1,641 research outputs found
The phosphoinositide-associated protein Rush hour regulates endosomal trafficking in<i>Drosophila</i>
No full textEndocytosis regulates multiple cellular processes, including the protein composition of the plasma membrane, intercellular signaling, and cell polarity. We have identified the highly conserved protein Rush hour (Rush) and show that it participates in the regulation of endocytosis. Rush localizes to endosomes via direct binding of its FYVE (Fab1p, YOTB, Vac1p, EEA1) domain to phosphatidylinositol 3-phosphate. Rush also directly binds to Rab GDP dissociation inhibitor (Gdi), which is involved in the activation of Rab proteins. Homozygous rush mutant flies are viable but show genetic interactions with mutations in Gdi, Rab5, hrs, and carnation, the fly homologue of Vps33. Overexpression of Rush disrupts progression of endocytosed cargo and increases late endosome size. Lysosomal marker staining is decreased in Rush-overexpressing cells, pointing to a defect in the transition between late endosomes and lysosomes. Rush also causes formation of endosome clusters, possibly by affecting fusion of endosomes via an interaction with the class C Vps/homotypic fusion and vacuole protein-sorting (HOPS) complex. These results indicate that Rush controls trafficking from early to late endosomes and from late endosomes to lysosomes by modulating the activity of Rab proteins.</jats:p
Adam M. Duncan, Utah Uranium Oral History Project
No full textTranscript (32 pages) of an interview by Mitch Haddard with Adam Duncan, on August 4, 1970. From tape number 131 in the Uranium Oral History ProjectDuncan, an attorney, was interviewed by Mitch Haddad in Salt Lake City. Subjects: uranium mining industry securities, penny stocks and uranium company shells, types of mining claims, the Gillette, Wyoming "new gold rush," multi-use of federal lands, Charlie Steen, Milton Love (SEC Commissioner), Canyonlands, typical prospector, Stella Dysart, government subsidies, shell game, gambling (32 pages)
Theatrical cannibalism (3MT - May 2015)
No full textAdam Rush Three Minute Thesis Competition (3MT) - 2015 EntryUniversity of Lincoln WINNER (Judge's and People's Choice)National Semi-Finalisthttps://www.youtube.com/watch?v=TFJsQDtOJRIMusical theatre is an inherent part of popular culture. From annual television viewings of The Sound of Music to dancing in the aisles at Mamma Mia!, musicals are indisputably popular across the globe. As the twenty-first century steps into full swing, musical theatre seems persistent in cannibalising popular culture in a way previously unthinkable. In referencing blockbuster movies, popular music, television shows, current events or the latest YouTube trend, musicals regurgitate popular culture live on stage; an epidemic, as many cynical critics have described, which continues to perpetuate musical theatre’s central position within popular culture.http://graduateschool.blogs.lincoln.ac.uk/2015/05/15/three-minute-thesis-final/https://www.vitae.ac.uk/events/three-minute-thesis-competition/copy_of_uk-3mt-semi-finalists-2015</p
Musical Theatre Histories:Expanding the Narrative
No full textMusical theatre is often perceived as either a Broadway based art form, or as having separate histories in London and New York. Musical Theatre Histories: Expanding the Narrative, however, depicts the musical as neither American nor British, but both and more, having grown out of frequent and substantial interactions between both centres (and beyond). Through multiple thematic 'histories', Millie Taylor and Adam Rush take readers on a series of journeys that include the art form's European and American origins, African American influences, negotiations arounddiversity, national identity, and the globalisation of the form, as well as revival culture, censorship and the place of social media in the 21st century.Each chapter includes case studies and key concept boxes to identify, explain and contextualise important discussions, offering an accessible study of a dynamic and ever evolving medium. Written and developed for undergraduate students, this introductory textbook provides a newly focused and alternative way of understanding musical theatre history
An inaugural dissertation on opium. Submitted to the examination of John Ewing, S.T.P. provost; and to the trustees and medical professors of the University of Pennsylvania; for the degree of Doctor of Medicine: on the second day of May, A.D. 1792. / By Valentine Seaman, of New-York.
