7 research outputs found

    ChatGPT and Death of an Author

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    The proposed piece seeks to critically explore pedagogical implication of ChatGPT, especially on students’ capacities to author a text. The piece suggests that increased reliance on the ChatGPT, while provide short term solution to produce a text, in the long term it is likely to lead to ‘death of an author’. Here the usage of the phrase is a twist to earlier usage by Barthes- which refers to ‘death of an author’ where once the text is written, it gets re-created in readers’ reception and through interpretive act and imagination. The overarching argument of the paper emphasizes that technology is not neutral, especially in a context where its opacity has risen concerns about surveillance, control, and manipulation of human behavior, and therefore its infiltration in education begs critical questioning and sensitive e-value-ation. The discussion argues that rise of AI in education should be checked and not embraced uncritically, but rather it should be critically scrutinized, debated, and scaffolded through critical theoretical, pedagogical, and ethical references to counter its hegemonic and de-humanization of learning. For empirical part, the analysis draws upon reflections generated through a focus group discussion with four undergraduate students enrolled in a Bachelors degree in Computer Science who employed use of ChatGPT in preparing their speeches in context of a humanities course. The students found ChatGPT useful in terms of composing a text/speech and saving time and efforts. However, they realized that its use caused them loss of authentic learning, imagination and suppressed self’s voice. Based on the analysis, the piece shares further insights into pedagogic implications, and suggest a pedagogical scaffolding using critical pedagogical references of relationship between technology and human/learners’ values, distinction between information, knowledge, and wisdom, application and experiential learning references, and praxis in learning

    Protein induced vitamin k absence(PIVKA-II) response in relation to treatment modalities among hepatocellular carcinoma patients at Hospital Universiti Sains Malaysia

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    Background: Hepatocellular carcinoma(HCC) is the commonest tumour of the liver with multiple aetiologies responsible for cirrhosis which evidently and eventually leads to hepatocellular carcinoma. With drastically increasing incidence since 1990 in Malaysia from 6.1 to 42.8% and with an annual mortality rate of 6.1%, the diagnosis of hepatocellular carcinoma is mainly dependent of imaging and biochemical markers. The commonest imaging modalities used to diagnose hepatocellular carcinoma are magnetic resonance imaging and computed tomography of the liver, while the commonest tumour marker used in conjunction with imaging is alpha-fetoprotein(AFP).In the setting of hepatocellular carcinoma, 30% of the time, the tumour marker alpha-fetoprotein is not elevated which leads to a conundrum during the time of diagnosis. A more robust tumour marker is required and PIVKA-II has shown potential in this regards with a few studies showing that PIVKA-II was superior in both sensitivity and specificity in the initial diagnosis, during follow up post treatment via hepatic artery embolization and hepatic artery infusion and it also shows a better correlation with overall survival in comparison to AFP. The purpose of this study is to evaluate the association between radiological response and PIVKA-II response among patients who undergo interventional radiological treatment, as radiological response is used as a bench mark to either proceed with more interventions or to observe the patients. Methods: A prospective study was conducted at Hospital Universiti Sains Malaysia(USM), Kota Bharu, Kelantan, Malaysia, where 66 patients who underwent interventional radiological treatment for hepatocellular carcinoma had blood investigation for PIVKA-II taken prior to the treatment, 6 weeks post treatment and 3 months post treatment with concurrent computed tomography or magnetic resonance imaging at baseline, 6 weeks post treatment and 3 months post treatment. Of the 66 patients, only 28 patients were available at the end of the 3rd month post intervention, this was due largely to the patients succumbing to their disease and partly due to the pandemic. The radiological response was based on modified response evaluation criteria(mRECIST) into four criteria’s of progressive disease, stable disease, partial response and complete response. PIVKA-II response was classified into either PIVKA-II responders or nonresponders. The association between radiological response and PIVKA response was carried out using Fischer exact test. Results: There was a significant association between radiological response and PIVKA-II response at 6 weeks post interventional radiological treatment with a P value of <0.001 and a Cramer’s V value of 0.71. However at 3 months post treatment, there was no significant association between radiological response and PIVKA-II response with a P value of 0.915 and Cramer’s V value of 0.141. Conclusion: The overall study shows that there was no significant association between post interventional radiological response at 3 months and PIVKA-II response and as of now, tumour marker PIVKA-II in itself cannot be a substitute for radiological imaging. However, it can be used in conjunction with imaging

