8,416 research outputs found
Tim Adams for Maryland Comptroller IHP Candidate Interview
No full textSunil Dasgupta speaks to Tim Adams, mayor of the City of Bowie, in Maryland. Adams is a businessman who built a large federal contracting firm starting out from the trunk of his car and continued to lead and grow his business even after he became wheelchair-bound almost two decades ago following a spinal cord injury. In his race to be comptroller of Maryland, Adams lent his campaign $1.8 million to draw abreast in fundraising with his Democratic primary opponent Delegate Brooke Lierman.https://open.spotify.com/episode/4N7K9LVYhqms4DT6xPede
Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection.
No full textThe S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation. We investigated whether galectin-9/Tim-3 interactions contribute to the deletion and exhaustion of the antiviral T cell response in chronic hepatitis B virus infection (CHB). We found Tim-3 to be expressed on a higher percentage of CD4 and CD8 T cells from patients with CHB than healthy controls (p<0.0001) and to be enriched on activated T cells and those infiltrating the HBV-infected liver. Direct ex vivo examination of virus-specific CD8 T cells binding HLA-A2/peptide multimers revealed that Tim-3 was more highly upregulated on HBV-specific CD8 T cells than CMV-specific CD8 T cells or the global CD8 T cell population in patients with CHB (p<0.001) or than on HBV-specific CD8 after resolution of infection. T cells expressing Tim-3 had an impaired ability to produce IFN-γ and TNF-α upon recognition of HBV-peptides and were susceptible to galectin-9-triggered cell death in vitro. Galectin-9 was detectable at increased concentrations in the sera of patients with active CHB-related liver inflammation (p = 0.02) and was strongly expressed by Kupffer cells within the liver sinusoidal network. Tim-3 blockade resulted in enhanced expansion of HBV-specific CD8 T cells able to produce cytokines and mediate cytotoxicity in vitro. Blocking PD-1 in combination with Tim-3 enhanced the number of patients from whom functional antiviral responses could be recovered and/or the strength of responses, indicating that these co-inhibitory molecules play a non-redundant role in driving T cell exhaustion in CHB. Patients taking antivirals able to potently suppress HBV viraemia continued to express Tim-3 on their T cells and respond to Tim-3 blockade. In summary, both Tim-3 and galectin-9 are increased in CHB and may contribute to the inhibition and deletion of T cells as they infiltrate the HBV-infected liver
Promising practices and core(al) innovation [video]
No full textPlenary Keynote Presentation VII. Cameo performance by Tim Sharp with Innismara Vocal Ensemble. Introduction: Ki Adams (Memorial University or Newfoundland, Canada)
Memo from Bill Adams: 1997-09-29
No full textMemo from Bill Adams to Mayor William Card, Tim Gilles, Marion Lawler, Ben McKibbens, David Altman, and Shirley Clowers regarding brief report on the Regional Academic Health Center (RAHC) meeting.https://scholarworks.utrgv.edu/hcard/1144/thumbnail.jp
Tim Daniel Interview
No full textMaj. Tim Daniel has served with the U.S. Air Force from January of 1983 to the present, as an A-10 Pilot, T-37 Instructor Pilot, an OA-10 Pilot and has 3500 hours of flight time with 100 hours of combat time in Iraq and Afghanistan
Do dolphins benefit from nonlinear mathematics when processing their sonar returns?
No full textAn interview with author Tim Leighton about the paper
Opportunities for linking young surveyors across professional surveying member organisations and FIG
No full textTim Di Muzio on 'Sabotage'
No full textIn a series of essays published in 2013 and 2014 on capitaspower.com, political economist Tim Di Muzio explored the concept of ‘sabotage’ as it applies to capitalist power. I recently rediscovered these essays and was so impressed by them that I have reposted them here as a single piece.
About the author: Tim Di Muzio is a researcher at the University of Wollongong. He is the author of numerous books, including Debt as power, Carbon capitalism, and The 1% and the Rest of us
1996-1997 Tim Gautreaux
No full textTim Gautreaux is the author of three novels and two earlier short story collections. His work has appeared in The New Yorker, The Best American Short Stories, The Atlantic, Harper’s, and GQ. After teaching for thirty years at Southeastern Louisiana University, he now lives, with his wife, in Chattanooga, Tennessee. (Photo credit: Randy Bergeron)https://egrove.olemiss.edu/grisham_res/1023/thumbnail.jp
First person - Tim Petzold
No full textFirst Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping researchers promote themselves alongside their papers. Tim Petzold is first author on ‘ Connexin 41.8 governs timely haematopoietic stem and progenitor cell specification’, published in BiO. Tim conducted the research described in this article while a PhD student in Julien Bertrand's lab at the Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland. He is now a postdoc in the lab of Holger Gerhardt at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, investigating developmental biology – previously his focus was on how blood stem cells develop and now it has shifted to how the vascular system develops
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