363 research outputs found
Travel literature and the development of the novel in eighteenth-century France
No full text"Travel Literature and the Development of the Novel in Eighteenth-Century France" follows the evolution of the French novel throughout the eighteenth century by examining the epistemological, aesthetic, and literary exchanges between historiography, travel literature, and the novel, three separate yet intertwined modes of representation that were in the process of creating or recreating their modern identities through a systematization of coherent literary rules. I argue that essential changes in the conceptualization and writing of history led to similar developments in the way travel accounts were written, organized, and consumed. As travel literature strengthened its own generic distinctiveness, novelists depicting foreign characters and/or landscapes selectively appropriated the legitimating discourse of travel literature to create an autonomous literary space for the novel. As these novels emulate travel literature, they critically incorporate the problematic questions of legitimacy of travel accounts, and force the novel's claims of truth to take place within a historical methodology discourse which in turn legitimizes it, delineating distinct profiles for history and fiction alike.Ph.D.Includes bibliographical references (p. 227-251)by Aya Tanak
Analysis of the September ε-Perseid outburst in 2013
No full text© 2018 The Author(s). Artículo firmado por 14 autores. We acknowledge support from the Spanish Ministry of Science and Innovation (projects AYA2015-68646-P and AYA 2015-67175-P).We analyze the outburst experienced by the September ε-Perseid meteor shower on 9 September 2013. As a result of our monitoring the atmospheric trajectory of 60 multistation events observed over Spain was obtained and accurate orbital data were derived from them. On the basis of these orbits, we have tried to determine the likely parent body of this meteoroid stream by employing orbital dissimilarity criteria. In addition, the emission spectra produced by two events belonging to this meteor shower were also recorded. The analysis of these spectra has provided information about the chemical nature of their progenitor meteoroids. We also present an estimation of the tensile strength for these particles.Ministerio de Ciencia e Innovación (MICINN)Depto. de Física de la Tierra y AstrofísicaFac. de Ciencias FísicasTRUEpu
Diagnostic accuracy of repetitive nerve stimulation in myasthenia gravis: A systematic review and meta-analysis
No full textOnce were Positivists: A Reply to Aya
No full textTbere are two basic issues in tbis essay. The first is tbe sloppy use of tbe term
'postmodernism' to designate a more or less organised collection of unsavoury
academics, who (it is argued) subscribe to various forms of nihilism and epistemological
hypochondria for some, as-yet-to-be-determined but clearly nefarious,
ends. The exact composition of this group is left vague (although the author
clearly has bis own list). It presumably includes a fair sampling of theorists of the
French persuasion, most feminists, authors who are interested in the entwining of
power and knowledge in human life, and nearly all 'relativists' who reject monistic
certainty. For Aya, the term clearly saves time, basically by assuring himself that
there has been little really worth reading in the social sciences (at least in anthropology)
for the past quarter century or so
Clinical application of genomic profiling to find druggable targets for adolescent and young adult (AYA) cancer patients with metastasis
No full textThis article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made.Background: Although adolescent and young adult (AYA) cancers are characterized by biological features and clinical outcomes distinct from those of other age groups, the molecular profile of AYA cancers has not been well defined. In this study, we analyzed cancer genomes from rare types of metastatic AYA cancers to identify driving and/or druggable genetic alterations. Methods: Prospectively collected AYA tumor samples from seven different patients were analyzed using three different genomics platforms (whole-exome sequencing, whole-transcriptome sequencing or OncoScan (TM)). Using well-known bioinformatics tools (bwa, Picard, GATK, MuTect, and Somatic Indel Detector) and our annotation approach with open access databases (DAVID and DGIdb), we processed sequencing data and identified driving genetic alterations and their druggability. Results: The mutation frequencies of AYA cancers were lower than those of other adult cancers (median = 0.56), except for a germ cell tumor with hypermutation. We identified patient-specific genetic alterations in candidate driving genes: RASA2 and NF1 (prostate cancer), TP53 and CDKN2C (olfactory neuroblastoma), FAT1, NOTCH1, and SMAD4 (head and neck cancer), KRAS (urachal carcinoma), EML4-ALK (lung cancer), and MDM2 and PTEN (liposarcoma). We then suggested potential drugs for each patient according to his or her altered genes and related pathways. By comparing candidate driving genes between AYA cancers and those from all age groups for the same type of cancer, we identified different driving genes in prostate cancer and a germ cell tumor in AYAs compared with all age groups, whereas three common alterations (TP53, FAT1, and NOTCH1) in head and neck cancer were identified in both groups. Conclusion: We identified the patient-specific genetic alterations and druggability of seven rare types of AYA cancers using three genomics platforms. Additionally, genetic alterations in cancers from AYA and those from all age groups varied by cancer type.Y