    Lissencephaly with subcortical band heterotopia in an East African child: A case report

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    Lissencephaly is a rare neuronal migration defect that results in a smooth cerebral surface, mental retardation, and seizures. It is diagnosed primarily by correlating clinical manifestations with MRI findings. We present a case of a 3-year-old girl with developmental delay and seizures. Her first seizure was at 14 months and MRI showed features of lissencephaly and subcortical band heterotopia. Lissencephaly is associated with gene mutations. Treatment focuses on antiseizure meds and physiotherapy to reduce seizures and improve motor skills. This case report highlights the importance of promptly diagnosing the LIS/SBH spectrum to enhance patient outcomes. Timely identification and treatment, such as physiotherapy, can significantly improve the quality of life, especially in resource-limited settings

    Dorsal pancreas agenesis, an incidental finding during acute appendicitis diagnosis: a case report

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    Introduction and importance: Dorsal pancreas agenesis is a rare congenital anomaly characterized by the absence or severe underdevelopment of the dorsal pancreatic bud. We report a case of a man who presented with features of appendicitis only to the incidentally discovery of dorsal pancreas agenesis during the diagnosis of acute appendicitis. We describe our experience on radiological diagnostic formulation and work up. Case presentation: We present the case of a 45-year-old male patient who presented to the emergency department with symptoms and signs suggestive of acute appendicitis. A computed tomography scan and laboratory investigations confirmed the diagnosis of appendicitis. Incidentally, the scan also revealed the absence of dorsal pancreatic tissue, leading to the incidental diagnosis of dorsal pancreas agenesis. Clinical discussion: Dorsal pancreas agenesis is often asymptomatic and can be incidentally discovered during imaging studies or surgical interventions for unrelated conditions. In our case, the initial presentation of acute appendicitis provided an opportunity for the fortuitous diagnosis of dorsal pancreas agenesis. This emphasizes the importance of comprehensive imaging reporting in patients who undergo imaging for other conditions. Conclusion: This case report highlights the fortuitous discovery of dorsal pancreas agenesis during the diagnostic workup for acute appendicitis. It emphasizes the need for thorough imaging evaluation and reporting along with the importance of considering anatomical variations in patients presenting with abdominal symptoms. Increased awareness among healthcare professionals about such congenital anomalies can lead to their early recognition and appropriate management

    Dorsal pancreas agenesis, an incidental finding during acute appendicitis diagnosis; A case report

    Get PDF
    Introduction and importance: Dorsal pancreas agenesis is a rare congenital anomaly characterized by the absence or severe underdevelopment of the dorsal pancreatic bud. We report a case of a man who presented with features of appendicitis only to the incidentally discovery of dorsal pancreas agenesis during the diagnosis of acute appendicitis. We describe our experience on radiological diagnostic formulation and work up. Case presentation: We present the case of a 45-year-old male patient who presented to the emergency department with symptoms and signs suggestive of acute appendicitis. A computed tomography scan and laboratory investigations confirmed the diagnosis of appendicitis. Incidentally, the scan also revealed the absence of dorsal pancreatic tissue, leading to the incidental diagnosis of dorsal pancreas agenesis. Clinical discussion: Dorsal pancreas agenesis is often asymptomatic and can be incidentally discovered during imaging studies or surgical interventions for unrelated conditions. In our case, the initial presentation of acute appendicitis provided an opportunity for the fortuitous diagnosis of dorsal pancreas agenesis. This emphasizes the importance of comprehensive imaging reporting in patients who undergo imaging for other conditions. Conclusion: This case report highlights the fortuitous discovery of dorsal pancreas agenesis during the diagnostic workup for acute appendicitis. It emphasizes the need for thorough imaging evaluation and reporting along with the importance of considering anatomical variations in patients presenting with abdominal symptoms. Increased awareness among healthcare professionals about such congenital anomalies can lead to their early recognition and appropriate management

    Author Correction: Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

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