179 research outputs found
Hikayat Sultan Ibrahim Adham: Perlambangan Ujian Hidup Berpandukan Kalam Tuhan
No full textLink to publisher's homepage at https://penerbit.unimap.edu.my/Sufi atau tasawuf merupakan salah satu wadah penyebaran Islam di Alam Melayu. Berbeza dengan disiplin ilmu fekah yang lebih mementingkan hal-hal berkaitan hukum hakam, tasawuf sebaliknya memberikan tumpuan khusus kepada aspek tazkiyatun nafs (penyucian jiwa). Alam Melayu telah menyaksikan munculnya ramai tokoh tasawuf, disamping turut mencetuskan perdebatan hebat yang masih menjadi perbincangan sehingga ke hari ini. Kesannya, wujud sebahagian masyarakat yang memandang serong terhadap hal-hal berkaitan kesufian. Sebagai sebuah hikayat yang popular dalam tradisi kesusasteraan sufi, Hikayat Sultan Ibrahim Adham telah memancarkan ketinggian akhlak, serta perjalanan salik seorang hamba dalam mencapai cinta Khaliqnya. Sehingga kini, terdapat pelbagai kajian yang telah menyentuh perihal kezuhudan watak utamanya, Sultan Ibrahim Adham. Walau bagaimanapun, penafsiran hikayat tersebut dalam konteks dakwah secara harfiah bakal menimbulkan tanggapan yang negatif, serta salah faham terhadap golongan sufi dalam menanggapi rentetan ujian hidup. Golongan sufi dilihat seolah-olah tidak bertanggungjawab terhadap kehidupan dengan meminggirkan hal-hal berkaitan keduniaan serta kekeluargaan, sehingga ia dilihat tidak lagi relevan dalam kehidupan masyarakat masa kini. Sebagaimana kebanyakan naskhah sufi yang lain, Hikayat Sultan Ibrahim Adham juga memiliki perlambangan yang perlu diterjemahkan dengan lapis makna yang lebih mendalam. Dengan berpandukan pendekatan Al-Quran, makalah ini akan menafsirkan Hikayat Sultan Ibrahim Adham sebagai sebuah perlambangan terhadap tiga bentuk ujian terbesar dalam kehidupan manusia iaitu wanita, zuriat keturunan, serta harta kekayaan. Kesemua ujian tersebut dilihat sentiasa hadir dan berputar sepanjang zaman. Justeru, ianya bakal memperbetulkan salah faham masyarakat, serta mengangkat kembali kedudukan hikayat tersebut sebagai naskhah sufi yang masih relevan untuk dihayati, serta diteladani sehinga ke hari ini
Analysis and optimal planning of nuclear-renewable hybrid energy systems for ships
No full textOcean-going ships are one of the sources of global GHG emissions. Several actions are being taken to reduce the GHG emissions from maritime vessels, and integration of Renewable Energy Sources (RESs) is one of them. Due to some limitations, RESs are not suitable for large ships and often mix with fossil fuel-based generators. Fossil fuel-based generators need to be replaced by emissions-free energy sources to make marine ships free from emissions. Nuclear energy is emissions-free, and small-scale nuclear reactors like Microreactors (MRs) have the potential to replace fossil fuel-based generators. In this study, the technical, economic, and environmental competitiveness of Nuclear-Renewable Hybrid Energy Systems (N-R HES) in marine ships are assessed. The results determine that N-R HES has the lowest NPC compared to the other conventional energy systems. A sensitivity analysis is carried out to see the impact of different system parameters on this study's findings.University of Ontario Institute of Technolog
Antibody and serum bactericidal response to Burkholderia pseudomallei in acute localized and septicemic melioidosis cases with diabetes mellitus
No full textBackground and objectives: Melioidosis, caused by the gram-negative bacillus Burkholderia pseudomallei, is a major cause of fatal community acquired infection in diabetic patients. Protective immune response in human melioidosis is not clearly understood yet. In this study, serum IgM/IgG and bactericidal antibody response to B. pseudomallei were determined in diabetic patients with acute localized abscess and septicemia.