SPITZER’S CONTRIBUTION TO THE AGN POPULATION
No full textRights Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author
Analysis of the September ε-Perseid outburst in 2013
No full text© 2018 The Author(s) Published by Oxford University Press on behalf of the Royal Astronomical Society. We acknowledge support from the Spanish Ministry of Science and Innovation (projects AYA2015-68646-P and AYA 2015-67175-P).We analyse the outburst experienced by the September epsilon-Perseid meteor shower on 2013 September 9. As a result of our monitoring, the atmospheric trajectory of 60 multistation events observed over Spain was obtained and accurate orbital data were derived from them. On the basis of these orbits, we have tried to determine the likely parent body of this meteoroid stream by employing orbital dissimilarity criteria. In addition, the emission spectra produced by two events belonging to this meteor shower were also recorded. The analysis of these spectra has provided information about the chemical nature of their progenitor meteoroids. We also present an estimation of the tensile strength for these particles.Ministerio de Ciencia e Innovación (MICINN)Depto. de Física de la Tierra y AstrofísicaFac. de Ciencias FísicasTRUEpu
Perceptions of stress in adolescent and young adult (AYA) cancer patients and survivors in Kansas City, KS, and Copenhagen, Denmark: A pilot study.
No full text 186 Background: Adolescent and Young Adult (AYA) Oncology is a developing field of medicine with unique challenges in the clinical setting. People at this stage of life face many difficulties, which may be compounded by lack of insurance coverage and barriers in accessing health care resources. The goal of this pilot study is to examine how stress levels and psychosocial well-being are affected by healthcare system, insurance status, and other AYA-specific factors. Methods: 38 AYA patients ages 15-30 who have received, or are currently receiving treatment for an oncology diagnosis completed an online survey and 10-item interview, with 29 patients at University of Kansas Medical Center, Kansas City, United States, and 9 patients at Rigshospitalet, Copenhagen, Denmark. Survey measures included the Perceived Stress Scale (PSS) standardized tool, and questions relating to patient concerns, resources utilized, and general thoughts on healthcare. Results: Differences in quantitative stress levels were not significant between the two study sites. In Kansas City, female gender was identified as a significant variable for increased PSS values. In addition, Kansas City patients expressed increased reported practical concerns, such as the role of social workers, transportation, insurance, and disruptions in work and school life due to treatment. Danish patients expressed more positive practical concern statements, citing Danish government resources such as physical therapy and psychiatry services. Qualitative data for both sites placed highest emphasis on the connection that AYA patients have with their healthcare team. Both U.S. and Danish patients reported diverse concerns and positive experiences. Conclusions: AYA oncology patients are a diverse group who have not yet been sufficiently studied, and face many struggles that are unique to this age group. More research on a broad scale is needed, as the data collected in this study suggest results that may prove significant with more time available and larger patient sample sizes. The first author of this abstract has been selected as a semifinalist by the Fulbright commission to expand this pilot project in 2017-2018. </jats:p
Designing sexuality and intimacy care for adolescents and young adults (AYAs) with cancer
No full textAdolescents and Young Adults (AYAs) with Cancer are making the transition from childhood to adulthood while handling the burden of cancer. During this extraordinarily challenging time in their growth and development, sexuality and intimacy, an important aspect of AYAs’ wellbeing, are often insufficiently addressed by the healthcare providers, and AYAs are dissatisfied with the available information. The objective of this study was to develop objectives that could help design properly address sexuality and intimacy in AYA care along with a design prototype. The research investigated the big picture of sexuality and intimacy care for AYAs in the Netherlands and looked into AYAs’ unmet needs through literature study, interviews with AYA using the Q-sort method and interviews with healthcare providers. The list of design objectives was proposed based on the interviewees’ opinions and insights, along with an iterative prototype designed by the researcher that reflected the objectives. Through a cyclic interview process, the list of design objectives was revised, and the prototype was refined as a possible solution in the end. Finally, a conclusion on the research findings and the design objectives is providedaccepted author manuscriptApplied Ergonomics and DesignDesign Aesthetic
- …
