5 research outputs found
Catalytic isomerization of cardanol monoene towards the conjugated cardanol monoene
No full textDe begeleider en/of auteur heeft geen toestemming gegeven tot het openbaar maken van de scriptie.
The supervisor and/or the author did not authorize public publication of the thesis.
Processing Lignocellulosic Feedstock Using Ionic Liquids for Biorefinery Application
No full textThe use of Lignocellulosic residues (LC) such as conventional food crop remains, for Bioenergy and Biorefinery applications is an attractive way to increase feedstock availability without the investment in additional land area. Moreover, it is noteworthy that biomolecules produced from LC, namely second generation (2G), has a potentially better greenhouse gases (GHG) emissions balance. One of the most economically successful lignocellulosic sources is the sugarcane crop, with a global production of about 1.7 gigatonnes in 2019. Although LC is rich in carbohydrates, 40 – 90 wt%, these sugars are not readily converted due to their molecular structure. Consequently, it must be treated, so that LC’s molecular nature is changed into a more convenient arrangement favoring subsequent conversions. Such process is called pretreatment (PT) and is considered the most important step to obtain an efficient conversion of LC’s constituents. Recently, ionic liquids (ILs) have emerged as an alternative technology for biomass pretreatment. ILs can break the H bonds which stabilize LC’s molecular structure, improving components solubility and/or turning LC’s structure more susceptible to further conversions, such as improving the enzymatic digestibility of pretreated solids.Errata for Ph.D. dissertation “Processing Lignocellulosic Feedstock Using Ionic Liquids for Biorefinery Application” by Felipe Augusto Ferrari * Incorrect language used on page ii: The complete and correct institutions name are: - São Paulo Research Foundation (FAPESP) - National Council for Scientific and Technological Development (CNPq) - Coordination for the Improvement of Higher Education Personnel (CAPES) * Missing information on page ii: Where it reads “The project was financed by the Be-Basic Foundation, The Netherlands, and CNPq, CAPES and FAPESP, Brazil” should read “The project was financed by São Paulo Research Foundation (FAPESP, São Paulo, Brazil; grant numbers 2015/50612-8, 2017/24520-4, 2019/19976-4, 2018/20173-0 and 2019/10439-6), National Council for Scientific and Technological Development (CNPq - Brazil), Coordination for the Improvement of Higher Education Personnel (CAPES – Brazil) and by the BE-BASIC Foundation, the Netherlands.”BT/Bioprocess Engineerin
Discovery of 95 PTSD loci provides insight into genetic architecture and neurobiology of trauma and stress-related disorders
Get PDFPosttraumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 novel). Convergent multi-omic approaches identified 43 potential causal genes, broadly classified as neurotransmitter and ion channel synaptic modulators (e.g., GRIA1, GRM8, CACNA1E), developmental, axon guidance, and transcription factors (e.g., FOXP2, EFNA5, DCC), synaptic structure and function genes (e.g., PCLO, NCAM1, PDE4B), and endocrine or immune regulators (e.g., ESR1, TRAF3, TANK). Additional top genes influence stress, immune, fear, and threat-related processes, previously hypothesized to underlie PTSD neurobiology. These findings strengthen our understanding of neurobiological systems relevant to PTSD pathophysiology, while also opening new areas for investigation.Competing Interest StatementL.J.B. is listed as an inventor on Issued U.S. Patent 8,080,371, "Markers for Addiction" covering the use of certain SNPs in determining the diagnosis, prognosis, and treatment of addiction. C.-Y.C. and H.R. are employees of Biogen. A.M.D. holds equity in CorTechs Labs, Inc., and serves on the Scientific Advisory Board of Human Longevity, Inc., and the Mohn Medical Imaging and Visualization Centre; A.M.D. receives funding through research grants with General Electric Healthcare. C.F. was a speaker for Janssen in 2021. I.B.H. is the Co-Director, Health and Policy at the Brain and Mind Centre (BMC) University of Sydney; the BMC operates an early-intervention youth services at Camperdown under contract to headspace. I.B.H. is the Chief Scientific Advisor to, and a 3.2 InnoWell Pty Ltd; InnoWell was formed by the University of Sydney (45 and PwC (Australia; 45 to deliver the $30 M Australian Government-funded Project Synergy. H.H. received consultancy fees from Ono Pharmaceutical and honorarium from Xian Janssen Pharmaceutical. In the past 3 years, R.C.K. was a consultant for Cambridge Health Alliance, Canandaigua VA Medical Center, Holmusk, Partners Healthcare, Inc., RallyPoint Networks, Inc., and Sage Therapeutics. He has stock options in Cerebral Inc., Mirah, PYM, Roga Sciences and Verisense Health. L.A.M.L. reports spousal IP payments from Vanderbilt University for technology licensed to Acadia Pharmaceuticals unrelated to the present work. C.M. has served on advisory boards of Receptor Life Sciences, Otsuka Pharmaceuticals and Roche Products Limited and has received support from National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health, Department