Material and methods: Culture positive melioidosis cases with diabetes mellitus were included in the study. Blood samples were collected from the respective cases in active phase of the disease within 1 or 2 days of being culture positive. Anti- B. pseudomallei IgM and IgG and serum bactericidal antibody were measured by ELISA and microplate based bactericidal assay respectively.
Results: A total of 10 culture positive acute melioidosis cases with diabetes mellitus were included in the study. Out of 10 cases, 5 had abscess in different organs and 5 had septicemia. The mean age of the patients was 48.5 ± 3.91 years and 7 (70%) were male and 3 (30%) were female. The mean anti- B. pseudomallei IgM titer of septicemic and abscess cases were not significantly different (14,080 ± 4,489.13 vs. 19,200 ± 3,620.39; p = 0.4) while the mean IgG titers of two groups were > 204,800. Out of 10 cases, 9 (90%) were positive for serum bactericidal antibody. Mean serum bactericidal antibody titer of septicemia cases (66 ± 26) was not significantly (p = 0.72) different than those of localized infection (80 ± 28.28).
Conclusion: The results indicate that high anti- B. pseudomallei IgM/IgG and serum bactericidal antibodies are induced in diabetic patients with septicemia and suppurative infections. This immune response in diabetics might be important to contain the infection and help in recovery.
January 2025; Vol. 19(1):009. DOI: https://doi.org/10.55010/imcjms.19.009
*Correspondence: Sraboni Mazumder, Department of Microbiology, Ibrahim Medical College, 1/A Ibrahim Sarani, Segunbaghicha, Dhaka, Bangladesh. Email: [email protected];
© 2025 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0)
In-Situ early anomaly detection and remaining useful lifetime prediction for high-power white LEDs with distance and entropy-based long short-term memory recurrent neural networks
No full textHigh-power white light-emitting diodes (LEDs) have demonstrated superior efficiency and reliability compared to traditional white light sources. However, ensuring maximum performance for a prolonged lifetime use presents a significant challenge for manufacturers and end users, especially in safety–critical applications. Thus, identifying functional anomalies and predicting the remaining useful lifetime (RUL) is of enormous importance in the operational longevity of the device. To address such challenges, this study proposes a combination of distance-based Mahalanobis distance (MD), entropy generation rate (EGR), and deep learning models for improved anomaly detection and RUL prediction accuracy. Unlike conventional health indicators based on luminous flux data that are challenging to monitor relevant optical performance, the MD and EGR methods are employed to extract in-situ monitored thermal and electrical data as new health indicators. Long short-term memory recurrent neural networks (LSTM-RNN) and convolutional neural networks (CNN) are established to detect anomalies and predict the RUL. The accelerated degradation tests of 3 W high-power white LED have been conducted, and the online and offline collected experimental data are deployed for model development and performance evaluation. The performance of the proposed methods is compared against the Illuminating Engineering Society of North America (IESNA) TM-21 method. The results indicate that LSTM-RNN, when combined with either MD or EGR, can detect anomalies with significantly fewer data (70 %) than is typically required. Furthermore, a significant improvement in prediction accuracy in RUL prediction based on MD and EGR-constructed time series health indicators and employed with the LSTM-RNN model demonstrates the effectiveness of the proposed methods.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic Components, Technology and Material
Cardio-metabolic risk and morbidity of a cohort in a rural community of Bangladesh
No full textBackground and objectives: Of the ever-increasing non-communicable diseases (NCDs), cardiometabolic morbidity and mortality constitute the major health burden world-wide. Several cross-sectional studies revealed the increasing prevalence of NCDs irrespective of cast, culture, ethnicity, socio-economic growth and geopolitical environment. Recent cross-sectional studies revealed South Asians are the most susceptible to cardiovascular diseases (CVD). Few cohort studies addressed cardiometabolic morbidity and related risks, particularly in the rural population.This study was carried out to find out the prevalence of metabolic syndrome (MetSyn) and its changes overtime in a rural cohort of Bangladesh.
