1,720,972 research outputs found
A. Addobbati, R. Bizzocchi, G. Salinero (a cura di). 2012. L’Italia dei cognomi. L’antroponimia italiana nel quadro mediterraneo
No full textRossebastiano Bart Alda. A. Addobbati, R. Bizzocchi, G. Salinero (a cura di). 2012. L’Italia dei cognomi. L’antroponimia italiana nel quadro mediterraneo. In: Nouvelle revue d'onomastique, n°55, 2013. pp. 322-339
"Il costume di esservi famiglie senza cognome". Il caso dell'Abruzzo teramano nella prima metà dell'Ottocento.
No full textIn 1834 tha Provincial Council of Teramo lays bare the existence of many individuals lacking a surname within the province. However, the Borbonic Ministers of Naples did not consider this problem to be a serious matter due to the fact that lacking surnames implied also missing requirements attached to the absence of ownership, property and family rights likewise.[...
Nutlin-3 differentially modulates miRNA34a and miRNA181 versus miR26a and miR155 in p53 proficient and p53 deficient B chronic lymphocytic leukemia (B-CLL) samples
No full textThe small molecule inhibitor of the MDM2/p53 interaction Nutlin-3 is a promising anti-cancer agent, which exhibits activity against a variety of cancers, including acute myeloid leukemia (AML). Previous studies have shown that Nutlin-3 variably induces apoptosis and cell cycle arrest in cancer cells while it shows low/absent cytotoxicity in normal cells. However, the reason for the selective pro-apoptotic activity in cancer cells with respect to normal counterparts is incompletely understood. In this study, we have compared the induction of several known target genes of p53 in two p53wild-type AML cell lines, OCI-AML3 and MOLM, in comparison with primary normal peripheral blood mononuclear cells (PBMC). Among several p53-target genes activated both in AML cell lines and normal PBMC (BBC3, BAX, MDM2, FAS, CDKN1A, GDF15, GADD45A, TNFRSF10B, TP53I3/PIG3), only TP53I3/PIG3 was selectively activated in MOLM and OCI-AML3, but not in PBMC. The important role of TP53I3/PIG3 in mediating the apoptotic activity of Nutlin-3 was underlined by knock-down experiments with siRNA specific for TP53I3/PIG3, which resulted in a significant decrease in the pro-apoptotic activity of Nutlin-3
La distribuzione dei cognomi come strumento per l'analisi sociale: l'esempio della docenza universitaria
No full textDenominarsi e distinguersi nella montagna bergamasca. I cognomi di Castione della Presolana dal XIII al XVI secolo
No full textPresence of CTAK/CCL27, MCP-3/CCL7 and LIF in human colostrum and breast milk
No full textHuman colostrum and breast milk are known to contain high levels of cytokines and chemokines, which are thought to contribute to the development of the newborn. The aim of this study was to investigate the difference in the presence and levels of 21 soluble cytokines and chemokines in paired samples of human colostrum (day 2 after delivery) and breast milk (day 4-5 after delivery) by using the multiplex technology. Of the 21 cytokine investigated in 10 pairs of samples, only β-NGF was absent in both colostrum and milk, while INF-α2, SCF and TNF-β were present in colostrum but not in human milk. As a general rule, colostrum contained higher concentrations of cytokines and chemokines with respect to breast milk. The majority of cytokines, detected in colostrum alone or in colostrum and human milk (IL-1α, IL-2Rα, IL-3, IL-16, IL-18, GRO-α, HGF, IFN-α2, M-CSF, MIF, MIG, TNF-β, SDF-1α, TRAIL) have been described in previous studies, while for the first time we describe the presence of additional cytokines either in colostrum alone (SCF) or in both colostrum and breast milk (CTAK/CCL27, MCP-3/CCL7, LIF). Our data confirm and expand previous studies showing that some cytokines/chemokines, which might contribute to the development of the gastro-intestinal and nervous systems, are overexpressed in human colostrum and breast milk, and might contribute to the development of these system
Il cognome nei registri parrocchiali pre-tridentini dell’Italia settentrionale e gli effetti del Concilio di Trento
No full textIl contributo ricostruisce la diffusione, l'origine e le modalità di stabilizzazione del cognome in Italia settentrionale. Particolare attenzione è prestata al sedicesimo secolo e al ruolo svolto dalla normativa introdotta dal Concilio di Trento nel favorire la stabilizzazione e standardizzazione dei cognom
Un progetto di analisi statistica dei dati genealogici relativi a Montecarlo di Lucca in eta' moderna
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