16,100 research outputs found
Professor Abrams offers four commonsense ideas for police reform
No full textPenn Law professor David Abrams offers insight into his new article that was recently published in The Hill, “Four commonsense ways to reform policing in America.
Professor Abrams’ City Crime Stats is your window into the relation between Covid-19 and city crime
No full textProfessor David Abrams’ City Crime Stats gives an overview of crime statistics across 28 cities during the pandemic
Erratum to: Analysis of E-cigarette use in the 2014 Eurobarometer survey: calling out deficiencies in epidemiology methods
No full textThe article Analysis of E-cigarette use in the 2014 Eurobarometer survey: calling out deficiencies in epidemiology methods, written by Riccardo Polosa, Pasquale Caponnetto, Ray Niaura, David Abrams, was originally published electronically on the publisher’s internet portal (currently SpringerLink) on May 5, 2017 without open access
Newton's Laws
No full textAuthored and curated by David P. Stern, this series of web pages, part of "From Stargazers to Starships," describes Newton's three laws of motion and the two concepts on which they are based, force and inertia. The author breaks down the page in this fashion: the concept of force, motion against outside resistance, and motion with significant resistance. The author also provides additional links for further study on the life of Issac Newton. A lesson plan for instructors is also provided
C.C. Slaughter's Lazy S Ranch in Cochran and Hockley counties, 1898-1921.
No full textLikely added to or created for the author's thesis: "A Cattle Kingdom on Texas' Last Frontier: C. C. Slaughter's Lazy S Ranch" (Texas Tech University, 1970).Scale approximately 1:337,920 (W 102°59'24"--W 102°18'53"/N 33°50'54"--N 33°24'07")The map illustrates the 250,000-acre holdings of C.C. Slaughter, known as the "Cattle King of Texas," before the ranch's liquidation and subdivision beginning in 1921 (following his death in 1919)
Dr. David Salisbury – Faculty Author Interview
No full textDavid Salisbury, Assistant Professor of Geography and the Environment, discusses his recent article, “Fronteras Vivas or Dead Ends? The Impact of Military Settlement Projects in the Amazon Borderlands”, in the Journal of Latin American Geography. This article describes a case study in the Peruvian Amazon which explores the natural resource management, household economics, and political geography of a borderland military base and associated settlement
Remembering BC\u27s 1983 Solidarity Uprising — with David Spaner
No full textBio: David Spaner has worked as a feature writer, movie critic, reporter, and editor for numerous newspapers and magazines. David\u27s also been a cultural/political organizer (Yippie, manager of the punk band The Subhumans). He is the author of Dreaming in the Rain and Shoot It! Hollywood, Inc. and the Rising of Independent Film.In 2021, Spaner published a behind-the-scenes book about the Solidarity resistance movement, Solidarity: Canada\u27s Unknown Revolution of 1983 (Ronsdale 2021) documenting the event using intimate storytelling and melding cultural and rebel politics to provide insight into the conflicts that are still with us. It was the largest political protest in the province\u27s history and threatened to end in an all-out general strike. Resources: Solidarity: Canada\u27s Unknown Revolution of 1983 (Ronsdale 2021): https://ronsdalepress.com/all-books/solidarity/SHOOT IT! Hollywood Inc. and the Rising of Independent Film (Arsenal Pulp Press 2012): https://arsenalpulp.com/Books/S/Shoot-ItDreaming in the Rain: How Vancouver Became Hollywood North by Northwest (Arsenal Pulp Press 2002): https://arsenalpulp.com/Books/D/Dreaming-in-the-Rai
Evolution of cooperation among tumor cells
No full textThe evolution of cooperation has a well established theoretical framework based on game theory. This approach has made valuable contributions to a wide variety of disciplines, including political science, economics, and evolutionary biology. Existing cancer theory suggests that individual clones of cancer cells evolve independently from one another, acquiring all of the genetic traits or hallmarks necessary to form a malignant tumor. It is also now recognized that tumors are heterotypic, with cancer cells interacting with normal stromal cells within the issue microenvironment, including endothelial, stromal, and nerve cells. This tumor cell???stromal cell interaction in itself is a form of commensalism, because it has been demonstrated that these nonmalignant cells support and even enable tumor growth. Here, we add to this theory by regarding tumor cells as game players whose interactions help to determine their Darwinian fitness. We marshal evidence that tumor cells overcome certain host defenses by means of diffusible products. Our original contribution is to raise the possibility that two nearby cells can protect each other from a set of host defenses that neither could survive alone. Cooperation can evolve as byproduct mutualism among genetically diverse tumor cells. Our hypothesis