Methods: The study used baseline data of a study conducted in 2011- 2013 on prevalence of coronary artery disease among a cohort living in 16 villages. During 2021-2023, the baseline data collected in 2011-2013 were retrieved and the participants were searched and categorized into a) physically present, b) died and c) missing. Those who were present were requested to volunteer for re-investigations. Briefly the investigations included interviewing on social, family, personal and clinical history, anthropometry, blood pressure measurement, blood biochemistry and electrocardiography (ECG).
Results: A total of 3928 people participated in baseline study of 2011- 2013. Of them, 1075 could be tracked by village and household. Of them, 953 were found alive. Of the 953 available participants, 651 (254 men and 397 women) volunteered to participate in 2021-2023 study. Compared to 2011-2013 baseline, the prevalence of MetSyn and type 2 diabetes mellitus (T2DM) increased to 31.6% and 5.2% from 7.5% and 0.8% respectively in 2021-2023. Similarly, compared to baseline, the prevalence of obesity and hypertension also showed significant increase overtime. Estimated incidence of MetSyn was 260.8 per 1000 population, which was more profound in women than men (W: M= 300.3:200.8).
Conclusions: The study revealed a significant increase of obesity, hypertension, diabetes and metabolic syndrome within a decade indicating an emerging health burden among the rural people of Bangladesh.
January 2025; Vol. 19(1):003. DOI:https://doi.org/10.55010/imcjms.19.003
*Correspondence: MA Sayeed, Department of Community Medicine, Ibrahim Medical College, 1/A Ibrahim Sarani, Segunbagicha, Dhaka 1000, Bangladesh. Email: [email protected];
© 2025 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License(CC BY 4.0)
Correction to: Nexus between vulnerability and adaptive capacity of drought-prone rural households in northern Bangladesh
No full textThe article was published with a spelling error in one of the co-author names. The correct spelling is reflected in this correction and the original work has been updated to reflect the correct spelling of the name as Md. Morshadul Hasan. The original article has been corrected
In silico designing of thermostabe β-Glucuronidase (GUS)
No full textThis research has used Molecular Dynamics (MD) techniquess as an in silico method of correlating the experimental studies done on GUS enzyme with computational study and has analyzed and identified the structural factors responsible for thermostability of this enzyme. GUS from E. coli is heat labile and inhibited by detergents and products, which hinder its usefulness as a reporter molecules in genetic
engineering. Therefore a more thermostable GUS enzyme needs to be designed for industrial applications. Using homology modeling, structures of mesophilic and thermophilic GUS enzymes from E. coli and T. maritima have been constructed based on the crystal structure of human GUS enzyme. MD
simulations of these mesophilic and thermophilic GUS enzymes at temperatures of 300 K and 353 K in vacuum and implicit solvent have provided information on thermolabile regions in the enzymatic structure to be targeted for thermal stability. The RMS deviation of backbone atoms and helical residues from their initial coordinates was analysed for the resulting simulation trajectories. A higher number of charged residues found in the thermostable GUS were found to be responsible for stability of the helices compared to mesophilic GUS. From analysis of salt bridges, the presence of higher number of Glu-Arg and Glu-Lys salt bridge pairs were found to be responsible for be responsible for thermostability of T.maritima GUS The thermolabile residues 150-155 in wild type E. coli GUS structures were identified, and have been suggested as mutation points for experimental studies to improve thermostability. These residues have not been identified before, and are suggested to be replaced with Ala, Arg, Glu, and Lys. The choice of Ala and Arg are supported by previous experimental mutations in other regions of GUS and
have resulted in thermostable GUS enzymes
Spectrum of thyroid disorders among patients with type 2 diabetes mellitus
No full textBackground and objectives: Thyroid disorders (TD) are common among patients with type 2 diabetes mellitus (T2DM). Information on types of functional and structural TDs among Bangladeshi patients with T2DM is scarce in the literature. The present study aimed to determine the magnitude and characteristics of different TDs among Bangladeshi diabetic patients attending an urban healthcare center in Dhaka.
