220 research outputs found
Recent advances in preventing neurodegenerative diseases
No full textThe worldwide health-care burden of neurodegenerative diseases is on the rise—a crisis created through a combination of increased caseload and lack of effective treatments. The limitations of pharmacotherapy in these disorders have led to an urgent shift toward research and clinical trials for the development of novel compounds, interventions, and methods that target shared features across the spectrum of neurodegenerative diseases. Research targets include neuronal cell death, mitochondrial dysfunction, protein aggregation, and neuroinflammation. In the past few years, there has been a growth in understanding of the pathophysiologic mechanisms of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and Huntington’s disease. This increase in knowledge has led to the discovery of numerous novel neuroprotective therapeutic targets. In this context, we reviewed and summarized recent advancements in neuroprotective strategies in neurodegenerative diseases.
We Appreciate Your Business, Not Your Abuse: Incivility by Customers Predicts Revenge Toward Customers
No full textTitle: We Appreciate Your Business, Not Your Abuse: Incivility by Customers Predicts Revenge Toward Customer, Author: Akanksha Bedi, Location: ThodePast research on organizational revenge has often focused on the organization or
organizational members (e.g., coworkers, or supervisors) as targets of revenge
behaviours. Building on Tripp et al.'s (2007, 2009) model of workplace revenge, the
present study examined the influence of customer incivility on customer directed revenge
behaviours. Data from a survey of 434 customer service employees suggested that
incivility from customers was positively associated with the service employee's desires
for revenge and actual revenge behaviours against the uncivil customer. Specifically,
employees who experienced customer incivility and blamed the customer for the
mistreatment were more likely to desire and engage in revenge. Empathic concern,
perspective taking and organizational tolerance of uncivil customers moderated the
relationship between blame attributions and desire for revenge such that individuals who
empathized with the transgressor, took his/her perspective, or perceived their
organization as intolerant of uncivil customer behaviours were less likely to desire
revenge. In addition, empathic concern moderated the relationship between blame
attribution and actual revenge behaviours such that employees who empathized with the
customer were less likely to act on their blame attributions and engage in revenge.
Finally, empathic concern and perspective taking moderated the relationship between
desire for revenge and actual revenge behaviours but in a direction opposite of the other
observed moderation effects. Specifically, employees who empathized with the customer
or took his/her perspective were more (not less) likely to act on their desires for revenge
and engage in revenge. The theoretical and practical implications of these findings and
directions for future research are discussed.ThesisDoctor of Philosophy (PhD
Supplemental materials for preprint: A Novel Artificial Intelligence and Machine learning-based scoring system for evaluating re-purposing potential of Valproic Acid drug in COVID-19.
No full textSupplemental materials for preprint: A Novel Artificial Intelligence and Machine learning-based scoring system for evaluating re-purposing potential of Valproic Acid drug in COVID-19.
No full textSupplemental materials for preprint: A Novel Artificial Intelligence and Machine learning-based scoring system for evaluating re-purposing potential of Valproic Acid drug in COVID-19.
No full text199— Socioeconomic Status and Child Death in 19th Century Rochester, New York
No full textSocioeconomic status, or SES, is the measure of one’s individual/familial social and economic position in society in relation to others. The higher one’s SES, the better their financial and social standing and, consequently, the better chance for a healthy and long life. This was especially the case for infants and children in the 19th century, when the United States lacked social safety net programs. During the latter part of the 19th century, deaths in urban areas like Rochester increased, due to growing populations and reduced sanitation. This study focuses on the correlation between socioeconomic status and the death of children from birth into childhood, in 19th century Rochester, through an analysis of death records from Mt. Hope Cemetery and census records. By looking at the correlation between death rates and social status, it is predicted that SES played a role in the death rates of children in 19th century Rochester
Supplemental materials for preprint: A Novel Artificial Intelligence and Machine learning-based scoring system for evaluating re-purposing potential of Valproic Acid drug in COVID-19.
No full text“Socioeconomic Status and Child Death in 19th Century Rochester, New York”
No full textSocioeconomic status, or SES, is the measure of one’s individual/familial social and economic position in society in relation to others. The higher one’s SES, the better their financial and social standing and, consequently, the better chance for a healthy and long life. This was especially the case for infants and children in the 19th century, when the United States lacked social safety net programs. During the latter part of the 19th century, deaths in urban areas like Rochester increased, due to growing populations and reduced sanitation. This study focuses on the correlation between socioeconomic status and the death of children from birth into childhood, in 19th century Rochester, through an analysis of death records from Mt. Hope Cemetery and census records. By looking at the correlation between death rates and social status, it is predicted that SES played a role in the death rates of children in 19th century Rochester
Examination of Service Quality Dimensions in Power Distribution Sector
No full textService quality has become a crucial parameter for determining the success of the service company in the market. Any servicing company can survive in this competitive world only if it fulfills all the customer expectations. Their customers� satisfaction level significantly impacts the monetary gains of the company. All these are dependent on their quality of services offered in terms of different service attributes. Tangibility, reliability, responsiveness, empathy and assurance are important attributes of the services, on which company has to perform well to satisfy the customers� needs. Providing good service quality on all these service attributes is equally important in power sector also. Power distribution companies generally could not fulfill the needs and expectations of their customers, as observed in this study. Mean score of customers� expectations and perceptions have large difference corresponding to each attribute of the services offered. The findings of this study showed the poor performance of power distribution companies on all parameters of service quality according to SERVQUAL model
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