No full text32 p. ; 19 cm. (8vo)Dedicated to Adam Kuhn, Benjamin Rush, and the thirteen commissioners of the alms-house in New York
Informal gold mining and mercury pollution in Brazil
No full textThe Amazon region has been responsible for a major share of Brazilian gold production in recent years. The region has witnessed a sizable gold rush comparable only to the California gold rush last century. The gold rush has spawned a powerful informal mining sector and has attracted many people - some who have come to the region in search of wealth and some who were already there but were displaced from other, unsuccessful economicactivities. What these people encounter at the mining sites are dreadful living and working conditions. Gold mining also causes substantial environmental problems, which may persist whether gold deposits do or not. The author discusses the environmental effects of gold mining in the region, focusing on mercury pollution. Mercury, an important input in gold extraction, is being discharged into the atmosphere and the rivers at alarming rates. The environmental costs of the present extraction, is being discharged into the atmosphere and the rivers at alarming rates. The environmental costs of the present extraction technology will be faced primarily by future generations, because of natural chemical processes. Although removing the mercury already discharged from the Amazonian environment may be an enormous task, at least future discharges should be curtailed through the use of appropriate technology, environmental education, and a combination of command and control measures and market-based incentives. The author describes the gold extraction process and the extent of mercury use and contamination. He analyzes key elements of the environmental problem, especially the informal miner and the fish economy. Finally, he suggests a combination of command and control regulations and market-based incentives adapted to the informal gold mining economic environment. He emphasizes the need for an education campaign about the perils of using mercury and the availability of more appropriate, and inexpensive, alternative extraction technologies.Mining&Extractive Industry (Non-Energy),Montreal Protocol,Water and Industry,Coastal and Marine Resources,Primary Metals
Gold Rush Queen The Extraordinary Life of Nellie Cashman
No full textIntro -- Title Page -- Dedication -- Contents -- Introduction -- Chapter One: Early Years -- Chapter Two: The Southwest -- Chapter Three: The Cassiar -- Chapter Four: Arizona -- Chapter Five: Baja and Tombstone -- Chapter Six: Restless Feet -- Chapter Seven: The Klondike Trail -- Chapter Eight: Dawson -- Chapter Nine: Alaska -- Endnotes -- Bibliography -- Acknowledgments -- Index -- About the Author -- Copyright PageDescription based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
1 X 1 Rush Hour with Fixed Blocks Is PSPACE-Complete
No full textConsider n²-1 unit-square blocks in an n × n square board, where each block is labeled as movable horizontally (only), movable vertically (only), or immovable - a variation of Rush Hour with only 1 × 1 cars and fixed blocks. We prove that it is PSPACE-complete to decide whether a given block can reach the left edge of the board, by reduction from Nondeterministic Constraint Logic via 2-color oriented Subway Shuffle. By contrast, polynomial-time algorithms are known for deciding whether a given block can be moved by one space, or when each block either is immovable or can move both horizontally and vertically. Our result answers a 15-year-old open problem by Tromp and Cilibrasi, and strengthens previous PSPACE-completeness results for Rush Hour with vertical 1 × 2 and horizontal 2 × 1 movable blocks and 4-color Subway Shuffle
Performance of rush-hour lanes and pluslanes: A study to behavioral factors and design factors
No full textRush-hour lanes and pluslanes have been operational in the Netherlands since 1996. They are intended as a measure to increase capacity without the need to add an extra lane to the cross section. Individually, rush-hour lanes and pluslanes have been evaluated. However, not much research, however, compares rush-hour lane or pluslane designs with each other. In this research, long-term data will be used to get detailed information about the performance of different rush-hour lane and pluslane designs. Also, a driving simulator study is performed to gain insight in the underlying behavioral factors and to analyze the performance of changes in rush-hour lane designs. The main question for the research is: What is the performance of rush-hour lanes and pluslanes, what are the behavioral factors and design factors causing differences in performance and what changes can be made to the design of rush-hour lanes to improve the performance? In the ex-post evaluation of performance, data is used for a period of 120 days of 5 highway sections with a rush-hour lane and 5 highway sections with a pluslane. The sections are compared using lane flow distributions that show the occupation of the lanes and intensity-speed relations that show the differences in free-flow speeds driven on the sections. In the first analysis, rush-hour lanes are compared with regular right lanes and pluslanes are compared with regular left lanes. The rush-hour lane section at the A50 between junction Ewijk and junction Valburg is designed in the driving simulator to analyze the behavioral factors that underlie the results from this first comparison. Also, a