450 research outputs found
A genome-wide search replicates evidence of a quantitative trait locus for circulating angiotensisn l-converting enzyme (ACE) unlinked to the ACE gene
No full textBackground: angiotensin I-converting enzyme (ACE) plays an important role in cardiovascular homeostasis. There is evidence from different ethnic groups that circulating ACE levels are influenced by a quantitative trait locus (QTL) at the ACE gene on chromosome 17. The finding of significant residual familial correlations in different ethnic groups, after accounting for this QTL, and the finding of support for linkage to a locus on chromosome 4 in Mexican-American families strongly suggest that there may well be QTLs for ACE unlinked to the ACE gene.Methods: a genome-wide panel of microsatellite markers, and a panel of biallelic polymorphisms in the ACE gene were typed in Nigerian families. Single locus models with fixed parameters were used to test for linkage to circulating ACE with and without adjustment for the effects of the ACE gene polymorphisms.Results: strong evidence was found for D17S2193 (Zmax = 3.5); other nearby markers on chromosome 17 also showed modest support. After adjustment for the effects of the ACE gene locus, evidence of "suggestive linkage" to circulating ACE was found for D4S1629 (Zmax = 2.2); this marker is very close to a locus previously shown to be linked to circulating ACE levels in Mexican-American families.Conclusion: in this report we have provided further support for the notion that there are QTLs for ACE unlinked to the ACE gene; our findings for chromosome 4, which appear to replicate the findings of a previous independent study, should be considered strong grounds for a more detailed examination of this region in the search for genes/variants which influence ACE levels.
The poor yields, thus far, in defining the genetic determinants of hypertension risk suggest a need to look beyond simple relationships between genotypes and the ultimate phenotype. In addition to incorporating information on important environmental exposures, a better understanding of the factors which influence the building blocks of the blood pressure homeostatic network is also required. Detailed studies of the genetic determinants of ACE, an important component of the renin-angiotensin system, have the potential to contribute to this strategic objectiv
sj-docx-1-cpc-10.1177_10556656211036316 - Supplemental material for Genome-Wide Scan for Parent-of-Origin Effects in a sub-Saharan African Cohort With Nonsyndromic Cleft Lip and/or Cleft Palate (CL/P)
No full textSupplemental material, sj-docx-1-cpc-10.1177_10556656211036316 for Genome-Wide Scan for Parent-of-Origin Effects in a sub-Saharan African Cohort With Nonsyndromic Cleft Lip and/or Cleft Palate (CL/P) by Lord J. J. Gowans, Carissa L. Comnick, Peter A. Mossey, Mekonen A. Eshete, Wasiu L. Adeyemo, Thirona Naicker, Waheed A. Awotoye, Aline Petrin, Chinyere Adeleke, Peter Donkor, Tamara D. Busch, Olutayo James, Mobolanle O. Ogunlewe, Mary Li, Joy Olotu, Mohaned Hassan, Oluwole A. Adeniyan, Solomon Obiri-Yeboah, Fareed K. N. Arthur, Pius Agbenorku, Alexander A. Oti, Olubukola Olatosi, Olawale O. Adamson, Azeez A. Fashina, Erliang Zeng, Mary L. Marazita, Adebowale A. Adeyemo, Jeffrey C. Murray and Azeez Butali in The Cleft Palate-Craniofacial Journal</p
sj-docx-2-cpc-10.1177_10556656211036316 - Supplemental material for Genome-Wide Scan for Parent-of-Origin Effects in a sub-Saharan African Cohort With Nonsyndromic Cleft Lip and/or Cleft Palate (CL/P)
No full textSupplemental material, sj-docx-2-cpc-10.1177_10556656211036316 for Genome-Wide Scan for Parent-of-Origin Effects in a sub-Saharan African Cohort With Nonsyndromic Cleft Lip and/or Cleft Palate (CL/P) by Lord J. J. Gowans, Carissa L. Comnick, Peter A. Mossey, Mekonen A. Eshete, Wasiu L. Adeyemo, Thirona Naicker, Waheed A. Awotoye, Aline Petrin, Chinyere Adeleke, Peter Donkor, Tamara D. Busch, Olutayo James, Mobolanle O. Ogunlewe, Mary Li, Joy Olotu, Mohaned Hassan, Oluwole A. Adeniyan, Solomon Obiri-Yeboah, Fareed K. N. Arthur, Pius Agbenorku, Alexander A. Oti, Olubukola Olatosi, Olawale O. Adamson, Azeez A. Fashina, Erliang Zeng, Mary L. Marazita, Adebowale A. Adeyemo, Jeffrey C. Murray and Azeez Butali in The Cleft Palate-Craniofacial Journal</p
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The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
No full textGenome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape
Oriki Ogun (Praise of the God of Iron) by Mayowa Adeyemo
No full textLagos State University music student, Mayowa Adeyemo, praises Ogun (Yoruba Orisha/God of Iron). Recorded on July 26, 2013 at Peter King College of Music near Badagry, Lagos State. Keywords: African History; African Languages and Societies; Critical and Cultural Studies; Dance; Digital Humanities; Ethnic Studies; Ethnomusicology; Folklore; Gender, Race, Sexuality, and Ethnicity in Communication; Linguistic Anthropology; Oral History; Performance Studies; Poetry; Race and Ethnicity; Social and Cultural Anthropology; Sociology of Culture
An evangelical voice in Africa: the worldview background of the theology of Tokunboh Adeyemo (1 October 1944-17 March 2010)
No full textAfrica was blessed with a son of the calibre of Dr Tokunboh Adeyemo. Since he only recently passed away, we do not yet have (as far as the author is aware) an assessment of the legacy of this eminent Christian leader. This article is the first preliminary evaluation written from a reformational worldview perspective.