Material and methods: The study included patients with T2DM who attended an urban Endocrinology Outpatient consultation center in Dhaka over a period of two years. Diagnosis of TDs was based either on previous medical records or on investigational results of thyroid functions/gland during the first visit. Standard criteria were used to diagnose TDs.
Results: Total 1424 patients with T2DM were enrolled in the study. The mean age of the study population was 48.8 ± 12.9 years and 45.2% and 54.8% were male and female respectively. Among 1424 participants 217 (15.2%) had functional and/or structural abnormalities of thyroid gland. For those with abnormal thyroid function (14.3%), the most common was clinical hypothyroidism (10.5%), followed by subclinical hypothyroidism (2.6%), and clinical thyrotoxicosis (1.3%). Except for one, all patients with overt hypothyroidism had primary hypothyroidism. Among patients with overt thyrotoxicosis, Graves’ disease was the most common entity (50%). Multinodular goiter was the most frequent diagnosis among structural abnormalities (7 out of 13). Female sex (OR: 3.0, 95%CI: 1.5, 6.1, p=0.003) and obesity (OR: 2.3, 95%CI: 1.1, 5.0, p=0.039) had higher odds of having a diagnosis of overt hypothyroidism among patients with T2DM. Hypertension, dyslipidemia and obesity were significantly (p < 0.05) higher in diabetic patients with overt hypothyroidism.
Conclusion: TDs especially hypothyroidism are common among female Bangladeshi patients with T2DM. Dyslipidemia and obesity are significantly more in overt hypothyroidism among patients with T2DM.
January 2025; Vol. 19(1):008. DOI: https://doi.org/10.55010/imcjms.19.008
*Correspondence: Md Rakibul Hasan, Department of Endocrinology, Medical College for Women and Hospital, Uttara, Dhaka 1230, Bangladesh. Email: [email protected];
© 2025 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License(CC BY 4.0)
SuperNatural inhibitors to reverse multidrug resistance emerged by ABCB1 transporter: Database mining, lipid-mediated molecular dynamics, and pharmacokinetics study
No full textCopyright: © 2023 Ibrahim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. cc-byAn effective approach to reverse multidrug resistance (MDR) is P-glycoprotein (P-gp, ABCB1) transport inhibition. To identify such molecular regulators, the SuperNatural II database, which comprises > 326,000 compounds, was virtually screened for ABCB1 transporter inhibitors. The Lipinski rule was utilized to initially screen the SuperNatural II database, identifying 128,126 compounds. Those natural compounds were docked against the ABCB1 transporter, and those with docking scores less than zosuquidar (ZQU) inhibitor were subjected to molecular dynamics (MD) simulations. Based on MM-GBA binding energy (ΔGbinding) estimations, UMHSN00009999 and UMHSN00097206 demonstrated ΔGbinding values of –68.3 and –64.1 kcal/mol, respectively, compared to ZQU with a ΔGbinding value of –49.8 kcal/mol. For an investigation of stability, structural and energetic analyses for UMHSN00009999- and UMHSN00097206-ABCB1 complexes were performed and proved the high steadiness of these complexes throughout 100 ns MD simulations. Pharmacokinetic properties of the identified compounds were also predicted. To mimic the physiological conditions, MD simulations in POPC membrane surroundings were applied to the UMHSN00009999- and UMHSN00097206-ABCB1 complexes. These results demonstrated that UMHSN00009999 and UMHSN00097206 are promising ABCB1 inhibitors for reversing MDR in cancer and warrant additional in-vitro/in-vivo studies
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