supplements, but does not supplant, the traditional view of carcinogenesis in which one clonal population of cells develops all of the necessary genetic traits independently to form a tumor. Cooperation through the sharing of diffusible products raises new questions about tumorigenesis and has implications for understanding observed phenomena, designing new experiments, and developing new therapeutic approaches.Author manuscript. Published in final edited form as: Proc Natl Acad Sci U S A. 2006 September 5; 103(36): 13474-13479.The final published version of this article is located at: www.pnas.org/cgi/doi/10.1073/pnas.0606053103NIH U56 CA113004; to David E. AxelrodR.A. was supported by National Science Foundation (NSF) Grant SES-0240852. D.E.A. was supported by NSF Grant IIS-0312953, National Institutes of Health (NIH) Grant U56 CA113004, and New Jersey Commission on Cancer Research Grant 1076-CCR-SO. K.J.P. is an American Cancer Society Clinical Research Professor and is supported by NIH Grants CA69568, CA102872, and CA093900.NIH CA69568; to Kenneth J. PientaNIH CA102872; to Kenneth J. PientaNIH CA093900; to Kenneth J. PientaNSF SES-0240852; to Robert AxelrodNJ Commission on Cancer Research 1076-CCR-SO; to David E. AxelrodAlso available in PubMed Central. PMCID: PMC155738
The M1 Abrams tank: a case study in major weapon systems acquisition and program management
No full textThe end of the Cold War has had a tremendous impact on the structure, size, and capabilities of the United States Armed Forces. The Defense buildup period of the early 1980's in which new programs flourished, is over. At a time when Defense dollars and resources are waning, both successful and unsuccessful acquisition programs must be closely scrutinized to learn how to most efficiently utilize current technology, private industry, and the existing industrial base. One highly-successful acquisition program worthy of study and review is the United States Army's Ml Abrams Tank Program. This program's acquisition strategy was well-planned and executed, efficiently managed, and amply supported by all constituents involved in the acquisition process. This analysis of the M1 Abrams acquisition strategy has provided numerous lessons-learned that can be practically applied to future major weapon system procurements. This study concludes that program advocacy, continuous interface between the program office and the end-user community, and continuity of key program personnel are but a few of the many reasons why the Ml Abrams family of vehicles is the most lethal, survivable, and technologically advanced main battle tank in the world today.NANAU.S. Army (USA) authorhttp://archive.org/details/themabramstankca109453147
Dynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy
No full textWe report single-molecule measurements on the folding and unfolding conformational equilibrium distributions and dynamics of a disulfide crosslinked version of the two-stranded coiled coil from GCN4. The peptide has a fluorescent donor and acceptor at the N termini of its two chains and a Cys disulfide near its C terminus. Thus, folding brings the two N termini of the two chains close together, resulting in an enhancement of fluorescent resonant energy transfer. End-to-end distance distributions have thus been characterized under conditions where the peptide is nearly fully folded (0 M urea), unfolded (7.4 M urea), and in dynamic exchange between folded and unfolded states (3.0 M urea). The distributions have been compared for the peptide freely diffusing in solution and deposited onto aminopropyl silanized glass. As the urea concentration is increased, the mean end-to-end distance shifts to longer distances both in free solution and on the modified surface. The widths of these distributions indicate that the molecules are undergoing millisecond conformational fluctuations. Under all three conditions, these fluctuations gave nonexponential correlations on 1- to 100-ms time scale. A component of the correlation decay that was sensitive to the concentration of urea corresponded to that measured by bulk relaxation kinetics. Thetrajectories provided effective intramolecular diffusion coefficients as a function of the end-to-end distances for the folded and unfolded states. Single-molecule folding studies provide information concerning the distributions of conformational states in the folded, unfolded, and dynamically interconverting states.Author manuscript. Published in final edited form as: Proc Natl Acad Sci U S A. 2000 November 21; 97(24): 13021-13026.The final published version of this article is located at: http://www.pnas.org/cgi/reprint/97/24/13021NIH GM54616; to William F. DeGradoNIH GM12592; to Robin M. HochstrasserNIH GM48130; to William F. Degrado and Robin M. HochstrasserThis work was supported by GM54616 (to W.F.D.), GM12592 (to R.M.H.) and GM48130 (to W.F.D. and R.M.H.) with instrumentation developed under RR01348. D.S.T. was supported by National Institutes of Health Grant NRSA F32-GM18589.Also available in PubMed Central. PMCID:PMC2717
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