The set-up of the investigation is as follows: Firstly, a brief out- line is given of his life history, especially his training in the Evangelical tradition. Then, the décor (the overall situation of African Christianity) that was the background against which he lived and worked is painted. Thirdly, it is followed by the strengths and weaknesses of Evangelical Christianity of which Adeyemo was a representative. Fourthly, it is indicated how Adeyemo thought in line with post-Lausanne Evangelicalism. In the fifth place a preliminary worldview evaluation of his legacy is given. To assist possible future research a bibliography of his most important publications concludes the investigation
sj-docx-1-cpc-10.1177_10556656221135926 - Supplemental material for Damaging Mutations in <b><i>AFDN</i></b> Contribute to Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate
No full textSupplemental material, sj-docx-1-cpc-10.1177_10556656221135926 for Damaging Mutations in AFDN Contribute
to Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate by Waheed Awotoye, Peter A Mossey, Jacqueline B Hetmanski, Lord J J Gowans, Mekonen A Eshete and
Wasiu L Adeyemo, Azeez Alade, Erliang Zeng, Olawale Adamson, Olutayo James,
Azeez Fashina, Modupe O Ogunlewe,
Thirona Naicker, Chinyere Adeleke, Tamara Busch,
Mary Li, Aline Petrin, Abimbola Oladayo, Sami Kayali, Joy Olotu, Veronica Sule, Mohaned Hassan, John Pape, Emmanuel T Aladenika, Peter Donkor, Fareed K N Arthur, Solomon Obiri-Yeboah, Daniel K Sabbah, Pius Agbenorku, Debashree Ray,
Gyikua Plange-Rhule, Alexander Acheampong Oti,
Daniah Albokhari, Nara Sobreira, Martine Dunnwald, Terri H Beaty, Margaret Taub, Mary L Marazita,
Adebowale A Adeyemo, Jeffrey C Murray, Azeez Butali in The Cleft Palate-Craniofacial Journal</p
Time Index: Oriki Ogun (Praise of the God of Iron) by Mayowa Adeyemo
No full textThis file is the time index for " Oriki Ogun (Praise of the God of Iron) by Mayowa Adeyemo
The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study
No full textCorrected by Erratum: Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study, in PLoS Genetics,12(6):e1006166. The arcOGEN Consortium should be listed as an author of this article.Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.Thomas W. Winkler ... Lyle J Palmer ... CHARGE Consortium, DIAGRAM Consortium, GLGC Consortium, Global-BPGen Consortium, ICBP Consortium, MAGIC Consortium ... et al
A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus
No full textAbstract Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with variable clinical presentation frequently affecting the skin, joints, haemopoietic system, kidneys, lungs and central nervous system. It can be life threatening when major organs are involved. The full pathological and genetic mechanisms of this complex disease are yet to be elucidated; although roles have been described for environmental triggers such as sunlight, drugs and chemicals, and infectious agents. Cellular processes such as inefficient clearing of apoptotic DNA fragments and generation of autoantibodies have been implicated in disease progression. A diverse array of disease-associated genes and microRNA regulatory molecules that are dysregulated through polymorphism and copy number variation have also been identified; and an effect of ethnicity on susceptibility has been described.</p
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