of Defense- CDMRP * US Army Research Office * DARPA, Bank of America Foundation, Brockman Foundation, Cohen Veterans Bioscience, Cohen Veterans Network, McCormick Foundation, Home Depot Foundation, New York City Council, New York State Health, Mother Cabrini Foundation, Tilray Pharmaceuticals, and Ananda Scientific. P.M.P. received payment or honoraria for lectures and presentations in educational events for Sandoz, Daiichi Sankyo, Eurofarma, Abbot, Libbs, Instituto Israelita de Pesquisa e Ensino Albert Einstein, Instituto D’Or de Pesquisa e Ensino. R.P. paid for his editorial work on the journal Complex Psychiatry and received a research grant outside the scope of this study from Alkermes. J.W.S. is a member of the Scientific Advisory Board of Sensorium Therapeutics (with equity), and has received grant support from Biogen, Inc.; J.W.S. is PI of a collaborative study of the genetics of depression and bipolar disorder sponsored by 23andMe for which 23andMe provides analysis time as in-kind support but no payments. M.B.S. has in the past 3 years received consulting income from Acadia Pharmaceuticals, Aptinyx, atai Life Sciences, BigHealth, Biogen, Bionomics, BioXcel Therapeutics, Boehringer Ingelheim, Clexio, Eisai, EmpowerPharm, Engrail Therapeutics, Janssen, Jazz Pharmaceuticals, NeuroTrauma Sciences, PureTech Health, Sage Therapeutics, Sumitomo Pharma, and Roche/Genentech. M.B.S. has stock options in Oxeia Biopharmaceuticals and EpiVario. M.B.S. has been paid for his editorial work on Depression and Anxiety (Editor-in-Chief), Biological Psychiatry (Deputy Editor), and UpToDate (Co-Editor-in-Chief for Psychiatry). M.B.S. has also received research support from NIH, Department of Veterans Affairs, and the Department of Defense. M.B.S. is on the scientific advisory board for the Brain and Behavior Research Foundation and the Anxiety and Depression Association of America. In the past 3 years, D.J.S. has received consultancy honoraria from Discovery Vitality, Johnson amp; Johnson, Kanna, L’Oreal, Lundbeck, Orion, Sanofi, Servier, Takeda and Vistagen. MLK reports unpaid membership on the Scientific Committee for the ISSTD.Funding StatementMajor financial support for the PTSD-PGC was provided by the Cohen Veterans Bioscience, Stanley Center for Psychiatric Research at the Broad Institute, and the National Institute of Mental Health (NIMH; R01MH106595, R01MH124847, R01MH124851).Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:IRB of University of California San Diego gave ethical approval for this workI confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).YesI have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.YesSummary statistics for PGC2.5 will be made available upon publication via the PGC (https://pgc.unc.edu/for-researchers/download-results/). Access to study level summary statistics and genotype data can be applied for by using the PGC data access portal (https://pgc.unc.edu/for-researchers/data-access-committee/data-access-portal/). Summary statistics for MVP are available from dbGAP (accession id phs001672.v3.p1) to qualified researchers. EHR dataset summary statistics availability follows the policies of the individual contributing cohorts
Long-range supercurrents through half-metallic ferromagnetic CrO2
Get PDFWe report on measurements of supercurrents through the half-metallic ferromagnet CrO2 grown on hexagonal Al2O3 (sapphire). The current was observed to flow over a distance of 700 nm between two superconducting amorphous Mo70Ge30 electrodes which were deposited on the CrO2 film. The critical current Ic increases as function of decreasing temperature. Upon applying an in-plane magnetic field, Ic goes through a maximum at the rather high field of 80 mT. We believe this to be a long-range proximity effect in the ferromagnet, carried by odd-frequency pairing correlations.Kavli Institute of NanoscienceApplied Science
Efektivitas Aplikasi Daun Pepaya dalam Pengendalian Kutu Tempurung Coccus celatus
Get PDFTanaman daun ungu (Graptophyllum pictum L) adalah tanaman obat yang digunakan sebagai bahan baku jamu saintifik hemoroid. Kendala yang dialami dalam budidaya tanaman daun ungu adalah serangan hama kutu tempurung (Coccus celatus L). Daun pepaya berpotensi untuk digunakan sebagai pestisida nabati. Penelitian ini bertujuan untuk mengetahui pemanfaatan daun pepaya sebagai pestisida nabati untuk mengatasi serangan kutu tempurung pada daun ungu. Percobaan eksperimental laboratoris ini menggunakan metode RAL dengan perlakuan meliputi ekstrak etanol daun pepaya dengan konsentrasi 10 ppm, 100 ppm, 1000 ppm, perasan segar (1:1), air rebusan (1:1), dan akuades. Setiap perlakuan diulang 3 kali. Variabel yang diamati adalah mortalitas kutu tempurung setelah aplikasi perlakuan. Pengamatan dilakukan sebanyak 4 kali dengan interval 3 jam sekali selama 12 jam pengamatan dengan 2 kali penyemprotan pada jam 09.00 dan 12.00 WIB. Data dianalisis dengan analisis ragam taraf 5% dan beda nyata diuji lanjut menggunakan uji Dunnet t(2-sided). Hasil penelitian menunjukkan bahwa penggunaan ekstrak etanol daun pepaya dengan konsentrasi 100 ppm cukup efektif dan efisien untuk mengendalikan kutu tempurung pada tanaman daun ungu
