614 research outputs found
Effects of ethylenediamine – a putative GABA-releasing agent – on rat hippocampal slices and neocortical activity in vivo
No full textThe simple diamine diaminoethane (ethylenediamine, EDA) has been shown to activate GABA receptors in the central and peripheral nervous systems, partly by a direct action and partly by releasing endogenous GABA. These effects have been shown to be produced by the complexation of EDA with bicarbonate to form a carbamate. The present work has compared EDA, GABA and [beta]-alanine responses in rat CA1 neurons using extracellular and intracellular recordings, as well as neocortical evoked potentials in vivo. Superfusion of GABA onto hippocampal slices produced depolarisation and a decrease of field epsps, both effects fading rapidly, but showing sensitivity to blockade by bicuculline. EDA produced an initial hyperpolarisation and increase of extracellular field epsp size with no fade and only partial sensitivity to bicuculline, with subsequent depolarisation, while [beta]-alanine produces a much larger underlying hyperpolarisation and increase in fepsps, followed by depolarisation and inhibition of fepsps. The responses to [beta]-alanine, but not GABA or EDA, were blocked by strychnine. In vivo experiments, recording somatosensory evoked potentials, confirmed that EDA produced an initial increase followed by depression, and that this effect was not fully blocked by bicuculline. Overall the results indicate that EDA has actions in addition to the activation of GABA receptors. These actions are not attributable to activation of [beta]-alanine-sensitive glycine receptors, but may involve the activation of sites sensitive to adipic acid, which is structurally equivalent to the dicarbamate of EDA. The results emphasise the complex pharmacology of simple amines in bicarbonate-containing solution
O specyfice języka J.I. Kraszewskiego w rękopisie zawierającym tłumaczenie Boskiej Komedii Dantego
No full textThe author analyses a translation of Dante’s Divine Comedy by J.I. Kraszewsk
On a study of the language of J.I. Kraszewski's epistolary output : two more letters not recorded in 'Nowy Korbut'
No full textConsiderations in the paper are focused on two questions: 1. the state of a study on language of ample mail of the most prolific Polish writer, J.I. Kraszewski; 2. description of two letters of the writer not recorded in 'Nowy Korbut' and being in possession of the Main Library of Świętokrzyska Academy in Kielce.
Estimating the state of a study on language of J.I. Kraszewski’s epistolary output the author presents the beginnings of her interest in the language of letters and novels by the writer, achievements in a study of elements of the borderland Polish testified in the writer’s mail and in linguo-slylistic analyses of manuscripts of the writer’s letters (by M. Olma). The author writes also about difficulties that researchers of Kraszewski’s manuscripts face and about their responsibility for results of a study.
The second part of the paper contains complete characterization of two letters mentioned above The author reads both manuscripts, edits them protecting their original spelling and punctuation, determines the date of the letter written in Żytomierz (in the year 1858), informs who its addressees were, and finally characterizes the handwriting, spelling and phonetics of the described texts
The serine protease subtilisin suppresses epileptiform activity in rat hippocampal slices and neocortex in vivo
No full textSerine proteases of the S8A family and those belonging to the subtilase group generate a long-lasting inhibition of hippocampal evoked potentials, which shows little recovery and resembles long-term depression. The present work investigates the effects of subtilisin A on epileptiform activity induced in hippocampal slices. Interictal bursts were generated by perfusion with 4-aminopyridine in magnesium-free medium, whereas ictal bursts were produced by the addition of baclofen. Subtilisin A superfused for 10 min at concentrations of 50 nM and above reduced the duration of ictal bursts, whereas higher concentrations reduced the frequency of interictal activity with little or no recovery, indicating similarity with the long-term depression reported previously. The anti-epileptiform activity was not prevented by inhibitors of phosphatases or several kinases, but the inhibition of ictal activity was selectively reduced by the tyrosine kinase inhibitor genistein. The rho-activated coiled-coil kinase (ROCK) inhibitor Y-27632 had no effect on the suppression of ictal or interictal bursts. Subtilisin applied at nanomolar concentrations to the surface of the cerebral cortex in vivo also suppressed epileptiform spikes induced by bicuculline. It is concluded that serine proteases of the subtilase group are highly potent inhibitors of epileptiform activity, especially ictal bursts, and that tyrosine kinases may be involved in that inhibition. The mechanism of inhibition is different from the long-lasting depression of evoked potentials, which is partly mediated via ROCK
Interview with Jens Zimmermann: Author of ‘Hermeneutics: A Very Short Introduction’
No full textDr. Jens Zimmermann is a German-Canadian philosopher and J.I. Packer Professor of Theology at Regent College. As the author of Hermeneutics: A Very Short Introduction, he held a lecture titled “Gadamer, Ricoeur and the Future of Philosophical Hermeneutics” at SFU. Hosted by the Department of World Languages and Literatures, the lecture focused on how we can use the art of hermeneutics to interpret literature and our identities of being human
Acts of the 19th century politeness etiquette (on the base of J.I. Kraszewski's letters to Wł. Chodźkiewicz)
No full textThe paper deals with the issue from the field of speech act theory including a study of a collection of about 220
private letters dating from the latter part of the 19th century. Several speech acts like greetings, farewells,
thanks, apologies, and wishes were arranged to show differentiation of their illocutionary power as well as
different character of the studied text types. It was also described how the author of the letters (J.I.
Kraszewski) had been using particular traditional expressions of great antiquity giving them not commonplace form
if necessary. The relations between types of the analyzed texts and localization of acts of politeness etiquette
was also considered. The aim of such politeness acts is to inform about positive emotions that the sender of
these expressions feels to the receiver of them.
Conventionalisms having been prevalent in the 19th century were considered from the perspective of their primary
function of constant creation and maintaining special politeness atmosphere of relations between people
Interactions of glutamate receptor agonists with long-term potentiation in the rat hippocampal slice
No full textHunting Party
No full textPhotograph - A group of men with guns on the shore in front of a boat. Athabasca, Alberta. Left to right: Charles Nancekivell, Mr. A.C. McKay, Chinese cook, J.I. Case (bank manager), unknown (seated), Frank Falconer, unknow
Kansen voor warmte- en koudewinning uit drinkwater
No full textDoor te verwarmen en te koelen met drinkwaterhoeven we minder aardgas te verstoken en kunnen weklimaatverandering beperken. Maar is dat drinkwaterdaarna nog wel goed voor onze gezondheid? Bij de TUDelft en Waternet zochten ze het uit.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Sanitary Engineerin
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