83 research outputs found
The HTLV-I model and chronic demyelinating neurologic diseases
No full textKrämer A, Blattner WA. The HTLV-I model and chronic demyelinating neurologic diseases. In: Notkins AL, Oldstone MBA, eds. Concepts in Viral Pathogenesis. Vol 3. New York, NY u.a.: Springer; 1989: 204-214
Half-life of polyreactive antibodies
No full textMonoclonal polyreactive antibodies bind to a variety of self and foreign antigens. In contrast, monoclonal monoreactive antibodies bind to a single or restricted number of known antigens. The rate at which polyreactive antibodies are removed from the circulation compared to monoreactive antibodies has not been determined. In the present experiments, human monoclonal polyreactive and monoreactive antibodies of different isotypes were injected intravenously into mice and the clearance from the circulation was determined. The half-life of polyreactive IgM, IgA, and IgG antibodies was 8.0, 8.2, and 9.8 hr, respectively, compared to 35.4, 26.6, and 280 hr for monoreactive IgM, IgA, and IgG antibodies, respectively. Examination of tissue sections from animals given intravenous antibody showed substantial deposition of polyreactive, but not monoreactive, antibodies in several organs, the liver being the principal site of deposition. It is concluded that polyreactive antibodies are cleared from the circulation substantially faster than monoreactive antibodies
INTERFERON AS A MEDIATOR OF CELLULAR IMMUNITY IN VIRAL INFECTIONS In recognition of the author's work undertaken as part of his official duty as a U. S. Government employee, this chapter is not covered by copyright.
No full textINFECTIOUS VIRUS-ANTIBODY COMPLEXES: INTERACTION WITH ANTI-IMMUNOGLOBULINS, COMPLEMENT, AND RHEUMATOID FACTOR
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