comparison is made between the occupation of different locations at rush-hour lanes and pluslanes. For this purpose, the start section and the end section are compared with a turbulence-free section. As a final analysis, the design factors that are researched for their influence on performance are: the lane width, the speed limit and the total number of lanes. A lot of variation in these design factors can be found on the rush-hour lane and pluslane sections that have been implemented today. However, some designs have not been implemented yet. The driving simulator provided the perfect opportunity to test new designs of rush-hour lanes. The simulator is used to test the influence of reducing the signaling by 50% and the influence of changing the markings from continuous to broken on the occupation of rush-hour lanes. Regarding the design factors, it can be concluded from this research that a high speed limit of 120 km/h has a negative effect on the occupation of rush-hour lanes and also on the speeds driven at rush-hour lane sections. The car-following behavior of vehicles on a rush-hour lane section with such speed limit is researched in the driving simulator study. It shows that the incentive of using the rush-hour lane at this speed limit is low. Changing the markings from continuous to broken in the driving simulator does not affect the occupation of the rush-hour lane at 120 km/h. Also, reducing the signaling by half does not affect the occupation. Further research needs to show if these design factors have an influence on the occupation of rush-hour lanes at lower speed limits. The models that are implemented in the simulator at the Delft University of Technology are not realistic enough for this kind of research, as the behavior of virtual traffic influences the results too much. Smaller lane widths appear to have a negative effect on the occupation of rush-hour lanes and on the speeds driven at rush-hour lane sections. This could, however, not be concluded from this research alone. At pluslane sections with a combination between a high speed limit (100 km/h) and a small lane width (< 2,80 m) the occupation of the pluslane becomes significantly less. Adding an extra lane to the section (making it 3+1) lowers the intensity shares at low intensity levels for that section for both rush-hour lanes and pluslanes. At higher intensity levels, no significant differences were found. Quantifying the influence of the design factors on the performance of rush-hour lanes and pluslanes is an interesting subject for further research. The performance of managed lanes to be implemented in the future can then be predicted by a model before realization. The differences between start sections and end sections also need to be analyzed in more detail for this purpose. The combination between an ex-post evaluation and a driving simulator study as is used in this research can also be well-suited for that new research.Transport & PlanningCivil Engineering and Geoscience
The impact of item-writing flaws and item complexity on examination item difficulty and discrimination value
No full textCitation: Rush, B. R., Rankin, D. C., & White, B. J. (2016). The impact of item-writing flaws and item complexity on examination item difficulty and discrimination value. BMC Medical Education, 16(1). doi:10.1186/s12909-016-0773-3Background: Failure to adhere to standard item-writing guidelines may render examination questions easier or more difficult than intended. Item complexity describes the cognitive skill level required to obtain a correct answer. Higher cognitive examination items promote critical thinking and are recommended to prepare students for clinical training. This study evaluated faculty-authored examinations to determine the impact of item-writing flaws and item complexity on the difficulty and discrimination value of examination items used to assess third year veterinary students. Methods: The impact of item-writing flaws and item complexity (cognitive level I-V) on examination item difficulty and discrimination value was evaluated on 1925 examination items prepared by clinical faculty for third year veterinary students. Results: The mean (± SE) percent correct (83.3 % ± 17.5) was consistent with target values in professional education, and the mean discrimination index (0.18 ± 0.17) was slightly lower than recommended (0.20). More than one item-writing flaw was identified in 37.3 % of questions. The most common item-writing flaws were awkward stem structure, implausible distractors, longest response is correct, and responses are series of true-false statements. Higher cognitive skills (complexity level III-IV) were required to correctly answer 38.4 % of examination items. As item complexity increased, item difficulty and discrimination values increased. The probability of writing discriminating, difficult examination items decreased when implausible distractors and all of the above were used, and increased if the distractors were comprised of a series of true/false statements. Items with four distractors were not more difficult or discriminating than items with three distractors. Conclusion: Preparation of examination questions targeting higher cognitive levels will increase the likelihood of constructing discriminating items. Use of implausible distractors to complete a five-option multiple choice question does not strengthen the discrimination value. © 2016 The Author(s)
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