrostruttura u l-mikrostruttura tiegħu

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    F'dan l-istudju se nagħti ħarsa kritika lejn il-manuskritt Dizzjunarju tal-Lsien Malti [sic] li, flimkien ma' xogħlijiet oħra, Michael Agius ippreżenta lil-Librerija tal-Università tà Malta fi-1978 (Ellul, Ħarsa 108). Fl-ewwel parti ta' din il-kitba se nirrapporta dak li sibt wara li għarbilt il-lista tal-kliem ewlieni (headwords) tà Agius u anke l-entrati nfushom u ngħaddi biex nagħmel ipoteżi dwar kienx hemm dizzjunarji oħra li Agius seta' sejjes tiegħu fuqhom u jekk iva liema setgħu kienu. Fit-tieni parti se nagħmel ftit kummenti kritiċi skont qafas għall-analiżi ta' xogħlijiet lessikografiċi (Ellul, Proposta 99-104). Għal raġunijiet prattiċi, nillimita ruħi għall makrostruttura u l-firxa tal-vokabolarju, kif ukoll għall-aspetti ewlenin tal-mikrostruttura: il-grammatika u d-definizzjonijiet.peer-reviewe

    MeSH term explosion and author rank improve expert recommendations

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    Information overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
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