93 research outputs found

    Will Cockrell on Everest, Inc.

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    Will Cockrell is the author of the book Everest, Inc.: The Renegades and Rogues Who Built an Industry at the Top of the World, a fascinating history of the guiding industry on the world’s highest peak. In this episode, Justin and Will discuss how his book challenges misconceptions about Everest, the evolving role of Sherpas, and why this mountain holds such a firm grip on our psyche.https://scholarworks.umt.edu/anewangle_podcasts/1342/thumbnail.jp

    A Conversation with Adam Heller

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    Adam Heller, Ernest Cockrell Sr. Chair in Engineering Emeritus of the John J. McKetta Department of Chemical Engineering at The University of Texas at Austin, recalls his childhood in the Holocaust and his contributions to science and technology that earned him the US National Medal of Technology and Innovation in a conversation with Elton J. Cairns, Professor of Chemical and Biomolecular Engineering at the University of California, Berkeley. Dr. Heller, born in 1933, describes the enslavement of his father by Hungarians in 1942; the confiscation of his family's home, business, and all its belongings in 1944; and his incarceration in a brick factory with 18,000 Jews who were shipped by the Hungarians to be gassed by Germans in Auschwitz. Dr. Heller and his immediate family survived the Holocaust and arrived in Israel in 1945. He studied under Ernst David Bergmann at the Hebrew University, and then worked at Bell Laboratories and GTE Laboratories, where he headed Bell Lab's Electronic Materials Research Department. At GTE Laboratories, he built in 1966 the first neodymium liquid lasers and in 1973 with Jim Auborn conceived and engineered the lithium thionyl chloride battery, one of the first to be manufactured lithium batteries, which is still in use. After joining the faculty of engineering of The University of Texas at Austin, he cofounded with his son Ephraim Heller TheraSense, now a major part of Abbott Diabetes Care, which produced a microcoulometer that made the monitoring of glucose painless by accurately measuring the blood glucose concentration in 300 nL of blood. He also describes the electrical wiring of enzymes, the basis for Abbott's state-of-the-art continuous glucose monitoring system. He discusses his perspective of reducing the risk of catastrophic global warming in a wealth-accumulating, more-energy-consuming world and provides advice for students entering careers in science or engineering

    Data adjuvant therapy dose schedules

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    Data file of simulated dose schedules that prevent the recurrence of colon cancer by apoptotic adjuvant therapy. Includes numerical data in columns for Interval, Duration, Treatment, and 50-year dose sum, ranked by 50-year dose sum. Supplementary file for article tentatively titled “Prevention of Colon Cancer Recurrence from Minimal Residual Disease: Computer Optimized Dose Schedule of Intermittent Apoptotic Adjuvant Therapy.”No restriction on public acces

    Supply market analysis: The moderating effect of social networking on cost reduction

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    As organizations look for more efficient ways to grow and optimize their supplier network to meet demands, the sourcing process must be streamlined through social networking. Kraljic’s (1983) purchasing portfolio approach argues that different types of purchases need different sourcing strategies. This study extends beyond this strategy by introducing a novel approach of social networking as a mechanism to amplify cost reduction. Through the theoretical underpinning of Transaction Cost Theory, this study builds upon the use of social networking to establish the foundation for future research in this area. In this study, existing and former Purchasing Managers (Sourcing Managers, Procurement Managers, or Buyers), responded to an online survey about their experience with purchasing in the context of three areas: supply market analysis, social networking, and cost reduction. Results revealed that Purchasing Managers use social networking as a strategic sourcing approach to find competitive suppliers. The strategic sourcing approach is identified as supply market analysis, which is the sourcing or supplier research aspect of the 7-step strategic sourcing methodology

    Curse of the Porcupine’s Ear (2006) | Image 001

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    Pictured: Andrea Messick, Chauncey Slater, Brian Seitel, Coty Cockrell, Britani Mason, Leesa Tucker, Steven DiBlasi, Ashley McDonald; Performed: 22-25 June 2006; Wayne Claeren\u27s The Curse of the Porcupine’s Ear is a comedy mystery set in a rustic cabin in the woods. Two honeymooners retreat to the woods to be alone, but are frustrated by invasions of many odd characters. The play was directed by Wayne H. Claeren, scenic designer and producer was Carlton Ward, costume designer was Freddy Clements, lighting design and technical director was David Keefer, sound designer was Adam Ellis, stage manager was Chris Whetstone. This item is contained within the Theatre & Film Production Archive.https://digitalcommons.jsu.edu/productions_images/9092/thumbnail.jp

    Insights into the mechanisms of HIV-1 cis elements and trans factors required for RNA encapsidation and transduction

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    The retroviral replication process is typically separated into early events of infection for the virus to enter a host cell, and late events that generate new viral particles. Encapsidation (late event) and early infection events are governed by several different cis elements located in the viral RNA, and viral, or cellular, trans factors (proteins). A number of viral encoded components have been identified to function in the encapsidation process, most notably the Gag polyprotein and genomic RNA cis elements in the 5' untranslated region (UTR). Although conventionally associated with nuclear export of HIV-1 RNA, there is also a burgeoning role for the Rev/RRE in the encapsidation process. Additionally, cis elements of the RNAs encapsidated into viral particles may influence different early stages of infection into host cells. This dissertation employs an innovative approach that affords separation of cis and trans viral components to investigate their independent, and combined, effects on encapsidation and early events of infection that will be referred to as transduction. HIV-1 cis elements were reconstructed in the context of heterologous RNAs to assess encapsidation and transduction functions. This work demonstrates for the first time that the Rev/RRE system can augment heterologous RNA encapsidation independent of all cis elements from the 5' UTR. In fact, the Rev/RRE system appears to be required for specific and efficient encapsidation into HIV-1 viral particles, a process more commonly associated with Gag recognition of the canonical packaging signal in the 5' UTR. Premised on encapsidation of a heterologous RNA into HIV-1 viral particles, our findings define a functional HIV-1 packaging system as comprising the 5' UTR cis elements, Gag, and the Rev/RRE system, in which the Rev/RRE system is required to make the RNA amenable to ensuing interactions between Gag and the canonical packaging signal for subsequent encapsidation. Lastly, we show that heterologous RNAs can conform to transduction properties commonly associated with HIV-1 viral particles. Furthermore, some heterologous RNAs exhibit an episomal profile in transduced cells that may have improved safety benefits over more conventional nonintegrating lentiviral vectors. These innovative vector systems may prove beneficial for therapeutic gene delivery to nondividing cells
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